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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7603

FusionGeneSummary for CMPK1_TNNT1

check button Fusion gene summary
Fusion gene informationFusion gene name: CMPK1_TNNT1
Fusion gene ID: 7603
HgeneTgene
Gene symbol

CMPK1

TNNT1

Gene ID

51727

7138

Gene namecytidine/uridine monophosphate kinase 1troponin T1, slow skeletal type
SynonymsCK|CMK|CMPK|UMK|UMP-CMPK|UMPKANM|NEM5|STNT|TNT|TNTS
Cytomap

1p33

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionUMP-CMP kinaseUMP/CMP kinasecytidine monophosphate (UMP-CMP) kinase 1, cytosoliccytidylate kinasedCMP kinasedeoxycytidylate kinasenucleoside-diphosphate kinaseuridine monophosphate kinaseuridine monophosphate/cytidine monophosphate kinasetroponin T, slow skeletal muscleslow skeletal muscle troponin Ttroponin T type 1 (skeletal, slow)troponin-T1, skeletal, slow
Modification date2018051920180523
UniProtAcc

P30085

P13805

Ensembl transtripts involved in fusion geneENST00000371873, ENST00000450808, 
ENST00000471289, 		ENST00000587758, 
ENST00000588426, ENST00000356783, 
ENST00000291901, ENST00000536926, 
ENST00000588981, ENST00000587465, 
ENST00000585321, ENST00000592920, 
Fusion gene scores* DoF score5 X 4 X 3=607 X 4 X 5=140
# samples 57
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMPK1 [Title/Abstract] AND TNNT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCMPK1

GO:0006165

nucleoside diphosphate phosphorylation

23416111

HgeneCMPK1

GO:0009142

nucleoside triphosphate biosynthetic process

23416111

TgeneTNNT1

GO:0045932

negative regulation of muscle contraction

18032382


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-51-6867-01ACMPK1chr1

47799788

+TNNT1chr19

55645524

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371873ENST00000587758CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000588426CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000356783CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000291901CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000536926CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000588981CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000587465CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000371873ENST00000585321CMPK1chr1

47799788

+TNNT1chr19

55645524

-
5CDS-intronENST00000371873ENST00000592920CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000587758CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000588426CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000356783CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000291901CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000536926CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000588981CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000587465CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000450808ENST00000585321CMPK1chr1

47799788

+TNNT1chr19

55645524

-
5CDS-intronENST00000450808ENST00000592920CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000587758CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000588426CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000356783CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000291901CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000536926CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000588981CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000587465CMPK1chr1

47799788

+TNNT1chr19

55645524

-
Frame-shiftENST00000471289ENST00000585321CMPK1chr1

47799788

+TNNT1chr19

55645524

-
5CDS-intronENST00000471289ENST00000592920CMPK1chr1

47799788

+TNNT1chr19

55645524

-

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FusionProtFeatures for CMPK1_TNNT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMPK1

P30085

TNNT1

P13805

Catalyzes the phosphorylation of pyrimidine nucleosidemonophosphates at the expense of ATP. Plays an important role inde novo pyrimidine nucleotide biosynthesis. Has preference for UMPand CMP as phosphate acceptors. Also displays broad nucleosidediphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172,ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132,ECO:0000269|PubMed:23416111}. Troponin T is the tropomyosin-binding subunit oftroponin, the thin filament regulatory complex which conferscalcium-sensitivity to striated muscle actomyosin ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CMPK1_TNNT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMPK1_TNNT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMPK1ELAVL1, MOV10, NXF1, TTC19, ACOT13, ETFA, ECE2, NIT2, TATDN1, TRIM25TNNT1TNNC1, CCDC85B, PLEKHF1, PPFIA1, TNNT1, ZMYND19, PSMC5, NINL, FXR2, TPM1, PRKG1, TRIM63, IMMT, SH3GL3, ZNF768, KAT5, PI4KA, NACAD, EEF1G, HMGXB4, BLOC1S2, SNW1, ZC3H15, HMP19, SERPINA4, UBE2D1, ZNF250, ZKSCAN5, NAGK, OSM, OSBP2, HSP90AB1, TRA2A, TMEM98, MARS, VIM, HAP1, ARMC8, SEC31A, FYN, C2orf44, CHD3, DDX5, FAF1, LARP1, NFE2L2, TPM3, TBPL1, MORF4L1, LDOC1, TFIP11, CCDC136, KRT40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMPK1_TNNT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCMPK1P30085DB00441GemcitabineUMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}small moleculeapproved

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RelatedDiseases for CMPK1_TNNT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource