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Fusion gene ID: 756 |
FusionGeneSummary for ADAMTS7_PEAK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS7_PEAK1 | Fusion gene ID: 756 | Hgene | Tgene | Gene symbol | ADAMTS7 | PEAK1 | Gene ID | 11173 | 79834 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 7 | pseudopodium enriched atypical kinase 1 | |
| Synonyms | ADAM-TS 7|ADAM-TS7|ADAMTS-7 | SGK269 | |
| Cytomap | 15q25.1 | 15q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7 | pseudopodium-enriched atypical kinase 1NKF3 kinase family membersugen kinase 269tyrosine-protein kinase SgK269 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UKP4 | Q9H792 | |
| Ensembl transtripts involved in fusion gene | ENST00000388820, ENST00000566303, | ENST00000560626, ENST00000558305, ENST00000567337, ENST00000312493, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 4=120 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS7 [Title/Abstract] AND PEAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADAMTS7 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
| Hgene | ADAMTS7 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
| Tgene | PEAK1 | GO:0016477 | cell migration | 20534451 |
| Tgene | PEAK1 | GO:0034446 | substrate adhesion-dependent cell spreading | 20534451 |
| Tgene | PEAK1 | GO:0046777 | protein autophosphorylation | 20534451 |
| Tgene | PEAK1 | GO:0051893 | regulation of focal adhesion assembly | 23105102 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A23R-01A | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000388820 | ENST00000560626 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5CDS-intron | ENST00000388820 | ENST00000558305 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5CDS-intron | ENST00000388820 | ENST00000567337 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5CDS-intron | ENST00000388820 | ENST00000312493 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5UTR-3CDS | ENST00000566303 | ENST00000560626 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5UTR-intron | ENST00000566303 | ENST00000558305 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5UTR-intron | ENST00000566303 | ENST00000567337 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
| 5UTR-intron | ENST00000566303 | ENST00000312493 | ADAMTS7 | chr15 | 79080573 | - | PEAK1 | chr15 | 77407661 | - |
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FusionProtFeatures for ADAMTS7_PEAK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS7 | PEAK1 |
| Metalloprotease that may play a role in the degradationof COMP. {ECO:0000269|PubMed:16585064}. | Probable catalytically inactive kinase. Scaffoldingprotein that regulates the cytoskeleton to control cell spreadingand migration by modulating focal adhesion dynamics(PubMed:23105102, PubMed:20534451). Acts as a scaffold formediating EGFR signaling (PubMed:23846654).{ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102,ECO:0000269|PubMed:23846654}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 202_209 | 440 | 1687 | Motif | Cysteine switch |
| Tgene | >PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 1670_1743 | 1359 | 1747 | Region | Required for homodimerization |
| Tgene | >PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 1670_1743 | 1359 | 1747 | Region | Required for homodimerization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 595_697 | 440 | 1687 | Compositional bias | Note=Cys-rich |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 1411_1459 | 440 | 1687 | Domain | TSP type-1 5 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 1462_1522 | 440 | 1687 | Domain | TSP type-1 6 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 1523_1567 | 440 | 1687 | Domain | TSP type-1 7 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 1569_1629 | 440 | 1687 | Domain | TSP type-1 8 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 1632_1672 | 440 | 1687 | Domain | PLAC |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 242_452 | 440 | 1687 | Domain | Peptidase M12B |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 462_537 | 440 | 1687 | Domain | Note=Disintegrin |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 538_593 | 440 | 1687 | Domain | TSP type-1 1 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 821_880 | 440 | 1687 | Domain | TSP type-1 2 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 881_940 | 440 | 1687 | Domain | TSP type-1 3 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 942_995 | 440 | 1687 | Domain | TSP type-1 4 |
| Hgene | >ADAMTS7 | chr15:79080573 | chr15:77407661 | ENST00000388820 | - | 8 | 24 | 698_809 | 440 | 1687 | Region | Note=Spacer |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 117_120 | 1359 | 1747 | Compositional bias | Note=Poly-Asn |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 324_406 | 1359 | 1747 | Compositional bias | Note=Ser-rich |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 500_503 | 1359 | 1747 | Compositional bias | Note=Poly-Ser |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 776_873 | 1359 | 1747 | Compositional bias | Note=Pro-rich |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 964_967 | 1359 | 1747 | Compositional bias | Note=Poly-Pro |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 117_120 | 1359 | 1747 | Compositional bias | Note=Poly-Asn |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 324_406 | 1359 | 1747 | Compositional bias | Note=Ser-rich |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 500_503 | 1359 | 1747 | Compositional bias | Note=Poly-Ser |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 776_873 | 1359 | 1747 | Compositional bias | Note=Pro-rich |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 964_967 | 1359 | 1747 | Compositional bias | Note=Poly-Pro |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 1313_1675 | 1359 | 1747 | Domain | Protein kinase |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 1313_1675 | 1359 | 1747 | Domain | Protein kinase |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000312493 | - | 3 | 5 | 1285_1311 | 1359 | 1747 | Region | Required for homodimerization |
| Tgene | PEAK1 | chr15:79080573 | chr15:77407661 | ENST00000560626 | - | 5 | 7 | 1285_1311 | 1359 | 1747 | Region | Required for homodimerization |
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FusionGeneSequence for ADAMTS7_PEAK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_828aa MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRE LRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQP HVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTI MNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLS HVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLESVRAKLKNL SSIITAWLSGRVWLSILTFSRTVVISLLKSLTVCFPGRIQMTLKRMRMTWKRLKKTPKEKRMGKTQSPVLKQHHPRKRIRESXARSRGAT LWSSPGRFHVLLWLILCETLWPSMGKALICMRGRCVCCSYSYALVLSTSNPTMSLTAIYAXRTCYLSTTSLGGLPKALGLQSPAPPHLIP LGLXXATSLRPSRRAIWWTPRSSGTSLALPQRSXQLPSIKSVMSSRQASSSMRCCTYPTPLMRTQSXRRGNTHEQTCLASHSAPPTPGVC SSWPAASXIPTLLSGSSFQTPKASSSVCSGAPAKISSRLSPPALAXYRGTPCSKTGXTSSEHCSXSSLLRSPWTGKVESALRTGFVLSIW |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_2486nt ATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCTCCTCTGCGCTCTGGCTCCCGGCGCCCCCGGA CCCGCACCAGGACGTGCAACCGAGGGCCGGGCGGCACTGGACATCGTGCACCCGGTTCGAGTCGACGCGGGGGGCTCCTTCCTGTCCTAC GAGCTGTGGCCCCGCGCACTGCGCAAGCGGGATGTATCTGTGCGCCGAGACGCGCCCGCCTTCTACGAGCTACAATACCGCGGGCGCGAG CTGCGCTTCAACCTGACCGCCAATCAGCACCTGCTGGCGCCCGGCTTTGTGAGCGAGACGCGGCGGCGCGGCGGCCTGGGCCGCGCGCAC ATCCGGGCCCACACCCCGGCCTGCCACCTGCTTGGCGAGGTGCAGGACCCTGAGCTCGAGGGTGGCCTGGCGGCCATCAGCGCCTGCGAC GGCCTGAAAGGTGTGTTCCAGCTCTCCAACGAGGACTACTTCATTGAGCCCCTGGACAGTGCCCCGGCCCGGCCTGGCCACGCCCAGCCC CATGTGGTGTACAAGCGTCAGGCCCCGGAGAGGCTGGCACAGCGGGGTGATTCCAGTGCTCCAAGCACCTGTGGAGTGCAAGTGTACCCA GAGCTGGAGTCTCGACGGGAGCGTTGGGAGCAGCGGCAGCAGTGGCGGCGGCCACGGCTGAGGCGTCTACACCAGCGGTCGGTCAGCAAA GAGAAGTGGGTGGAGACCCTGGTAGTAGCTGATGCCAAAATGGTGGAGTACCACGGACAGCCGCAGGTTGAGAGCTATGTGCTGACCATC ATGAACATGGTGGCTGGCCTGTTTCATGACCCCAGCATTGGGAACCCCATCCACATCACCATTGTGCGCCTGGTCCTGCTGGAAGATGAG GAGGAGGACCTAAAGATCACGCACCATGCAGACAACACCCTGAAGAGCTTCTGCAAGTGGCAGAAAAGCATCAACATGAAGGGGGATGCC CATCCCCTGCACCATGACACTGCCATCCTGCTCACCAGAAAGGACCTGTGTGCAGCCATGAACCGGCCCTGTGAGACCCTGGGACTGTCC CATGTGGCGGGCATGTGCCAGCCGCACCGCAGCTGCAGCATCAACGAGGACACGGGCCTGCCGCTGGCCTTCACTGTAGCCCACGAGCTC GGGCACAGTTTTGGCATTCAGCATGACGGAAGCGGCAATGACTGTGAGCCCGTTGGGAAACGACCTTTCATCATGTCTCCACAGCTCCTG TACGACGCCGCTCCCCTCACCTGGTCCCGCTGCAGCCGCCAGTATATCACCAGGTTCCTTGAATCTGTAAGAGCAAAGCTAAAGAATCTC AGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAGCAGGACTGTGGTCATTTCCTTGCTGAAGTCC CTAACCGTCTGCTTCCCTGGGAGGATCCAGATGACCCTGAAAAGGATGAGGATGACATGGAAGAGACTGAAGAAGACGCCAAAGGAGAAA CGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAGGGAGTCATGAGCAAGAAGCAGAGGAGCCACG TTGTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCTCTGGCCCAGCATGGGAAAAGCCCTGATTTGT ATGAGAGGCAGGTGTGTCTGCTGCTCTTACAGCTATGCTCTGGTCTTGAGCACCTCAAACCCTACCATGTCACTCACTGCGATCTACGCC TAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCTGCAGAGCCCAGCCCCACCTCATCTTATCCCA CTAGGCTTATAGTGAGCAACTTCTCTCAGGCCAAGCAGAAGAGCCATCTGGTGGACCCCGAGATCCTCCGGGACCAGTCTCGCCTTGCCC CAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTCATCTATGAGATGCTGCACCTACCCAACCCCT TTGATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATCCCATTCCGCTCCCCCTACTCCCGGGGTCTGC AGCAGCTGGCCAGCTGCCTCCTGAATCCCAACCCTTCTGAGCGGATCCTCATTTCAGACGCCAAAGGCATCCTCCAGTGTCTGCTCTGGG GCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAACACCCTGCTCCAAAACTGGCTAGACATCAAGC GAACACTGCTCATGATCAAGTTTGCTGAGAAGTCCCTGGACAGGGAAGGTGGAATCAGCCTTGAGGACTGGCTTTGTGCTCAGTATTTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_8695nt CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGACGTGCAACCGAGGGCCGGGCGGCACTGGACATCGTGCACCCGGTTCG AGTCGACGCGGGGGGCTCCTTCCTGTCCTACGAGCTGTGGCCCCGCGCACTGCGCAAGCGGGATGTATCTGTGCGCCGAGACGCGCCCGC CTTCTACGAGCTACAATACCGCGGGCGCGAGCTGCGCTTCAACCTGACCGCCAATCAGCACCTGCTGGCGCCCGGCTTTGTGAGCGAGAC GCGGCGGCGCGGCGGCCTGGGCCGCGCGCACATCCGGGCCCACACCCCGGCCTGCCACCTGCTTGGCGAGGTGCAGGACCCTGAGCTCGA GGGTGGCCTGGCGGCCATCAGCGCCTGCGACGGCCTGAAAGGTGTGTTCCAGCTCTCCAACGAGGACTACTTCATTGAGCCCCTGGACAG TGCCCCGGCCCGGCCTGGCCACGCCCAGCCCCATGTGGTGTACAAGCGTCAGGCCCCGGAGAGGCTGGCACAGCGGGGTGATTCCAGTGC TCCAAGCACCTGTGGAGTGCAAGTGTACCCAGAGCTGGAGTCTCGACGGGAGCGTTGGGAGCAGCGGCAGCAGTGGCGGCGGCCACGGCT GAGGCGTCTACACCAGCGGTCGGTCAGCAAAGAGAAGTGGGTGGAGACCCTGGTAGTAGCTGATGCCAAAATGGTGGAGTACCACGGACA GCCGCAGGTTGAGAGCTATGTGCTGACCATCATGAACATGGTGGCTGGCCTGTTTCATGACCCCAGCATTGGGAACCCCATCCACATCAC CATTGTGCGCCTGGTCCTGCTGGAAGATGAGGAGGAGGACCTAAAGATCACGCACCATGCAGACAACACCCTGAAGAGCTTCTGCAAGTG GCAGAAAAGCATCAACATGAAGGGGGATGCCCATCCCCTGCACCATGACACTGCCATCCTGCTCACCAGAAAGGACCTGTGTGCAGCCAT GAACCGGCCCTGTGAGACCCTGGGACTGTCCCATGTGGCGGGCATGTGCCAGCCGCACCGCAGCTGCAGCATCAACGAGGACACGGGCCT GCCGCTGGCCTTCACTGTAGCCCACGAGCTCGGGCACAGTTTTGGCATTCAGCATGACGGAAGCGGCAATGACTGTGAGCCCGTTGGGAA ACGACCTTTCATCATGTCTCCACAGCTCCTGTACGACGCCGCTCCCCTCACCTGGTCCCGCTGCAGCCGCCAGTATATCACCAGGTTCCT TGAATCTGTAAGAGCAAAGCTAAAGAATCTCAGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAG CAGGACTGTGGTCATTTCCTTGCTGAAGTCCCTAACCGTCTGCTTCCCTGGGAGGATCCAGATGACCCTGAAAAGGATGAGGATGACATG GAAGAGACTGAAGAAGACGCCAAAGGAGAAACGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAG GGAGTCATGAGCAAGAAGCAGAGGAGCCACGTTGTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCT CTGGCCCAGCATGGGAAAAGCCCTGATTTGTATGAGAGGCAGGTGTGTCTGCTGCTCTTACAGCTATGCTCTGGTCTTGAGCACCTCAAA CCCTACCATGTCACTCACTGCGATCTACGCCTAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCT GCAGAGCCCAGCCCCACCTCATCTTATCCCACTAGGCTTATAGTGAGCAACTTCTCTCAGGCCAAGCAGAAGAGCCATCTGGTGGACCCC GAGATCCTCCGGGACCAGTCTCGCCTTGCCCCAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTC ATCTATGAGATGCTGCACCTACCCAACCCCTTTGATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATC CCATTCCGCTCCCCCTACTCCCGGGGTCTGCAGCAGCTGGCCAGCTGCCTCCTGAATCCCAACCCTTCTGAGCGGATCCTCATTTCAGAC GCCAAAGGCATCCTCCAGTGTCTGCTCTGGGGCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAAC ACCCTGCTCCAAAACTGGCTAGACATCAAGCGAACACTGCTCATGATCAAGTTTGCTGAGAAGTCCCTGGACAGGGAAGGTGGAATCAGC CTTGAGGACTGGCTTTGTGCTCAGTATTTGGCTTTTGCCACTACAGACTCCCTCAGTTGTATTGTGAAAATTCTGCAGCACCGTTAATGT GTACCTGGATGATGCTTTTACTACATCTTCACCTTCTTCATGTCACCCATGCACTTCCCCTCCCTAGTGCTCACTCCAAATTCAAGGAAA GAAGAAAGGCAAACCTCTATCCCTGTCCGTGAACAAGTGGGTCTATTCAGAAAGGTTATCCACTGCCCCAGATTGAATGAGAAGCTGAGT CTGTCTTAACTTTACAGAAATTCAGCTGCACAAACTTGCAGTTGCCTTCCCTTGAAACACCTTCTATCCTAATAGTCCCATAAATGCAGG TAAAAATGAAAATCCATATTCTTGAAGGGACAGCTTCTTTGGTATGAACTCAGCCAGTGAGCTGTGTCCATTTCCTCCATAATTCTGGAT ATCACCTATCTTTTTAGCACCAAGTATTTATTCTCACTAGCAGTAGACAGACTTAACCAGTCTCTACCACGACCCAGTAGACTCTGACAA CAGACTCTTCCTTTAAGGTGTCAACAACTGACTTACTAGGCAGGACTGCCATCCTTAGCATCAGCCCAGTTTTGGTTACCAGGGACTATA TCTTTTGTTCCAGGAGAGAGTAGAAAGAAAAGGAGAGATCCCATCCTTGGGTCATAGACCCATTTTCATTGCCATTATCTGTAAGTATGT GCACTGCATGGAGGACAGCCCTAATAGTCTCCCCTCTGCTGCCACTGCCTGATTCTCCACTCTGTCCCCACTTGCCAGTGAAGTTTGGAT TTATCAGCCACTTGTGGCCCATTACAGAGCTGACCCAAGGTGGTGTCACCAATGCCTCAGCAGGGTGGAGTGCAGTTCAGAGCTTATAAA TAGCTGGCAGGGCATGAGGAGATGATTTTCTTGCATGTGCAATTCTCTAGGGGCCATCAGGAAACAGAGTTTAAAGTACCCTTTGATTAC TGTCAGAACTGTCAGCATTTGCAGTTTTCCCCGAGCAGTAATTGGCCAGCTCCCTTCTATCAGTAGCCAGTGTTAACTAGTTTACCAAAT GCTGTAAACAATTGCCCTGAATGAAATAGCTGTCAGTGGAGCTCTAAGATCTCCTTTAGAGGGCACAGTGAGGTGGGCTGTTGGGATGGC CGTAGGCAGGGGAGAGGAAGAAGGCCACTGATGAGACTGCTGACCTCCTCAGAAGGTTGACCTCTTCTAGAGAGACTGCCTCCCAGTGTT TAAGTGGCTCATTGCTCCTTCTGACTCTGTAAAATGGCTCTGGAGGACAGCTCACAGGAATTCTGATTGCTGAGGTGGGTGATTGAGAGC TGTTCACCATGTGTGCAGCCTGTGCTCCCCTTCTATGGATATGTGTGCAATTTTTGTATGTATTTTTTTAGCTGTATATTACAGTGTTTA TGTTGCAACTTCACCTGAAGCGAGTCTACAGAAACCCTCCCCCTTCTTCCCTTGGCACATATTTGCGCTAAGAGATGAGCGTTCCTTCCA CTGGGGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATACACATGTTCACCTGTGCTTGTTTTATTCAAA ACTGTGAGTATGTGTTTACTTTGACCTTGAAATCCCAAGAGTCACTCGAACAATGTGTGTGTACACTTGTGTGCCCATGTGTGCGTGCAC ACGCATGCTGGAAGTAGAGGCCAGGCCTCTAGAAAAGCAACCTGTGGCAGGGTTGACAGACATGTTCTCTGTGCCTAGTGAGTGAGTGAG CCCTGAGGCCCCTCATCTACCAGTGCAGAGTTTCCTTAAAGCCAAGACTGACTGTGCAGTATTACTTACATAGCACATTAGTGGCCTTGG AAATTTCTAAACTTTTAACATTTTTAACAGCTTTTCATGTGATTCATGTATAACAAAGAGGATCAGGAAAGGAAAATAATGTATTTTATT GTGCTCTTATTACTTTTTTAAGTGATTGTAATATGTGAGGCTCTATTTGGAGAATGTCCCTTATCCCCTGGCCAGCAATATAGGACTCAC AGGAAAGAAGGCTGGTTAGCCCACAAAGAGTCTTGCCTCCTCTAGCCAGAGTGCAGGGCTCTGCTCCTAGGAATGGCCATGGAGTGGGCA TGCTGCTGCAGGCCAGCAGTCTGCTCTTGGTGTCCTGTGGCATGGCCGCGCCTTGCCTTGAAGGTTGGTGTTTGGTTCATCTTAGCATAG AACATGTGCACATAACTCCTTGCCTGATTATGCACTGAAGGGCAGCACACAGACCACTGACCATGTCAGCCAGCACATTCCCTTAACCTC CCCCACCTCCCATCTTGCAATGTCTTGCATATTGAGATATACCTTCTCAATGTCATGTTCGTGGTGCCTTGCCCATGTAAATTTCAATGT TGACTATTTAATGAGGTTACATATTTAATGCTGAATGTTTCCTGGTCCCTCTATTTGTTATGTCTCTACTTATCTTTTTTTTTCTTTCTC TTTTTCTGTTATGATTTGGATCCAGTCTTCACTTTAACTCTATGGTATAATAAGCATGGACACCTCCACTACCATTATCTTACAGCACTG GTAAACCAAGCACCTCTTCATATCAGATGTTTTTAGTACTGTTTTTATATTCAGATTTGTTAAGGGCAAAAGATGAATGCAAACTAGCCA GAGAAAAGCCTCAGGCTTCCCAGAGACAGGTGGCTAGATTAATTTTTCTCTGGGTGATGGCCAAAGAATGTGAGATAGAGAGGGAAGGGG GTGTTACAGGTTAGAGCAGAATAGAGAAAGAAACTATATTTCTAGGCAAAAAGTACTACATGAGTTGGTCTTCAGAATATTTTTCCAAAA AAATGAAATTCAGTCAGTTTAACATTATCACAAATATTTTTCATTTTAATTGTGGTAGGACCTTTGAATTTGTTCATCAACTGGAAAGAA ATCCTACCCTCTGTAGACACATACACACACATTTATATATCTATGTGTTTGAATTGTGACTAGTATAGCACTTTACATTTTCTCAAGTAA CAGGAAGTTATTGCCTTCAATATTGATTGGAAATTGTTTTCTATTGAAGTCTATACTGTAGAGTTTTCCATTTATATTGAGAGTTTGAAC AATTAAGCTCCTATTGGAACTTTTCCTTAAGCCACATGAGCATGAACAATCTCTGTGACACTTGGGTGCTAGAGAAACACAACAGTGGCT AAAGTAGCCAAGAGCAAGACTGAATGTATAGCAGAGTGCCTTGTTAGAGTGGTAACCTAGTCTTGGAAGCAATTCAGTGGATGTTTCATA AAGAGGACTAGAACTTCAAGAAGCCTCCTGTGCTGGCTGAGGTGAGCCCTTTTGGTATATGTACACTACTGGGTTGCCTAGAAGCCAATT CATGAAGAATAACAGCAGGATGAGAAAAAGAGTCACTGTAACCTGTGGAACAACAACGTAAGAATCACCAACCCCTAGGCTGAGCTAGAA CTGGAAGCCAGGAATATGGCAATGAGTTTCAAGATTTGCCCTCAGAAGATGAACTGGGTGAGGTATGGGTTGAGGTGAGGGCACAAGCAC TCATCCTACCTACCCTGCTGCTGTTGAGGAGCTAGAAGTAAAACATATTGGTTAGGATTTTAACAGTTGGAGTAGCCTCCCATTATCAGA TTAAGTGGGGGTCACTTTTGCTTCCAAACTCAGAATAAGTTTGTAAACATGGGAAAGTCTAAGCCAAGAGATCTAAAGCTCTAGAAATAT TAATGACATTTCTGGGAGTAAAACTACTAAAAATTATATCTTAAAAGTTTCTAGTAGTATGAAGTTCCCAGGCCAGGCGCAGTGGCTCAC GCCTGTAATCCCAACACTTTAGGAGGGCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTC CATCTCTACTAAAAATACAAAAATTAGCCGGGCATGATGGCAGGCACCTGTAATCTAAGCTACTCGGGAGGCTGAGGCAAGAGAATCTCT TGAACCCAGGAGGCAAAGGTTGCAGTGAGCCAAGATCACGCCATCGCACTCCAGCCTGGGAGATTGAGCAACTTCGTCTCAAAAAAAAGT TTCCAGGAAAGATCTTTGGGTCCTACTAAGCGTCTCAATTTTGAGTTATGAATACTTTGGTTCAGGGAAGTAACCTGACATTTGGTTTTG CTGGAATTAGGGTTTTCGCTAGATTTGACTGCAATTAGGATTTCTTCTAGATTTTACCAGCAGTGATCTGAAAAAGTACAGGCTAGTCAC AGAAATAGAGATGGATTTAGGATACTACACTATATTTCAAATGATTCTAGATGTGTAAATATAGTATGAACATTCTTGGAGAGGGGTGAG ACAAACTGGACTTGCTGGGCCAACCCTGGCATGTTTTTCATTCTCCTCACTAGTTGACAAGGATTGAAAATTCCGCTCCAGCCTAATGAG TGAACAGGATGGCTGCCCACAAAACCAAGTTATTAGCTTTATGTCATCGAAGCTCATATTCTCAAAGGCCCAAAGTGCTGTGCCGAGACA AATCCAAGTGCTGCTCTTGCTGAAGTGCGCACTGAAGTCCAGCTGTCCGTGCTTACAGCAGTGCCAAAAGTGGGGATTCCATGGACCAAA AACGGTGCCATAAGGGAAGCCAGAAGAGTTGCAGTGCAAGATCCTGGGAGAGATTATACCAAAGAAATCAAGCCTTTTTATCCTGATGCT TCTAAGATGATGAGGGTGAGCTGTGACAGATGCTGTGGGAGGGGAGTTCACATACATTCCATGTCAAGGCATTTAGCTGATAAATCCATC CTCAGAAAAGCACCTTTTTAAAAAGAAGTCCATTTTGTATATTAGAAGATGATGATGATGATGAAGATGAAGAAAGCCCTGGCAGATACA AAGTTCCTCAGTATTTAAGGAGAAGGATCTCTTCCATGTCCCCTTGACATGACTGTGGCTATTGCCCAAACCTCAGCTTGAGAACATCAT ATAATACTGAGAGCGGAAGATTTTTTTAAAGAGATATGGTAGTTTAAATAGGTTTGTTTAAAGAACTCTTGGGAAATTTCTTAACAAATT GTAATTGTTTTTATAAACCTTCCTACAGAGTTGTGTACCATTCATCATCACCATCATTTAATATCTGTAAGTGCCCAGAAGGTACAAGGT GCTATACAGCCGTTAAACACCCCCTCCCTGCAACTGTTTAAAATTAGAATAGATTTTTGCATCAACCACTGCTAGAAGCTTTCCCCACCT AGGTGGGCTGCAAGGGCCTGCATTCCCAACATCCCATTACATGTTTCCCACTCCAGAAAGTCTCTGGGTTTATTCCAGCTTTTTATCTTG ACGTGTCCCATTCACCCCCATGGTTTGGTTTGGTTTGGTTTTGTTTTTTAAATCAAGAAAGTTTCAGGGAATCAAAAGAGGTCGGACATT TTTTAACCTAGCAGAAGTACAGAGTCATATATTTTGCTACGAATATTGTTGTAGTACAGAAAACCCACTTTGCCCGTTAGTGTGTGGATA GTATGTGTGTGTCCGCACTCATGATAACTTGAATGTTGAACCAGACATAGGGTTCATTTTTGAAAGGTTAAACCACACTGTTTCAGGAAC TTGCTCCAAATACTACTTGGTTATCCCTTCCTTTACCAGTTAGAACTAAAGAGTGTGATGTATGAACACACTGGGTTGGGATTTTCTGTT GAGGATATGCAGGGCATTTTGGCATGAGGCAAATACAGAAGCAAGATTTCATTCTACTTGGTGATTTGAATCATGACAGTCCTCATTCCA ATCTCTCTTTAATTCTCTCTGGCCCTGCCCACACTCTGTATTTGAAAATCTTGTTTTTGCTCTTTCCGGAGCTTCACCCCTCTACTTACA TATTGTAAAGTTGTATAAATCTATCATTGAAAGGTCCTCTCTGCCAGCAGTGGTGCCACCCTTTGGTTTGCTGTGGTACTTTGCTGTGTA |
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FusionGenePPI for ADAMTS7_PEAK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADAMTS7 | PEAK1 | CRK, GRB2, PPP1CC, PPP1CA, NCK2, CARD8, SH2D2A, AURKA, PPP1R3A, CRKL, SORT1, XRCC5, TOR1AIP1, CDH1, PTPRK, SHC1, VWA5A, BBS7, DQX1, PCDHB11, AARSD1, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAMTS7_PEAK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAMTS7_PEAK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADAMTS7 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| Hgene | ADAMTS7 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
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