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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7506

FusionGeneSummary for CLSTN1_SLC7A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CLSTN1_SLC7A2
Fusion gene ID: 7506
HgeneTgene
Gene symbol

CLSTN1

SLC7A2

Gene ID

22883

6542

Gene namecalsyntenin 1solute carrier family 7 member 2
SynonymsALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2ATRC2|CAT2|HCAT2
Cytomap

1p36.22

8p22

Type of geneprotein-codingprotein-coding
Descriptioncalsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alphacationic amino acid transporter 2low affinity cationic amino acid transporter 2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Modification date2018052320180523
UniProtAcc

O94985

P52569

Ensembl transtripts involved in fusion geneENST00000377298, ENST00000361311, 
ENST00000377288, ENST00000477264, 
ENST00000494857, ENST00000522656, 
ENST00000470360, ENST00000004531, 
ENST00000398090, 
Fusion gene scores* DoF score11 X 10 X 5=5502 X 2 X 1=4
# samples 152
** MAII scorelog2(15/550*10)=-1.87446911791614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: CLSTN1 [Title/Abstract] AND SLC7A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP395070CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000377298ENST00000494857CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-intronENST00000377298ENST00000522656CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377298ENST00000470360CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377298ENST00000004531CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377298ENST00000398090CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000361311ENST00000494857CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-intronENST00000361311ENST00000522656CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000361311ENST00000470360CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000361311ENST00000004531CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000361311ENST00000398090CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377288ENST00000494857CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-intronENST00000377288ENST00000522656CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377288ENST00000470360CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377288ENST00000004531CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000377288ENST00000398090CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000477264ENST00000494857CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-intronENST00000477264ENST00000522656CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000477264ENST00000470360CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000477264ENST00000004531CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+
intron-3UTRENST00000477264ENST00000398090CLSTN1chr1

9789921

+SLC7A2chr8

17427501

+

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FusionProtFeatures for CLSTN1_SLC7A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLSTN1

O94985

SLC7A2

P52569

Induces KLC1 association with vesicles and functions asa cargo in axonal anterograde transport. Complex formation withAPBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to theretardation of intracellular APP maturation. In complex with APBA2and C99, a C-terminal APP fragment, abolishes C99 interaction withPSEN1 and thus APP C99 cleavage by gamma-secretase, most probablythrough stabilization of the direct interaction between APBA2 andAPP. The intracellular fragment AlcICD suppresses APBB1-dependenttransactivation stimulated by APP C-terminal intracellularfragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12972431}. Functions as permease involved in the transport of thecationic amino acids (arginine, lysine and ornithine); theaffinity for its substrates differs between isoforms created byalternative splicing. Isoform 1 functions as permease thatmediates the transport of the cationic amino acids (arginine,lysine and ornithine), and it has much higher affinity forarginine than isoform 2. Isoform 2 functions as low-affinity, highcapacity permease involved in the transport of the cationic aminoacids (arginine, lysine and ornithine) (PubMed:9174363). May playa role in classical or alternative activation of macrophages viaits role in arginine transport. {ECO:0000250|UniProtKB:P18581,ECO:0000269|PubMed:9174363}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLSTN1_SLC7A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLSTN1_SLC7A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLSTN1_SLC7A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC7A2P52569DB00123L-LysineCationic amino acid transporter 2small moleculeapproved|nutraceutical

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RelatedDiseases for CLSTN1_SLC7A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource