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Fusion gene ID: 7581 |
FusionGeneSummary for CMBL_FAM76A |
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Fusion gene information | Fusion gene name: CMBL_FAM76A | Fusion gene ID: 7581 | Hgene | Tgene | Gene symbol | CMBL | FAM76A | Gene ID | 134147 | 199870 |
Gene name | carboxymethylenebutenolidase homolog | family with sequence similarity 76 member A | |
Synonyms | JS-1 | - | |
Cytomap | 5p15.2 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxymethylenebutenolidase homologcarboxymethylenebutenolidase homolog (Pseudomonas)carboxymethylenebutenolidase-like (Pseudomonas) | protein FAM76A | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q96DG6 | Q8TAV0 | |
Ensembl transtripts involved in fusion gene | ENST00000296658, ENST00000510532, | ENST00000373954, ENST00000419687, ENST00000530324, ENST00000234549, ENST00000373949, ENST00000010299, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/50*10)=0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CMBL [Title/Abstract] AND FAM76A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA602984 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000296658 | ENST00000373954 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000296658 | ENST00000419687 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000296658 | ENST00000530324 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000296658 | ENST00000234549 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000296658 | ENST00000373949 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000296658 | ENST00000010299 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000373954 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000419687 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000530324 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000234549 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000373949 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
intron-intron | ENST00000510532 | ENST00000010299 | CMBL | chr5 | 10279785 | + | FAM76A | chr1 | 28064261 | + |
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FusionProtFeatures for CMBL_FAM76A |
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Hgene | Tgene |
CMBL | FAM76A |
Cysteine hydrolase. Can convert the prodrug olmesartanmedoxomil into its pharmacologically active metaboliteolmerstatan, an angiotensin receptor blocker, in liver andintestine. May also activate beta-lactam antibiotics faropenemmedoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CMBL_FAM76A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CMBL_FAM76A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CMBL_FAM76A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CMBL_FAM76A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |