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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7581

FusionGeneSummary for CMBL_FAM76A

check button Fusion gene summary
Fusion gene informationFusion gene name: CMBL_FAM76A
Fusion gene ID: 7581
HgeneTgene
Gene symbol

CMBL

FAM76A

Gene ID

134147

199870

Gene namecarboxymethylenebutenolidase homologfamily with sequence similarity 76 member A
SynonymsJS-1-
Cytomap

5p15.2

1p35.3

Type of geneprotein-codingprotein-coding
Descriptioncarboxymethylenebutenolidase homologcarboxymethylenebutenolidase homolog (Pseudomonas)carboxymethylenebutenolidase-like (Pseudomonas)protein FAM76A
Modification date2018051920180519
UniProtAcc

Q96DG6

Q8TAV0

Ensembl transtripts involved in fusion geneENST00000296658, ENST00000510532, 
ENST00000373954, ENST00000419687, 
ENST00000530324, ENST00000234549, 
ENST00000373949, ENST00000010299, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 3 X 3=27
# samples 53
** MAII scorelog2(5/50*10)=0log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CMBL [Title/Abstract] AND FAM76A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA602984CMBLchr5

10279785

+FAM76Achr1

28064261

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000296658ENST00000373954CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000296658ENST00000419687CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000296658ENST00000530324CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000296658ENST00000234549CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000296658ENST00000373949CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000296658ENST00000010299CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000373954CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000419687CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000530324CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000234549CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000373949CMBLchr5

10279785

+FAM76Achr1

28064261

+
intron-intronENST00000510532ENST00000010299CMBLchr5

10279785

+FAM76Achr1

28064261

+

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FusionProtFeatures for CMBL_FAM76A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMBL

Q96DG6

FAM76A

Q8TAV0

Cysteine hydrolase. Can convert the prodrug olmesartanmedoxomil into its pharmacologically active metaboliteolmerstatan, an angiotensin receptor blocker, in liver andintestine. May also activate beta-lactam antibiotics faropenemmedoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CMBL_FAM76A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMBL_FAM76A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMBL_FAM76A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMBL_FAM76A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource