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Fusion gene ID: 7538 |
FusionGeneSummary for CLTC_FCHO2 |
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Fusion gene information | Fusion gene name: CLTC_FCHO2 | Fusion gene ID: 7538 | Hgene | Tgene | Gene symbol | CLTC | FCHO2 | Gene ID | 1213 | 115548 |
Gene name | clathrin heavy chain | FCH domain only 2 | |
Synonyms | CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56 | - | |
Cytomap | 17q23.1 | 5q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2 | F-BAR domain only protein 2FCH domain only protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q00610 | Q0JRZ9 | |
Ensembl transtripts involved in fusion gene | ENST00000393043, ENST00000269122, ENST00000579456, ENST00000579815, | ENST00000341845, ENST00000430046, ENST00000512348, ENST00000287761, | |
Fusion gene scores | * DoF score | 14 X 8 X 8=896 | 3 X 3 X 1=9 |
# samples | 14 | 3 | |
** MAII score | log2(14/896*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CLTC [Title/Abstract] AND FCHO2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CLTC | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 24251095 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI989296 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000393043 | ENST00000341845 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-3CDS | ENST00000393043 | ENST00000430046 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-3CDS | ENST00000393043 | ENST00000512348 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-intron | ENST00000393043 | ENST00000287761 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000269122 | ENST00000341845 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000269122 | ENST00000430046 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000269122 | ENST00000512348 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-intron | ENST00000269122 | ENST00000287761 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000579456 | ENST00000341845 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000579456 | ENST00000430046 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-3CDS | ENST00000579456 | ENST00000512348 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
3UTR-intron | ENST00000579456 | ENST00000287761 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-3CDS | ENST00000579815 | ENST00000341845 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-3CDS | ENST00000579815 | ENST00000430046 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-3CDS | ENST00000579815 | ENST00000512348 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
intron-intron | ENST00000579815 | ENST00000287761 | CLTC | chr17 | 57771247 | - | FCHO2 | chr5 | 72383502 | + |
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FusionProtFeatures for CLTC_FCHO2 |
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Hgene | Tgene |
CLTC | FCHO2 |
Clathrin is the major protein of the polyhedral coat ofcoated pits and vesicles. Two different adapter protein complexeslink the clathrin lattice either to the plasma membrane or to thetrans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization ofkinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737,PubMed:21297582). The TACC3/ch-TOG/clathrin complex is requiredfor the maintenance of kinetochore fiber tension(PubMed:23532825). Plays a role in early autophagosome formation(PubMed:20639872). {ECO:0000269|PubMed:15858577,ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872,ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. | Functions in an early step of clathrin-mediatedendocytosis. Has both a membrane binding/bending activity and theability to recruit proteins essential to the formation offunctional clathrin-coated pits. Has a lipid-binding activity witha preference for membranes enriched in phosphatidylserine andphosphoinositides (Pi(4,5) biphosphate) like the plasma membrane.Its membrane-bending activity might be important for thesubsequent action of clathrin and adaptors in the formation ofclathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it alsofunctions in the AP-2-independent endocytosis of the LDL receptor.{ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150,ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLTC_FCHO2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLTC_FCHO2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLTC_FCHO2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLTC_FCHO2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CLTC | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |