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Fusion gene ID: 7442 |
FusionGeneSummary for CLN6_CHST2 |
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Fusion gene information | Fusion gene name: CLN6_CHST2 | Fusion gene ID: 7442 | Hgene | Tgene | Gene symbol | CLN6 | CHST2 | Gene ID | 54982 | 9435 |
Gene name | CLN6, transmembrane ER protein | carbohydrate sulfotransferase 2 | |
Synonyms | CLN4A|HsT18960|nclf | C6ST|GST-2|GST2|Gn6ST-1|HEL-S-75|glcNAc6ST-1 | |
Cytomap | 15q23 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | ceroid-lipofuscinosis neuronal protein 6ceroid-lipofuscinosis neuronal 6 late infantileceroid-lipofuscinosis, neuronal 6, late infantile | carbohydrate sulfotransferase 2N-acetylglucosamine 6-O-sulfotransferase 1carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2carbohydrate (chondroitin 6/keratan) sulfotransferase 2epididymis secretory protein Li 75galactose/N-acetylglucosamine/N | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NWW5 | Q9Y4C5 | |
Ensembl transtripts involved in fusion gene | ENST00000249806, ENST00000565471, ENST00000418702, ENST00000566347, ENST00000538696, ENST00000564752, ENST00000569336, | ENST00000309575, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CLN6 [Title/Abstract] AND CHST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CHST2 | GO:0006044 | N-acetylglucosamine metabolic process | 9722682 |
Tgene | CHST2 | GO:0006790 | sulfur compound metabolic process | 9722682 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ188039 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000249806 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000565471 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000418702 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000566347 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000538696 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000564752 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
intron-3UTR | ENST00000569336 | ENST00000309575 | CLN6 | chr15 | 68499350 | - | CHST2 | chr3 | 142841558 | + |
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FusionProtFeatures for CLN6_CHST2 |
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Hgene | Tgene |
CLN6 | CHST2 |
Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the transfer ofsulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc)residues within keratan-like structures on N-linked glycans andwithin mucin-associated glycans that can ultimately serve as SELLligands. SELL ligands are present in high endothelial cells (HEVs)and play a central role in lymphocyte homing at sites ofinflammation. Participates in biosynthesis of the SELL ligandsialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches.Has no activity toward O-linked sugars. Its substrate specificitymay be influenced by its subcellular location. Sulfates GlcNAcresidues at terminal, non-reducing ends of oligosaccharide chains.{ECO:0000269|PubMed:11042394}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLN6_CHST2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLN6_CHST2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLN6_CHST2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLN6_CHST2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CLN6 | C1866282 | CEROID LIPOFUSCINOSIS, NEURONAL, 6 | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | CLN6 | C0021368 | Inflammation | 1 | CTD_human |
Hgene | CLN6 | C0022797 | Adult Neuronal Ceroid Lipofuscinosis | 1 | ORPHANET;UNIPROT |
Hgene | CLN6 | C0026613 | Motor Skills Disorders | 1 | CTD_human |
Hgene | CLN6 | C0027877 | Neuronal Ceroid-Lipofuscinoses | 1 | CTD_human |
Hgene | CLN6 | C0042790 | Vision Disorders | 1 | CTD_human |
Hgene | CLN6 | C0333641 | Atrophic | 1 | CTD_human |
Hgene | CLN6 | C0751778 | Myoclonic Epilepsies, Progressive | 1 | CTD_human |
Hgene | CLN6 | C1262477 | Weight decreased | 1 | CTD_human |