FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7429

FusionGeneSummary for CLK3_ZSWIM7

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK3_ZSWIM7
Fusion gene ID: 7429
HgeneTgene
Gene symbol

CLK3

ZSWIM7

Gene ID

1198

125150

Gene nameCDC like kinase 3zinc finger SWIM-type containing 7
SynonymsPHCLK3|PHCLK3/152SWS1
Cytomap

15q24.1

17p12

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK3zinc finger SWIM domain-containing protein 7SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7
Modification date2018052220180523
UniProtAcc

P49761

Q19AV6

Ensembl transtripts involved in fusion geneENST00000564353, ENST00000345005, 
ENST00000395066, ENST00000348245, 
ENST00000352989, 
ENST00000399277, 
ENST00000399280, ENST00000486655, 
ENST00000472495, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CLK3 [Title/Abstract] AND ZSWIM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLK3

GO:0006468

protein phosphorylation

9637771

HgeneCLK3

GO:0043484

regulation of RNA splicing

9637771


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI859068CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000564353ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-5UTRENST00000564353ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-3UTRENST00000564353ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-3UTRENST00000564353ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000345005ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000345005ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000345005ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000345005ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000395066ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000395066ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000395066ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000395066ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3CDSENST00000348245ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-5UTRENST00000348245ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3UTRENST00000348245ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3UTRENST00000348245ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000352989ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000352989ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000352989ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000352989ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-

Top

FusionProtFeatures for CLK3_ZSWIM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK3

P49761

ZSWIM7

Q19AV6

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicingof tissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}. Involved in early stages of the homologous recombinationrepair (HRR) pathway of double-stranded DNA breaks arising duringDNA replication or induced by DNA-damaging agents.{ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CLK3_ZSWIM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_193aa
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR
HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERWKSQVALKIIRNVGKYREAARLEIN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_581nt
ATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACAT
GAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGG
TACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGT
CATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGC
GCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGAT
TGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLK3_ENST00000345005_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_705nt
GGGGCACTGGTACCTCCAGGACCTGGAGTGTACTGGAAGAAATGGTGCAGTCCAGATGCATCACTGTAAGCGATACCGCTCCCCTGAACC
AGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCC
TCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTG
TGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCG
GACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAG
CAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCT
GGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGG

>In-frame_CLK3_ENST00000395066_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_1555nt
AGTTTTCTCATCTGGAAAGTGGGGCCTCGTAATCCTGTCCGACCCGGCGCGGGACAGTAGGTGTCAGGGATTTTGGTGACCCCACGCTCG
AGGCCTCTGCAAAAGGGGGCTGTCCAGTGGCCCAGAGACGCAGCCGGCGGGGCTTTTGTCTAGCGGGGGAGTCTTAACTGAGAGGCCACG
CAGGCCGGCAGGAAGCCGCTCCACAGGAGGGGGCTCAAGGAGAGGGGATCTCCTCCCTCCAGACTCCGGCCCCGCCAGAGTAGCTCTAGG
GTATCTTCCCAGAAACTGCCCCGCACGCACTGGCGAGCTGGGAGCGCCACCACGGCTTTCAAAAAACCCGCACACACCAAGATAATAATG
TGTCGTTCGCTCGTTTCGCGCAAGCGGAGTCGCGTCCGCCTTCCCGAGCTCCGGCACACAGACCTCAGGCCGCTCTCGCGCTCTCCGGGG
CCCCGAGAACAATGCCCGTCCTCTCCGCGCGCAGGAGGGAGTTGGCGGACCACGCGGGGTCGGGGCGACGGAGCGGGCCCAGCCCCACGG
CCAGGTCGGGGCCCCACCTCTCGGCTCTGAGAGCCCAGCCGGCCCGGGCCGCGCACCTGTCAGGTCGGGGGACCTACGTGCGCCGCGACA
CGGCGGGAGGCGGGCCGGGCCAGGCTCGTCCCCTCGGCCCTCCCGGAACTAGTCTCCTAGGCCGCGGCGCCCGCCGGAGCGGAGAGGGCT
GGTGCCCCGGAGCCTTCGAGTCGGGGGCTAGAGCGGCCAGGCCTCCGAGCCGGGTCGAGCCGAGGCTGGCGACGGCTGCGTCACGCGAGG
GGGCGGGGCTGCCACGGGCGGAGGTCGCAGCCGGAAGCGGAAGAGGCGCTCGGAGCGGGGAGTGGGGCCTAGCTGCAGCCGGAGCCTGGG
AGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGG
AACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGA
GGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTT
CTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTA
GCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCG
GCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAG
GGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCA

>In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_606nt
AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG
GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA
TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA
CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA
ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGG
TCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCG


Top

FusionGenePPI for CLK3_ZSWIM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CLK3_ZSWIM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CLK3_ZSWIM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource