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Fusion gene ID: 7367 |
FusionGeneSummary for CLEC16A_RMI2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLEC16A_RMI2 | Fusion gene ID: 7367 | Hgene | Tgene | Gene symbol | CLEC16A | RMI2 | Gene ID | 23274 | 116028 |
| Gene name | C-type lectin domain containing 16A | RecQ mediated genome instability 2 | |
| Synonyms | Gop-1|KIAA0350 | BLAP18|C16orf75 | |
| Cytomap | 16p13.13 | 16p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein CLEC16AC-type lectin domain family 16 member A | recQ-mediated genome instability protein 2BLM-associated protein of 18 kDaRMI2, RecQ mediated genome instability 2, homolog | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q2KHT3 | Q96E14 | |
| Ensembl transtripts involved in fusion gene | ENST00000409790, ENST00000409552, ENST00000465491, ENST00000381822, | ENST00000572173, ENST00000572992, ENST00000381820, ENST00000312499, ENST00000576027, | |
| Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 7 X 4 X 5=140 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/378*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLEC16A [Title/Abstract] AND RMI2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-FU-A40J-01A | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409790 | ENST00000572173 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409790 | ENST00000572992 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409790 | ENST00000381820 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409790 | ENST00000312499 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409790 | ENST00000576027 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| In-frame | ENST00000409552 | ENST00000572173 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409552 | ENST00000572992 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409552 | ENST00000381820 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409552 | ENST00000312499 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5CDS-intron | ENST00000409552 | ENST00000576027 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| intron-3CDS | ENST00000465491 | ENST00000572173 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| intron-intron | ENST00000465491 | ENST00000572992 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| intron-intron | ENST00000465491 | ENST00000381820 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| intron-intron | ENST00000465491 | ENST00000312499 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| intron-intron | ENST00000465491 | ENST00000576027 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5UTR-3CDS | ENST00000381822 | ENST00000572173 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5UTR-intron | ENST00000381822 | ENST00000572992 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5UTR-intron | ENST00000381822 | ENST00000381820 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5UTR-intron | ENST00000381822 | ENST00000312499 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
| 5UTR-intron | ENST00000381822 | ENST00000576027 | CLEC16A | chr16 | 11220003 | + | RMI2 | chr16 | 11444499 | + |
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FusionProtFeatures for CLEC16A_RMI2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLEC16A | RMI2 |
| Regulator of mitophagy through the upstream regulationof the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form ofautophagy necessary for mitochondrial quality control. TheRNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusionduring late mitophagy. May protect RNF41/NRDP1 from proteosomaldegradation, RNF41/NRDP1 which regulates proteosomal degradationof PRKN. Plays a key role in beta cells functions by regulatingmitophagy/autophagy and mitochondrial health.{ECO:0000269|PubMed:24949970}. | Essential component of the RMI complex, a complex thatplays an important role in the processing of homologousrecombination intermediates. It is required to regulate sisterchromatid segregation and to limit DNA crossover. Essential forthe stability, localization, and function of BLM, TOP3A, andcomplexes containing BLM. In the RMI complex, it is required totarget BLM to chromatin and stress-induced nuclear foci andmitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082,ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000409790 | + | 22 | 24 | 51_198 | 880 | 1054 | Domain | FPL |
| Tgene | >RMI2 | chr16:11220003 | chr16:11444499 | ENST00000381820 | + | 0 | 2 | 44_114 | 35 | 85 | DNA binding | Note=OB |
| Tgene | >RMI2 | chr16:11220003 | chr16:11444499 | ENST00000572173 | + | 3 | 5 | 44_114 | 35 | 85 | DNA binding | Note=OB |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000381822 | + | 1 | 4 | 892_933 | -74 | 141 | Compositional bias | Note=Ser-rich |
| Hgene | >CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000409552 | + | 1 | 21 | 892_933 | -46 | 907 | Compositional bias | Note=Ser-rich |
| Hgene | >CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000409790 | + | 22 | 24 | 892_933 | 880 | 1054 | Compositional bias | Note=Ser-rich |
| Hgene | >CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000381822 | + | 1 | 4 | 51_198 | -74 | 141 | Domain | FPL |
| Hgene | >CLEC16A | chr16:11220003 | chr16:11444499 | ENST00000409552 | + | 1 | 21 | 51_198 | -46 | 907 | Domain | FPL |
| Tgene | RMI2 | chr16:11220003 | chr16:11444499 | ENST00000312499 | + | 0 | 2 | 44_114 | 98 | 148 | DNA binding | Note=OB |
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FusionGeneSequence for CLEC16A_RMI2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CLEC16A_ENST00000409790_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_930aa MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSG RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFN HPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILII NCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKP SIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELA ASTSVQEQNTTDEEKSAAATCSESTQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLA ERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEY LMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDG GMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAK GRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGKYVMVMGVVQACSPEPCLQ >In-frame_CLEC16A_ENST00000409552_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_978aa MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSG RYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFN HPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINC EFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSI RCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKEIEMVIMERSKLSELAASTSVQEQNTTDEEKSAA ATCSESTQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLAERLIRIMNNAAQPDGKIR LATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTG IDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVE PDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLD LPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGEPAPRPAPQLVHHGGRSRSFSLWSLCELPFLSQKPRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CLEC16A_ENST00000409790_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_2790nt ATGTTTGGCCGCTCGCGGAGCTGGGTGGGCGGGGGCCATGGCAAGACTTCCCGCAACATCCACTCCTTGGACCACCTCAAGTATCTGTAC CACGTTTTGACCAAAAACACCACAGTCACAGAACAGAACCGGAACCTGCTAGTGGAGACCATCCGTTCCATCACTGAGATCCTGATCTGG GGAGATCAAAATGACAGCTCTGTATTTGACTTCTTCCTGGAGAAGAATATGTTTGTTTTCTTCTTGAACATCTTGCGGCAAAAGTCGGGC CGTTACGTGTGCGTTCAGCTGCTGCAGACCTTGAACATCCTCTTTGAGAACATCAGTCACGAGACCTCACTTTATTATTTGCTCTCAAAT AACTACGTAAATTCTATCATCGTTCATAAATTTGACTTTTCTGATGAGGAGATTATGGCCTATTATATATCGTTCCTGAAAACACTTTCG TTAAAACTCAACAACCACACTGTCCATTTCTTTTATAATGAGCACACCAATGACTTTGCCCTGTACACAGAAGCCATCAAGTTTTTCAAC CACCCTGAAAGCATGGTTAGAATTGCTGTAAGAACCATAACTTTGAATGTCTATAAAGTGTCATTGGATAACCAGGCCATGCTGCACTAC ATCCGAGATAAAACTGCTGTTCCTTACTTCTCCAATTTGGTCTGGTTCATTGGGAGCCATGTGATCGAACTCGATGACTGCGTGCAGACT GATGAGGAGCATCGGAATCGGGGTAAACTGAGTGATCTGGTGGCAGAGCACCTAGACCACCTGCACTATCTCAATGACATCCTGATCATC AACTGTGAGTTCCTCAACGATGTGCTCACTGACCACCTGCTCAACAGGCTCTTCCTGCCCCTCTACGTGTACTCACTGGAGAACCAGGAC AAGGGAGGAGAACGGCCGAAAATTAGCCTGCCGGTGTCTCTTTATCTTCTGTCACAGGTCTTCTTAATTATACATCATGCACCGCTGGTG AACTCGTTAGCTGAAGTCATTCTGAATGGTGATCTGTCTGAGATGTACGCTAAGACTGAACAGGATATTCAGAGAAGTTCTGCCAAGCCC AGCATTCGGTGCTTCATTAAACCCACCGAGACACTCGAGCGGTCCCTTGAGATGAACAAGCACAAGGGCAAGAGGCGGGTGCAAAAGAGA CCCAACTACAAAAACGTTGGGGAAGAAGAAGATGAGGAGAAAGGGCCCACCGAGGATGCCCAAGAAGACGCCGAGAAGGCTAAAGGTACA GAGGGTGGTTCAAAAGGCATCAAGACGAGTGGGGAGAGTGAAGAGATCGAGATGGTGATCATGGAGCGTAGCAAGCTCTCAGAGCTGGCC GCCAGCACCTCCGTGCAGGAGCAGAACACCACGGACGAGGAGAAAAGCGCCGCCGCCACCTGCTCTGAGAGCACGCAATGGAGCAGACCC TTCCTGGATATGGTGTACCACGCGCTGGACAGCCCGGATGATGATTACCATGCCCTGTTCGTGCTCTGCCTCCTCTATGCCATGTCTCAT AATAAAGGCATGGATCCTGAAAAATTAGAGCGAATCCAGCTCCCCGTGCCAAATGCGGCCGAGAAGACCACCTACAACCACCCGCTAGCT GAAAGACTCATCAGGATCATGAACAACGCTGCCCAGCCAGATGGGAAGATCCGGCTGGCGACGCTGGAGCTGAGCTGCCTGCTTCTGAAG CAGCAAGTCCTGATGAGTGCTGGCTGCATCATGAAGGACGTGCACCTGGCCTGCCTGGAGGGTGCGAGAGAAGAAAGTGTTCACCTTGTA CGACATTTTTATAAGGGAGAAGACATTTTTTTGGACATGTTTGAAGATGAGTATAGGAGCATGACAATGAAGCCCATGAACGTGGAATAT CTCATGATGGACGCCTCCATCCTGCTGCCCCCAACAGGCACGCCACTGACGGGCATTGACTTCGTGAAGCGGCTGCCGTGTGGCGATGTG GAGAAGACCCGGCGGGCCATCCGGGTGTTCTTCATGCTGCGTTCCCTGTCACTGCAATTGCGAGGGGAGCCTGAGACACAGTTGCCGCTG ACTCGGGAGGAGGACCTGATCAAGACTGATGATGTCCTGGATCTGAATAACAGCGACTTGATTGCATGTACAGTGATCACCAAGGATGGC GGCATGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGATGAGTTTGGTGGAGCCTGATGTGTCCAGGCTTGGCTGGGGAGTGGTCAAG TTTGCAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGGAGGACGACAGCCGTGCCCTGAACATCACCATCCACAAGCCTGCGTCCAGC CCCCATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCATCTTCTCAGACCACATCCGCTGCATCATCGCCAAGCAGCGCCTGGCCAAA GGCCGCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAGCTGCCCTCCTGGACCTCCCAATCCAGCCCACCACTGAAGTCCTGGGGTTT GGACTCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCCGCTTCTACGACCAGGGGCGCCGGGGCAGCAGCGACCCCACAGTGCAGCGC TCCGTGTTTGCATCGGTGGACAAGGTGCCAGGAAAGTATGTGATGGTGATGGGAGTGGTTCAGGCCTGCAGCCCTGAGCCCTGCCTGCAG GCTGTGAAGATGACAGACCTTTCTGATAATCCCATCCATGAAAGTATGTGGGAACTGGAGGTAGAAGATTTACACAGGAATATTCCTTAG >In-frame_CLEC16A_ENST00000409552_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_2934nt ATGTTTGGCCGCTCGCGGAGCTGGGTGGGCGGGGGCCATGGCAAGACTTCCCGCAACATCCACTCCTTGGACCACCTCAAGTATCTGTAC CACGTTTTGACCAAAAACACCACAGTCACAGAACAGAACCGGAACCTGCTAGTGGAGACCATCCGTTCCATCACTGAGATCCTGATCTGG GGAGATCAAAATGACAGCTCTGTATTTGACTTCTTCCTGGAGAAGAATATGTTTGTTTTCTTCTTGAACATCTTGCGGCAAAAGTCGGGC CGTTACGTGTGCGTTCAGCTGCTGCAGACCTTGAACATCCTCTTTGAGAACATCAGTCACGAGACCTCACTTTATTATTTGCTCTCAAAT AACTACGTAAATTCTATCATCGTTCATAAATTTGACTTTTCTGATGAGGAGATTATGGCCTATTATATATCGTTCCTGAAAACACTTTCG TTAAAACTCAACAACCACACTGTCCATTTCTTTTATAATGAGCACACCAATGACTTTGCCCTGTACACAGAAGCCATCAAGTTTTTCAAC CACCCTGAAAGCATGGTTAGAATTGCTGTAAGAACCATAACTTTGAATGTCTATAAAGTGGATAACCAGGCCATGCTGCACTACATCCGA GATAAAACTGCTGTTCCTTACTTCTCCAATTTGGTCTGGTTCATTGGGAGCCATGTGATCGAACTCGATGACTGCGTGCAGACTGATGAG GAGCATCGGAATCGGGGTAAACTGAGTGATCTGGTGGCAGAGCACCTAGACCACCTGCACTATCTCAATGACATCCTGATCATCAACTGT GAGTTCCTCAACGATGTGCTCACTGACCACCTGCTCAACAGGCTCTTCCTGCCCCTCTACGTGTACTCACTGGAGAACCAGGACAAGGGA GGAGAACGGCCGAAAATTAGCCTGCCGGTGTCTCTTTATCTTCTGTCACAGGTCTTCTTAATTATACATCATGCACCGCTGGTGAACTCG TTAGCTGAAGTCATTCTGAATGGTGATCTGTCTGAGATGTACGCTAAGACTGAACAGGATATTCAGAGAAGTTCTGCCAAGCCCAGCATT CGGTGCTTCATTAAACCCACCGAGACACTCGAGCGGTCCCTTGAGATGAACAAGCACAAGGGCAAGAGGCGGGTGCAAAAGAGACCCAAC TACAAAAACGTTGGGGAAGAAGAAGATGAGGAGAAAGGGCCCACCGAGGATGCCCAAGAAGACGCCGAGAAGGCTAAAGAGATCGAGATG GTGATCATGGAGCGTAGCAAGCTCTCAGAGCTGGCCGCCAGCACCTCCGTGCAGGAGCAGAACACCACGGACGAGGAGAAAAGCGCCGCC GCCACCTGCTCTGAGAGCACGCAATGGAGCAGACCCTTCCTGGATATGGTGTACCACGCGCTGGACAGCCCGGATGATGATTACCATGCC CTGTTCGTGCTCTGCCTCCTCTATGCCATGTCTCATAATAAAGGCATGGATCCTGAAAAATTAGAGCGAATCCAGCTCCCCGTGCCAAAT GCGGCCGAGAAGACCACCTACAACCACCCGCTAGCTGAAAGACTCATCAGGATCATGAACAACGCTGCCCAGCCAGATGGGAAGATCCGG CTGGCGACGCTGGAGCTGAGCTGCCTGCTTCTGAAGCAGCAAGTCCTGATGAGTGCTGGCTGCATCATGAAGGACGTGCACCTGGCCTGC CTGGAGGGTGCGAGAGAAGAAAGTGTTCACCTTGTACGACATTTTTATAAGGGAGAAGACATTTTTTTGGACATGTTTGAAGATGAGTAT AGGAGCATGACAATGAAGCCCATGAACGTGGAATATCTCATGATGGACGCCTCCATCCTGCTGCCCCCAACAGGCACGCCACTGACGGGC ATTGACTTCGTGAAGCGGCTGCCGTGTGGCGATGTGGAGAAGACCCGGCGGGCCATCCGGGTGTTCTTCATGCTGCGTTCCCTGTCACTG CAATTGCGAGGGGAGCCTGAGACACAGTTGCCGCTGACTCGGGAGGAGGACCTGATCAAGACTGATGATGTCCTGGATCTGAATAACAGC GACTTGATTGCATGTACAGTGATCACCAAGGATGGCGGCATGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGATGAGTTTGGTGGAG CCTGATGTGTCCAGGCTTGGCTGGGGAGTGGTCAAGTTTGCAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGGAGGACGACAGCCGT GCCCTGAACATCACCATCCACAAGCCTGCGTCCAGCCCCCATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCATCTTCTCAGACCAC ATCCGCTGCATCATCGCCAAGCAGCGCCTGGCCAAAGGCCGCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAGCTGCCCTCCTGGAC CTCCCAATCCAGCCCACCACTGAAGTCCTGGGGTTTGGACTCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCCGCTTCTACGACCAG GGGCGCCGGGGCAGCAGCGACCCCACAGTGCAGCGCTCCGTGTTTGCATCGGTGGACAAGGTGCCAGGTGAGCCAGCCCCCCGCCCTGCG CCACAGCTCGTTCATCATGGTGGGCGTTCAAGGTCTTTCTCTCTGTGGAGCCTGTGTGAGCTGCCCTTCCTCTCTCAGAAGCCCCGTCGG CTGGCAGCACCAGCTTCTTAGAATTTGTCAAAGCACAGCGCAAGATTAAACACAGCCCCCAAAATAAATTTTGGCTTTCCCTTTAGAAAG TATGTGATGGTGATGGGAGTGGTTCAGGCCTGCAGCCCTGAGCCCTGCCTGCAGGCTGTGAAGATGACAGACCTTTCTGATAATCCCATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CLEC16A_ENST00000409790_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_3985nt AACTGCATTTCCCAGCGCCCCACGCGGCGGCGGCCGTAAAGCGCGGCGGTCGAACGGCCGGTTCCGGCTGAATGTCAGTGCTGGGCTGTG GGCCGGGGAGGAAGGCGGCTCGCGGTTCCTCCACCGCCTCCGCCGCCGCATCCTCCGCTTGTGCTACCGCCGCGGGCGCTGGGCCGCTCT GCTGGTCCGGCATGAGACCGTGAGACGAGAGACGGGTCGGGGCCGCCGACATGTTTGGCCGCTCGCGGAGCTGGGTGGGCGGGGGCCATG GCAAGACTTCCCGCAACATCCACTCCTTGGACCACCTCAAGTATCTGTACCACGTTTTGACCAAAAACACCACAGTCACAGAACAGAACC GGAACCTGCTAGTGGAGACCATCCGTTCCATCACTGAGATCCTGATCTGGGGAGATCAAAATGACAGCTCTGTATTTGACTTCTTCCTGG AGAAGAATATGTTTGTTTTCTTCTTGAACATCTTGCGGCAAAAGTCGGGCCGTTACGTGTGCGTTCAGCTGCTGCAGACCTTGAACATCC TCTTTGAGAACATCAGTCACGAGACCTCACTTTATTATTTGCTCTCAAATAACTACGTAAATTCTATCATCGTTCATAAATTTGACTTTT CTGATGAGGAGATTATGGCCTATTATATATCGTTCCTGAAAACACTTTCGTTAAAACTCAACAACCACACTGTCCATTTCTTTTATAATG AGCACACCAATGACTTTGCCCTGTACACAGAAGCCATCAAGTTTTTCAACCACCCTGAAAGCATGGTTAGAATTGCTGTAAGAACCATAA CTTTGAATGTCTATAAAGTGTCATTGGATAACCAGGCCATGCTGCACTACATCCGAGATAAAACTGCTGTTCCTTACTTCTCCAATTTGG TCTGGTTCATTGGGAGCCATGTGATCGAACTCGATGACTGCGTGCAGACTGATGAGGAGCATCGGAATCGGGGTAAACTGAGTGATCTGG TGGCAGAGCACCTAGACCACCTGCACTATCTCAATGACATCCTGATCATCAACTGTGAGTTCCTCAACGATGTGCTCACTGACCACCTGC TCAACAGGCTCTTCCTGCCCCTCTACGTGTACTCACTGGAGAACCAGGACAAGGGAGGAGAACGGCCGAAAATTAGCCTGCCGGTGTCTC TTTATCTTCTGTCACAGGTCTTCTTAATTATACATCATGCACCGCTGGTGAACTCGTTAGCTGAAGTCATTCTGAATGGTGATCTGTCTG AGATGTACGCTAAGACTGAACAGGATATTCAGAGAAGTTCTGCCAAGCCCAGCATTCGGTGCTTCATTAAACCCACCGAGACACTCGAGC GGTCCCTTGAGATGAACAAGCACAAGGGCAAGAGGCGGGTGCAAAAGAGACCCAACTACAAAAACGTTGGGGAAGAAGAAGATGAGGAGA AAGGGCCCACCGAGGATGCCCAAGAAGACGCCGAGAAGGCTAAAGGTACAGAGGGTGGTTCAAAAGGCATCAAGACGAGTGGGGAGAGTG AAGAGATCGAGATGGTGATCATGGAGCGTAGCAAGCTCTCAGAGCTGGCCGCCAGCACCTCCGTGCAGGAGCAGAACACCACGGACGAGG AGAAAAGCGCCGCCGCCACCTGCTCTGAGAGCACGCAATGGAGCAGACCCTTCCTGGATATGGTGTACCACGCGCTGGACAGCCCGGATG ATGATTACCATGCCCTGTTCGTGCTCTGCCTCCTCTATGCCATGTCTCATAATAAAGGCATGGATCCTGAAAAATTAGAGCGAATCCAGC TCCCCGTGCCAAATGCGGCCGAGAAGACCACCTACAACCACCCGCTAGCTGAAAGACTCATCAGGATCATGAACAACGCTGCCCAGCCAG ATGGGAAGATCCGGCTGGCGACGCTGGAGCTGAGCTGCCTGCTTCTGAAGCAGCAAGTCCTGATGAGTGCTGGCTGCATCATGAAGGACG TGCACCTGGCCTGCCTGGAGGGTGCGAGAGAAGAAAGTGTTCACCTTGTACGACATTTTTATAAGGGAGAAGACATTTTTTTGGACATGT TTGAAGATGAGTATAGGAGCATGACAATGAAGCCCATGAACGTGGAATATCTCATGATGGACGCCTCCATCCTGCTGCCCCCAACAGGCA CGCCACTGACGGGCATTGACTTCGTGAAGCGGCTGCCGTGTGGCGATGTGGAGAAGACCCGGCGGGCCATCCGGGTGTTCTTCATGCTGC GTTCCCTGTCACTGCAATTGCGAGGGGAGCCTGAGACACAGTTGCCGCTGACTCGGGAGGAGGACCTGATCAAGACTGATGATGTCCTGG ATCTGAATAACAGCGACTTGATTGCATGTACAGTGATCACCAAGGATGGCGGCATGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGA TGAGTTTGGTGGAGCCTGATGTGTCCAGGCTTGGCTGGGGAGTGGTCAAGTTTGCAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGG AGGACGACAGCCGTGCCCTGAACATCACCATCCACAAGCCTGCGTCCAGCCCCCATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCA TCTTCTCAGACCACATCCGCTGCATCATCGCCAAGCAGCGCCTGGCCAAAGGCCGCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAG CTGCCCTCCTGGACCTCCCAATCCAGCCCACCACTGAAGTCCTGGGGTTTGGACTCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCC GCTTCTACGACCAGGGGCGCCGGGGCAGCAGCGACCCCACAGTGCAGCGCTCCGTGTTTGCATCGGTGGACAAGGTGCCAGGAAAGTATG TGATGGTGATGGGAGTGGTTCAGGCCTGCAGCCCTGAGCCCTGCCTGCAGGCTGTGAAGATGACAGACCTTTCTGATAATCCCATCCATG AAAGTATGTGGGAACTGGAGGTAGAAGATTTACACAGGAATATTCCTTAGAGTATGTTGGAACTGTCGTTAAAAACAACCAAAATCCCGA AACTATTTAGAAGCTTATAATGATGTGGATTTCATGGACACTTTTCAATGCGTATTTTTCAAATGCTTCTCAGAGAGCCTTGCTTTGGTT GACCAAGGAGTCCGGATGTAGGAATGTTTAAATCCTCGGATACTTCAGTGACACAGCCTCTGCTGCCCCTTGCTTTGCCTGTGTTTGCTG ATGAAAAGCAGATGCTTGTGTTTCATTTTCCTTCCTGGTTTGTGTGTGTTAATTCTCTCTCTCTCTCTCAGACACAGAAGTCTCATGTTG CATTTTCCAAATTTTATGAGTGATGATACTTTTTCCATTACTGCTGCGTCCCTGTTTTACAATGCAAAATTTAAGTACGGTCGTTGCCCA TGGTGATTAAAGTGTGGTTATGGGCAGGAAGACAGACTGTGTAAAAAAGGAATGACATCCTGGCTCCTCATCTTCTTCATCAGCAACTAC CATAACCAGTTTGCGAGTCAAATGGCATTTCCTAACGGCAGGCATGGCGGCCCCTGAAAGACAACAGCTCCCTTTCTGCTTCGGACACCA CTCAAACATTTAGACGCAGCTCTATCCCTTTTCCTAGCTAGAGAAGGTGATGCCTTCTTCCATTACTCAGAGATGTTGAGACGTTTTCAG AATTTCTTGTTGAAATGAAAAACATCAAGATAAAGGACGCCTTTCAGGCATTAGCTAAACTTCCACTTCATAACTTTCGGCGAGACATGG TGAGCCTCCTGGTGTAGAGTTCTTTTGTCTTTGTATGGAATGACTTTTTGCTGTGATGGTTTTGAATGTTGGGTTTCTGCTGTCTGCTTA GTACCCATGCCTGAATTTTTTGAGATTGTAAATATCAAAGGAGTTAGATTGTGTTCTGACATGGTTGTAGACTTTCACCTGGATTATTGA >In-frame_CLEC16A_ENST00000409552_chr16_11220003_+_RMI2_ENST00000572173_chr16_11444499_+_4129nt AACTGCATTTCCCAGCGCCCCACGCGGCGGCGGCCGTAAAGCGCGGCGGTCGAACGGCCGGTTCCGGCTGAATGTCAGTGCTGGGCTGTG GGCCGGGGAGGAAGGCGGCTCGCGGTTCCTCCACCGCCTCCGCCGCCGCATCCTCCGCTTGTGCTACCGCCGCGGGCGCTGGGCCGCTCT GCTGGTCCGGCATGAGACCGTGAGACGAGAGACGGGTCGGGGCCGCCGACATGTTTGGCCGCTCGCGGAGCTGGGTGGGCGGGGGCCATG GCAAGACTTCCCGCAACATCCACTCCTTGGACCACCTCAAGTATCTGTACCACGTTTTGACCAAAAACACCACAGTCACAGAACAGAACC GGAACCTGCTAGTGGAGACCATCCGTTCCATCACTGAGATCCTGATCTGGGGAGATCAAAATGACAGCTCTGTATTTGACTTCTTCCTGG AGAAGAATATGTTTGTTTTCTTCTTGAACATCTTGCGGCAAAAGTCGGGCCGTTACGTGTGCGTTCAGCTGCTGCAGACCTTGAACATCC TCTTTGAGAACATCAGTCACGAGACCTCACTTTATTATTTGCTCTCAAATAACTACGTAAATTCTATCATCGTTCATAAATTTGACTTTT CTGATGAGGAGATTATGGCCTATTATATATCGTTCCTGAAAACACTTTCGTTAAAACTCAACAACCACACTGTCCATTTCTTTTATAATG AGCACACCAATGACTTTGCCCTGTACACAGAAGCCATCAAGTTTTTCAACCACCCTGAAAGCATGGTTAGAATTGCTGTAAGAACCATAA CTTTGAATGTCTATAAAGTGGATAACCAGGCCATGCTGCACTACATCCGAGATAAAACTGCTGTTCCTTACTTCTCCAATTTGGTCTGGT TCATTGGGAGCCATGTGATCGAACTCGATGACTGCGTGCAGACTGATGAGGAGCATCGGAATCGGGGTAAACTGAGTGATCTGGTGGCAG AGCACCTAGACCACCTGCACTATCTCAATGACATCCTGATCATCAACTGTGAGTTCCTCAACGATGTGCTCACTGACCACCTGCTCAACA GGCTCTTCCTGCCCCTCTACGTGTACTCACTGGAGAACCAGGACAAGGGAGGAGAACGGCCGAAAATTAGCCTGCCGGTGTCTCTTTATC TTCTGTCACAGGTCTTCTTAATTATACATCATGCACCGCTGGTGAACTCGTTAGCTGAAGTCATTCTGAATGGTGATCTGTCTGAGATGT ACGCTAAGACTGAACAGGATATTCAGAGAAGTTCTGCCAAGCCCAGCATTCGGTGCTTCATTAAACCCACCGAGACACTCGAGCGGTCCC TTGAGATGAACAAGCACAAGGGCAAGAGGCGGGTGCAAAAGAGACCCAACTACAAAAACGTTGGGGAAGAAGAAGATGAGGAGAAAGGGC CCACCGAGGATGCCCAAGAAGACGCCGAGAAGGCTAAAGAGATCGAGATGGTGATCATGGAGCGTAGCAAGCTCTCAGAGCTGGCCGCCA GCACCTCCGTGCAGGAGCAGAACACCACGGACGAGGAGAAAAGCGCCGCCGCCACCTGCTCTGAGAGCACGCAATGGAGCAGACCCTTCC TGGATATGGTGTACCACGCGCTGGACAGCCCGGATGATGATTACCATGCCCTGTTCGTGCTCTGCCTCCTCTATGCCATGTCTCATAATA AAGGCATGGATCCTGAAAAATTAGAGCGAATCCAGCTCCCCGTGCCAAATGCGGCCGAGAAGACCACCTACAACCACCCGCTAGCTGAAA GACTCATCAGGATCATGAACAACGCTGCCCAGCCAGATGGGAAGATCCGGCTGGCGACGCTGGAGCTGAGCTGCCTGCTTCTGAAGCAGC AAGTCCTGATGAGTGCTGGCTGCATCATGAAGGACGTGCACCTGGCCTGCCTGGAGGGTGCGAGAGAAGAAAGTGTTCACCTTGTACGAC ATTTTTATAAGGGAGAAGACATTTTTTTGGACATGTTTGAAGATGAGTATAGGAGCATGACAATGAAGCCCATGAACGTGGAATATCTCA TGATGGACGCCTCCATCCTGCTGCCCCCAACAGGCACGCCACTGACGGGCATTGACTTCGTGAAGCGGCTGCCGTGTGGCGATGTGGAGA AGACCCGGCGGGCCATCCGGGTGTTCTTCATGCTGCGTTCCCTGTCACTGCAATTGCGAGGGGAGCCTGAGACACAGTTGCCGCTGACTC GGGAGGAGGACCTGATCAAGACTGATGATGTCCTGGATCTGAATAACAGCGACTTGATTGCATGTACAGTGATCACCAAGGATGGCGGCA TGGTCCAGCGATTCCTGGCTGTGGATATTTACCAGATGAGTTTGGTGGAGCCTGATGTGTCCAGGCTTGGCTGGGGAGTGGTCAAGTTTG CAGGCCTATTGCAGGACATGCAGGTGACTGGCGTGGAGGACGACAGCCGTGCCCTGAACATCACCATCCACAAGCCTGCGTCCAGCCCCC ATTCCAAGCCCTTCCCCATCCTCCAGGCCACCTTCATCTTCTCAGACCACATCCGCTGCATCATCGCCAAGCAGCGCCTGGCCAAAGGCC GCATCCAGGCAAGGCGCATGAAGATGCAGAGAATAGCTGCCCTCCTGGACCTCCCAATCCAGCCCACCACTGAAGTCCTGGGGTTTGGAC TCGGCTCCTCCACCTCCACTCAGCACCTGCCTTTCCGCTTCTACGACCAGGGGCGCCGGGGCAGCAGCGACCCCACAGTGCAGCGCTCCG TGTTTGCATCGGTGGACAAGGTGCCAGGTGAGCCAGCCCCCCGCCCTGCGCCACAGCTCGTTCATCATGGTGGGCGTTCAAGGTCTTTCT CTCTGTGGAGCCTGTGTGAGCTGCCCTTCCTCTCTCAGAAGCCCCGTCGGCTGGCAGCACCAGCTTCTTAGAATTTGTCAAAGCACAGCG CAAGATTAAACACAGCCCCCAAAATAAATTTTGGCTTTCCCTTTAGAAAGTATGTGATGGTGATGGGAGTGGTTCAGGCCTGCAGCCCTG AGCCCTGCCTGCAGGCTGTGAAGATGACAGACCTTTCTGATAATCCCATCCATGAAAGTATGTGGGAACTGGAGGTAGAAGATTTACACA GGAATATTCCTTAGAGTATGTTGGAACTGTCGTTAAAAACAACCAAAATCCCGAAACTATTTAGAAGCTTATAATGATGTGGATTTCATG GACACTTTTCAATGCGTATTTTTCAAATGCTTCTCAGAGAGCCTTGCTTTGGTTGACCAAGGAGTCCGGATGTAGGAATGTTTAAATCCT CGGATACTTCAGTGACACAGCCTCTGCTGCCCCTTGCTTTGCCTGTGTTTGCTGATGAAAAGCAGATGCTTGTGTTTCATTTTCCTTCCT GGTTTGTGTGTGTTAATTCTCTCTCTCTCTCTCAGACACAGAAGTCTCATGTTGCATTTTCCAAATTTTATGAGTGATGATACTTTTTCC ATTACTGCTGCGTCCCTGTTTTACAATGCAAAATTTAAGTACGGTCGTTGCCCATGGTGATTAAAGTGTGGTTATGGGCAGGAAGACAGA CTGTGTAAAAAAGGAATGACATCCTGGCTCCTCATCTTCTTCATCAGCAACTACCATAACCAGTTTGCGAGTCAAATGGCATTTCCTAAC GGCAGGCATGGCGGCCCCTGAAAGACAACAGCTCCCTTTCTGCTTCGGACACCACTCAAACATTTAGACGCAGCTCTATCCCTTTTCCTA GCTAGAGAAGGTGATGCCTTCTTCCATTACTCAGAGATGTTGAGACGTTTTCAGAATTTCTTGTTGAAATGAAAAACATCAAGATAAAGG ACGCCTTTCAGGCATTAGCTAAACTTCCACTTCATAACTTTCGGCGAGACATGGTGAGCCTCCTGGTGTAGAGTTCTTTTGTCTTTGTAT GGAATGACTTTTTGCTGTGATGGTTTTGAATGTTGGGTTTCTGCTGTCTGCTTAGTACCCATGCCTGAATTTTTTGAGATTGTAAATATC |
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FusionGenePPI for CLEC16A_RMI2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLEC16A | WRAP73, RNF41, TSSC1, RAB39B | RMI2 | APITD1, FANCM, RMI1, LSM4, LSM5, NOTCH3, C17orf70, FANCA, TOP3A, BLM, CCDC69 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLEC16A_RMI2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLEC16A_RMI2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLEC16A | C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | CTD_human |
| Hgene | CLEC16A | C0026769 | Multiple Sclerosis | 2 | CTD_human |
| Hgene | CLEC16A | C0162538 | Immunoglobulin A deficiency (disorder) | 2 | CTD_human |
| Hgene | CLEC16A | C0001403 | Addison Disease | 1 | CTD_human |
| Hgene | CLEC16A | C0023892 | Biliary cirrhosis | 1 | CTD_human |
| Hgene | CLEC16A | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
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