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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7425

FusionGeneSummary for CLK2_DLGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK2_DLGAP1
Fusion gene ID: 7425
HgeneTgene
Gene symbol

CLK2

DLGAP1

Gene ID

9894

9229

Gene nametelomere maintenance 2DLG associated protein 1
SynonymsCLK2|TEL2|YHFSDAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1
Cytomap

16p13.3

18p11.31

Type of geneprotein-codingprotein-coding
Descriptiontelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homologdisks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated protein
Modification date2018052320180519
UniProtAcc

P49760

O14490

Ensembl transtripts involved in fusion geneENST00000361168, ENST00000368361, 
ENST00000355560, ENST00000497188, 
ENST00000536801, 		ENST00000315677, 
ENST00000581527, ENST00000400147, 
ENST00000400149, ENST00000400155, 
ENST00000400150, ENST00000584874, 
ENST00000534970, ENST00000539435, 
ENST00000581699, ENST00000400145, 
ENST00000515196, ENST00000478161, 
Fusion gene scores* DoF score5 X 5 X 5=12514 X 11 X 7=1078
# samples 515
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1078*10)=-2.84532277225662
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK2 [Title/Abstract] AND DLGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW385079CLK2chr1

155233833

+DLGAP1chr18

4345828

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361168ENST00000315677CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000581527CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000400147CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000400149CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000400155CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000400150CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000584874CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000534970CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000539435CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000581699CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000400145CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000515196CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000361168ENST00000478161CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000315677CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000581527CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000400147CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000400149CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000400155CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000400150CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000584874CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000534970CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000539435CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000581699CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000400145CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000515196CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000368361ENST00000478161CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000315677CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000581527CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000400147CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000400149CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000400155CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000400150CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000584874CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000534970CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000539435CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000581699CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000400145CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000515196CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000355560ENST00000478161CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000315677CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000581527CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000400147CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000400149CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000400155CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000400150CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000584874CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000534970CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000539435CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000581699CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000400145CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000515196CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000497188ENST00000478161CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000315677CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000581527CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000400147CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000400149CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000400155CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000400150CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000584874CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000534970CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000539435CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000581699CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000400145CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000515196CLK2chr1

155233833

+DLGAP1chr18

4345828

-
intron-intronENST00000536801ENST00000478161CLK2chr1

155233833

+DLGAP1chr18

4345828

-

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FusionProtFeatures for CLK2_DLGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK2

P49760

DLGAP1

O14490

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLK2_DLGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLK2_DLGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLK2_DLGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLK2_DLGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLGAP1C0036341Schizophrenia3PSYGENET