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Fusion gene ID: 7417 |
FusionGeneSummary for CLIP4_IPO4 |
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Fusion gene information | Fusion gene name: CLIP4_IPO4 | Fusion gene ID: 7417 | Hgene | Tgene | Gene symbol | CLIP4 | IPO4 | Gene ID | 79745 | 79711 |
Gene name | CAP-Gly domain containing linker protein family member 4 | importin 4 | |
Synonyms | RSNL2 | Imp4 | |
Cytomap | 2p23.2 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | CAP-Gly domain-containing linker protein 4CAP-GLY domain containing linker protein family, member 4restin-like protein 2 | importin-4imp4bimportin-4bran-binding protein 4ranBP4 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N3C7 | Q8TEX9 | |
Ensembl transtripts involved in fusion gene | ENST00000401605, ENST00000401617, ENST00000404424, ENST00000320081, ENST00000481628, | ENST00000354464, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 2 X 2 X 1=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: CLIP4 [Title/Abstract] AND IPO4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IPO4 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
Tgene | IPO4 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE179163 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000401605 | ENST00000354464 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
intron-intron | ENST00000401617 | ENST00000354464 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
intron-intron | ENST00000404424 | ENST00000354464 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
intron-intron | ENST00000320081 | ENST00000354464 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
intron-intron | ENST00000481628 | ENST00000354464 | CLIP4 | chr2 | 29381336 | - | IPO4 | chr14 | 24658812 | - |
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FusionProtFeatures for CLIP4_IPO4 |
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Hgene | Tgene |
CLIP4 | IPO4 |
Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of RPS3A. Invitro, mediates the nuclear import of human cytomegalovirus UL84by recognizing a non-classical NLS. {ECO:0000250,ECO:0000269|PubMed:11823430}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLIP4_IPO4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLIP4_IPO4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLIP4_IPO4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLIP4_IPO4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |