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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7303

FusionGeneSummary for CLASP2_STT3B

check button Fusion gene summary
Fusion gene informationFusion gene name: CLASP2_STT3B
Fusion gene ID: 7303
HgeneTgene
Gene symbol

CLASP2

STT3B

Gene ID

23122

201595

Gene namecytoplasmic linker associated protein 2STT3B, catalytic subunit of the oligosaccharyltransferase complex
Synonyms-CDG1X|SIMP|STT3-B
Cytomap

3p22.3

3p23

Type of geneprotein-codingprotein-coding
DescriptionCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3BSTT3, subunit of the oligosaccharyltransferase complex, homolog BSTT3B, subunit of the oligosaccharyltransferase complex (catalytic)dolichyl-diphosphooligosaccharide protein gl
Modification date2018052220180523
UniProtAcc

O75122

Q8TCJ2

Ensembl transtripts involved in fusion geneENST00000468888, ENST00000399362, 
ENST00000539981, ENST00000359576, 
ENST00000307312, ENST00000480013, 
ENST00000461133, ENST00000313350, 
ENST00000487200, ENST00000333778, 
ENST00000482896, 
ENST00000453168, 
ENST00000295770, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLASP2 [Title/Abstract] AND STT3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-LI-A9QH-01ACLASP2chr3

33725851

-STT3Bchr3

31617888

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000468888ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5CDS-3UTRENST00000468888ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5CDS-3UTRENST00000399362ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5CDS-3UTRENST00000399362ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000539981ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000539981ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5CDS-3UTRENST00000359576ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5CDS-3UTRENST00000359576ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5UTR-3UTRENST00000307312ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
5UTR-3UTRENST00000307312ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000480013ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000480013ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000461133ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000461133ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000313350ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000313350ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000487200ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000487200ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000333778ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000333778ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000482896ENST00000453168CLASP2chr3

33725851

-STT3Bchr3

31617888

+
intron-3UTRENST00000482896ENST00000295770CLASP2chr3

33725851

-STT3Bchr3

31617888

+

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FusionProtFeatures for CLASP2_STT3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLASP2

O75122

STT3B

Q8TCJ2

Catalytic subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. N-glycosylation occurscotranslationally and the complex associates with the Sec61complex at the channel-forming translocon complex that mediatesprotein translocation across the endoplasmic reticulum (ER). STT3Bis present in a small subset of OST complexes and mediates bothcotranslational and post-translational N-glycosylation of targetproteins: STT3B-containing complexes are required for efficientpost-translational glycosylation and while they are less competentthan STT3A-containing complexes for cotranslational glycosylation,they have the ability to mediate glycosylation of some nascentsites that are not accessible for STT3A. STT3B-containingcomplexes also act post-translationally and mediate modificationof skipped glycosylation sites in unfolded proteins. Plays a rolein ER-associated degradation (ERAD) pathway that mediatesubiquitin-dependent degradation of misfolded endoplasmic reticulumproteins by mediating N-glycosylation of unfolded proteins, whichare then recognized by the ERAD pathway and targeted fordegradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.{ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:22607976,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLASP2_STT3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLASP2_STT3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLASP2SMYD2, LXN, CLIP2, MARK2, FEZ1, FEZ2, RAD21, TP53BP1, SMURF1, CSNK2A1, YWHAE, GRB2, MPG, PAN2, YWHAB, ASB3, GSK3B, MOV10, NXF1, MAPRE1, LYPD3, GOPC, FAM43A, NTRK1, AKT1, SRPK2, NIN, DCTN1, XPO1, CENPE, CENPJ, RC3H1, C10orf76, PPP4C, KLHDC3, CSGALNACT2, GORASP1, ID2, DCAF7STT3BTMEM173, UNC93B1, AUP1, FBXO6, RPN1, RPN2, DDOST, MAGT1, RPS19, RPS15, SYNCRIP, PTRH2, SRSF7, CORO1C, HADHA, PLP2, ABCC1, CACNA2D1, OST4, UNK, NTRK1, KRTCAP2, TP53, TCTN2, TCTN3, FBF1, EVC2, TCTN1, TMEM216, TMEM67, RAB7A, VAPA, TMEM258, MLEC, CLPTM1, EDEM3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLASP2_STT3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLASP2_STT3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource