![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 7446 |
FusionGeneSummary for CLNK_CCT4 |
![]() |
Fusion gene information | Fusion gene name: CLNK_CCT4 | Fusion gene ID: 7446 | Hgene | Tgene | Gene symbol | CLNK | CCT4 | Gene ID | 116449 | 10575 |
Gene name | cytokine dependent hematopoietic cell linker | chaperonin containing TCP1 subunit 4 | |
Synonyms | MIST | CCT-DELTA|Cctd|SRB | |
Cytomap | 4p16.1 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | cytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducer | T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7Z7G1 | P50991 | |
Ensembl transtripts involved in fusion gene | ENST00000226951, ENST00000442825, ENST00000507719, ENST00000515667, | ENST00000394440, ENST00000461540, ENST00000544079, ENST00000544185, ENST00000538252, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 6 X 4=120 |
# samples | 3 | 6 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CLNK [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CLNK | GO:0035556 | intracellular signal transduction | 10744659 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE698729 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000226951 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-5UTR | ENST00000226951 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000226951 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000226951 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000226951 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000442825 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-5UTR | ENST00000442825 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000442825 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000442825 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000442825 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000507719 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-5UTR | ENST00000507719 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000507719 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000507719 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000507719 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000515667 | ENST00000394440 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-5UTR | ENST00000515667 | ENST00000461540 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000515667 | ENST00000544079 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000515667 | ENST00000544185 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
intron-3UTR | ENST00000515667 | ENST00000538252 | CLNK | chr4 | 10602071 | - | CCT4 | chr2 | 62095781 | - |
Top |
FusionProtFeatures for CLNK_CCT4 |
![]() |
Hgene | Tgene |
CLNK | CCT4 |
Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CLNK_CCT4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CLNK_CCT4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CLNK_CCT4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CLNK_CCT4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CLNK | C0042900 | Vitiligo | 1 | CTD_human |