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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 756

FusionGeneSummary for ADAMTS7_PEAK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS7_PEAK1
Fusion gene ID: 756
HgeneTgene
Gene symbol

ADAMTS7

PEAK1

Gene ID

11173

79834

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 7pseudopodium enriched atypical kinase 1
SynonymsADAM-TS 7|ADAM-TS7|ADAMTS-7SGK269
Cytomap

15q25.1

15q24.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 7COMPasea disintegrin and metalloprotease with thrombospondin motifs-7 preproproteina disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7pseudopodium-enriched atypical kinase 1NKF3 kinase family membersugen kinase 269tyrosine-protein kinase SgK269
Modification date2018052220180523
UniProtAcc

Q9UKP4

Q9H792

Ensembl transtripts involved in fusion geneENST00000388820, ENST00000566303, 
ENST00000560626, ENST00000558305, 
ENST00000567337, ENST00000312493, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS7 [Title/Abstract] AND PEAK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS7

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS7

GO:0071773

cellular response to BMP stimulus

22247065

TgenePEAK1

GO:0016477

cell migration

20534451

TgenePEAK1

GO:0034446

substrate adhesion-dependent cell spreading

20534451

TgenePEAK1

GO:0046777

protein autophosphorylation

20534451

TgenePEAK1

GO:0051893

regulation of focal adhesion assembly

23105102


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23R-01AADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000388820ENST00000560626ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5CDS-intronENST00000388820ENST00000558305ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5CDS-intronENST00000388820ENST00000567337ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5CDS-intronENST00000388820ENST00000312493ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5UTR-3CDSENST00000566303ENST00000560626ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5UTR-intronENST00000566303ENST00000558305ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5UTR-intronENST00000566303ENST00000567337ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-
5UTR-intronENST00000566303ENST00000312493ADAMTS7chr15

79080573

-PEAK1chr15

77407661

-

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FusionProtFeatures for ADAMTS7_PEAK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS7

Q9UKP4

PEAK1

Q9H792

Metalloprotease that may play a role in the degradationof COMP. {ECO:0000269|PubMed:16585064}. Probable catalytically inactive kinase. Scaffoldingprotein that regulates the cytoskeleton to control cell spreadingand migration by modulating focal adhesion dynamics(PubMed:23105102, PubMed:20534451). Acts as a scaffold formediating EGFR signaling (PubMed:23846654).{ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102,ECO:0000269|PubMed:23846654}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824202_2094401687MotifCysteine switch
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-351670_174313591747RegionRequired for homodimerization
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-571670_174313591747RegionRequired for homodimerization

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824595_6974401687Compositional biasNote=Cys-rich
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-8241411_14594401687DomainTSP type-1 5
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-8241462_15224401687DomainTSP type-1 6
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-8241523_15674401687DomainTSP type-1 7
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-8241569_16294401687DomainTSP type-1 8
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-8241632_16724401687DomainPLAC
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824242_4524401687DomainPeptidase M12B
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824462_5374401687DomainNote=Disintegrin
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824538_5934401687DomainTSP type-1 1
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824821_8804401687DomainTSP type-1 2
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824881_9404401687DomainTSP type-1 3
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824942_9954401687DomainTSP type-1 4
HgeneADAMTS7chr15:79080573chr15:77407661ENST00000388820-824698_8094401687RegionNote=Spacer
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-35117_12013591747Compositional biasNote=Poly-Asn
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-35324_40613591747Compositional biasNote=Ser-rich
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-35500_50313591747Compositional biasNote=Poly-Ser
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-35776_87313591747Compositional biasNote=Pro-rich
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-35964_96713591747Compositional biasNote=Poly-Pro
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-57117_12013591747Compositional biasNote=Poly-Asn
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-57324_40613591747Compositional biasNote=Ser-rich
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-57500_50313591747Compositional biasNote=Poly-Ser
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-57776_87313591747Compositional biasNote=Pro-rich
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-57964_96713591747Compositional biasNote=Poly-Pro
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-351313_167513591747DomainProtein kinase
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-571313_167513591747DomainProtein kinase
TgenePEAK1chr15:79080573chr15:77407661ENST00000312493-351285_131113591747RegionRequired for homodimerization
TgenePEAK1chr15:79080573chr15:77407661ENST00000560626-571285_131113591747RegionRequired for homodimerization


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FusionGeneSequence for ADAMTS7_PEAK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_828aa
MPGGPSPRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRE
LRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQP
HVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTI
MNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLS
HVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLESVRAKLKNL
SSIITAWLSGRVWLSILTFSRTVVISLLKSLTVCFPGRIQMTLKRMRMTWKRLKKTPKEKRMGKTQSPVLKQHHPRKRIRESXARSRGAT
LWSSPGRFHVLLWLILCETLWPSMGKALICMRGRCVCCSYSYALVLSTSNPTMSLTAIYAXRTCYLSTTSLGGLPKALGLQSPAPPHLIP
LGLXXATSLRPSRRAIWWTPRSSGTSLALPQRSXQLPSIKSVMSSRQASSSMRCCTYPTPLMRTQSXRRGNTHEQTCLASHSAPPTPGVC
SSWPAASXIPTLLSGSSFQTPKASSSVCSGAPAKISSRLSPPALAXYRGTPCSKTGXTSSEHCSXSSLLRSPWTGKVESALRTGFVLSIW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_2486nt
ATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCTCCTCTGCGCTCTGGCTCCCGGCGCCCCCGGA
CCCGCACCAGGACGTGCAACCGAGGGCCGGGCGGCACTGGACATCGTGCACCCGGTTCGAGTCGACGCGGGGGGCTCCTTCCTGTCCTAC
GAGCTGTGGCCCCGCGCACTGCGCAAGCGGGATGTATCTGTGCGCCGAGACGCGCCCGCCTTCTACGAGCTACAATACCGCGGGCGCGAG
CTGCGCTTCAACCTGACCGCCAATCAGCACCTGCTGGCGCCCGGCTTTGTGAGCGAGACGCGGCGGCGCGGCGGCCTGGGCCGCGCGCAC
ATCCGGGCCCACACCCCGGCCTGCCACCTGCTTGGCGAGGTGCAGGACCCTGAGCTCGAGGGTGGCCTGGCGGCCATCAGCGCCTGCGAC
GGCCTGAAAGGTGTGTTCCAGCTCTCCAACGAGGACTACTTCATTGAGCCCCTGGACAGTGCCCCGGCCCGGCCTGGCCACGCCCAGCCC
CATGTGGTGTACAAGCGTCAGGCCCCGGAGAGGCTGGCACAGCGGGGTGATTCCAGTGCTCCAAGCACCTGTGGAGTGCAAGTGTACCCA
GAGCTGGAGTCTCGACGGGAGCGTTGGGAGCAGCGGCAGCAGTGGCGGCGGCCACGGCTGAGGCGTCTACACCAGCGGTCGGTCAGCAAA
GAGAAGTGGGTGGAGACCCTGGTAGTAGCTGATGCCAAAATGGTGGAGTACCACGGACAGCCGCAGGTTGAGAGCTATGTGCTGACCATC
ATGAACATGGTGGCTGGCCTGTTTCATGACCCCAGCATTGGGAACCCCATCCACATCACCATTGTGCGCCTGGTCCTGCTGGAAGATGAG
GAGGAGGACCTAAAGATCACGCACCATGCAGACAACACCCTGAAGAGCTTCTGCAAGTGGCAGAAAAGCATCAACATGAAGGGGGATGCC
CATCCCCTGCACCATGACACTGCCATCCTGCTCACCAGAAAGGACCTGTGTGCAGCCATGAACCGGCCCTGTGAGACCCTGGGACTGTCC
CATGTGGCGGGCATGTGCCAGCCGCACCGCAGCTGCAGCATCAACGAGGACACGGGCCTGCCGCTGGCCTTCACTGTAGCCCACGAGCTC
GGGCACAGTTTTGGCATTCAGCATGACGGAAGCGGCAATGACTGTGAGCCCGTTGGGAAACGACCTTTCATCATGTCTCCACAGCTCCTG
TACGACGCCGCTCCCCTCACCTGGTCCCGCTGCAGCCGCCAGTATATCACCAGGTTCCTTGAATCTGTAAGAGCAAAGCTAAAGAATCTC
AGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAGCAGGACTGTGGTCATTTCCTTGCTGAAGTCC
CTAACCGTCTGCTTCCCTGGGAGGATCCAGATGACCCTGAAAAGGATGAGGATGACATGGAAGAGACTGAAGAAGACGCCAAAGGAGAAA
CGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAGGGAGTCATGAGCAAGAAGCAGAGGAGCCACG
TTGTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCTCTGGCCCAGCATGGGAAAAGCCCTGATTTGT
ATGAGAGGCAGGTGTGTCTGCTGCTCTTACAGCTATGCTCTGGTCTTGAGCACCTCAAACCCTACCATGTCACTCACTGCGATCTACGCC
TAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCTGCAGAGCCCAGCCCCACCTCATCTTATCCCA
CTAGGCTTATAGTGAGCAACTTCTCTCAGGCCAAGCAGAAGAGCCATCTGGTGGACCCCGAGATCCTCCGGGACCAGTCTCGCCTTGCCC
CAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTCATCTATGAGATGCTGCACCTACCCAACCCCT
TTGATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATCCCATTCCGCTCCCCCTACTCCCGGGGTCTGC
AGCAGCTGGCCAGCTGCCTCCTGAATCCCAACCCTTCTGAGCGGATCCTCATTTCAGACGCCAAAGGCATCCTCCAGTGTCTGCTCTGGG
GCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAACACCCTGCTCCAAAACTGGCTAGACATCAAGC
GAACACTGCTCATGATCAAGTTTGCTGAGAAGTCCCTGGACAGGGAAGGTGGAATCAGCCTTGAGGACTGGCTTTGTGCTCAGTATTTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ADAMTS7_ENST00000388820_chr15_79080573_-_PEAK1_ENST00000560626_chr15_77407661_-_8695nt
CTTTTCTTTGCCTCTGCAGCGGCCAAGGGGGCGGGCCCTGCAGCCTTTGTTGCCCGCGGACCGAGCGCAGCCGAACGGAGTCGGGGCCGG
GTCGCCGGGAGCTGCACGCCGGCCGGGCATGTCCTGAGCCGGACCTGGGACCAGGCAGCGACCGGACGGGACGGACGAGAGCGTGCGCGC
GGGGTCACCCGGCGGCCGCCCGGTTCCTGCCATGCCCGGCGGCCCCAGTCCCCGCAGCCCCGCGCCTTTGCTGCGCCCCCTCCTCCTGCT
CCTCTGCGCTCTGGCTCCCGGCGCCCCCGGACCCGCACCAGGACGTGCAACCGAGGGCCGGGCGGCACTGGACATCGTGCACCCGGTTCG
AGTCGACGCGGGGGGCTCCTTCCTGTCCTACGAGCTGTGGCCCCGCGCACTGCGCAAGCGGGATGTATCTGTGCGCCGAGACGCGCCCGC
CTTCTACGAGCTACAATACCGCGGGCGCGAGCTGCGCTTCAACCTGACCGCCAATCAGCACCTGCTGGCGCCCGGCTTTGTGAGCGAGAC
GCGGCGGCGCGGCGGCCTGGGCCGCGCGCACATCCGGGCCCACACCCCGGCCTGCCACCTGCTTGGCGAGGTGCAGGACCCTGAGCTCGA
GGGTGGCCTGGCGGCCATCAGCGCCTGCGACGGCCTGAAAGGTGTGTTCCAGCTCTCCAACGAGGACTACTTCATTGAGCCCCTGGACAG
TGCCCCGGCCCGGCCTGGCCACGCCCAGCCCCATGTGGTGTACAAGCGTCAGGCCCCGGAGAGGCTGGCACAGCGGGGTGATTCCAGTGC
TCCAAGCACCTGTGGAGTGCAAGTGTACCCAGAGCTGGAGTCTCGACGGGAGCGTTGGGAGCAGCGGCAGCAGTGGCGGCGGCCACGGCT
GAGGCGTCTACACCAGCGGTCGGTCAGCAAAGAGAAGTGGGTGGAGACCCTGGTAGTAGCTGATGCCAAAATGGTGGAGTACCACGGACA
GCCGCAGGTTGAGAGCTATGTGCTGACCATCATGAACATGGTGGCTGGCCTGTTTCATGACCCCAGCATTGGGAACCCCATCCACATCAC
CATTGTGCGCCTGGTCCTGCTGGAAGATGAGGAGGAGGACCTAAAGATCACGCACCATGCAGACAACACCCTGAAGAGCTTCTGCAAGTG
GCAGAAAAGCATCAACATGAAGGGGGATGCCCATCCCCTGCACCATGACACTGCCATCCTGCTCACCAGAAAGGACCTGTGTGCAGCCAT
GAACCGGCCCTGTGAGACCCTGGGACTGTCCCATGTGGCGGGCATGTGCCAGCCGCACCGCAGCTGCAGCATCAACGAGGACACGGGCCT
GCCGCTGGCCTTCACTGTAGCCCACGAGCTCGGGCACAGTTTTGGCATTCAGCATGACGGAAGCGGCAATGACTGTGAGCCCGTTGGGAA
ACGACCTTTCATCATGTCTCCACAGCTCCTGTACGACGCCGCTCCCCTCACCTGGTCCCGCTGCAGCCGCCAGTATATCACCAGGTTCCT
TGAATCTGTAAGAGCAAAGCTAAAGAATCTCAGCAGTATTATCACAGCTTGGCTGTCCGGCAGAGTCTGGCTGTCCATTTTAACATTCAG
CAGGACTGTGGTCATTTCCTTGCTGAAGTCCCTAACCGTCTGCTTCCCTGGGAGGATCCAGATGACCCTGAAAAGGATGAGGATGACATG
GAAGAGACTGAAGAAGACGCCAAAGGAGAAACGGATGGGAAAAACCCAAAGCCCTGTTCTGAAGCAGCATCATCCCAGAAAGAGAATCAG
GGAGTCATGAGCAAGAAGCAGAGGAGCCACGTTGTGGTCATCACCAGGGAGGTTCCATGTCTTACTGTGGCTGATTTTGTGCGAGACTCT
CTGGCCCAGCATGGGAAAAGCCCTGATTTGTATGAGAGGCAGGTGTGTCTGCTGCTCTTACAGCTATGCTCTGGTCTTGAGCACCTCAAA
CCCTACCATGTCACTCACTGCGATCTACGCCTAGAGAACCTGCTACTTGTCCACTACCAGCCTGGGGGGACTGCCCAAGGCTTTGGGCCT
GCAGAGCCCAGCCCCACCTCATCTTATCCCACTAGGCTTATAGTGAGCAACTTCTCTCAGGCCAAGCAGAAGAGCCATCTGGTGGACCCC
GAGATCCTCCGGGACCAGTCTCGCCTTGCCCCAGAGATCATAACAGCTACCCAGTATAAAAAGTGTGATGAGTTCCAGACAGGCATCCTC
ATCTATGAGATGCTGCACCTACCCAACCCCTTTGATGAGAACCCAGAGCTGAAGGAGAGGGAATACACACGAGCAGACCTGCCTCGCATC
CCATTCCGCTCCCCCTACTCCCGGGGTCTGCAGCAGCTGGCCAGCTGCCTCCTGAATCCCAACCCTTCTGAGCGGATCCTCATTTCAGAC
GCCAAAGGCATCCTCCAGTGTCTGCTCTGGGGCCCCCGCGAAGATCTCTTCCAGACTTTCACCGCCTGCCCTAGCCTAGTACAGAGGAAC
ACCCTGCTCCAAAACTGGCTAGACATCAAGCGAACACTGCTCATGATCAAGTTTGCTGAGAAGTCCCTGGACAGGGAAGGTGGAATCAGC
CTTGAGGACTGGCTTTGTGCTCAGTATTTGGCTTTTGCCACTACAGACTCCCTCAGTTGTATTGTGAAAATTCTGCAGCACCGTTAATGT
GTACCTGGATGATGCTTTTACTACATCTTCACCTTCTTCATGTCACCCATGCACTTCCCCTCCCTAGTGCTCACTCCAAATTCAAGGAAA
GAAGAAAGGCAAACCTCTATCCCTGTCCGTGAACAAGTGGGTCTATTCAGAAAGGTTATCCACTGCCCCAGATTGAATGAGAAGCTGAGT
CTGTCTTAACTTTACAGAAATTCAGCTGCACAAACTTGCAGTTGCCTTCCCTTGAAACACCTTCTATCCTAATAGTCCCATAAATGCAGG
TAAAAATGAAAATCCATATTCTTGAAGGGACAGCTTCTTTGGTATGAACTCAGCCAGTGAGCTGTGTCCATTTCCTCCATAATTCTGGAT
ATCACCTATCTTTTTAGCACCAAGTATTTATTCTCACTAGCAGTAGACAGACTTAACCAGTCTCTACCACGACCCAGTAGACTCTGACAA
CAGACTCTTCCTTTAAGGTGTCAACAACTGACTTACTAGGCAGGACTGCCATCCTTAGCATCAGCCCAGTTTTGGTTACCAGGGACTATA
TCTTTTGTTCCAGGAGAGAGTAGAAAGAAAAGGAGAGATCCCATCCTTGGGTCATAGACCCATTTTCATTGCCATTATCTGTAAGTATGT
GCACTGCATGGAGGACAGCCCTAATAGTCTCCCCTCTGCTGCCACTGCCTGATTCTCCACTCTGTCCCCACTTGCCAGTGAAGTTTGGAT
TTATCAGCCACTTGTGGCCCATTACAGAGCTGACCCAAGGTGGTGTCACCAATGCCTCAGCAGGGTGGAGTGCAGTTCAGAGCTTATAAA
TAGCTGGCAGGGCATGAGGAGATGATTTTCTTGCATGTGCAATTCTCTAGGGGCCATCAGGAAACAGAGTTTAAAGTACCCTTTGATTAC
TGTCAGAACTGTCAGCATTTGCAGTTTTCCCCGAGCAGTAATTGGCCAGCTCCCTTCTATCAGTAGCCAGTGTTAACTAGTTTACCAAAT
GCTGTAAACAATTGCCCTGAATGAAATAGCTGTCAGTGGAGCTCTAAGATCTCCTTTAGAGGGCACAGTGAGGTGGGCTGTTGGGATGGC
CGTAGGCAGGGGAGAGGAAGAAGGCCACTGATGAGACTGCTGACCTCCTCAGAAGGTTGACCTCTTCTAGAGAGACTGCCTCCCAGTGTT
TAAGTGGCTCATTGCTCCTTCTGACTCTGTAAAATGGCTCTGGAGGACAGCTCACAGGAATTCTGATTGCTGAGGTGGGTGATTGAGAGC
TGTTCACCATGTGTGCAGCCTGTGCTCCCCTTCTATGGATATGTGTGCAATTTTTGTATGTATTTTTTTAGCTGTATATTACAGTGTTTA
TGTTGCAACTTCACCTGAAGCGAGTCTACAGAAACCCTCCCCCTTCTTCCCTTGGCACATATTTGCGCTAAGAGATGAGCGTTCCTTCCA
CTGGGGTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATACACATGTTCACCTGTGCTTGTTTTATTCAAA
ACTGTGAGTATGTGTTTACTTTGACCTTGAAATCCCAAGAGTCACTCGAACAATGTGTGTGTACACTTGTGTGCCCATGTGTGCGTGCAC
ACGCATGCTGGAAGTAGAGGCCAGGCCTCTAGAAAAGCAACCTGTGGCAGGGTTGACAGACATGTTCTCTGTGCCTAGTGAGTGAGTGAG
CCCTGAGGCCCCTCATCTACCAGTGCAGAGTTTCCTTAAAGCCAAGACTGACTGTGCAGTATTACTTACATAGCACATTAGTGGCCTTGG
AAATTTCTAAACTTTTAACATTTTTAACAGCTTTTCATGTGATTCATGTATAACAAAGAGGATCAGGAAAGGAAAATAATGTATTTTATT
GTGCTCTTATTACTTTTTTAAGTGATTGTAATATGTGAGGCTCTATTTGGAGAATGTCCCTTATCCCCTGGCCAGCAATATAGGACTCAC
AGGAAAGAAGGCTGGTTAGCCCACAAAGAGTCTTGCCTCCTCTAGCCAGAGTGCAGGGCTCTGCTCCTAGGAATGGCCATGGAGTGGGCA
TGCTGCTGCAGGCCAGCAGTCTGCTCTTGGTGTCCTGTGGCATGGCCGCGCCTTGCCTTGAAGGTTGGTGTTTGGTTCATCTTAGCATAG
AACATGTGCACATAACTCCTTGCCTGATTATGCACTGAAGGGCAGCACACAGACCACTGACCATGTCAGCCAGCACATTCCCTTAACCTC
CCCCACCTCCCATCTTGCAATGTCTTGCATATTGAGATATACCTTCTCAATGTCATGTTCGTGGTGCCTTGCCCATGTAAATTTCAATGT
TGACTATTTAATGAGGTTACATATTTAATGCTGAATGTTTCCTGGTCCCTCTATTTGTTATGTCTCTACTTATCTTTTTTTTTCTTTCTC
TTTTTCTGTTATGATTTGGATCCAGTCTTCACTTTAACTCTATGGTATAATAAGCATGGACACCTCCACTACCATTATCTTACAGCACTG
GTAAACCAAGCACCTCTTCATATCAGATGTTTTTAGTACTGTTTTTATATTCAGATTTGTTAAGGGCAAAAGATGAATGCAAACTAGCCA
GAGAAAAGCCTCAGGCTTCCCAGAGACAGGTGGCTAGATTAATTTTTCTCTGGGTGATGGCCAAAGAATGTGAGATAGAGAGGGAAGGGG
GTGTTACAGGTTAGAGCAGAATAGAGAAAGAAACTATATTTCTAGGCAAAAAGTACTACATGAGTTGGTCTTCAGAATATTTTTCCAAAA
AAATGAAATTCAGTCAGTTTAACATTATCACAAATATTTTTCATTTTAATTGTGGTAGGACCTTTGAATTTGTTCATCAACTGGAAAGAA
ATCCTACCCTCTGTAGACACATACACACACATTTATATATCTATGTGTTTGAATTGTGACTAGTATAGCACTTTACATTTTCTCAAGTAA
CAGGAAGTTATTGCCTTCAATATTGATTGGAAATTGTTTTCTATTGAAGTCTATACTGTAGAGTTTTCCATTTATATTGAGAGTTTGAAC
AATTAAGCTCCTATTGGAACTTTTCCTTAAGCCACATGAGCATGAACAATCTCTGTGACACTTGGGTGCTAGAGAAACACAACAGTGGCT
AAAGTAGCCAAGAGCAAGACTGAATGTATAGCAGAGTGCCTTGTTAGAGTGGTAACCTAGTCTTGGAAGCAATTCAGTGGATGTTTCATA
AAGAGGACTAGAACTTCAAGAAGCCTCCTGTGCTGGCTGAGGTGAGCCCTTTTGGTATATGTACACTACTGGGTTGCCTAGAAGCCAATT
CATGAAGAATAACAGCAGGATGAGAAAAAGAGTCACTGTAACCTGTGGAACAACAACGTAAGAATCACCAACCCCTAGGCTGAGCTAGAA
CTGGAAGCCAGGAATATGGCAATGAGTTTCAAGATTTGCCCTCAGAAGATGAACTGGGTGAGGTATGGGTTGAGGTGAGGGCACAAGCAC
TCATCCTACCTACCCTGCTGCTGTTGAGGAGCTAGAAGTAAAACATATTGGTTAGGATTTTAACAGTTGGAGTAGCCTCCCATTATCAGA
TTAAGTGGGGGTCACTTTTGCTTCCAAACTCAGAATAAGTTTGTAAACATGGGAAAGTCTAAGCCAAGAGATCTAAAGCTCTAGAAATAT
TAATGACATTTCTGGGAGTAAAACTACTAAAAATTATATCTTAAAAGTTTCTAGTAGTATGAAGTTCCCAGGCCAGGCGCAGTGGCTCAC
GCCTGTAATCCCAACACTTTAGGAGGGCGAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTC
CATCTCTACTAAAAATACAAAAATTAGCCGGGCATGATGGCAGGCACCTGTAATCTAAGCTACTCGGGAGGCTGAGGCAAGAGAATCTCT
TGAACCCAGGAGGCAAAGGTTGCAGTGAGCCAAGATCACGCCATCGCACTCCAGCCTGGGAGATTGAGCAACTTCGTCTCAAAAAAAAGT
TTCCAGGAAAGATCTTTGGGTCCTACTAAGCGTCTCAATTTTGAGTTATGAATACTTTGGTTCAGGGAAGTAACCTGACATTTGGTTTTG
CTGGAATTAGGGTTTTCGCTAGATTTGACTGCAATTAGGATTTCTTCTAGATTTTACCAGCAGTGATCTGAAAAAGTACAGGCTAGTCAC
AGAAATAGAGATGGATTTAGGATACTACACTATATTTCAAATGATTCTAGATGTGTAAATATAGTATGAACATTCTTGGAGAGGGGTGAG
ACAAACTGGACTTGCTGGGCCAACCCTGGCATGTTTTTCATTCTCCTCACTAGTTGACAAGGATTGAAAATTCCGCTCCAGCCTAATGAG
TGAACAGGATGGCTGCCCACAAAACCAAGTTATTAGCTTTATGTCATCGAAGCTCATATTCTCAAAGGCCCAAAGTGCTGTGCCGAGACA
AATCCAAGTGCTGCTCTTGCTGAAGTGCGCACTGAAGTCCAGCTGTCCGTGCTTACAGCAGTGCCAAAAGTGGGGATTCCATGGACCAAA
AACGGTGCCATAAGGGAAGCCAGAAGAGTTGCAGTGCAAGATCCTGGGAGAGATTATACCAAAGAAATCAAGCCTTTTTATCCTGATGCT
TCTAAGATGATGAGGGTGAGCTGTGACAGATGCTGTGGGAGGGGAGTTCACATACATTCCATGTCAAGGCATTTAGCTGATAAATCCATC
CTCAGAAAAGCACCTTTTTAAAAAGAAGTCCATTTTGTATATTAGAAGATGATGATGATGATGAAGATGAAGAAAGCCCTGGCAGATACA
AAGTTCCTCAGTATTTAAGGAGAAGGATCTCTTCCATGTCCCCTTGACATGACTGTGGCTATTGCCCAAACCTCAGCTTGAGAACATCAT
ATAATACTGAGAGCGGAAGATTTTTTTAAAGAGATATGGTAGTTTAAATAGGTTTGTTTAAAGAACTCTTGGGAAATTTCTTAACAAATT
GTAATTGTTTTTATAAACCTTCCTACAGAGTTGTGTACCATTCATCATCACCATCATTTAATATCTGTAAGTGCCCAGAAGGTACAAGGT
GCTATACAGCCGTTAAACACCCCCTCCCTGCAACTGTTTAAAATTAGAATAGATTTTTGCATCAACCACTGCTAGAAGCTTTCCCCACCT
AGGTGGGCTGCAAGGGCCTGCATTCCCAACATCCCATTACATGTTTCCCACTCCAGAAAGTCTCTGGGTTTATTCCAGCTTTTTATCTTG
ACGTGTCCCATTCACCCCCATGGTTTGGTTTGGTTTGGTTTTGTTTTTTAAATCAAGAAAGTTTCAGGGAATCAAAAGAGGTCGGACATT
TTTTAACCTAGCAGAAGTACAGAGTCATATATTTTGCTACGAATATTGTTGTAGTACAGAAAACCCACTTTGCCCGTTAGTGTGTGGATA
GTATGTGTGTGTCCGCACTCATGATAACTTGAATGTTGAACCAGACATAGGGTTCATTTTTGAAAGGTTAAACCACACTGTTTCAGGAAC
TTGCTCCAAATACTACTTGGTTATCCCTTCCTTTACCAGTTAGAACTAAAGAGTGTGATGTATGAACACACTGGGTTGGGATTTTCTGTT
GAGGATATGCAGGGCATTTTGGCATGAGGCAAATACAGAAGCAAGATTTCATTCTACTTGGTGATTTGAATCATGACAGTCCTCATTCCA
ATCTCTCTTTAATTCTCTCTGGCCCTGCCCACACTCTGTATTTGAAAATCTTGTTTTTGCTCTTTCCGGAGCTTCACCCCTCTACTTACA
TATTGTAAAGTTGTATAAATCTATCATTGAAAGGTCCTCTCTGCCAGCAGTGGTGCCACCCTTTGGTTTGCTGTGGTACTTTGCTGTGTA


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FusionGenePPI for ADAMTS7_PEAK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAMTS7PEAK1CRK, GRB2, PPP1CC, PPP1CA, NCK2, CARD8, SH2D2A, AURKA, PPP1R3A, CRKL, SORT1, XRCC5, TOR1AIP1, CDH1, PTPRK, SHC1, VWA5A, BBS7, DQX1, PCDHB11, AARSD1, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAMTS7_PEAK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAMTS7_PEAK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAMTS7C0032460Polycystic Ovary Syndrome1CTD_human
HgeneADAMTS7C1956346Coronary Artery Disease1CTD_human