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Fusion gene ID: 7364 |
FusionGeneSummary for CLEC16A_NBAS |
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Fusion gene information | Fusion gene name: CLEC16A_NBAS | Fusion gene ID: 7364 | Hgene | Tgene | Gene symbol | CLEC16A | NBAS | Gene ID | 23274 | 51594 |
Gene name | C-type lectin domain containing 16A | neuroblastoma amplified sequence | |
Synonyms | Gop-1|KIAA0350 | ILFS2|NAG|SOPH | |
Cytomap | 16p13.13 | 2p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein CLEC16AC-type lectin domain family 16 member A | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | Q2KHT3 | A2RRP1 | |
Ensembl transtripts involved in fusion gene | ENST00000409790, ENST00000409552, ENST00000465491, ENST00000381822, | ENST00000441750, ENST00000281513, | |
Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 8 X 9 X 3=216 |
# samples | 12 | 9 | |
** MAII score | log2(12/378*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CLEC16A [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ380493 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000409790 | ENST00000441750 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000409790 | ENST00000281513 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000409552 | ENST00000441750 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000409552 | ENST00000281513 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000465491 | ENST00000441750 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000465491 | ENST00000281513 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000381822 | ENST00000441750 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
intron-intron | ENST00000381822 | ENST00000281513 | CLEC16A | chr16 | 11102571 | + | NBAS | chr2 | 15315355 | + |
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FusionProtFeatures for CLEC16A_NBAS |
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Hgene | Tgene |
CLEC16A | NBAS |
Regulator of mitophagy through the upstream regulationof the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form ofautophagy necessary for mitochondrial quality control. TheRNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusionduring late mitophagy. May protect RNF41/NRDP1 from proteosomaldegradation, RNF41/NRDP1 which regulates proteosomal degradationof PRKN. Plays a key role in beta cells functions by regulatingmitophagy/autophagy and mitochondrial health.{ECO:0000269|PubMed:24949970}. | Involved in Golgi-to-endoplasmic reticulum (ER)retrograde transport; the function is proposed to depend on itsassociation in the NRZ complex which is believed to play a role inSNARE assembly at the ER (PubMed:19369418).{ECO:0000269|PubMed:19369418, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLEC16A_NBAS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLEC16A_NBAS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLEC16A_NBAS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLEC16A_NBAS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CLEC16A | C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | CTD_human |
Hgene | CLEC16A | C0026769 | Multiple Sclerosis | 2 | CTD_human |
Hgene | CLEC16A | C0162538 | Immunoglobulin A deficiency (disorder) | 2 | CTD_human |
Hgene | CLEC16A | C0001403 | Addison Disease | 1 | CTD_human |
Hgene | CLEC16A | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Hgene | CLEC16A | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Tgene | NBAS | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | NBAS | C3541319 | SHORT STATURE, OPTIC NERVE ATROPHY, AND PELGER-HUET ANOMALY | 1 | ORPHANET;UNIPROT |
Tgene | NBAS | C3809651 | INFANTILE LIVER FAILURE SYNDROME 2 | 1 | ORPHANET;UNIPROT |