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Fusion gene ID: 7611 |
FusionGeneSummary for CMTM4_CMTM3 |
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Fusion gene information | Fusion gene name: CMTM4_CMTM3 | Fusion gene ID: 7611 | Hgene | Tgene | Gene symbol | CMTM4 | CMTM3 | Gene ID | 146223 | 123920 |
Gene name | CKLF like MARVEL transmembrane domain containing 4 | CKLF like MARVEL transmembrane domain containing 3 | |
Synonyms | CKLFSF4 | BNAS2|CKLFSF3 | |
Cytomap | 16q21-q22.1 | 16q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | CKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4 | CKLF-like MARVEL transmembrane domain-containing protein 3chemokine-like factor superfamily member 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IZR5 | Q96MX0 | |
Ensembl transtripts involved in fusion gene | ENST00000330687, ENST00000394106, ENST00000563952, | ENST00000424011, ENST00000360086, ENST00000562707, ENST00000361909, ENST00000460097, ENST00000565666, ENST00000567572, ENST00000564060, ENST00000565922, ENST00000565003, ENST00000568477, ENST00000566121, | |
Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CMTM4 [Title/Abstract] AND CMTM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8077-01A | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000330687 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000330687 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000330687 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000330687 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000330687 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000330687 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
In-frame | ENST00000394106 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000394106 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000394106 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000394106 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-intron | ENST00000394106 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
5CDS-5UTR | ENST00000394106 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-3CDS | ENST00000563952 | ENST00000424011 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-intron | ENST00000563952 | ENST00000360086 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-intron | ENST00000563952 | ENST00000562707 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-intron | ENST00000563952 | ENST00000361909 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000460097 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000565666 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000567572 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000564060 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-intron | ENST00000563952 | ENST00000565922 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000565003 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000568477 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
intron-5UTR | ENST00000563952 | ENST00000566121 | CMTM4 | chr16 | 66730243 | - | CMTM3 | chr16 | 66642212 | + |
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FusionProtFeatures for CMTM4_CMTM3 |
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Hgene | Tgene |
CMTM4 | CMTM3 |
Acts as a backup for CMTM6 to regulate plasma membraneexpression of PD-L1/CD274, an immune inhibitory ligand criticalfor immune tolerance to self and antitumor immunity. May protectPD-L1/CD274 from being polyubiquitinated and targeted fordegradation. {ECO:0000269|PubMed:28813410}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000360086 | + | 0 | 3 | 36_155 | -142 | 60 | Domain | MARVEL |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000565922 | + | 0 | 2 | 36_155 | -25 | 60 | Domain | MARVEL |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000360086 | + | 0 | 3 | 101_121 | -142 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000360086 | + | 0 | 3 | 131_151 | -142 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000360086 | + | 0 | 3 | 64_84 | -142 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000361909 | + | 1 | 6 | 101_121 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000361909 | + | 1 | 6 | 131_151 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000361909 | + | 1 | 6 | 64_84 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000424011 | + | 1 | 6 | 101_121 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000424011 | + | 1 | 6 | 131_151 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000424011 | + | 1 | 6 | 64_84 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000562707 | + | 1 | 6 | 101_121 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000562707 | + | 1 | 6 | 131_151 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000562707 | + | 1 | 6 | 64_84 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000565922 | + | 0 | 2 | 101_121 | -25 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000565922 | + | 0 | 2 | 131_151 | -25 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000565922 | + | 0 | 2 | 64_84 | -25 | 60 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000567572 | + | 0 | 5 | 101_121 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000567572 | + | 0 | 5 | 131_151 | 49 | 183 | Transmembrane | Helical |
Tgene | >CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000567572 | + | 0 | 5 | 64_84 | 49 | 183 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000330687 | - | 1 | 5 | 49_176 | 62 | 235 | Domain | MARVEL |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000394106 | - | 1 | 4 | 49_176 | 62 | 209 | Domain | MARVEL |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000563952 | - | 1 | 4 | 49_176 | -61 | 180 | Domain | MARVEL |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000330687 | - | 1 | 5 | 123_143 | 62 | 235 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000330687 | - | 1 | 5 | 151_171 | 62 | 235 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000330687 | - | 1 | 5 | 59_79 | 62 | 235 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000330687 | - | 1 | 5 | 85_105 | 62 | 235 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000394106 | - | 1 | 4 | 123_143 | 62 | 209 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000394106 | - | 1 | 4 | 151_171 | 62 | 209 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000394106 | - | 1 | 4 | 59_79 | 62 | 209 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000394106 | - | 1 | 4 | 85_105 | 62 | 209 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000563952 | - | 1 | 4 | 123_143 | -61 | 180 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000563952 | - | 1 | 4 | 151_171 | -61 | 180 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000563952 | - | 1 | 4 | 59_79 | -61 | 180 | Transmembrane | Helical |
Hgene | >CMTM4 | chr16:66730243 | chr16:66642212 | ENST00000563952 | - | 1 | 4 | 85_105 | -61 | 180 | Transmembrane | Helical |
Tgene | CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000361909 | + | 1 | 6 | 36_155 | 49 | 183 | Domain | MARVEL |
Tgene | CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000424011 | + | 1 | 6 | 36_155 | 49 | 183 | Domain | MARVEL |
Tgene | CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000562707 | + | 1 | 6 | 36_155 | 49 | 183 | Domain | MARVEL |
Tgene | CMTM3 | chr16:66730243 | chr16:66642212 | ENST00000567572 | + | 0 | 5 | 36_155 | 49 | 183 | Domain | MARVEL |
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FusionGeneSequence for CMTM4_CMTM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CMTM4_CMTM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CMTM4 | MRPL2, APPL1, TMEM171, PTGER3, MANSC1, LPAR1, VIPR2, SLC7A1, SPPL2B, MPPE1, TRIM25 | CMTM3 | RABAC1, MEST, SPP1, APP, MOB1A, MOB3C, LMNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CMTM4_CMTM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CMTM4_CMTM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CMTM3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |