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Fusion gene ID: 7616 |
FusionGeneSummary for CMTM4_SULT1E1 |
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Fusion gene information | Fusion gene name: CMTM4_SULT1E1 | Fusion gene ID: 7616 | Hgene | Tgene | Gene symbol | CMTM4 | SULT1E1 | Gene ID | 146223 | 6783 |
Gene name | CKLF like MARVEL transmembrane domain containing 4 | sulfotransferase family 1E member 1 | |
Synonyms | CKLFSF4 | EST|EST-1|ST1E1|STE | |
Cytomap | 16q21-q22.1 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | CKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4 | estrogen sulfotransferaseestrone sulfotransferasesulfotransferase 1E1sulfotransferase family 1E, estrogen-preferring, member 1sulfotransferase, estrogen-preferring | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8IZR5 | P49888 | |
Ensembl transtripts involved in fusion gene | ENST00000330687, ENST00000394106, ENST00000563952, | ENST00000226444, | |
Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CMTM4 [Title/Abstract] AND SULT1E1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SULT1E1 | GO:0006068 | ethanol catabolic process | 23207770 |
Tgene | SULT1E1 | GO:0006711 | estrogen catabolic process | 23207770 |
Tgene | SULT1E1 | GO:0008210 | estrogen metabolic process | 11884392 |
Tgene | SULT1E1 | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 23207770 |
Tgene | SULT1E1 | GO:0051923 | sulfation | 19548878|20056724|23207770 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-BA-A4IG-01A | CMTM4 | chr16 | 66730243 | - | SULT1E1 | chr4 | 70723371 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000330687 | ENST00000226444 | CMTM4 | chr16 | 66730243 | - | SULT1E1 | chr4 | 70723371 | - |
5CDS-5UTR | ENST00000394106 | ENST00000226444 | CMTM4 | chr16 | 66730243 | - | SULT1E1 | chr4 | 70723371 | - |
intron-5UTR | ENST00000563952 | ENST00000226444 | CMTM4 | chr16 | 66730243 | - | SULT1E1 | chr4 | 70723371 | - |
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FusionProtFeatures for CMTM4_SULT1E1 |
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Hgene | Tgene |
CMTM4 | SULT1E1 |
Acts as a backup for CMTM6 to regulate plasma membraneexpression of PD-L1/CD274, an immune inhibitory ligand criticalfor immune tolerance to self and antitumor immunity. May protectPD-L1/CD274 from being polyubiquitinated and targeted fordegradation. {ECO:0000269|PubMed:28813410}. | Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of estradiol and estrone. May play a role in theregulation of estrogen receptor activity by metabolizing freeestradiol. Maximally sulfates beta-estradiol and estrone atconcentrations of 20 nM. Also sulfates dehydroepiandrosterone,pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and1-naphthol, at significantly higher concentrations; however,cortisol, testosterone and dopamine are not sulfated.{ECO:0000269|PubMed:11884392}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CMTM4_SULT1E1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CMTM4_SULT1E1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CMTM4 | MRPL2, APPL1, TMEM171, PTGER3, MANSC1, LPAR1, VIPR2, SLC7A1, SPPL2B, MPPE1, TRIM25 | SULT1E1 | ENOX1, SULT2B1, C14orf1, COPS6, RBM48, IGSF21, EEF1A1, LRIF1, SETDB1, TP53, UNC119, PDE9A, AGL, GK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CMTM4_SULT1E1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SULT1E1 | P49888 | DB01176 | Cyclizine | Estrogen sulfotransferase | small molecule | approved |
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RelatedDiseases for CMTM4_SULT1E1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SULT1E1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | SULT1E1 | C0023895 | Liver diseases | 1 | CTD_human |
Tgene | SULT1E1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | SULT1E1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | SULT1E1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |