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Fusion gene ID: 7429 |
FusionGeneSummary for CLK3_ZSWIM7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLK3_ZSWIM7 | Fusion gene ID: 7429 | Hgene | Tgene | Gene symbol | CLK3 | ZSWIM7 | Gene ID | 1198 | 125150 |
| Gene name | CDC like kinase 3 | zinc finger SWIM-type containing 7 | |
| Synonyms | PHCLK3|PHCLK3/152 | SWS1 | |
| Cytomap | 15q24.1 | 17p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity protein kinase CLK3 | zinc finger SWIM domain-containing protein 7SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P49761 | Q19AV6 | |
| Ensembl transtripts involved in fusion gene | ENST00000564353, ENST00000345005, ENST00000395066, ENST00000348245, ENST00000352989, | ENST00000399277, ENST00000399280, ENST00000486655, ENST00000472495, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CLK3 [Title/Abstract] AND ZSWIM7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLK3 | GO:0006468 | protein phosphorylation | 9637771 |
| Hgene | CLK3 | GO:0043484 | regulation of RNA splicing | 9637771 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI859068 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000564353 | ENST00000399277 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| intron-5UTR | ENST00000564353 | ENST00000399280 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| intron-3UTR | ENST00000564353 | ENST00000486655 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| intron-3UTR | ENST00000564353 | ENST00000472495 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| In-frame | ENST00000345005 | ENST00000399277 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-5UTR | ENST00000345005 | ENST00000399280 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000345005 | ENST00000486655 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000345005 | ENST00000472495 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| In-frame | ENST00000395066 | ENST00000399277 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-5UTR | ENST00000395066 | ENST00000399280 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000395066 | ENST00000486655 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000395066 | ENST00000472495 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 3UTR-3CDS | ENST00000348245 | ENST00000399277 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 3UTR-5UTR | ENST00000348245 | ENST00000399280 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 3UTR-3UTR | ENST00000348245 | ENST00000486655 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 3UTR-3UTR | ENST00000348245 | ENST00000472495 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| In-frame | ENST00000352989 | ENST00000399277 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-5UTR | ENST00000352989 | ENST00000399280 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000352989 | ENST00000486655 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
| 5CDS-3UTR | ENST00000352989 | ENST00000472495 | CLK3 | chr15 | 74917357 | + | ZSWIM7 | chr17 | 15881382 | - |
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FusionProtFeatures for CLK3_ZSWIM7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLK3 | ZSWIM7 |
| Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicingof tissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}. | Involved in early stages of the homologous recombinationrepair (HRR) pathway of double-stranded DNA breaks arising duringDNA replication or induced by DNA-damaging agents.{ECO:0000269|PubMed:16710300, ECO:0000269|PubMed:21965664}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLK3_ZSWIM7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_193aa MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERWKSQVALKIIRNVGKYREAARLEIN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_581nt ATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACAT GAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGG TACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGT CATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGC GCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGAT TGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CLK3_ENST00000345005_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_705nt GGGGCACTGGTACCTCCAGGACCTGGAGTGTACTGGAAGAAATGGTGCAGTCCAGATGCATCACTGTAAGCGATACCGCTCCCCTGAACC AGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCC TCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTG TGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCG GACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAG CAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCT GGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGG >In-frame_CLK3_ENST00000395066_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_1555nt AGTTTTCTCATCTGGAAAGTGGGGCCTCGTAATCCTGTCCGACCCGGCGCGGGACAGTAGGTGTCAGGGATTTTGGTGACCCCACGCTCG AGGCCTCTGCAAAAGGGGGCTGTCCAGTGGCCCAGAGACGCAGCCGGCGGGGCTTTTGTCTAGCGGGGGAGTCTTAACTGAGAGGCCACG CAGGCCGGCAGGAAGCCGCTCCACAGGAGGGGGCTCAAGGAGAGGGGATCTCCTCCCTCCAGACTCCGGCCCCGCCAGAGTAGCTCTAGG GTATCTTCCCAGAAACTGCCCCGCACGCACTGGCGAGCTGGGAGCGCCACCACGGCTTTCAAAAAACCCGCACACACCAAGATAATAATG TGTCGTTCGCTCGTTTCGCGCAAGCGGAGTCGCGTCCGCCTTCCCGAGCTCCGGCACACAGACCTCAGGCCGCTCTCGCGCTCTCCGGGG CCCCGAGAACAATGCCCGTCCTCTCCGCGCGCAGGAGGGAGTTGGCGGACCACGCGGGGTCGGGGCGACGGAGCGGGCCCAGCCCCACGG CCAGGTCGGGGCCCCACCTCTCGGCTCTGAGAGCCCAGCCGGCCCGGGCCGCGCACCTGTCAGGTCGGGGGACCTACGTGCGCCGCGACA CGGCGGGAGGCGGGCCGGGCCAGGCTCGTCCCCTCGGCCCTCCCGGAACTAGTCTCCTAGGCCGCGGCGCCCGCCGGAGCGGAGAGGGCT GGTGCCCCGGAGCCTTCGAGTCGGGGGCTAGAGCGGCCAGGCCTCCGAGCCGGGTCGAGCCGAGGCTGGCGACGGCTGCGTCACGCGAGG GGGCGGGGCTGCCACGGGCGGAGGTCGCAGCCGGAAGCGGAAGAGGCGCTCGGAGCGGGGAGTGGGGCCTAGCTGCAGCCGGAGCCTGGG AGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGG AACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGA GGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTT CTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTA GCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCG GCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAG GGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCA >In-frame_CLK3_ENST00000352989_chr15_74917357_+_ZSWIM7_ENST00000399277_chr17_15881382_-_606nt AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGG TCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCG |
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FusionGenePPI for CLK3_ZSWIM7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLK3_ZSWIM7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLK3_ZSWIM7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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