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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7398

FusionGeneSummary for CLINT1_NEDD9

check button Fusion gene summary
Fusion gene informationFusion gene name: CLINT1_NEDD9
Fusion gene ID: 7398
HgeneTgene
Gene symbol

CLINT1

NEDD9

Gene ID

9685

4739

Gene nameclathrin interactor 1neural precursor cell expressed, developmentally down-regulated 9
SynonymsCLINT|ENTH|EPN4|EPNRCAS-L|CAS2|CASL|CASS2|HEF1
Cytomap

5q33.3

6p24.2

Type of geneprotein-codingprotein-coding
Descriptionclathrin interactor 1clathrin interacting protein localized in the trans-Golgi regionenthoprotinepsin 4epsin-related proteinepsinRenhancer of filamentation 1Cas scaffolding protein family member 2Crk-associated substrate related protein Cas-LEnhancer of filamentation 1 p55cas-like dockingneural precursor cell expressed developmentally down-regulated protein 9p130Cas-related pr
Modification date2018052220180523
UniProtAcc

Q14677

Q14511

Ensembl transtripts involved in fusion geneENST00000523094, ENST00000530742, 
ENST00000296951, ENST00000411809, 
ENST00000523908, 
ENST00000504387, 
ENST00000379446, ENST00000379433, 
ENST00000508800, 
Fusion gene scores* DoF score3 X 4 X 2=246 X 4 X 5=120
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLINT1 [Title/Abstract] AND NEDD9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW862003CLINT1chr5

157263679

+NEDD9chr6

11186909

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000523094ENST00000504387CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523094ENST00000379446CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523094ENST00000379433CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523094ENST00000508800CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000530742ENST00000504387CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000530742ENST00000379446CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000530742ENST00000379433CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000530742ENST00000508800CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000296951ENST00000504387CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000296951ENST00000379446CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000296951ENST00000379433CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000296951ENST00000508800CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000411809ENST00000504387CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000411809ENST00000379446CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000411809ENST00000379433CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000411809ENST00000508800CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523908ENST00000504387CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523908ENST00000379446CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523908ENST00000379433CLINT1chr5

157263679

+NEDD9chr6

11186909

-
intron-intronENST00000523908ENST00000508800CLINT1chr5

157263679

+NEDD9chr6

11186909

-

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FusionProtFeatures for CLINT1_NEDD9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLINT1

Q14677

NEDD9

Q14511

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport viaclathrin-coated vesicles from the trans-Golgi network toendosomes. Stimulates clathrin assembly.{ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. Docking protein which plays a central coordinating rolefor tyrosine-kinase-based signaling related to cell adhesion. Mayfunction in transmitting growth control signals between focaladhesions at the cell periphery and the mitotic spindle inresponse to adhesion or growth factor signals initiating cellproliferation. May play an important role in integrin beta-1 or Bcell antigen receptor (BCR) mediated signaling in B- and T-cells.Integrin beta-1 stimulation leads to recruitment of variousproteins including CRK, NCK and SHPTP2 to the tyrosinephosphorylated form.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLINT1_NEDD9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLINT1_NEDD9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLINT1_NEDD9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLINT1_NEDD9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource