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Fusion gene ID: 7310 |
FusionGeneSummary for CLASRP_TOMM40 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLASRP_TOMM40 | Fusion gene ID: 7310 | Hgene | Tgene | Gene symbol | CLASRP | TOMM40 | Gene ID | 11129 | 10452 |
| Gene name | CLK4 associating serine/arginine rich protein | translocase of outer mitochondrial membrane 40 | |
| Synonyms | CLASP|SFRS16|SWAP2 | C19orf1|D19S1177E|PER-EC1|PEREC1|TOM40 | |
| Cytomap | 19q13.32 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CLK4-associating serine/arginine rich proteinClk4 associating SR-related proteinsplicing factor, arginine/serine-rich 16 (suppressor-of-white-apricot homolog, Drosophila)suppressor of white apricot homolog 2 | mitochondrial import receptor subunit TOM40 homologmitochondrial outer membrane proteinp38.5protein Haymakertranslocase of outer membrane 40 kDa subunit homologtranslocase of outer mitochondrial membrane 40 homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N2M8 | O96008 | |
| Ensembl transtripts involved in fusion gene | ENST00000221455, ENST00000391953, ENST00000544944, | ENST00000405636, ENST00000252487, ENST00000592434, ENST00000426677, | |
| Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 3 X 2 X 3=18 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLASRP [Title/Abstract] AND TOMM40 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1845-01A | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000221455 | ENST00000405636 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| Frame-shift | ENST00000221455 | ENST00000252487 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| 5CDS-3UTR | ENST00000221455 | ENST00000592434 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| 5CDS-3UTR | ENST00000221455 | ENST00000426677 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| In-frame | ENST00000391953 | ENST00000405636 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| Frame-shift | ENST00000391953 | ENST00000252487 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| 5CDS-3UTR | ENST00000391953 | ENST00000592434 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| 5CDS-3UTR | ENST00000391953 | ENST00000426677 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| intron-3CDS | ENST00000544944 | ENST00000405636 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| intron-3CDS | ENST00000544944 | ENST00000252487 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| intron-3UTR | ENST00000544944 | ENST00000592434 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
| intron-3UTR | ENST00000544944 | ENST00000426677 | CLASRP | chr19 | 45571738 | + | TOMM40 | chr19 | 45406287 | + |
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FusionProtFeatures for CLASRP_TOMM40 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLASRP | TOMM40 |
| Probably functions as an alternative splicing regulator.May regulate the mRNA splicing of genes such as CLK1. May act byregulating members of the CLK kinase family (By similarity).{ECO:0000250}. | Channel-forming protein essential for import of proteinprecursors into mitochondria. {ECO:0000269|PubMed:15644312}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CLASRP | chr19:45571738 | chr19:45406287 | ENST00000221455 | + | 16 | 21 | 377_535 | 589 | 675 | Compositional bias | Note=Ser-rich |
| Tgene | >TOMM40 | chr19:45571738 | chr19:45406287 | ENST00000592434 | + | 0 | 9 | 10_39 | -31 | 330 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CLASRP | chr19:45571738 | chr19:45406287 | ENST00000221455 | + | 16 | 21 | 585_647 | 589 | 675 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CLASRP | chr19:45571738 | chr19:45406287 | ENST00000221455 | + | 16 | 21 | 369_673 | 589 | 675 | Compositional bias | Note=Arg-rich |
| Tgene | TOMM40 | chr19:45571738 | chr19:45406287 | ENST00000252487 | + | 8 | 10 | 10_39 | 315 | 362 | Compositional bias | Note=Pro-rich |
| Tgene | TOMM40 | chr19:45571738 | chr19:45406287 | ENST00000405636 | + | 8 | 10 | 10_39 | 315 | 362 | Compositional bias | Note=Pro-rich |
| Tgene | TOMM40 | chr19:45571738 | chr19:45406287 | ENST00000426677 | + | 7 | 9 | 10_39 | 315 | 362 | Compositional bias | Note=Pro-rich |
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FusionGeneSequence for CLASRP_TOMM40 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CLASRP_ENST00000221455_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_636aa MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIP DYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAE KPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQ RREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPP QPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDG HRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREK LTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQCSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGF >In-frame_CLASRP_ENST00000391953_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_574aa MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDE KKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKD KEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSF GGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSW SRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSR SHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQCSVDSNWIVGATL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CLASRP_ENST00000221455_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_1908nt ATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTAT GAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCCTGGCCGCT GAGAGCCCTGTTAATATGATGCCCTGGCAGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACCACATCCCC GACTACACCCCCCCTCTGCTCACCACCATCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTG CAGAACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAA GATGAGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAA AAGCCAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTG GATGAATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGGATGCTCCGG AAAGACAAGGAGGAGGCAGAGGCCATCAAGCATGCCAAGGCTCTTGAGGAGGAGAAGGCCATGTACTCGGGACGCCGCTCTCGACGCCAG CGGAGAGAGTTTCGGGAGAAGCGGCTGAGGGGTCGCAAGATCAGCCCACCCAGCTATGCCCGCCGAGACAGCCCCACCTATGACCCCTAT AAGCGGTCACCCTCGGAGTCCAGCTCAGAGTCCCGCTCCCGCTCCCGCTCCCCGACCCCGGGCCGCGAGGAGAAGATCACGTTCATCACC AGTTTTGGGGGCAGCGATGAGGAGGCAGCCGCAGCCGCTGCTGCCGCAGCAGCATCAGGAGTCACCACAGGGAAGCCCCCCGCACCTCCC CAGCCTGGCGGCCCCGCCCCGGGACGTAATGCCAGCGCCCGCCGCCGCTCCTCCTCCTCCTCCTCCTCCTCTTCTGCCTCGAGGACCTCC AGCTCCCGCTCCAGCTCTCGCTCCAGCTCCCGCTCTCGCCGTGGTGGGGGCTACTACCGTTCCGGCCGCCACGCCCGCTCCCGGTCCCGC TCCTGGTCCCGCTCCCGCTCCCGCTCCCGGCGCTATTCCCGGTCCCGTAGCCGTGGCCGGCGGCACTCAGGTGGGGGCTCCCGAGACGGA CACCGGTACTCCCGCTCGCCCGCCCGGCGTGGTGGTTACGGGCCCCGGCGCAGAAGCAGGAGCCGCTCCCACTCAGGGGACCGCTACAGG CGGGGCGGCCGGGGCCTCAGGCACCACAGCAGTAGCCGCAGCCGCAGCAGCTGGTCCCTCAGCCCGTCCCGCAGTCGCAGCCTGACTCGC AGCCGCAGCCATAGCCCCAGCCCCAGCCAGAGCCGCAGCCGCAGCCGCAGCCGCAGCCAGAGCCCCTCGCCATCACCCGCAAGAGAGAAG CTGACCAGGCCGGCCGCGTCCCCTGCTGTGGGCGAGAAGCTGAAAAAGACCGAACCTGCCGCTGGTAAAGAGACAGGAGCTGCCAAACCC AAGCTGACGCCTCAGGAGAAGCTGAAACTGAGGATGCAGAAGGCGCTGAACAGGCAGTGCTCTGTGGATAGCAACTGGATCGTGGGTGCC ACGCTGGAGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAGTTTCAGTGTGGCTTT >In-frame_CLASRP_ENST00000391953_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_1722nt ATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATTAT GAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGAAC GACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATGAG AAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGCCA GAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATGAA TTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGGATGCTCCGGAAAGAC AAGGAGGAGGCAGAGGCCATCAAGCATGCCAAGGCTCTTGAGGAGGAGAAGGCCATGTACTCGGGACGCCGCTCTCGACGCCAGCGGAGA GAGTTTCGGGAGAAGCGGCTGAGGGGTCGCAAGATCAGCCCACCCAGCTATGCCCGCCGAGACAGCCCCACCTATGACCCCTATAAGCGG TCACCCTCGGAGTCCAGCTCAGAGTCCCGCTCCCGCTCCCGCTCCCCGACCCCGGGCCGCGAGGAGAAGATCACGTTCATCACCAGTTTT GGGGGCAGCGATGAGGAGGCAGCCGCAGCCGCTGCTGCCGCAGCAGCATCAGGAGTCACCACAGGGAAGCCCCCCGCACCTCCCCAGCCT GGCGGCCCCGCCCCGGGACGTAATGCCAGCGCCCGCCGCCGCTCCTCCTCCTCCTCCTCCTCCTCTTCTGCCTCGAGGACCTCCAGCTCC CGCTCCAGCTCTCGCTCCAGCTCCCGCTCTCGCCGTGGTGGGGGCTACTACCGTTCCGGCCGCCACGCCCGCTCCCGGTCCCGCTCCTGG TCCCGCTCCCGCTCCCGCTCCCGGCGCTATTCCCGGTCCCGTAGCCGTGGCCGGCGGCACTCAGGTGGGGGCTCCCGAGACGGACACCGG TACTCCCGCTCGCCCGCCCGGCGTGGTGGTTACGGGCCCCGGCGCAGAAGCAGGAGCCGCTCCCACTCAGGGGACCGCTACAGGCGGGGC GGCCGGGGCCTCAGGCACCACAGCAGTAGCCGCAGCCGCAGCAGCTGGTCCCTCAGCCCGTCCCGCAGTCGCAGCCTGACTCGCAGCCGC AGCCATAGCCCCAGCCCCAGCCAGAGCCGCAGCCGCAGCCGCAGCCGCAGCCAGAGCCCCTCGCCATCACCCGCAAGAGAGAAGCTGACC AGGCCGGCCGCGTCCCCTGCTGTGGGCGAGAAGCTGAAAAAGACCGAACCTGCCGCTGGTAAAGAGACAGGAGCTGCCAAACCCAAGCTG ACGCCTCAGGAGAAGCTGAAACTGAGGATGCAGAAGGCGCTGAACAGGCAGTGCTCTGTGGATAGCAACTGGATCGTGGGTGCCACGCTG GAGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAGTTTCAGTGTGGCTTTGGCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CLASRP_ENST00000221455_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_2515nt GCGGCCTTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCC TCACCACAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGG AGTATTATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGTACATGGCCGAGCTTGCAAGGTGCACCTGGATTCTGCAGTCGCCC TGGCCGCTGAGAGCCCTGTTAATATGATGCCCTGGCAGGGGGACACCAACAACATGATTGACCGATTCGATGTCCGTGCCCACCTGGACC ACATCCCCGACTACACCCCCCCTCTGCTCACCACCATCTCCCCAGAACAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAG GCCTGGTGCAGAACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGAC CCAGCGAAGATGAGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGG CGGCAGAAAAGCCAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGG TGGACGTGGATGAATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGGA TGCTCCGGAAAGACAAGGAGGAGGCAGAGGCCATCAAGCATGCCAAGGCTCTTGAGGAGGAGAAGGCCATGTACTCGGGACGCCGCTCTC GACGCCAGCGGAGAGAGTTTCGGGAGAAGCGGCTGAGGGGTCGCAAGATCAGCCCACCCAGCTATGCCCGCCGAGACAGCCCCACCTATG ACCCCTATAAGCGGTCACCCTCGGAGTCCAGCTCAGAGTCCCGCTCCCGCTCCCGCTCCCCGACCCCGGGCCGCGAGGAGAAGATCACGT TCATCACCAGTTTTGGGGGCAGCGATGAGGAGGCAGCCGCAGCCGCTGCTGCCGCAGCAGCATCAGGAGTCACCACAGGGAAGCCCCCCG CACCTCCCCAGCCTGGCGGCCCCGCCCCGGGACGTAATGCCAGCGCCCGCCGCCGCTCCTCCTCCTCCTCCTCCTCCTCTTCTGCCTCGA GGACCTCCAGCTCCCGCTCCAGCTCTCGCTCCAGCTCCCGCTCTCGCCGTGGTGGGGGCTACTACCGTTCCGGCCGCCACGCCCGCTCCC GGTCCCGCTCCTGGTCCCGCTCCCGCTCCCGCTCCCGGCGCTATTCCCGGTCCCGTAGCCGTGGCCGGCGGCACTCAGGTGGGGGCTCCC GAGACGGACACCGGTACTCCCGCTCGCCCGCCCGGCGTGGTGGTTACGGGCCCCGGCGCAGAAGCAGGAGCCGCTCCCACTCAGGGGACC GCTACAGGCGGGGCGGCCGGGGCCTCAGGCACCACAGCAGTAGCCGCAGCCGCAGCAGCTGGTCCCTCAGCCCGTCCCGCAGTCGCAGCC TGACTCGCAGCCGCAGCCATAGCCCCAGCCCCAGCCAGAGCCGCAGCCGCAGCCGCAGCCGCAGCCAGAGCCCCTCGCCATCACCCGCAA GAGAGAAGCTGACCAGGCCGGCCGCGTCCCCTGCTGTGGGCGAGAAGCTGAAAAAGACCGAACCTGCCGCTGGTAAAGAGACAGGAGCTG CCAAACCCAAGCTGACGCCTCAGGAGAAGCTGAAACTGAGGATGCAGAAGGCGCTGAACAGGCAGTGCTCTGTGGATAGCAACTGGATCG TGGGTGCCACGCTGGAGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAGTTTCAGT GTGGCTTTGGCCTCACCATCGGCTGAGCCCTCCTGGCCCCCGCCTTCCACGCCCTTCCGATTCCACCTCCACCTCCACCTCCCCCTGCCA CAGAGGGGAGACCTGAGCCCCCCTCCCTTCCCTCCCCCCTTGGGGGTCGGGGGGGACATTGGAAAGGAGGGACCCCGCCACCCCAGCAGC TGAGGAGGGGATTCTGGAACTGAATGGCGCTTCGGGATTCTGAGTAGCAGGGGCAGCATGCCCAGTGGGCCTGGGGTCCCGGGAGGGATT CCGGAATTGAGGGGCACGCAGGATTCTGAGCACCAGGGGCAGAGGCGGCCAGACAACCTCAGGGAGGAGTGTCCTGGCGTCCCCATCCTC CAAAGGGCCTGGGCCCGCCCCGAGGGGGCAGCGAGAGGAGCTTCCCCATCCCCGGTCAGTCCACCCTGCCCCGTCCACTTTCCCATCTCC >In-frame_CLASRP_ENST00000391953_chr19_45571738_+_TOMM40_ENST00000405636_chr19_45406287_+_2323nt TTTCATTTCCGCTTCCGGTGCGGGCCGCGCGCGAGCGCAGCGGTGGGAGGCGGCGACCAGCCGGTTGAGGCCCCAGGCTTGGCCTCACCA CAATGTGGCACGAGGCTCGGAAGCATGAGCGGAAGCTTCGAGGCATGATGGTCGACTACAAGAAGAGGGCGGAGCGGAGACGGGAGTATT ATGAAAAGATCAAGAAGGACCCAGCCCAGTTCCTGCAGGAGTCGGACGAACGGAAGTGTAACTACGAGCGCTACAGAGGCCTGGTGCAGA ACGACTTTGCCGGCATCTCAGAGGAGCAGTGCCTGTACCAGATCTACATTGATGAGTTGTACGGAGGCCTCCAGAGACCCAGCGAAGATG AGAAGAAGAAGCTGGCAGAGAAGAAGGCTTCCATCGGTTATACCTACGAGGACAGCACGGTGGCCAAGGTAGAGAAGGCGGCAGAAAAGC CAGAGGAGGAGGAGTCAGCGGCCGAGGAGGAGAGCAACTCGGACGAAGATGAGGTCATCCCCGACATCGACGTGGAGGTGGACGTGGATG AATTGAACCAGGAGCAGGTGGCAGATCTCAACAAACAGGCCACGACTTATGGCATGGCCGACGGTGACTTCGTCAGGATGCTCCGGAAAG ACAAGGAGGAGGCAGAGGCCATCAAGCATGCCAAGGCTCTTGAGGAGGAGAAGGCCATGTACTCGGGACGCCGCTCTCGACGCCAGCGGA GAGAGTTTCGGGAGAAGCGGCTGAGGGGTCGCAAGATCAGCCCACCCAGCTATGCCCGCCGAGACAGCCCCACCTATGACCCCTATAAGC GGTCACCCTCGGAGTCCAGCTCAGAGTCCCGCTCCCGCTCCCGCTCCCCGACCCCGGGCCGCGAGGAGAAGATCACGTTCATCACCAGTT TTGGGGGCAGCGATGAGGAGGCAGCCGCAGCCGCTGCTGCCGCAGCAGCATCAGGAGTCACCACAGGGAAGCCCCCCGCACCTCCCCAGC CTGGCGGCCCCGCCCCGGGACGTAATGCCAGCGCCCGCCGCCGCTCCTCCTCCTCCTCCTCCTCCTCTTCTGCCTCGAGGACCTCCAGCT CCCGCTCCAGCTCTCGCTCCAGCTCCCGCTCTCGCCGTGGTGGGGGCTACTACCGTTCCGGCCGCCACGCCCGCTCCCGGTCCCGCTCCT GGTCCCGCTCCCGCTCCCGCTCCCGGCGCTATTCCCGGTCCCGTAGCCGTGGCCGGCGGCACTCAGGTGGGGGCTCCCGAGACGGACACC GGTACTCCCGCTCGCCCGCCCGGCGTGGTGGTTACGGGCCCCGGCGCAGAAGCAGGAGCCGCTCCCACTCAGGGGACCGCTACAGGCGGG GCGGCCGGGGCCTCAGGCACCACAGCAGTAGCCGCAGCCGCAGCAGCTGGTCCCTCAGCCCGTCCCGCAGTCGCAGCCTGACTCGCAGCC GCAGCCATAGCCCCAGCCCCAGCCAGAGCCGCAGCCGCAGCCGCAGCCGCAGCCAGAGCCCCTCGCCATCACCCGCAAGAGAGAAGCTGA CCAGGCCGGCCGCGTCCCCTGCTGTGGGCGAGAAGCTGAAAAAGACCGAACCTGCCGCTGGTAAAGAGACAGGAGCTGCCAAACCCAAGC TGACGCCTCAGGAGAAGCTGAAACTGAGGATGCAGAAGGCGCTGAACAGGCAGTGCTCTGTGGATAGCAACTGGATCGTGGGTGCCACGC TGGAGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAGTTTCAGTGTGGCTTTGGCC TCACCATCGGCTGAGCCCTCCTGGCCCCCGCCTTCCACGCCCTTCCGATTCCACCTCCACCTCCACCTCCCCCTGCCACAGAGGGGAGAC CTGAGCCCCCCTCCCTTCCCTCCCCCCTTGGGGGTCGGGGGGGACATTGGAAAGGAGGGACCCCGCCACCCCAGCAGCTGAGGAGGGGAT TCTGGAACTGAATGGCGCTTCGGGATTCTGAGTAGCAGGGGCAGCATGCCCAGTGGGCCTGGGGTCCCGGGAGGGATTCCGGAATTGAGG GGCACGCAGGATTCTGAGCACCAGGGGCAGAGGCGGCCAGACAACCTCAGGGAGGAGTGTCCTGGCGTCCCCATCCTCCAAAGGGCCTGG GCCCGCCCCGAGGGGGCAGCGAGAGGAGCTTCCCCATCCCCGGTCAGTCCACCCTGCCCCGTCCACTTTCCCATCTCCTCGGTATAAATC |
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FusionGenePPI for CLASRP_TOMM40 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLASRP | RHOXF2, DYRK1A, CLK4, TERF2, VDR, ATXN1, APP, BARD1, CDK6, SRPK2, DAB1, DAZAP2, LUC7L, LUC7L2, SNIP1, CLK1, XPO1, CFAP20, ATXN1L, U2AF2, TMEM184B, WSB2, PUM2, CLK2, PIP4K2A, GAK, JPH4, ACADVL, ZNF703, RBM38, HELZ, PUM1, ATXN2, EED | TOMM40 | BAX, TOMM22, TOMM20, PINK1, TOMM7, TOMM70A, NIPBL, SF1, ABCB6, SRPRB, BAK1, SRP9, OXA1L, LAMTOR3, SDHB, FIS1, FAF2, C1QBP, SEPT11, SBDS, FLOT2, MRPL55, NDUFA7, SAMM50, TIMM50, CPT1A, ALDH5A1, NUPL1, TAX1BP3, PRDX5, UBAP2, ACAA2, SFPQ, RMDN3, ABCD3, EIF3A, SLC9A3R2, TIAL1, TAGLN2, SERPINH1, SNRPC, FMNL1, HSP90AA1, HSPA4, MTX1, PARK2, UBAC2, TRABD, SLAMF1, LYPD3, WNT4, LRRTM2, KLRF1, LDLRAD4, AIFM1, ANXA11, CAB39, CHCHD2, CISD1, COX5B, CPT2, CYC1, EEF2, FUBP1, MTCH1, MTCH2, NDUFA2, NDUFB8, NDUFS1, NDUFV1, PHB2, PRCP, QARS, RAB1B, SGPL1, SLC25A3, AP2B1, ATP1B1, ATP1B3, CAPZB, DLD, GSR, HADHA, HMGCL, HSD17B10, PSMD7, VAPA, VDAC1, VDAC2, VDAC3, ATP2B1, ATP5I, FKBP1A, ITIH1, RNF5, BAG2, NOS1AP, STUB1, CEPT1, FARS2, IMMT, CHCHD3, SLC35F6, CCDC94, PHACTR4, TUBB6, LAMA1, FOXA3, FOXB1, FOXI1, FOXJ2, FOXL1, COQ9, NDUFA4, OCIAD1, DUSP21, DUSP22, NCR3LG1, KRBA1, FOXRED2, CYP2C9, PDHA1, UBE2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLASRP_TOMM40 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLASRP_TOMM40 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TOMM40 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | TOMM40 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | TOMM40 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | TOMM40 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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