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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 7321

FusionGeneSummary for CLCN3_UBE2D3

check button Fusion gene summary
Fusion gene informationFusion gene name: CLCN3_UBE2D3
Fusion gene ID: 7321
HgeneTgene
Gene symbol

CLCN3

UBE2D3

Gene ID

1182

7323

Gene namechloride voltage-gated channel 3ubiquitin conjugating enzyme E2 D3
SynonymsCLC3|ClC-3E2(17)KB3|UBC4/5|UBCH5C
Cytomap

4q33

4q24

Type of geneprotein-codingprotein-coding
DescriptionH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3ubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme
Modification date2018052320180523
UniProtAcc

P51790

P61077

Ensembl transtripts involved in fusion geneENST00000513761, ENST00000347613, 
ENST00000360642, ENST00000504131, 
ENST00000506924, 		ENST00000453744, 
ENST00000394801, ENST00000394803, 
ENST00000394804, ENST00000343106, 
ENST00000321805, ENST00000350435, 
ENST00000338145, ENST00000349311, 
ENST00000504211, ENST00000357194, 
ENST00000505207, ENST00000507845, 
ENST00000502404, ENST00000513098, 
Fusion gene scores* DoF score8 X 7 X 4=2243 X 3 X 2=18
# samples 94
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLCN3 [Title/Abstract] AND UBE2D3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166

TgeneUBE2D3

GO:0000209

protein polyubiquitination

14765125|16522193

TgeneUBE2D3

GO:0006513

protein monoubiquitination

20347421

TgeneUBE2D3

GO:0016567

protein ubiquitination

9990509|21532592

TgeneUBE2D3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneUBE2D3

GO:0051865

protein autoubiquitination

21068390

TgeneUBE2D3

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2D3

GO:0070979

protein K11-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A2LR-01ACLCN3chr4

170557239

+UBE2D3chr4

103731012

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000513761ENST00000453744CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000394801CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000394803CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000394804CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000343106CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000321805CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000350435CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000338145CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000513761ENST00000349311CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000504211CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000357194CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000505207CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000507845CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000502404CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000513761ENST00000513098CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000453744CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000394801CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000394803CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000394804CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000343106CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000321805CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000350435CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000338145CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000347613ENST00000349311CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000504211CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000357194CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000505207CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000507845CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000502404CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000347613ENST00000513098CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000453744CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000394801CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000394803CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000394804CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000343106CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000321805CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000350435CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000338145CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
Frame-shiftENST00000360642ENST00000349311CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000504211CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000357194CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000505207CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000507845CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000502404CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000360642ENST00000513098CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000453744CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000394801CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000394803CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000394804CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000343106CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000321805CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000350435CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000338145CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
In-frameENST00000504131ENST00000349311CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000504211CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000357194CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000505207CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000507845CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000502404CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
5CDS-5UTRENST00000504131ENST00000513098CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000453744CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000394801CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000394803CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000394804CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000343106CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000321805CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000350435CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000338145CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-3CDSENST00000506924ENST00000349311CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000504211CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000357194CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000505207CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000507845CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000502404CLCN3chr4

170557239

+UBE2D3chr4

103731012

-
3UTR-5UTRENST00000506924ENST00000513098CLCN3chr4

170557239

+UBE2D3chr4

103731012

-

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FusionProtFeatures for CLCN3_UBE2D3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLCN3

P51790

UBE2D3

P61077

Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}. Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperateswith the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for thepolyubiquitination of NFKBIA leading to its subsequent proteasomaldegradation. Acts as an initiator E2, priming the phosphorylatedNFKBIA target at positions 'Lys-21' and/or 'Lys-22' with amonoubiquitin. Ubiquitin chain elongation is then performed byCDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunctionwith RNF8, for the priming of PCNA. Monoubiquitination of PCNA,and its subsequent polyubiquitination, are essential events in theoperation of the DNA damage tolerance (DDT) pathway that isactivated after DNA damage caused by UV or chemical agents duringS-phase. Associates with the BRCA1/BARD1 E3 ligase complex toperform ubiquitination at DNA damage sites following ionizingradiation leading to DNA repair. Targets DAPK3 for ubiquitinationwhich influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 andTOPORS E3 ligases, functions ubiquitination of p53/TP53. SupportsNRDP1-mediated ubiquitination and degradation of ERBB3 and ofBRUCE which triggers apoptosis. In conjunction with the CBL E3ligase, targets EGFR for polyubiquitination at the plasma membraneas well as during its internalization and transport on endosomes.In conjunction with the STUB1 E3 quality control E3 ligase,ubiquitinates unfolded proteins to catalyze their immediatedestruction. {ECO:0000269|PubMed:10329681,ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252,ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377,ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214,ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924,ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421,ECO:0000269|PubMed:21532592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLCN3_UBE2D3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000453744_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394801_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394803_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394804_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000343106_chr4_103731012_-_6aa

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000321805_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000350435_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000338145_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000349311_chr4_103731012_-_146aa
MVTLQLELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000453744_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394801_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394803_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394804_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000343106_chr4_103731012_-_18nt

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000321805_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000350435_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000338145_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000349311_chr4_103731012_-_438nt
ATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGGTCCAGTTGGGGATGATATGTTTCAT
TGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAATTCATTTTCCTACAGACTACCCCTTC
AAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCATTTGTCTCGATATTCTAAGATCACAG
TGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAACCCAGATGACCCCCTAGTGCCAGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000453744_chr4_103731012_-_3855nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT
TAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAACTGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAA
AAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCT
GAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAA
GCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATC
AGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATAAAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAAC
ACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTC
CAATACACTGTTTAATATAGCACTGAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTAT
TTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGCCTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTT
TTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAA
AGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTG
CACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTTTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTT
TCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAACAACATGGGAGTAATAATGGGTCA
AAATTTGCAAAATAAAGTACTGTTTTGGTGTGGGAGTTGTCATGAGGCTGTGTTGAAGTGACTTATCTATGTGGGATATTGAGTATCCAT
TGAAATGGATTTGTTCAGCCATTTACATTAATGAGCATTTAAATGCAACAGATATCATTTCAGGTGACTTAACATGAATGAATAAAAGTC
AATGCTATTGGATTGTTTTTTGTTTGACAAGTGCTATCTGTGCCACTGATTTAACTTCTGTAGTAACAAGGGCATTACCATTCTTCACCT
TTCCTAATTCTGATCCCATAGTTTTACATTTTTCCTGTTTATTTTGATTTTGTTCACTGCTTTATTTCTTAAAGTTCTAGCACATCTGTG
ACTCCTCCACTTCCACATTTTTGCACTGCTTACACTTACGTGCAATCTTATTCCTTGTCTGCACACACATGTGGAAAGCTAGAAATAAAT
GTTAAAACTTACTTTTTATAAACATTTTAATATGTAGTTTGGACATGATTTATTGACTTAAGGTTCTTCTCTAAACTGGAAGTGAAATGC
ATGCCTTCTGAAGATGTTCTGGCTTTGTTAATTCTGTAATCATTTCATTGGGGAAAAAACCAGCTACGCAGTTTTTCCAATGAGTGAATT
TTTTCATTTTGTGTTTTGCTTAAAACGGCTCCTTCAGGGTAGATGTCATACTGCATAACTTTTTTGGATTCAAATTATGAATGAGAAATT
AGTTAACATTCTGCTCCACAAGGTAAGAAAAACTGCTCTTTGGCTCTATTTTCAAAATTACTTCTGAGATGCATATAGTCTCAAAATAAC
AGCTTTAGTAGGCATATCACTTCTTGAAAGCCAAACATGAGTGTAAGACACTTTTATGAAACACGGTGGATCCCTAACTGGCTTTCAAAT
TGACCTTTATAGCCTTAGACAACCCTTAGGTATTTACGGAGATGACTTCTTTGATTGTCATAACAATTAGTGGATGTGTCCAGTTCTCTG
TATCTTTGACTTGATGCTTTATACATCATTTCATTTGTTGCTTCTAAGGGAATAAGCCATAGAGGCTTCTCCAGGTTTAAAAGAACAGTA
AAGTACCTGGAAAACCAACATTTTTGAATGTATGGACACTGGACATGAGATATGTACAATGAAATCTTAAAAGAATCTAAGAATTTGCCC
TCTTTGCCCCACTCCACCCAGTAATTTGACATTACTAGTGCCATGTATAGGACCCAACTGAGTATTAGAATCAGTTTTGACTATGTCTTT
GTATTTCCTAAATCTTTTAATGCATAAACCGAATTAGGGTCCAGTTGGCCTGTTAATGGTAAATTTACATTTTAAATGACTCAGTTTGTT
TTTCCTGGGCGAGTTTGCAATGTGATAATCAGATTTTTTAAAACTGATTAATTTGCTTTCTTGTGTGGGTGTACTCACATTTTAAAGTAT
GAACCACAGTTAACTAGTGGTCTCAGGGGTAGTGAAACACTCACTTTTTTTTTTGTTTGTTTTTTTTTGTTTGTTGAAATGGCTTAGTTG
AAGTATACTTAAGGTACTGATCATGCTGTGTTAGTAATTTGGGCGGGGAGGGGGGTAACTCAGCCATGTTTTGTGTTGGCATAACAAAAC
TGTTAATGATTGTTGATTACACTTTTAAGTGAATTTGTCTTTTATGAGGAACCCAGTGCAAGTCACTAAATATTGTCTAATAGTGACATC

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394801_chr4_103731012_-_2262nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT
TAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAACTGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAA
AAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCT
GAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAA
GCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATC
AGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATAAAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAAC
ACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTC
CAATACACTGTTTAATATAGCACTGAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTAT
TTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGCCTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTT
TTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAA
AGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTG
CACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTTTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTT
TCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAACAACATGGGAGTAATAATGGGTCA
AAATTTGCAAAATAAAGTACTGTTTTGGTGTGGGAGTTGTCATGAGGCTGTGTTGAAGTGACTTATCTATGTGGGATATTGAGTATCCAT
TGAAATGGATTTGTTCAGCCATTTACATTAATGAGCATTTAAATGCAACAGATATCATTTCAGGTGACTTAACATGAATGAATAAAAGTC

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394803_chr4_103731012_-_2262nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT
TAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAACTGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAA
AAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCT
GAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAA
GCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATC
AGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATAAAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAAC
ACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTC
CAATACACTGTTTAATATAGCACTGAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTAT
TTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGCCTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTT
TTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAA
AGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTG
CACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTTTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTT
TCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAACAACATGGGAGTAATAATGGGTCA
AAATTTGCAAAATAAAGTACTGTTTTGGTGTGGGAGTTGTCATGAGGCTGTGTTGAAGTGACTTATCTATGTGGGATATTGAGTATCCAT
TGAAATGGATTTGTTCAGCCATTTACATTAATGAGCATTTAAATGCAACAGATATCATTTCAGGTGACTTAACATGAATGAATAAAAGTC

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000394804_chr4_103731012_-_2261nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT
TAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAACTGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAA
AAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCACTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCT
GAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTTGTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAA
GCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTTTATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATC
AGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATAAAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAAC
ACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAATTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTC
CAATACACTGTTTAATATAGCACTGAATAAATGATGCAAGTTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTAT
TTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGCCTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTT
TTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCAAATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAA
AGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTGATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTG
CACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTTTGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTT
TCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACCTTGTACACTTGACAGCTGAAAAAAAACAACATGGGAGTAATAATGGGTCA
AAATTTGCAAAATAAAGTACTGTTTTGGTGTGGGAGTTGTCATGAGGCTGTGTTGAAGTGACTTATCTATGTGGGATATTGAGTATCCAT
TGAAATGGATTTGTTCAGCCATTTACATTAATGAGCATTTAAATGCAACAGATATCATTTCAGGTGACTTAACATGAATGAATAAAAGTC

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000343106_chr4_103731012_-_2154nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAATAGGTTAGCAAGAGAGTGGACAGAGAA
ATACGCTATGTTGTAGGGTACAACAGAATATCTCGGGAATGGACTCAGAAGTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGC
ATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTATCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTT
ATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACTTAAGTTCTTCCAGCTTTGGACAATAACTGCTTTTAGAAAC
TGTAAAGTAGTTACAAGAGAACAGTTGCCCAAGACTCAGAATTTTTAAAAAAAAAAATGGAGCATGTGTATTATGTGGCCAATGTCTTCA
CTCTAACTTGGTTATGAGACTAAAACCATTCCTCACTGCTCTAACATGCTGAAGAAATCATCTGAGGGGGAGGGAGATGGATGCTCAGTT
GTCACATCAAAGGATACAGCATTATTCTAGCAGCATCCATTCTTGTTTAAGCCTTCCACTGTTAGAGATTTGAGGTTACATGATATGCTT
TATGCTCATAACTGATGTGGCTGGAGAATTGGTATTGAATTTATAGCATCAGCAGAACAGAAAATGTGATGTATTTTATGCATGTCAATA
AAGGAATGACCTGTTCTTGTTCTACAGAGAATGGAAATTGGAAGTCAAACACCCTTTGTATTCCAAAATAGGGTCTCAAACATTTTGTAA
TTTTCATTTAAATTGTTAGGAGGCTTGGAGCTATTAGTTAATCTATCTTCCAATACACTGTTTAATATAGCACTGAATAAATGATGCAAG
TTGTCAATGGATGAGTGATCAACTAATAGCTCTGCTAGTAATTGATTTATTTTTCTTCAATAAAGTTGCATAAACCAATGAGTTAGCTGC
CTGGATTAATCAGTATGGGAAACAATCTTTTGTAAATGCAAAGCTGTTTTTTGTATATACTGTTGGGATTTGCTTCATTGTTTGACATCA
AATGATGATGTAAAGTTCGAAAGAGTGAATATTTTGCCATGTTCAGTTAAAGTGCACAGTCTGTTACAGGTTGACACATTGCTTGACCTG
ATTTATGCAGAATTAATAAGCTATTTGGATAGTGTAGCTTTAATGTGCTGCACATGATACTGGCAGCCCTAGAGTTCATAGATGGACTTT
TGGGACCCAGCAGTTTTGAAATGTGTTTATGGAGTTTAAGAAATTTATTTTCCAGGTGCAGCCCCTGTCTAACTGAAATTTCTCTTCACC

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000321805_chr4_103731012_-_1003nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000350435_chr4_103731012_-_991nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA
TCCGGCTGCTCCCCTATCAGACCTCATCTTTTTTAATTTTATTTTTTGTTTACCTCCCTCCATTCATTCACATGCTCATCTGAGAAGACT

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000338145_chr4_103731012_-_986nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA

>In-frame_CLCN3_ENST00000504131_chr4_170557239_+_UBE2D3_ENST00000349311_chr4_103731012_-_974nt
TTGCTCCCGTGTTTGAAGGAGGACAATAAAAGTCCCACCGGGCAAAATTTTCGTAACCTCTGCGGTAGAAAACGTCAGGTATCTTTTAAA
TCGCGATAGTTTTCGCTGTGTCAGGCTTTCTTCGGTGGAGCTCCGAGGGTAGCTAGGTTCTAGGTTTGAAACAGATGCAGAATCCAAAGG
CAGCGCAAAAAACAGCCACCGATTTTGCTATGTCTCTGAGCTGCGAGATAATCAGACAGCTAAATGGAGTCTGAGCAGCTGTTCCATAGA
GGCTACTATAGAAACAGCTACAACAGTATAACAAGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAA
ACATCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTGGAACTTAGTGATTTGGCCCGTGACCCTCCAGCACAATGTTCTGCAGG
TCCAGTTGGGGATGATATGTTTCATTGGCAAGCCACAATTATGGGACCTAATGACAGCCCATATCAAGGCGGTGTATTCTTTTTGACAAT
TCATTTTCCTACAGACTACCCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGTAATGGCAGCAT
TTGTCTCGATATTCTAAGATCACAGTGGTCGCCTGCTTTAACAATTTCTAAAGTTCTTTTATCCATTTGTTCACTGCTATGTGATCCAAA
CCCAGATGACCCCCTAGTGCCAGAGATTGCACGGATCTATAAAACAGACAGAGATAAGTACAACAGAATATCTCGGGAATGGACTCAGAA
GTATGCCATGTGATGCTACCTTAAAGTCAGAATAACCTGCATTATAGCTGGAATAAACTTTAAATTACTGTTCCTTTTTTGATTTTCTTA


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FusionGenePPI for CLCN3_UBE2D3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25UBE2D3TRIM39, RNF126, DTX3L, NEDD4, UBE3A, MEX3B, DAPK3, RBCK1, DDX58, RNF125, ISG15, STAM2, EPS15, POLM, POLL, HDAC6, UBASH3B, UFM1, AMFR, MUL1, CADPS2, CNOT4, DTX1, UBE4A, RNF103, RNF181, MAP3K1, MIB1, PJA2, RFWD3, RMND5B, RNF11, RNF111, RNF13, RNF130, RNF150, RNF165, RNF167, RNF25, RNF26, RNF43, SIAH1, RNF4, TOPORS, UHRF2, RNF115, ZNRF1, ZNRF2, ZNRF4, XIAP, UBOX5, RNF5, DTX3, RNF14, RNF114, TRIM8, DZIP3, MID1, MKRN3, TRIM27, RNF10, RNF166, RNF185, RNF2, TRIM43, TRAF6, BIRC8, BFAR, RING1, MARCH3, RSPRY1, RLIM, LRSAM1, CHFR, ARIH2, MGRN1, TRIM55, RNF38, TRIM17, TRIM2, TRIM25, TRIM26, TRIM31, TRIM35, TRIM5, BIRC2, BIRC3, STUB1, UBE4B, UBC, BIRC7, BRCA1, DBN1, STAU1, KIAA1107, FOCAD, TUBA1A, MKRN1, RPLP1, XPNPEP1, STK25, PDCD5, BMI1, ELAVL1, NFKBIA, MID2, TRIM10, TRIM11, TRIM50, TRIM7, TRIM37, TRIM38, TRIM45, TRIM32, UBA1, RELA, FBXO25, PCNA, FZR1, SMURF2, MDM2, SMURF1, TRIM28, TRIM23, MYLIP, TRIM33, WSB1, PARK2, PJA1, TRIM54, TRIM63, RFFL, RBX1, RNF146, UBR5, RNF168, RNF8, RNF41, RABGEF1, RNF220, TRIM68, FBXO2, FBXW8, TRAIP, SH3RF1, RNF122, SYVN1, MARCH8, MDM4, MARCH5, HERC2, BARD1, HUWE1, CBL, KAT2B, RNF31, MSL2, NHLRC1, FBXO32, FBXL2, NEDD4L, ITCH, WWP2, TERT, SIAH2, AMBRA1, HERC1, UBTD1, UBE2D3, MSL1, CBLC, UBA6, FBXW11, ARIH1, MARCH7, BTRC, TRIM58, PRPF19, OTUB1, DTX2, HECW2, RCHY1, RNF7, TMEM129, NEDD8, UBE2C, CSNK2A1, AREL1, UBE3C, WWP1, HECW1, FBXL12, UHRF1, USP7, PCGF1, PCGF2, PCGF3, PCGF5, PCGF6, MCM2, NOSIP, F12, HECTD1, TRIM69, PTAR1, CUL4B, RNF216, FBXO7, KDM1B, UBE2S, CDC34, F3, ANAPC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLCN3_UBE2D3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLCN3_UBE2D3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLCN3C0017638Glioma1CTD_human
HgeneCLCN3C0038356Stomach Neoplasms1CTD_human
HgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human