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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7427

FusionGeneSummary for CLK2_PPP1R12B

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK2_PPP1R12B
Fusion gene ID: 7427
HgeneTgene
Gene symbol

CLK2

PPP1R12B

Gene ID

9894

4660

Gene nametelomere maintenance 2protein phosphatase 1 regulatory subunit 12B
SynonymsCLK2|TEL2|YHFSMYPT2|PP1bp55
Cytomap

16p13.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptiontelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homologprotein phosphatase 1 regulatory subunit 12Bmyosin phosphatase target subunit 2myosin phosphatase-targeting subunit 2protein phosphatase 1, regulatory (inhibitor) subunit 12B
Modification date2018052320180523
UniProtAcc

P49760

O60237

Ensembl transtripts involved in fusion geneENST00000361168, ENST00000368361, 
ENST00000355560, ENST00000497188, 
ENST00000536801, 
ENST00000608999, 
ENST00000336894, ENST00000480184, 
ENST00000356764, ENST00000290419, 
ENST00000391959, ENST00000367270, 
Fusion gene scores* DoF score5 X 5 X 5=1258 X 8 X 5=320
# samples 510
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK2 [Title/Abstract] AND PPP1R12B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-HU-8610-01ACLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000361168ENST00000608999CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3CDSENST00000361168ENST00000336894CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000361168ENST00000480184CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000361168ENST00000356764CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3UTRENST00000361168ENST00000290419CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000361168ENST00000391959CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000361168ENST00000367270CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3CDSENST00000368361ENST00000608999CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3CDSENST00000368361ENST00000336894CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000368361ENST00000480184CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000368361ENST00000356764CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3UTRENST00000368361ENST00000290419CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000368361ENST00000391959CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000368361ENST00000367270CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3CDSENST00000355560ENST00000608999CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3CDSENST00000355560ENST00000336894CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000355560ENST00000480184CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-intronENST00000355560ENST00000356764CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-3UTRENST00000355560ENST00000290419CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000355560ENST00000391959CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
5UTR-5UTRENST00000355560ENST00000367270CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3CDSENST00000497188ENST00000608999CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3CDSENST00000497188ENST00000336894CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-intronENST00000497188ENST00000480184CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-intronENST00000497188ENST00000356764CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3UTRENST00000497188ENST00000290419CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-5UTRENST00000497188ENST00000391959CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-5UTRENST00000497188ENST00000367270CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3CDSENST00000536801ENST00000608999CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3CDSENST00000536801ENST00000336894CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-intronENST00000536801ENST00000480184CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-intronENST00000536801ENST00000356764CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-3UTRENST00000536801ENST00000290419CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-5UTRENST00000536801ENST00000391959CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+
intron-5UTRENST00000536801ENST00000367270CLK2chr1

155242992

-PPP1R12Bchr1

202457661

+

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FusionProtFeatures for CLK2_PPP1R12B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK2

P49760

PPP1R12B

O60237

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLK2_PPP1R12B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLK2_PPP1R12B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLK2CLK3, UBL5, FANCM, C19orf40, YWHAG, HSP90AA1, AKT1, SNRNP70, PNN, HNRNPM, LUC7L, TNPO3, CLK2, HUWE1, PSME3, SKIV2L2, ZCCHC8, BCLAF1, CPSF1, FIP1L1, RBBP6, WDR33, PPHLN1, RBM7, ACIN1, PABPC1, SETD2, PKP2, THRAP3, CPSF2, RBM39, SON, ZNF30, HNRNPF, CPSF4, CDKN2A, ECE1, TRIM27, SDCBP, SRPK2, U2AF1, UBE2I, ZRSR2, ZNF263, SRRM1, RNPS1, KLHL2, ZNF473, MRPL4, LUZP4, RSRP1, ZNF398, GMCL1, SNIP1, CPSF7, ZNF394, LNX1, PRPF38A, YTHDC1, BRCA1, EED, TRA2A, LUC7L2, TBC1D9B, NKTR, ZC3H18, CLK1, RBMXL1, SRSF8, ELAVL2, CLASRP, GPATCH8, ZNF638, C11orf57, SRSF12, MDK, SRSF10, NCOA5, EPB41L2, RSBN1L, C17orf85, GPALPP1, APOBEC3D, U2AF2, CDX1, ZC3H14, GSPT2, REPIN1, SRRT, JPH4, CASC3, PRPF4B, PTPN1PPP1R12BIL16, HSPA8, PRKG1, PPP1CB, COPS6, PAN2, NUAK1, PPP2R1A, FKBP6, SKP1, PIK3R3, CD14, MYH9, IQGAP1, SYNPO, ANLN, MYO19, MYO18A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLK2_PPP1R12B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLK2_PPP1R12B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource