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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7587

FusionGeneSummary for CMC1_WDR72

check button Fusion gene summary
Fusion gene informationFusion gene name: CMC1_WDR72
Fusion gene ID: 7587
HgeneTgene
Gene symbol

CMC1

WDR72

Gene ID

152100

256764

Gene nameC-X9-C motif containing 1WD repeat domain 72
SynonymsC3orf68AI2A3
Cytomap

3p24.1

15q21.3

Type of geneprotein-codingprotein-coding
DescriptionCOX assembly mitochondrial protein homologC-x(9)-C motif containing 1COX assembly mitochondrial protein 1 homologCX9C mitochondrial protein required for full expression of COX 1cmc1pmitochondrial metallochaperone-like proteinWD repeat-containing protein 72
Modification date2018052320180329
UniProtAcc

Q7Z7K0

Q3MJ13

Ensembl transtripts involved in fusion geneENST00000466830, ENST00000423894, 
ENST00000469102, 		ENST00000396328, 
ENST00000557913, ENST00000360509, 
ENST00000559418, ENST00000567224, 
Fusion gene scores* DoF score7 X 3 X 7=1474 X 3 X 3=36
# samples 83
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMC1 [Title/Abstract] AND WDR72 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKICHTCGA-KL-8341-01ACMC1chr3

28304871

+WDR72chr15

53815519

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000466830ENST00000396328CMC1chr3

28304871

+WDR72chr15

53815519

-
In-frameENST00000466830ENST00000557913CMC1chr3

28304871

+WDR72chr15

53815519

-
In-frameENST00000466830ENST00000360509CMC1chr3

28304871

+WDR72chr15

53815519

-
In-frameENST00000466830ENST00000559418CMC1chr3

28304871

+WDR72chr15

53815519

-
5CDS-5UTRENST00000466830ENST00000567224CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000423894ENST00000396328CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000423894ENST00000557913CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000423894ENST00000360509CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000423894ENST00000559418CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-5UTRENST00000423894ENST00000567224CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000469102ENST00000396328CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000469102ENST00000557913CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000469102ENST00000360509CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-3CDSENST00000469102ENST00000559418CMC1chr3

28304871

+WDR72chr15

53815519

-
intron-5UTRENST00000469102ENST00000567224CMC1chr3

28304871

+WDR72chr15

53815519

-

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FusionProtFeatures for CMC1_WDR72


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMC1

Q7Z7K0

WDR72

Q3MJ13

Component of the MITRAC (mitochondrial translationregulation assembly intermediate of cytochrome c oxidase complex)complex, that regulates cytochrome c oxidase assembly.{ECO:0000250}. Plays a major role in formation of tooth enamel(PubMed:19853237, PubMed:25008349). Specifically required duringthe maturation phase of amelogenesis for normal formation of theenamel matrix and clearance of enamel proteins. May be involved inlocalization of the calcium transporter SLC24A4 to the ameloblastcell membrane. {ECO:0000250|UniProtKB:D3YYM4,ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCMC1chr3:28304871chr15:53815519ENST00000466830+2428_7136107DomainCHCH
HgeneCMC1chr3:28304871chr15:53815519ENST00000466830+2431_4136107MotifCx9C motif 1
HgeneCMC1chr3:28304871chr15:53815519ENST00000466830+2453_6336107MotifCx9C motif 2
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-172015_5410491103RepeatNote=WD 1
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720160_19710491103RepeatNote=WD 3
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720318_36210491103RepeatNote=WD 4
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720402_44110491103RepeatNote=WD 5
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720459_50410491103RepeatNote=WD 6
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720507_55210491103RepeatNote=WD 7
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-1720555_59410491103RepeatNote=WD 8
TgeneWDR72chr3:28304871chr15:53815519ENST00000360509-172060_10210491103RepeatNote=WD 2
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-172015_5410491103RepeatNote=WD 1
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720160_19710491103RepeatNote=WD 3
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720318_36210491103RepeatNote=WD 4
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720402_44110491103RepeatNote=WD 5
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720459_50410491103RepeatNote=WD 6
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720507_55210491103RepeatNote=WD 7
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-1720555_59410491103RepeatNote=WD 8
TgeneWDR72chr3:28304871chr15:53815519ENST00000396328-172060_10210491103RepeatNote=WD 2


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FusionGeneSequence for CMC1_WDR72


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000396328_chr15_53815519_-_90aa
MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQAPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPRHHSWIAKVCPCKVSX

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000557913_chr15_53815519_-_90aa
MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQAPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPRHHSWIAKVCPCKVSX

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000360509_chr15_53815519_-_90aa
MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQAPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPRHHSWIAKVCPCKVSX

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000559418_chr15_53815519_-_90aa
MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQAPVSPVKHDSNSNSANFQDVEDMPDRCALEESESPGEPRHHSWIAKVCPCKVSX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000396328_chr15_53815519_-_270nt
ATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAGAGAAAAGGCCAAAGAGAGG
TGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCAAGACGTGGAGGACATGCCT
GACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTGCCCCTGCAAGGTGTCTTAA

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000557913_chr15_53815519_-_270nt
ATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAGAGAAAAGGCCAAAGAGAGG
TGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCAAGACGTGGAGGACATGCCT
GACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTGCCCCTGCAAGGTGTCTTAA

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000360509_chr15_53815519_-_270nt
ATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAGAGAAAAGGCCAAAGAGAGG
TGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCAAGACGTGGAGGACATGCCT
GACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTGCCCCTGCAAGGTGTCTTAA

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000559418_chr15_53815519_-_270nt
ATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAGAGAAAAGGCCAAAGAGAGG
TGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCAAGACGTGGAGGACATGCCT
GACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTGCCCCTGCAAGGTGTCTTAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000396328_chr15_53815519_-_4427nt
GGCGCAACGGGCGGCGGAAGTAGGAGCCTGGGAAGGAAGAGGGAACGGGTCCTGGCGGTGCTTTGCAAAGGGCCCGTGTTTCTGTTGCGG
GAAGCTCCCGGGGGTCGCACGTGCGTCCGAGCCCAAGCCCCTCCCCTCCACTCCCCTTCCTGCGTGCCCCGGAGCCGCCAAGCGGCTACG
TTCTTCTCGGCCCGCCGAGATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAG
AGAAAAGGCCAAAGAGAGGTGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCA
AGACGTGGAGGACATGCCTGACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTG
CCCCTGCAAGGTGTCTTAAATGGAATCTCATCAGTAGGAGCTGAATTTGGACAAATTAAGAAATCCAAAAGATGCCATTTGTTTATTACT
GTATAAAAGCATTGTTGTTATTGGTCAAGTTATTAGGCTGTAGTGGATTTGCTAATACTTTAGCCAACATGTATTAAAGTGATTTTAATA
CATGCTGATTACAATGCAATACATACTGATTGAAAATATTCATATTCATCTAATTTTAGAAAAATATTGCCTAGATCATTCTCTATTCCT
GTTTCTTACTTTTTCTGTTAATATTTCCAACAGGGAATGCCAGTCCACAGACACAAATTTAATACTGCTTTAAATTTTCTCCTATCCTTT
TAGTCCCTGAATTATATAATAAACAATGTTAAAACCAATGTAGTACACAATACTTACTTACAAATTTAATACTGCTTCAAGGTATTTAAT
CTAAAATTTTACCAACTTTGATTTGTCTGGTTAGGATATTTTGTTTTAGTGGATATGCTTTAATTCGGATCAATTACTGCAGTAAATCTC
ATCCCTAAGCATGAAATGTTGTCAACAAATACCCAGTTCCATTTAGTTATCAATTAGCCCAAATAAGAGATACAAAGTATAACAGTGACC
AACCTTGTACTGTTGAGTTAATTTGAACTTCTAATGACATTGAGGCTAATGTCTTTAGCTCAAGGTTGATCTTGTTGGCCATATAGATGT
GAACTAGGGAAGGGGAATCAACTTACAGCATATCACAATTGATCCTTATTAAGTATAAACTCTTGTAGGTCTTTTCCCAGAAAGAAGCTT
GACTAGCAGGAATTCTAAAACTGAAATATATCAAACAGCATAAATAGGAATAGACATAAAGTGCTCTTCTATTAAAGCCTTTGGTGATCT
ATTTACTATGATTTATATTGTACAGTTCCTCGATTTACAGAAAATCATCAAAATTATTAATCTACATATCTTATGTATATAAATATTGCC
TAATCCATAGAAAAAAGGATATAAAGTATTAAATATGTGATATATAGCTATATCTATCTATCTATGTATCTAATAGGGAAGTCCAAGTCA
CTTCAATTGAAGAAACATATCTCTGAGCATAGGAGCAGCCTCAGGTCCTATGGTGGGATGCAGTGGACAGGAGAGGGGGAAATTAGAAAA
GAGAACTATATAATTGAAAAAGGGATATAAAGCATTAAATATATGATATATAGCTATATCTATGTATGTATCTAACAGAGAAGTTCAAGT
CACTTCAATTAAAGAAACATTTTTGAGCATGGGACCAGCCTCAGGTCTTATGCTGGGATGCAGTAGACAGGAGATGGGGAAATTAGAAAA
GAGAACTGTGTAATTGAAATGACGTGGGCTGCACCCTTAAGGAACTTATAATTAATGATGATCTGAATAAACATACCAGGATAAAGATGT
CAAATGAGTGTGACTCCCTTAAAGTAGATTAAAGTGTGCATTCTTTGTTTCCTAAAATATGATTTTACTGCTTGAAATTACATTTGAGTT
GAAGTTTAGAAACTAACATAGCATTAATATGAATAATCATGGAAAATTATTATCCTTTGAAAACTGATTGATAAATATATTCCCCCTCCT
TTAGAAACAGTCAAAAGCCACTTCAAACAAGTTTCAAAATAAAGGAAGGTAGCAAGTTAGGCGATGGATTATATTTTCTTGCTTGTTGTA
TACCAGTTGTCAAGGACATTATAAGGACTCCCAAAAGCATTTTGAAGGATGGCAATATCAAATAAGTGTATGTCCTCTCAAATGAGGCAT
TTTTAATTGTTAAAATCTATTTGGACGCTCAGGTTATGATATGTTTATGAAAAATAAGCTTCATTATTTTTATAGCTACATCCTATTATT
CCCTTTTAGAAACAAGAATAACAATAGGTTTTAATAGTTGCCATACTTAGCATTTATCAGTTCTAATGAAACCAATATTGAATCTCTGAT
AAATATTTTCTGATGTTACTAGCTATGGGAAATTAGAACTGGCACAACCCTGACATTACTAAGTGGAAATGTTAGGATTTTTCGGCATCG
CATGTTAGAATCTCTAAAATTTAAACATTCCTGTTAAATGACTAAGGTTTGCTTTTATCAATATGAATTCTGAAGGCCAATATCATACCA
TTAACTATGAAAGCTTTTAATTCCTAAAAATAGTTTTAGAGATATTCAAGCAATGCTCTCCTAATATCCATACGCAAGTGTGTTTATGAC
ACAAATTCACTAGTCTGTTTAAAAATGAATTCTTTATATTGACTGGTGTTCCACATATTTCAGTAATTTCTGTTATGAGAGGACTTGAAA
TAGCAAATTGCCACACAGTTAACTGGATAGACCACGTACGTGGTGATCATAACCACTTGGTACTACACCCAGAAACTCAAAATTGTCTTT
CTCCTGATGAGATATGGGTGTCCTTTTGTACGTCTAGGCCTAGGTAACCAGTGGAGTGATTATATTAGCAAATGTGTTTGTATCCGGAGT
CTTCCTGTCATTGTAATAAAAAATTTATTTAAAAATTTTGTCTTGTGTTTCTTTTTTGGTAATCATCTTGGTGATATTTATGAATGTATT
TGTGTGTGTGTGTGTGTGTGTATACATACATATATATGTGTGTATATATATACACACATATATATACACATATATATGTGTGTATATATA
TATATATATGGCATATCCCCCAAAGGAATATCATATTTTCATTTGCAAGCCTTGATTCTTTGACTTGCTGTTGAGTTTCACATTGGCTCC
ATTGTATATTGCAGGAAAAAGTACCTGGAAAGCCTGGAGGGTTAAAAGCAGAGGCTCCTCGGCAGCGTGTCCAGGCCGTGTGTGCTTGCT
GTGCTTGTCAGAGCCTCATTCCCTCCCCTGTGTTGGAGAGCTTTCTCACAGGGCTCATCCAGAGGTGCTAGAAAGCAATGTGAGCACTAT
TAAACACTTCAAATATAAGGAAAAATGTATAATGTTAGAAACACACAGTTAAAAAGTAGCCCCAGGTATCAAACATTCTGTTACTATTTT
AGAAACTAAATTAAGGCTGCTTTGAACATGATGGTATTAGAAAAATGGTAGAATACAGTTTGTTAAATATTAATATTCTATCTTTAGATG
ATAGCATTTGGTGACTTTTATTTCTTTTCTCATACATTTTTTCCAGTGTTCTGTATTTTTAAAATCCTTTCATAATTATTATAATGAACA
CTTTAGAAAAGATACTATTTCTCTTCCATCCTTAGAGGGCACATTATAATAATTGAGTATTTTAAAATTAAATTTTATGCCATGTATTTA
AAATGAAAGTTCAGGTTACATTAATTCCAACTGATTTTAAAGCCTTATTTTCACAGAGTGGACTCATTCAATTTTTTAAATTTTATATTC
ATACATTTTGATTGCTCAGTTATATAAAAGCGGTGTTATAGACTCCTTTATTCTCCACAAAATGTTGTCTTATATGTAAAGTGCCAAAAG
TTGTGTTTAATTTCCTAAGAAAGTCATTGCTTTGTAAACATTTGCATAATACTTAGTGTTTTTTGTAATTTTAAAAAATTAGCTTAACCA
AAAGAGTTGCAAAATTAAAACTTACTTGAGTAGGTATCTTTCAGACAAAGCTGCATGGCTTCATGTACAATAGTCCCCAGATCACCTCGC
ACTGTAGTTTGCTCAAGAAGGAGCCTACAGATGGCAGGTAGGAGAAGGTAAACTGGAAATTAACAGGTCTGTCTGTAAGAGCATGCCACT
GGAAACACCCATCCAATTTGGGACCCCTGGAAGACAGCATGTGTCTAATGGGAGGCCTGTCCTAGTACAACTCCTTTACTCTTTTCACCT
TCATCTTGACCTTCTCAGATACCATCTTTATGTAAAATGTTGATGTTGTGGAGTTTTTGCAGTAATTTAATTTTTATAAATATTGTATTA

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000557913_chr15_53815519_-_3009nt
GGCGCAACGGGCGGCGGAAGTAGGAGCCTGGGAAGGAAGAGGGAACGGGTCCTGGCGGTGCTTTGCAAAGGGCCCGTGTTTCTGTTGCGG
GAAGCTCCCGGGGGTCGCACGTGCGTCCGAGCCCAAGCCCCTCCCCTCCACTCCCCTTCCTGCGTGCCCCGGAGCCGCCAAGCGGCTACG
TTCTTCTCGGCCCGCCGAGATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAG
AGAAAAGGCCAAAGAGAGGTGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCA
AGACGTGGAGGACATGCCTGACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTG
CCCCTGCAAGGTGTCTTAAATGGAATCTCATCAGTAGGAGCTGAATTTGGACAAATTAAGAAATCCAAAAGATGCCATTTGTTTATTACT
GTATAAAAGCATTGTTGTTATTGGTCAAGTTATTAGGCTGTAGTGGATTTGCTAATACTTTAGCCAACATGTATTAAAGTGATTTTAATA
CATGCTGATTACAATGCAATACATACTGATTGAAAATATTCATATTCATCTAATTTTAGAAAAATATTGCCTAGATCATTCTCTATTCCT
GTTTCTTACTTTTTCTGTTAATATTTCCAACAGGGAATGCCAGTCCACAGACACAAATTTAATACTGCTTTAAATTTTCTCCTATCCTTT
TAGTCCCTGAATTATATAATAAACAATGTTAAAACCAATGTAGTACACAATACTTACTTACAAATTTAATACTGCTTCAAGGTATTTAAT
CTAAAATTTTACCAACTTTGATTTGTCTGGTTAGGATATTTTGTTTTAGTGGATATGCTTTAATTCGGATCAATTACTGCAGTAAATCTC
ATCCCTAAGCATGAAATGTTGTCAACAAATACCCAGTTCCATTTAGTTATCAATTAGCCCAAATAAGAGATACAAAGTATAACAGTGACC
AACCTTGTACTGTTGAGTTAATTTGAACTTCTAATGACATTGAGGCTAATGTCTTTAGCTCAAGGTTGATCTTGTTGGCCATATAGATGT
GAACTAGGGAAGGGGAATCAACTTACAGCATATCACAATTGATCCTTATTAAGTATAAACTCTTGTAGGTCTTTTCCCAGAAAGAAGCTT
GACTAGCAGGAATTCTAAAACTGAAATATATCAAACAGCATAAATAGGAATAGACATAAAGTGCTCTTCTATTAAAGCCTTTGGTGATCT
ATTTACTATGATTTATATTGTACAGTTCCTCGATTTACAGAAAATCATCAAAATTATTAATCTACATATCTTATGTATATAAATATTGCC
TAATCCATAGAAAAAAGGATATAAAGTATTAAATATGTGATATATAGCTATATCTATCTATCTATGTATCTAATAGGGAAGTCCAAGTCA
CTTCAATTGAAGAAACATATCTCTGAGCATAGGAGCAGCCTCAGGTCCTATGGTGGGATGCAGTGGACAGGAGAGGGGGAAATTAGAAAA
GAGAACTATATAATTGAAAAAGGGATATAAAGCATTAAATATATGATATATAGCTATATCTATGTATGTATCTAACAGAGAAGTTCAAGT
CACTTCAATTAAAGAAACATTTTTGAGCATGGGACCAGCCTCAGGTCTTATGCTGGGATGCAGTAGACAGGAGATGGGGAAATTAGAAAA
GAGAACTGTGTAATTGAAATGACGTGGGCTGCACCCTTAAGGAACTTATAATTAATGATGATCTGAATAAACATACCAGGATAAAGATGT
CAAATGAGTGTGACTCCCTTAAAGTAGATTAAAGTGTGCATTCTTTGTTTCCTAAAATATGATTTTACTGCTTGAAATTACATTTGAGTT
GAAGTTTAGAAACTAACATAGCATTAATATGAATAATCATGGAAAATTATTATCCTTTGAAAACTGATTGATAAATATATTCCCCCTCCT
TTAGAAACAGTCAAAAGCCACTTCAAACAAGTTTCAAAATAAAGGAAGGTAGCAAGTTAGGCGATGGATTATATTTTCTTGCTTGTTGTA
TACCAGTTGTCAAGGACATTATAAGGACTCCCAAAAGCATTTTGAAGGATGGCAATATCAAATAAGTGTATGTCCTCTCAAATGAGGCAT
TTTTAATTGTTAAAATCTATTTGGACGCTCAGGTTATGATATGTTTATGAAAAATAAGCTTCATTATTTTTATAGCTACATCCTATTATT
CCCTTTTAGAAACAAGAATAACAATAGGTTTTAATAGTTGCCATACTTAGCATTTATCAGTTCTAATGAAACCAATATTGAATCTCTGAT
AAATATTTTCTGATGTTACTAGCTATGGGAAATTAGAACTGGCACAACCCTGACATTACTAAGTGGAAATGTTAGGATTTTTCGGCATCG
CATGTTAGAATCTCTAAAATTTAAACATTCCTGTTAAATGACTAAGGTTTGCTTTTATCAATATGAATTCTGAAGGCCAATATCATACCA
TTAACTATGAAAGCTTTTAATTCCTAAAAATAGTTTTAGAGATATTCAAGCAATGCTCTCCTAATATCCATACGCAAGTGTGTTTATGAC
ACAAATTCACTAGTCTGTTTAAAAATGAATTCTTTATATTGACTGGTGTTCCACATATTTCAGTAATTTCTGTTATGAGAGGACTTGAAA
TAGCAAATTGCCACACAGTTAACTGGATAGACCACGTACGTGGTGATCATAACCACTTGGTACTACACCCAGAAACTCAAAATTGTCTTT
CTCCTGATGAGATATGGGTGTCCTTTTGTACGTCTAGGCCTAGGTAACCAGTGGAGTGATTATATTAGCAAATGTGTTTGTATCCGGAGT

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000360509_chr15_53815519_-_3005nt
GGCGCAACGGGCGGCGGAAGTAGGAGCCTGGGAAGGAAGAGGGAACGGGTCCTGGCGGTGCTTTGCAAAGGGCCCGTGTTTCTGTTGCGG
GAAGCTCCCGGGGGTCGCACGTGCGTCCGAGCCCAAGCCCCTCCCCTCCACTCCCCTTCCTGCGTGCCCCGGAGCCGCCAAGCGGCTACG
TTCTTCTCGGCCCGCCGAGATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAG
AGAAAAGGCCAAAGAGAGGTGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCA
AGACGTGGAGGACATGCCTGACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTG
CCCCTGCAAGGTGTCTTAAATGGAATCTCATCAGTAGGAGCTGAATTTGGACAAATTAAGAAATCCAAAAGATGCCATTTGTTTATTACT
GTATAAAAGCATTGTTGTTATTGGTCAAGTTATTAGGCTGTAGTGGATTTGCTAATACTTTAGCCAACATGTATTAAAGTGATTTTAATA
CATGCTGATTACAATGCAATACATACTGATTGAAAATATTCATATTCATCTAATTTTAGAAAAATATTGCCTAGATCATTCTCTATTCCT
GTTTCTTACTTTTTCTGTTAATATTTCCAACAGGGAATGCCAGTCCACAGACACAAATTTAATACTGCTTTAAATTTTCTCCTATCCTTT
TAGTCCCTGAATTATATAATAAACAATGTTAAAACCAATGTAGTACACAATACTTACTTACAAATTTAATACTGCTTCAAGGTATTTAAT
CTAAAATTTTACCAACTTTGATTTGTCTGGTTAGGATATTTTGTTTTAGTGGATATGCTTTAATTCGGATCAATTACTGCAGTAAATCTC
ATCCCTAAGCATGAAATGTTGTCAACAAATACCCAGTTCCATTTAGTTATCAATTAGCCCAAATAAGAGATACAAAGTATAACAGTGACC
AACCTTGTACTGTTGAGTTAATTTGAACTTCTAATGACATTGAGGCTAATGTCTTTAGCTCAAGGTTGATCTTGTTGGCCATATAGATGT
GAACTAGGGAAGGGGAATCAACTTACAGCATATCACAATTGATCCTTATTAAGTATAAACTCTTGTAGGTCTTTTCCCAGAAAGAAGCTT
GACTAGCAGGAATTCTAAAACTGAAATATATCAAACAGCATAAATAGGAATAGACATAAAGTGCTCTTCTATTAAAGCCTTTGGTGATCT
ATTTACTATGATTTATATTGTACAGTTCCTCGATTTACAGAAAATCATCAAAATTATTAATCTACATATCTTATGTATATAAATATTGCC
TAATCCATAGAAAAAAGGATATAAAGTATTAAATATGTGATATATAGCTATATCTATCTATCTATGTATCTAATAGGGAAGTCCAAGTCA
CTTCAATTGAAGAAACATATCTCTGAGCATAGGAGCAGCCTCAGGTCCTATGGTGGGATGCAGTGGACAGGAGAGGGGGAAATTAGAAAA
GAGAACTATATAATTGAAAAAGGGATATAAAGCATTAAATATATGATATATAGCTATATCTATGTATGTATCTAACAGAGAAGTTCAAGT
CACTTCAATTAAAGAAACATTTTTGAGCATGGGACCAGCCTCAGGTCTTATGCTGGGATGCAGTAGACAGGAGATGGGGAAATTAGAAAA
GAGAACTGTGTAATTGAAATGACGTGGGCTGCACCCTTAAGGAACTTATAATTAATGATGATCTGAATAAACATACCAGGATAAAGATGT
CAAATGAGTGTGACTCCCTTAAAGTAGATTAAAGTGTGCATTCTTTGTTTCCTAAAATATGATTTTACTGCTTGAAATTACATTTGAGTT
GAAGTTTAGAAACTAACATAGCATTAATATGAATAATCATGGAAAATTATTATCCTTTGAAAACTGATTGATAAATATATTCCCCCTCCT
TTAGAAACAGTCAAAAGCCACTTCAAACAAGTTTCAAAATAAAGGAAGGTAGCAAGTTAGGCGATGGATTATATTTTCTTGCTTGTTGTA
TACCAGTTGTCAAGGACATTATAAGGACTCCCAAAAGCATTTTGAAGGATGGCAATATCAAATAAGTGTATGTCCTCTCAAATGAGGCAT
TTTTAATTGTTAAAATCTATTTGGACGCTCAGGTTATGATATGTTTATGAAAAATAAGCTTCATTATTTTTATAGCTACATCCTATTATT
CCCTTTTAGAAACAAGAATAACAATAGGTTTTAATAGTTGCCATACTTAGCATTTATCAGTTCTAATGAAACCAATATTGAATCTCTGAT
AAATATTTTCTGATGTTACTAGCTATGGGAAATTAGAACTGGCACAACCCTGACATTACTAAGTGGAAATGTTAGGATTTTTCGGCATCG
CATGTTAGAATCTCTAAAATTTAAACATTCCTGTTAAATGACTAAGGTTTGCTTTTATCAATATGAATTCTGAAGGCCAATATCATACCA
TTAACTATGAAAGCTTTTAATTCCTAAAAATAGTTTTAGAGATATTCAAGCAATGCTCTCCTAATATCCATACGCAAGTGTGTTTATGAC
ACAAATTCACTAGTCTGTTTAAAAATGAATTCTTTATATTGACTGGTGTTCCACATATTTCAGTAATTTCTGTTATGAGAGGACTTGAAA
TAGCAAATTGCCACACAGTTAACTGGATAGACCACGTACGTGGTGATCATAACCACTTGGTACTACACCCAGAAACTCAAAATTGTCTTT
CTCCTGATGAGATATGGGTGTCCTTTTGTACGTCTAGGCCTAGGTAACCAGTGGAGTGATTATATTAGCAAATGTGTTTGTATCCGGAGT

>In-frame_CMC1_ENST00000466830_chr3_28304871_+_WDR72_ENST00000559418_chr15_53815519_-_698nt
GGCGCAACGGGCGGCGGAAGTAGGAGCCTGGGAAGGAAGAGGGAACGGGTCCTGGCGGTGCTTTGCAAAGGGCCCGTGTTTCTGTTGCGG
GAAGCTCCCGGGGGTCGCACGTGCGTCCGAGCCCAAGCCCCTCCCCTCCACTCCCCTTCCTGCGTGCCCCGGAGCCGCCAAGCGGCTACG
TTCTTCTCGGCCCGCCGAGATGGCGCTCGACCCCGCAGACCAGCATCTCAGACATGTCGAAAAAGATGTTTTGATCCCTAAAATAATGAG
AGAAAAGGCCAAAGAGAGGTGTTCTGAACAAGTTCAAGCTCCAGTCAGCCCGGTCAAGCATGACAGCAACTCAAACTCGGCAAACTTCCA
AGACGTGGAGGACATGCCTGACAGATGTGCCTTGGAAGAGTCTGAGAGTCCAGGTGAGCCAAGGCATCATTCATGGATAGCAAAGGTCTG
CCCCTGCAAGGTGTCTTAAATGGAATCTCATCAGTAGGAGCTGAATTTGGACAAATTAAGAAATCCAAAAGATGCCATTTGTTTATTACT
GTATAAAAGCATTGTTGTTATTGGTCAAGTTATTAGGCTGTAGTGGATTTGCTAATACTTTAGCCAACATGTATTAAAGTGATTTTAATA


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FusionGenePPI for CMC1_WDR72


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMC1WDR72


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMC1_WDR72


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMC1_WDR72


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource