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Fusion gene ID: 7298 |
FusionGeneSummary for CLASP1_HSD17B11 |
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Fusion gene information | Fusion gene name: CLASP1_HSD17B11 | Fusion gene ID: 7298 | Hgene | Tgene | Gene symbol | CLASP1 | HSD17B11 | Gene ID | 23332 | 51170 |
Gene name | cytoplasmic linker associated protein 1 | hydroxysteroid 17-beta dehydrogenase 11 | |
Synonyms | MAST1 | 17-BETA-HSD11|17-BETA-HSDXI|17BHSD11|DHRS8|PAN1B|RETSDR2|SDR16C2 | |
Cytomap | 2q14.2-q14.3 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1 | estradiol 17-beta-dehydrogenase 1117-beta-hydroxysteroid dehydrogenase type XICTCL tumor antigen HD-CL-03CTCL-associated antigen HD-CL-03cutaneous T-cell lymphoma-associated antigen HD-CL-03dehydrogenase/reductase SDR family member 8retinal short-ch | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q7Z460 | Q8NBQ5 | |
Ensembl transtripts involved in fusion gene | ENST00000409078, ENST00000541859, ENST00000541377, ENST00000455322, ENST00000397587, ENST00000263710, ENST00000545861, ENST00000430234, | ENST00000358290, ENST00000507518, ENST00000507286, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 3 X 1=9 |
# samples | 6 | 3 | |
** MAII score | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CLASP1 [Title/Abstract] AND HSD17B11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CLASP1 | GO:0051294 | establishment of spindle orientation | 21822276 |
Hgene | CLASP1 | GO:0051301 | cell division | 21822276 |
Tgene | HSD17B11 | GO:0006710 | androgen catabolic process | 12697717 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA039499 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000409078 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000409078 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000409078 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000541859 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000541859 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000541859 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000541377 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000541377 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000541377 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000455322 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000455322 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000455322 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000397587 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000397587 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000397587 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000263710 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000263710 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000263710 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000545861 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000545861 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000545861 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-5UTR | ENST00000430234 | ENST00000358290 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000430234 | ENST00000507518 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
intron-intron | ENST00000430234 | ENST00000507286 | CLASP1 | chr2 | 122288587 | + | HSD17B11 | chr4 | 88312341 | - |
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FusionProtFeatures for CLASP1_HSD17B11 |
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Hgene | Tgene |
CLASP1 | HSD17B11 |
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participatein androgen metabolism during steroidogenesis. May act bymetabolizing compounds that stimulate steroid synthesis and/or bygenerating metabolites that inhibit it. Has no activity towardDHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione),and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLASP1_HSD17B11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLASP1_HSD17B11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLASP1_HSD17B11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLASP1_HSD17B11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |