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Fusion gene ID: 74 |
FusionGeneSummary for AATF_LIG3 |
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Fusion gene information | Fusion gene name: AATF_LIG3 | Fusion gene ID: 74 | Hgene | Tgene | Gene symbol | AATF | LIG3 | Gene ID | 26574 | 121227 |
Gene name | apoptosis antagonizing transcription factor | leucine rich repeats and immunoglobulin like domains 3 | |
Synonyms | BFR2|CHE-1|CHE1|DED | LIG3 | |
Cytomap | 17q12 | 12q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein AATFrb-binding protein Che-1 | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NY61 | P49916 | |
Ensembl transtripts involved in fusion gene | ENST00000225402, ENST00000590321, | ENST00000378526, ENST00000262327, ENST00000586407, | |
Fusion gene scores | * DoF score | 13 X 8 X 7=728 | 5 X 5 X 4=100 |
# samples | 13 | 5 | |
** MAII score | log2(13/728*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AATF [Title/Abstract] AND LIG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AATF | GO:0032929 | negative regulation of superoxide anion generation | 15207272 |
Hgene | AATF | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18049476 |
Hgene | AATF | GO:2000378 | negative regulation of reactive oxygen species metabolic process | 15207272 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-EP-A2KA-01A | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000225402 | ENST00000378526 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
In-frame | ENST00000225402 | ENST00000262327 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
5CDS-intron | ENST00000225402 | ENST00000586407 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
intron-3CDS | ENST00000590321 | ENST00000378526 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
intron-3CDS | ENST00000590321 | ENST00000262327 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
intron-intron | ENST00000590321 | ENST00000586407 | AATF | chr17 | 35348156 | + | LIG3 | chr17 | 33325623 | + |
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FusionProtFeatures for AATF_LIG3 |
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Hgene | Tgene |
AATF | LIG3 |
May function as a general inhibitor of the histonedeacetylase HDAC1. Binding to the pocket region of RB1 maydisplace HDAC1 from RB1/E2F complexes, leading to activation ofE2F target genes and cell cycle progression. Conversely,displacement of HDAC1 from SP1 bound to the CDKN1A promoter leadsto increased expression of this CDK inhibitor and blocks cellcycle progression. Also antagonizes PAWR mediated induction ofaberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis forthis phenomenon has not been described to date.{ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090,ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}. | Isoform 3 functions as heterodimer with DNA-repairprotein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatmentwith ionizing radiation and alkylating agents. Isoform 1 istargeted to mitochondria, where it functions as DNA ligase inmitochondrial base-excision DNA repair (PubMed:10207110,PubMed:24674627). {ECO:0000269|PubMed:10207110,ECO:0000269|PubMed:24674627}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AATF | chr17:35348156 | chr17:33325623 | ENST00000225402 | + | 8 | 12 | 96_195 | 466 | 561 | Compositional bias | Note=Glu-rich |
Hgene | AATF | chr17:35348156 | chr17:33325623 | ENST00000225402 | + | 8 | 12 | 273_315 | 466 | 561 | Region | Note=POLR2J binding |
Hgene | AATF | chr17:35348156 | chr17:33325623 | ENST00000225402 | + | 8 | 12 | 316_372 | 466 | 561 | Region | Note=RB1 binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >AATF | chr17:35348156 | chr17:33325623 | ENST00000225402 | + | 8 | 12 | 373_472 | 466 | 561 | Region | Note=RB1 and SP1 binding |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000262327 | + | 12 | 20 | 93_185 | 663 | 950 | Zinc finger | PARP-type |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000378526 | + | 12 | 20 | 93_185 | 663 | 1010 | Zinc finger | PARP-type |
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FusionGeneSequence for AATF_LIG3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000378526_chr17_33325623_+_813aa MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTL PGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGM EEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPE FSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFT VYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHL KDLDEEIFDDDDFYHQGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDAT LARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKE LYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKV GEKRKAADETLCQTKVLLDIFTGVRLYLPPSTPDFSRLRRYFVAFDGDLVQEFDMTSATHVLGSRDKNPAAQQVSPEWIWACIRKRRLVA >In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000262327_chr17_33325623_+_753aa MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTL PGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGM EEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPE FSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFT VYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHL KDLDEEIFDDDDFYHQGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDAT LARLQNELDMVKISKDPSKIPSWLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKE LYQLSKEKADFTVVAGDEGSSTTGGSSEENKGPSGSAVSRKAPSKPSASTKKAEGKLSNSNSKDGNMQTAKPSAMKVGEKLATKSSPVKV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000378526_chr17_33325623_+_2439nt ATGGCGGGGCCGCAGCCCCTGGCGCTGCAACTGGAACAGTTGTTGAACCCGCGACCAAGCGAGGCGGACCCTGAAGCGGACCCCGAGGAA GCCACTGCTGCCAGGGTGATTGACAGGTTTGATGAAGGGGAAGATGGGGAAGGTGATTTCCTAGTAGTGGGTAGCATTAGAAAACTGGCA TCAGCCTCCCTCTTGGACACGGACAAAAGGTATTGCGGCAAAACCACCTCTAGAAAAGCATGGAATGAAGACCATTGGGAGCAGACTCTG CCAGGATCGTCTGATGAGGAAATATCTGATGAGGAAGGGTCTGGAGATGAAGATTCAGAGGGACTGGGTCTGGAGGAATATGATGAGGAC GACCTGGGTGCTGCTGAGGAACAGGAGTGTGGTGATCACAGGGAGAGCAAGAAGAGCAGAAGCCACTCTGCAAAAACACCGGGCTTCAGT GTCCAGAGTATCAGTGACTTTGAGAAATTTACCAAGGGAATGGATGACCTTGGGAGCAGTGAGGAGGAGGAAGACGAAGAGAGTGGCATG GAAGAAGGGGATGACGCGGAAGACTCCCAAGGCGAGAGTGAGGAAGACAGGGCTGGAGATAGAAACAGTGAGGATGATGGTGTGGTGATG ACCTTCTCTAGTGTCAAAGTTTCTGAGGAAGTGGAGAAAGGAAGAGCCGTGAAGAACCAGATAGCACTGTGGGACCAGCTCTTGGAAGGA AGGATCAAACTACAAAAAGCTCTGTTGACCACCAACCAGCTTCCTCAACCAGATGTTTTCCCATTGTTCAAGGACAAAGGTGGCCCAGAA TTTTCCAGTGCCCTGAAAAATAGTCACAAGGCACTTAAAGCATTGTTGAGGTCATTGGTAGGTCTTCAGGAAGAGTTGCTTTTCCAGTAC CCAGACACTAGATATCTAGTAGATGGGACAAAGCCCAATGCGGGAAGTGAGGAGATTTCTAGTGAAGATGATGAGCTGGTAGAAGAGAAG AAGCAGCAACGAAGAAGGGTCCCTGCAAAGAGGAAGCTGGAGATGGAGGACTATCCCAGCTTCATGGCAAAGCGCTTTGCCGACTTTACA GTCTACAGGAACCGCACACTTCAGAAATGGCACGATAAGACCAAACTGGCTTCTGGAAAACTGGGGAAGGGTTTTGGTGCCTTTGAACGC TCAATCTTGACTCAGATCGACCATATTCTGATGGACAAAGAGAGATTACTTCGAAGGACACAGACCAAGCGCTCTGTCTATCGAGTTCTT GGCAAACCTGAGCCAGCAGCTCAGCCTGTCCCAGAGAGTTTGCCAGGGGAACCGGAGATCCTTCCTCAAGCCCCTGCTAATGCTCATCTG AAGGACTTGGATGAAGAAATCTTTGATGATGATGACTTTTACCACCAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAG AAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATG ATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACG CTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTAC TATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCT GACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAA CTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAAT AAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCC AACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTA GGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCC TCCACACCAGACTTCAGCCGTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCCACGCAC GTGCTGGGTAGCAGGGACAAGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCT >In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000262327_chr17_33325623_+_2259nt ATGGCGGGGCCGCAGCCCCTGGCGCTGCAACTGGAACAGTTGTTGAACCCGCGACCAAGCGAGGCGGACCCTGAAGCGGACCCCGAGGAA GCCACTGCTGCCAGGGTGATTGACAGGTTTGATGAAGGGGAAGATGGGGAAGGTGATTTCCTAGTAGTGGGTAGCATTAGAAAACTGGCA TCAGCCTCCCTCTTGGACACGGACAAAAGGTATTGCGGCAAAACCACCTCTAGAAAAGCATGGAATGAAGACCATTGGGAGCAGACTCTG CCAGGATCGTCTGATGAGGAAATATCTGATGAGGAAGGGTCTGGAGATGAAGATTCAGAGGGACTGGGTCTGGAGGAATATGATGAGGAC GACCTGGGTGCTGCTGAGGAACAGGAGTGTGGTGATCACAGGGAGAGCAAGAAGAGCAGAAGCCACTCTGCAAAAACACCGGGCTTCAGT GTCCAGAGTATCAGTGACTTTGAGAAATTTACCAAGGGAATGGATGACCTTGGGAGCAGTGAGGAGGAGGAAGACGAAGAGAGTGGCATG GAAGAAGGGGATGACGCGGAAGACTCCCAAGGCGAGAGTGAGGAAGACAGGGCTGGAGATAGAAACAGTGAGGATGATGGTGTGGTGATG ACCTTCTCTAGTGTCAAAGTTTCTGAGGAAGTGGAGAAAGGAAGAGCCGTGAAGAACCAGATAGCACTGTGGGACCAGCTCTTGGAAGGA AGGATCAAACTACAAAAAGCTCTGTTGACCACCAACCAGCTTCCTCAACCAGATGTTTTCCCATTGTTCAAGGACAAAGGTGGCCCAGAA TTTTCCAGTGCCCTGAAAAATAGTCACAAGGCACTTAAAGCATTGTTGAGGTCATTGGTAGGTCTTCAGGAAGAGTTGCTTTTCCAGTAC CCAGACACTAGATATCTAGTAGATGGGACAAAGCCCAATGCGGGAAGTGAGGAGATTTCTAGTGAAGATGATGAGCTGGTAGAAGAGAAG AAGCAGCAACGAAGAAGGGTCCCTGCAAAGAGGAAGCTGGAGATGGAGGACTATCCCAGCTTCATGGCAAAGCGCTTTGCCGACTTTACA GTCTACAGGAACCGCACACTTCAGAAATGGCACGATAAGACCAAACTGGCTTCTGGAAAACTGGGGAAGGGTTTTGGTGCCTTTGAACGC TCAATCTTGACTCAGATCGACCATATTCTGATGGACAAAGAGAGATTACTTCGAAGGACACAGACCAAGCGCTCTGTCTATCGAGTTCTT GGCAAACCTGAGCCAGCAGCTCAGCCTGTCCCAGAGAGTTTGCCAGGGGAACCGGAGATCCTTCCTCAAGCCCCTGCTAATGCTCATCTG AAGGACTTGGATGAAGAAATCTTTGATGATGATGACTTTTACCACCAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAG AAAGACTATTTGAACGAGGGGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATG ATGTCAATCTTCCTCATGGGCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACG CTTGCCCGCCTGCAGAATGAACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTAC TATCCTGACTTCATCGTCCCAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCT GACGGGATCTCCATCCGATTCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAA CTGTACCAGTTGTCCAAGGAGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAAT AAGGGTCCCTCAGGGTCTGCTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCC AACAGCAAAGATGGCAACATGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTA GGGGAGAAGCGGAAAGCTGCTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCAGCAGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000378526_chr17_33325623_+_3248nt AATCCCTTCAACCTTCTGCGCGCTTCCGCCTTCATGCTAGCAACGCCCGCAGTGACGCGCAGGCCCCGCCCCCTCCCGCGCGCCTCCCGG AAGTGGCCGGTCCAGAGCTGTGGGGTGGCCTCCGCGCGGTCTCTGGCGGAGTCGGGGAATCGGATCAAGGCGAGAGGATCCGGCAGGGAA GGAGCTTCGGGGCCGGGGGTTGGGCCGCACATTTACGTGCGCGAAGCGGAGTGGACCGGGAGCTGGTGACGATGGCGGGGCCGCAGCCCC TGGCGCTGCAACTGGAACAGTTGTTGAACCCGCGACCAAGCGAGGCGGACCCTGAAGCGGACCCCGAGGAAGCCACTGCTGCCAGGGTGA TTGACAGGTTTGATGAAGGGGAAGATGGGGAAGGTGATTTCCTAGTAGTGGGTAGCATTAGAAAACTGGCATCAGCCTCCCTCTTGGACA CGGACAAAAGGTATTGCGGCAAAACCACCTCTAGAAAAGCATGGAATGAAGACCATTGGGAGCAGACTCTGCCAGGATCGTCTGATGAGG AAATATCTGATGAGGAAGGGTCTGGAGATGAAGATTCAGAGGGACTGGGTCTGGAGGAATATGATGAGGACGACCTGGGTGCTGCTGAGG AACAGGAGTGTGGTGATCACAGGGAGAGCAAGAAGAGCAGAAGCCACTCTGCAAAAACACCGGGCTTCAGTGTCCAGAGTATCAGTGACT TTGAGAAATTTACCAAGGGAATGGATGACCTTGGGAGCAGTGAGGAGGAGGAAGACGAAGAGAGTGGCATGGAAGAAGGGGATGACGCGG AAGACTCCCAAGGCGAGAGTGAGGAAGACAGGGCTGGAGATAGAAACAGTGAGGATGATGGTGTGGTGATGACCTTCTCTAGTGTCAAAG TTTCTGAGGAAGTGGAGAAAGGAAGAGCCGTGAAGAACCAGATAGCACTGTGGGACCAGCTCTTGGAAGGAAGGATCAAACTACAAAAAG CTCTGTTGACCACCAACCAGCTTCCTCAACCAGATGTTTTCCCATTGTTCAAGGACAAAGGTGGCCCAGAATTTTCCAGTGCCCTGAAAA ATAGTCACAAGGCACTTAAAGCATTGTTGAGGTCATTGGTAGGTCTTCAGGAAGAGTTGCTTTTCCAGTACCCAGACACTAGATATCTAG TAGATGGGACAAAGCCCAATGCGGGAAGTGAGGAGATTTCTAGTGAAGATGATGAGCTGGTAGAAGAGAAGAAGCAGCAACGAAGAAGGG TCCCTGCAAAGAGGAAGCTGGAGATGGAGGACTATCCCAGCTTCATGGCAAAGCGCTTTGCCGACTTTACAGTCTACAGGAACCGCACAC TTCAGAAATGGCACGATAAGACCAAACTGGCTTCTGGAAAACTGGGGAAGGGTTTTGGTGCCTTTGAACGCTCAATCTTGACTCAGATCG ACCATATTCTGATGGACAAAGAGAGATTACTTCGAAGGACACAGACCAAGCGCTCTGTCTATCGAGTTCTTGGCAAACCTGAGCCAGCAG CTCAGCCTGTCCCAGAGAGTTTGCCAGGGGAACCGGAGATCCTTCCTCAAGCCCCTGCTAATGCTCATCTGAAGGACTTGGATGAAGAAA TCTTTGATGATGATGACTTTTACCACCAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACTATTTGAACGAGG GGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGTCAATCTTCCTCATGG GCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCCGCCTGCAGAATG AACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATCCTGACTTCATCGTCC CAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGATCTCCATCCGAT TCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGTACCAGTTGTCCAAGG AGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTCCCTCAGGGTCTG CTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACAGCAAAGATGGCAACA TGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGAAGCGGAAAGCTG CTGATGAGACGCTGTGCCAAACAAAGGTATTGCTGGACATCTTCACTGGGGTGCGGCTTTACTTGCCACCCTCCACACCAGACTTCAGCC GTCTCAGACGCTACTTTGTGGCATTCGACGGGGACCTGGTACAGGAATTTGATATGACTTCAGCCACGCACGTGCTGGGTAGCAGGGACA AGAACCCTGCGGCCCAGCAGGTCTCCCCAGAGTGGATTTGGGCATGTATCCGGAAACGGAGACTGGTAGCTCCCTGCTAGGTTTGCTGTC TTCCCTCTCCCTCAGGCCATACTCTCCTTTACCATACTACTGGACTGGACTCAGGCTGGAGGCAGATAGACACAGTATAGGGGGAATGGG CTTGCTTCTCCCAAACCCACCAGTTCTCCACTGTCTCTTCTGGACCAGGAATTAGTTGCTGTGGGTGCCACAGCTGAAGTCAGTTTGTCT TGCTGGTTTAAATAGATCTTTCAGAGCTGGGTGCTGGGTTTGCCATCTTTTTGTTTTCTTTGAAAAGCAGCTTAGTTACCCTTTTTATAA ATAAAATATCTTGCAGTTATCTTTGTCCTTTCCCCACCTACACCCCCAATAATTTCCCTAGAGATTAAGGAGTAAAGGCTGGGCTATGGC AGCTCTGTCCACAAAGCCTTCTCTCCCATCCTTGCCTGTTCCTTTGTACTTCCAGGCTCATTTTAAAGTTGTATTTAAAGGACTGCCCTC GGAAATGCTTCTGTTTAGCGGAACTTGTATTCAGCCTGACACGCTTTGCCAGGAACAAACCTCATGTGAAAGAAAACAAAATGAATTTTT >In-frame_AATF_ENST00000225402_chr17_35348156_+_LIG3_ENST00000262327_chr17_33325623_+_2634nt AATCCCTTCAACCTTCTGCGCGCTTCCGCCTTCATGCTAGCAACGCCCGCAGTGACGCGCAGGCCCCGCCCCCTCCCGCGCGCCTCCCGG AAGTGGCCGGTCCAGAGCTGTGGGGTGGCCTCCGCGCGGTCTCTGGCGGAGTCGGGGAATCGGATCAAGGCGAGAGGATCCGGCAGGGAA GGAGCTTCGGGGCCGGGGGTTGGGCCGCACATTTACGTGCGCGAAGCGGAGTGGACCGGGAGCTGGTGACGATGGCGGGGCCGCAGCCCC TGGCGCTGCAACTGGAACAGTTGTTGAACCCGCGACCAAGCGAGGCGGACCCTGAAGCGGACCCCGAGGAAGCCACTGCTGCCAGGGTGA TTGACAGGTTTGATGAAGGGGAAGATGGGGAAGGTGATTTCCTAGTAGTGGGTAGCATTAGAAAACTGGCATCAGCCTCCCTCTTGGACA CGGACAAAAGGTATTGCGGCAAAACCACCTCTAGAAAAGCATGGAATGAAGACCATTGGGAGCAGACTCTGCCAGGATCGTCTGATGAGG AAATATCTGATGAGGAAGGGTCTGGAGATGAAGATTCAGAGGGACTGGGTCTGGAGGAATATGATGAGGACGACCTGGGTGCTGCTGAGG AACAGGAGTGTGGTGATCACAGGGAGAGCAAGAAGAGCAGAAGCCACTCTGCAAAAACACCGGGCTTCAGTGTCCAGAGTATCAGTGACT TTGAGAAATTTACCAAGGGAATGGATGACCTTGGGAGCAGTGAGGAGGAGGAAGACGAAGAGAGTGGCATGGAAGAAGGGGATGACGCGG AAGACTCCCAAGGCGAGAGTGAGGAAGACAGGGCTGGAGATAGAAACAGTGAGGATGATGGTGTGGTGATGACCTTCTCTAGTGTCAAAG TTTCTGAGGAAGTGGAGAAAGGAAGAGCCGTGAAGAACCAGATAGCACTGTGGGACCAGCTCTTGGAAGGAAGGATCAAACTACAAAAAG CTCTGTTGACCACCAACCAGCTTCCTCAACCAGATGTTTTCCCATTGTTCAAGGACAAAGGTGGCCCAGAATTTTCCAGTGCCCTGAAAA ATAGTCACAAGGCACTTAAAGCATTGTTGAGGTCATTGGTAGGTCTTCAGGAAGAGTTGCTTTTCCAGTACCCAGACACTAGATATCTAG TAGATGGGACAAAGCCCAATGCGGGAAGTGAGGAGATTTCTAGTGAAGATGATGAGCTGGTAGAAGAGAAGAAGCAGCAACGAAGAAGGG TCCCTGCAAAGAGGAAGCTGGAGATGGAGGACTATCCCAGCTTCATGGCAAAGCGCTTTGCCGACTTTACAGTCTACAGGAACCGCACAC TTCAGAAATGGCACGATAAGACCAAACTGGCTTCTGGAAAACTGGGGAAGGGTTTTGGTGCCTTTGAACGCTCAATCTTGACTCAGATCG ACCATATTCTGATGGACAAAGAGAGATTACTTCGAAGGACACAGACCAAGCGCTCTGTCTATCGAGTTCTTGGCAAACCTGAGCCAGCAG CTCAGCCTGTCCCAGAGAGTTTGCCAGGGGAACCGGAGATCCTTCCTCAAGCCCCTGCTAATGCTCATCTGAAGGACTTGGATGAAGAAA TCTTTGATGATGATGACTTTTACCACCAGGGTACATATGAGCCTGGGAAGCGGCACTGGCTGAAAGTGAAGAAAGACTATTTGAACGAGG GGGCCATGGCCGACACAGCTGACCTGGTGGTCCTTGGAGCCTTCTATGGGCAAGGGAGCAAAGGCGGCATGATGTCAATCTTCCTCATGG GCTGCTACGACCCTGGCAGCCAGAAGTGGTGCACAGTCACCAAGTGTGCAGGAGGCCATGATGATGCCACGCTTGCCCGCCTGCAGAATG AACTAGACATGGTGAAGATCAGCAAGGACCCCAGCAAAATACCCAGCTGGTTGAAGGTCAACAAGATCTACTATCCTGACTTCATCGTCC CAGACCCAAAGAAAGCTGCCGTGTGGGAGATCACAGGGGCTGAATTCTCCAAATCGGAGGCTCATACAGCTGACGGGATCTCCATCCGAT TCCCTCGCTGCACCCGAATCCGAGATGATAAGGACTGGAAATCTGCCACTAACCTTCCCCAACTCAAGGAACTGTACCAGTTGTCCAAGG AGAAGGCAGACTTCACTGTAGTGGCTGGAGATGAGGGGAGCTCCACTACAGGGGGTAGCAGTGAAGAGAATAAGGGTCCCTCAGGGTCTG CTGTGTCCCGCAAGGCCCCCAGCAAGCCCTCAGCCAGTACCAAGAAAGCAGAAGGGAAGCTGAGTAACTCCAACAGCAAAGATGGCAACA TGCAGACTGCAAAGCCTTCCGCTATGAAGGTGGGGGAGAAGCTGGCCACAAAGTCTTCTCCAGTGAAAGTAGGGGAGAAGCGGAAAGCTG CTGATGAGACGCTGTGCCAAACAAAGAGGCGGCCAGCCAGTGAGCAGAGAGGAAGAACTGTGCCAGCAGGCAGGAGATAGAACAGCCCGG CCTAGCCAGGAGAGACTGCAGGGACTCACTCAGCTGCTGGCCCCAAGTCAAAATTTACATTAAAGGGAAAAGACCAGTCTGGGTGTGGGA |
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FusionGenePPI for AATF_LIG3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AATF | RB1, MPP6, DAZAP2, LDOC1, MAPT, PAWR, SP1, RBL2, RBL1, POLR2J, LZTR1, SS18L1, PCBD2, MAGED1, CHEK2, RELA, SIRT7, MDM2, PIN1, CAND1, MMS19, CPD, EFNB3, SMAD3, NEDD4L, ZNF468, LIN28A, HIPK2, AR, DAPK3, TSG101, NGDN, NXF1, OBSL1, BTRC, FBXW11, RPS2, RPS8, DDX56, EBNA1BP2, ESF1, KRR1, NOL10, TBL3, WDR36, BRIX1, DDX52, KIAA0020, KRI1, MPHOSPH10, NOC2L, NOL6, RPF2, SCARNA22, IFI16, CEP164, XPO1, HNRNPU, RPL10, RTEL1, AURKA, CDC14B, FGF8, ZNF324B, ZNF2, FOXA1 | LIG3 | XRCC1, PNKP, NEIL1, NCAPG, THRA, THRB, PARP1, XRCC5, XRCC6, NBN, APP, APTX, CBX8, RPA1, RPA2, RPA3, MOV10, NXF1, PYCARD, CCDC8, EED, TOP3A, PREPL, JMJD4, CLPX, RSAD1, C7orf55, PSME3, NDUFS6, RNF146, POLB, APLF, HIST1H2BA, KIF23, RACGAP1, NTRK1, HIST1H2BG, HIST1H3A, BAX, TMPO, EMC2, EXOSC4, MMGT1, SPC24, JUN, MAX, FOXB1, FOXD3, FOXE1, FOXK2, FOXP1, NF2, NFATC1, NFATC2, H2AFX, RNF166, WDR76, MACROD1, LARS2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000262327 | + | 12 | 20 | 277_280 | 663 | 950 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000262327 | + | 12 | 20 | 318_323 | 663 | 950 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000262327 | + | 12 | 20 | 388_391 | 663 | 950 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000262327 | + | 12 | 20 | 421_427 | 663 | 950 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000378526 | + | 12 | 20 | 277_280 | 663 | 1010 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000378526 | + | 12 | 20 | 318_323 | 663 | 1010 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000378526 | + | 12 | 20 | 388_391 | 663 | 1010 | DNA |
Tgene | LIG3 | chr17:35348156 | chr17:33325623 | ENST00000378526 | + | 12 | 20 | 421_427 | 663 | 1010 | DNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AATF_LIG3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LIG3 | P49916 | DB00290 | Bleomycin | DNA ligase 3 | small molecule | approved|investigational |
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RelatedDiseases for AATF_LIG3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |