![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 7314 |
FusionGeneSummary for CLCN3_ASIC4 |
![]() |
Fusion gene information | Fusion gene name: CLCN3_ASIC4 | Fusion gene ID: 7314 | Hgene | Tgene | Gene symbol | CLCN3 | ASIC4 | Gene ID | 1182 | 55515 |
Gene name | chloride voltage-gated channel 3 | acid sensing ion channel subunit family member 4 | |
Synonyms | CLC3|ClC-3 | ACCN4|BNAC4 | |
Cytomap | 4q33 | 2q35 | |
Type of gene | protein-coding | protein-coding | |
Description | H(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3 | acid-sensing ion channel 4acid sensing ion channel family member 4acid-sensing (proton-gated) ion channel family member 4amiloride-sensitive cation channel 4, pituitaryamiloride-sensitive cation channel family member 4, pituitarybrain sodium channel | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P51790 | Q96FT7 | |
Ensembl transtripts involved in fusion gene | ENST00000513761, ENST00000347613, ENST00000360642, ENST00000504131, ENST00000506924, | ENST00000358078, ENST00000347842, ENST00000473709, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CLCN3 [Title/Abstract] AND ASIC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CLCN3 | GO:1902476 | chloride transmembrane transport | 11274166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | R12599 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000513761 | ENST00000358078 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000513761 | ENST00000347842 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000513761 | ENST00000473709 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000347613 | ENST00000358078 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000347613 | ENST00000347842 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000347613 | ENST00000473709 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000360642 | ENST00000358078 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000360642 | ENST00000347842 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000360642 | ENST00000473709 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000504131 | ENST00000358078 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000504131 | ENST00000347842 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
5CDS-intron | ENST00000504131 | ENST00000473709 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
intron-intron | ENST00000506924 | ENST00000358078 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
intron-intron | ENST00000506924 | ENST00000347842 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
intron-intron | ENST00000506924 | ENST00000473709 | CLCN3 | chr4 | 170641124 | - | ASIC4 | chr2 | 220383146 | + |
Top |
FusionProtFeatures for CLCN3_ASIC4 |
![]() |
Hgene | Tgene |
CLCN3 | ASIC4 |
Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}. | Probable cation channel with high affinity for sodium.In vitro, has no proton-gated channel activity.{ECO:0000269|PubMed:10852210}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CLCN3_ASIC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CLCN3_ASIC4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CLCN3_ASIC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CLCN3_ASIC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CLCN3 | C0017638 | Glioma | 1 | CTD_human |
Hgene | CLCN3 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | CLCN3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |