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Fusion gene ID: 7423 |
FusionGeneSummary for CLK2_ASH1L |
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Fusion gene information | Fusion gene name: CLK2_ASH1L | Fusion gene ID: 7423 | Hgene | Tgene | Gene symbol | CLK2 | ASH1L | Gene ID | 9894 | 55870 |
Gene name | telomere maintenance 2 | ASH1 like histone lysine methyltransferase | |
Synonyms | CLK2|TEL2|YHFS | ASH1|ASH1L1|KMT2H|MRD52 | |
Cytomap | 16p13.3 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | telomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P49760 | Q9NR48 | |
Ensembl transtripts involved in fusion gene | ENST00000361168, ENST00000368361, ENST00000355560, ENST00000497188, ENST00000536801, | ENST00000368346, ENST00000392403, ENST00000548830, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 9 X 8 X 5=360 |
# samples | 5 | 9 | |
** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CLK2 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-91-6836-01A | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000361168 | ENST00000368346 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
In-frame | ENST00000361168 | ENST00000392403 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5CDS-intron | ENST00000361168 | ENST00000548830 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
In-frame | ENST00000368361 | ENST00000368346 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
In-frame | ENST00000368361 | ENST00000392403 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5CDS-intron | ENST00000368361 | ENST00000548830 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
In-frame | ENST00000355560 | ENST00000368346 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
In-frame | ENST00000355560 | ENST00000392403 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5CDS-intron | ENST00000355560 | ENST00000548830 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5UTR-3CDS | ENST00000497188 | ENST00000368346 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5UTR-3CDS | ENST00000497188 | ENST00000392403 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5UTR-intron | ENST00000497188 | ENST00000548830 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
Frame-shift | ENST00000536801 | ENST00000368346 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
Frame-shift | ENST00000536801 | ENST00000392403 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
5CDS-intron | ENST00000536801 | ENST00000548830 | CLK2 | chr1 | 155236520 | - | ASH1L | chr1 | 155313533 | - |
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FusionProtFeatures for CLK2_ASH1L |
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Hgene | Tgene |
CLK2 | ASH1L |
Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. | Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CLK2 | chr1:155236520 | chr1:155313533 | ENST00000361168 | - | 7 | 13 | 169_177 | 278 | 499 | Nucleotide binding | ATP |
Hgene | CLK2 | chr1:155236520 | chr1:155313533 | ENST00000368361 | - | 7 | 13 | 169_177 | 279 | 500 | Nucleotide binding | ATP |
Hgene | CLK2 | chr1:155236520 | chr1:155313533 | ENST00000536801 | - | 7 | 13 | 169_177 | 279 | 500 | Nucleotide binding | ATP |
Tgene | >ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2661_2798 | 2660 | 2965 | Domain | BAH |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CLK2 | chr1:155236520 | chr1:155313533 | ENST00000361168 | - | 7 | 13 | 163_479 | 278 | 499 | Domain | Protein kinase |
Hgene | >CLK2 | chr1:155236520 | chr1:155313533 | ENST00000368361 | - | 7 | 13 | 163_479 | 279 | 500 | Domain | Protein kinase |
Hgene | >CLK2 | chr1:155236520 | chr1:155313533 | ENST00000536801 | - | 7 | 13 | 163_479 | 279 | 500 | Domain | Protein kinase |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 1380_1424 | 2665 | 2970 | Compositional bias | Note=Pro-rich |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 1580_1791 | 2665 | 2970 | Compositional bias | Note=Ser-rich |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 1380_1424 | 2660 | 2965 | Compositional bias | Note=Pro-rich |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 1580_1791 | 2660 | 2965 | Compositional bias | Note=Ser-rich |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 1347_1359 | 2665 | 2970 | DNA binding | Note=A.T hook 2 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 1847_1859 | 2665 | 2970 | DNA binding | Note=A.T hook 3 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 887_899 | 2665 | 2970 | DNA binding | Note=A.T hook 1 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 1347_1359 | 2660 | 2965 | DNA binding | Note=A.T hook 2 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 1847_1859 | 2660 | 2965 | DNA binding | Note=A.T hook 3 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 887_899 | 2660 | 2965 | DNA binding | Note=A.T hook 1 |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2091_2142 | 2665 | 2970 | Domain | AWS |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2145_2261 | 2665 | 2970 | Domain | SET |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2269_2285 | 2665 | 2970 | Domain | Post-SET |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2463_2533 | 2665 | 2970 | Domain | Bromo |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2661_2798 | 2665 | 2970 | Domain | BAH |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2091_2142 | 2660 | 2965 | Domain | AWS |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2145_2261 | 2660 | 2965 | Domain | SET |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2269_2285 | 2660 | 2965 | Domain | Post-SET |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2463_2533 | 2660 | 2965 | Domain | Bromo |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2069_2288 | 2665 | 2970 | Region | Note=Catalytic domain |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2069_2288 | 2660 | 2965 | Region | Note=Catalytic domain |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000368346 | - | 21 | 28 | 2585_2631 | 2665 | 2970 | Zinc finger | Note=PHD-type |
Tgene | ASH1L | chr1:155236520 | chr1:155313533 | ENST00000392403 | - | 21 | 28 | 2585_2631 | 2660 | 2965 | Zinc finger | Note=PHD-type |
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FusionGeneSequence for CLK2_ASH1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLK2_ASH1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CLK2 | CLK3, UBL5, FANCM, C19orf40, YWHAG, HSP90AA1, AKT1, SNRNP70, PNN, HNRNPM, LUC7L, TNPO3, CLK2, HUWE1, PSME3, SKIV2L2, ZCCHC8, BCLAF1, CPSF1, FIP1L1, RBBP6, WDR33, PPHLN1, RBM7, ACIN1, PABPC1, SETD2, PKP2, THRAP3, CPSF2, RBM39, SON, ZNF30, HNRNPF, CPSF4, CDKN2A, ECE1, TRIM27, SDCBP, SRPK2, U2AF1, UBE2I, ZRSR2, ZNF263, SRRM1, RNPS1, KLHL2, ZNF473, MRPL4, LUZP4, RSRP1, ZNF398, GMCL1, SNIP1, CPSF7, ZNF394, LNX1, PRPF38A, YTHDC1, BRCA1, EED, TRA2A, LUC7L2, TBC1D9B, NKTR, ZC3H18, CLK1, RBMXL1, SRSF8, ELAVL2, CLASRP, GPATCH8, ZNF638, C11orf57, SRSF12, MDK, SRSF10, NCOA5, EPB41L2, RSBN1L, C17orf85, GPALPP1, APOBEC3D, U2AF2, CDX1, ZC3H14, GSPT2, REPIN1, SRRT, JPH4, CASC3, PRPF4B, PTPN1 | ASH1L | HIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLK2_ASH1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLK2_ASH1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |