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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7446

FusionGeneSummary for CLNK_CCT4

check button Fusion gene summary
Fusion gene informationFusion gene name: CLNK_CCT4
Fusion gene ID: 7446
HgeneTgene
Gene symbol

CLNK

CCT4

Gene ID

116449

10575

Gene namecytokine dependent hematopoietic cell linkerchaperonin containing TCP1 subunit 4
SynonymsMISTCCT-DELTA|Cctd|SRB
Cytomap

4p16.1

2p15

Type of geneprotein-codingprotein-coding
Descriptioncytokine-dependent hematopoietic cell linkermast cell immunoreceptor signal transducerT-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding
Modification date2018052320180523
UniProtAcc

Q7Z7G1

P50991

Ensembl transtripts involved in fusion geneENST00000226951, ENST00000442825, 
ENST00000507719, ENST00000515667, 
ENST00000394440, ENST00000461540, 
ENST00000544079, ENST00000544185, 
ENST00000538252, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 4=120
# samples 36
** MAII scorelog2(3/8*10)=1.90689059560852log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLNK [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLNK

GO:0035556

intracellular signal transduction

10744659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE698729CLNKchr4

10602071

-CCT4chr2

62095781

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000226951ENST00000394440CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-5UTRENST00000226951ENST00000461540CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000226951ENST00000544079CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000226951ENST00000544185CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000226951ENST00000538252CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000442825ENST00000394440CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-5UTRENST00000442825ENST00000461540CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000442825ENST00000544079CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000442825ENST00000544185CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000442825ENST00000538252CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000507719ENST00000394440CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-5UTRENST00000507719ENST00000461540CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000507719ENST00000544079CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000507719ENST00000544185CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000507719ENST00000538252CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000515667ENST00000394440CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-5UTRENST00000515667ENST00000461540CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000515667ENST00000544079CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000515667ENST00000544185CLNKchr4

10602071

-CCT4chr2

62095781

-
intron-3UTRENST00000515667ENST00000538252CLNKchr4

10602071

-CCT4chr2

62095781

-

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FusionProtFeatures for CLNK_CCT4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLNK

Q7Z7G1

CCT4

P50991

Plays a role in the regulation of immunoreceptorsignaling, including PLC-gamma-mediated B-cell antigen receptor(BCR) signaling and FC-epsilon R1-mediated mast celldegranulation. Involved in phosphorylation of LAT (By similarity).{ECO:0000250}. Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLNK_CCT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLNK_CCT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLNK_CCT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLNK_CCT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLNKC0042900Vitiligo1CTD_human