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Fusion gene ID: 7506 |
FusionGeneSummary for CLSTN1_SLC7A2 |
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Fusion gene information | Fusion gene name: CLSTN1_SLC7A2 | Fusion gene ID: 7506 | Hgene | Tgene | Gene symbol | CLSTN1 | SLC7A2 | Gene ID | 22883 | 6542 |
Gene name | calsyntenin 1 | solute carrier family 7 member 2 | |
Synonyms | ALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2 | ATRC2|CAT2|HCAT2 | |
Cytomap | 1p36.22 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | calsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alpha | cationic amino acid transporter 2low affinity cationic amino acid transporter 2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O94985 | P52569 | |
Ensembl transtripts involved in fusion gene | ENST00000377298, ENST00000361311, ENST00000377288, ENST00000477264, | ENST00000494857, ENST00000522656, ENST00000470360, ENST00000004531, ENST00000398090, | |
Fusion gene scores | * DoF score | 11 X 10 X 5=550 | 2 X 2 X 1=4 |
# samples | 15 | 2 | |
** MAII score | log2(15/550*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: CLSTN1 [Title/Abstract] AND SLC7A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP395070 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000377298 | ENST00000494857 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-intron | ENST00000377298 | ENST00000522656 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377298 | ENST00000470360 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377298 | ENST00000004531 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377298 | ENST00000398090 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000361311 | ENST00000494857 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-intron | ENST00000361311 | ENST00000522656 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000361311 | ENST00000470360 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000361311 | ENST00000004531 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000361311 | ENST00000398090 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377288 | ENST00000494857 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-intron | ENST00000377288 | ENST00000522656 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377288 | ENST00000470360 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377288 | ENST00000004531 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000377288 | ENST00000398090 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000477264 | ENST00000494857 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-intron | ENST00000477264 | ENST00000522656 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000477264 | ENST00000470360 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000477264 | ENST00000004531 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
intron-3UTR | ENST00000477264 | ENST00000398090 | CLSTN1 | chr1 | 9789921 | + | SLC7A2 | chr8 | 17427501 | + |
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FusionProtFeatures for CLSTN1_SLC7A2 |
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Hgene | Tgene |
CLSTN1 | SLC7A2 |
Induces KLC1 association with vesicles and functions asa cargo in axonal anterograde transport. Complex formation withAPBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to theretardation of intracellular APP maturation. In complex with APBA2and C99, a C-terminal APP fragment, abolishes C99 interaction withPSEN1 and thus APP C99 cleavage by gamma-secretase, most probablythrough stabilization of the direct interaction between APBA2 andAPP. The intracellular fragment AlcICD suppresses APBB1-dependenttransactivation stimulated by APP C-terminal intracellularfragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12972431}. | Functions as permease involved in the transport of thecationic amino acids (arginine, lysine and ornithine); theaffinity for its substrates differs between isoforms created byalternative splicing. Isoform 1 functions as permease thatmediates the transport of the cationic amino acids (arginine,lysine and ornithine), and it has much higher affinity forarginine than isoform 2. Isoform 2 functions as low-affinity, highcapacity permease involved in the transport of the cationic aminoacids (arginine, lysine and ornithine) (PubMed:9174363). May playa role in classical or alternative activation of macrophages viaits role in arginine transport. {ECO:0000250|UniProtKB:P18581,ECO:0000269|PubMed:9174363}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLSTN1_SLC7A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLSTN1_SLC7A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLSTN1_SLC7A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SLC7A2 | P52569 | DB00123 | L-Lysine | Cationic amino acid transporter 2 | small molecule | approved|nutraceutical |
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RelatedDiseases for CLSTN1_SLC7A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |