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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7621

FusionGeneSummary for CMTM7_CMTM8

check button Fusion gene summary
Fusion gene informationFusion gene name: CMTM7_CMTM8
Fusion gene ID: 7621
HgeneTgene
Gene symbol

CMTM7

CMTM8

Gene ID

112616

152189

Gene nameCKLF like MARVEL transmembrane domain containing 7CKLF like MARVEL transmembrane domain containing 8
SynonymsCKLFSF7CKLFSF8|CKLFSF8-V2
Cytomap

3p22.3

3p22.3

Type of geneprotein-codingprotein-coding
DescriptionCKLF-like MARVEL transmembrane domain-containing protein 7chemokine-like factor super family 7chemokine-like factor super family member 7 variant 2chemokine-like factor superfamily 7chemokine-like factor superfamily member 7CKLF-like MARVEL transmembrane domain-containing protein 8chemokine-like factor superfamily member 8
Modification date2018052320180523
UniProtAcc

Q96FZ5

Q8IZV2

Ensembl transtripts involved in fusion geneENST00000334983, ENST00000349718, 
ENST00000458535, ENST00000307526, 
Fusion gene scores* DoF score7 X 4 X 5=1402 X 1 X 2=4
# samples 72
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: CMTM7 [Title/Abstract] AND CMTM8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A9SK-01ACMTM7chr3

32433557

+CMTM8chr3

32409364

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000334983ENST00000458535CMTM7chr3

32433557

+CMTM8chr3

32409364

+
In-frameENST00000334983ENST00000307526CMTM7chr3

32433557

+CMTM8chr3

32409364

+
In-frameENST00000349718ENST00000458535CMTM7chr3

32433557

+CMTM8chr3

32409364

+
In-frameENST00000349718ENST00000307526CMTM7chr3

32433557

+CMTM8chr3

32409364

+

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FusionProtFeatures for CMTM7_CMTM8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMTM7

Q96FZ5

CMTM8

Q8IZV2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCMTM8chr3:32433557chr3:32409364ENST00000307526+14105_125107174TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000307526+14147_167107174TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000458535+03105_12549116TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000458535+03147_16749116TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000458535+0370_9049116TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCMTM7chr3:32433557chr3:32409364ENST00000334983+1540_16653176DomainMARVEL
HgeneCMTM7chr3:32433557chr3:32409364ENST00000349718+1440_16653143DomainMARVEL
HgeneCMTM7chr3:32433557chr3:32409364ENST00000334983+15110_13053176TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000334983+15140_16053176TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000334983+1543_6353176TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000334983+1577_9753176TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000349718+14110_13053143TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000349718+14140_16053143TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000349718+1443_6353143TransmembraneHelical
HgeneCMTM7chr3:32433557chr3:32409364ENST00000349718+1477_9753143TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000307526+1436_168107174DomainMARVEL
TgeneCMTM8chr3:32433557chr3:32409364ENST00000458535+0336_16849116DomainMARVEL
TgeneCMTM8chr3:32433557chr3:32409364ENST00000307526+1440_60107174TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000307526+1470_90107174TransmembraneHelical
TgeneCMTM8chr3:32433557chr3:32409364ENST00000458535+0340_6049116TransmembraneHelical


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FusionGeneSequence for CMTM7_CMTM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMTM7_CMTM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMTM7LMNACMTM8TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMTM7_CMTM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMTM7_CMTM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource