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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7295

FusionGeneSummary for CKS2_PCSK5

check button Fusion gene summary
Fusion gene informationFusion gene name: CKS2_PCSK5
Fusion gene ID: 7295
HgeneTgene
Gene symbol

CKS2

PCSK5

Gene ID

1164

5125

Gene nameCDC28 protein kinase regulatory subunit 2proprotein convertase subtilisin/kexin type 5
SynonymsCKSHS2PC5|PC6|PC6A|SPC6
Cytomap

9q22.2

9q21.13

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinases regulatory subunit 2CDC28 protein kinase 2CKS-2CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2proprotein convertase subtilisin/kexin type 5prohormone convertase 5proprotein convertase 6protease PC6subtilasesubtilisin/kexin-like protease PC5
Modification date2018052320180522
UniProtAcc

P33552

Q92824

Ensembl transtripts involved in fusion geneENST00000314355, ENST00000545128, 
ENST00000376767, ENST00000376752, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CKS2 [Title/Abstract] AND PCSK5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePCSK5

GO:0006465

signal peptide processing

16912035

TgenePCSK5

GO:0016485

protein processing

8901832|15606899

TgenePCSK5

GO:0016486

peptide hormone processing

8901832

TgenePCSK5

GO:0043043

peptide biosynthetic process

8901832


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-E1-5304-01ACKS2chr9

91930212

+PCSK5chr9

78789902

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314355ENST00000545128CKS2chr9

91930212

+PCSK5chr9

78789902

+
In-frameENST00000314355ENST00000376767CKS2chr9

91930212

+PCSK5chr9

78789902

+
In-frameENST00000314355ENST00000376752CKS2chr9

91930212

+PCSK5chr9

78789902

+

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FusionProtFeatures for CKS2_PCSK5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CKS2

P33552

PCSK5

Q92824

Binds to the catalytic subunit of the cyclin dependentkinases and is essential for their biological function. Serine endoprotease that processes various proproteinsby cleavage at paired basic amino acids, recognizing the RXXX[KR]Rconsensus motif. Likely functions in the constitutive andregulated secretory pathways. Plays an essential role in pregnancyestablishment by proteolytic activation of a number of importantfactors such as BMP2, CALD1 and alpha-integrins.{ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025,ECO:0000269|PubMed:22740495}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211812_1853585914Compositional biasNote=Asp-rich
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371812_18535851861Compositional biasNote=Asp-rich
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221869_913585914DomainNote=PLAC
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237869_9135851861DomainNote=PLAC
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211807_1826585914RegionAC 1
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211838_1860585914RegionAC 2
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221636_1727585914RegionNote=CRM (Cys-rich motif)
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371807_18265851861RegionAC 1
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371838_18605851861RegionAC 2
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237636_17275851861RegionNote=CRM (Cys-rich motif)
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211032_1077585914RepeatNote=FU 9
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211079_1121585914RepeatNote=FU 10
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211125_1168585914RepeatNote=FU 11
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211177_1221585914RepeatNote=FU 12
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211225_1272585914RepeatNote=FU 13
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211274_1318585914RepeatNote=FU 14
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211320_1363585914RepeatNote=FU 15
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211365_1411585914RepeatNote=FU 16
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211415_1461585914RepeatNote=FU 17
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211465_1510585914RepeatNote=FU 18
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211514_1559585914RepeatNote=FU 19
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211563_1610585914RepeatNote=FU 20
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211614_1659585914RepeatNote=FU 21
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211665_1712585914RepeatNote=FU 22
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221630_680585914RepeatNote=FU 1
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221683_730585914RepeatNote=FU 2
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221734_777585914RepeatNote=FU 3
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221779_824585914RepeatNote=FU 4
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221832_879585914RepeatNote=FU 5
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221882_927585914RepeatNote=FU 6
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221929_979585914RepeatNote=FU 7
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221982_1028585914RepeatNote=FU 8
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371032_10775851861RepeatNote=FU 9
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371079_11215851861RepeatNote=FU 10
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371125_11685851861RepeatNote=FU 11
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371177_12215851861RepeatNote=FU 12
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371225_12725851861RepeatNote=FU 13
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371274_13185851861RepeatNote=FU 14
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371320_13635851861RepeatNote=FU 15
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371365_14115851861RepeatNote=FU 16
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371415_14615851861RepeatNote=FU 17
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371465_15105851861RepeatNote=FU 18
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371514_15595851861RepeatNote=FU 19
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371563_16105851861RepeatNote=FU 20
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371614_16595851861RepeatNote=FU 21
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371665_17125851861RepeatNote=FU 22
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237630_6805851861RepeatNote=FU 1
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237683_7305851861RepeatNote=FU 2
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237734_7775851861RepeatNote=FU 3
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237779_8245851861RepeatNote=FU 4
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237832_8795851861RepeatNote=FU 5
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237882_9275851861RepeatNote=FU 6
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237929_9795851861RepeatNote=FU 7
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237982_10285851861RepeatNote=FU 8
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211765_1860585914Topological domainCytoplasmic
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371765_18605851861Topological domainCytoplasmic
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+12211744_1764585914TransmembraneHelical
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+12371744_17645851861TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221166_453585914DomainNote=Peptidase S8
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221461_601585914DomainP/Homo B
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237166_4535851861DomainNote=Peptidase S8
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237461_6015851861DomainP/Homo B
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221519_521585914MotifCell attachment site
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237519_5215851861MotifCell attachment site
TgenePCSK5chr9:91930212chr9:78789902ENST00000376752+1221115_1743585914Topological domainExtracellular
TgenePCSK5chr9:91930212chr9:78789902ENST00000545128+1237115_17435851861Topological domainExtracellular


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FusionGeneSequence for CKS2_PCSK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000545128_chr9_78789902_+_1338aa
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKLKEWSLVLYGTSVQPYSPTNEFPKVE
RFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQ
CMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCA
GAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHG
HCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSC
PEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRF
DHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGL
QLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADL
CKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDC
IHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHK
SCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADED
SNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRS
CPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANL
VLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAGYEKLA

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376767_chr9_78789902_+_168aa
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKLKEWSLVLYGTSVQPYSPTNEFPKVE

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376752_chr9_78789902_+_391aa
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKLKEWSLVLYGTSVQPYSPTNEFPKVE
RFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQ
CMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCA
GAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000545128_chr9_78789902_+_4014nt
ATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTTCCAAA
CAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGATTCAT
GAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAA
CGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTGAGGTT
GGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCTCCAGC
TGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTGACCAA
TGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATACCAAG
AAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCCTGCAG
GGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTTGTGCT
GGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCTATTAC
TTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGAACTGT
ACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGGAGAATATGTTGATGAGCATGGC
CACTGCCAGACCTGTGAGGCCTCATGTGCCAAGTGCCAGGGACCAACCCAGGAAGACTGCACTACCTGCCCCATGACAAGGATTTTTGAT
GATGGCCGCTGTGTTTCGAACTGCCCCTCATGGAAATTTGAATTTGAGAACCAATGCCATCCATGCCACCACACCTGCCAGAGATGCCAA
GGAAGTGGCCCTACCCACTGCACCTCCTGTGGAGCAGACAACTATGGCCGAGAGCACTTCCTGTACCAGGGAGAGTGTGGAGATAGCTGC
CCAGAGGGCCACTATGCCACTGAGGGGAACACCTGCCTGCCCTGCCCAGACAACTGTGAGCTTTGCCACAGCGTGCATGTCTGCACAAGA
TGCATGAAGGGCTACTTCATAGCGCCCACCAACCACACATGCCAGAAGTTAGAGTGTGGACAAGGTGAAGTCCAAGACCCAGACTATGAA
GAATGTGTCCCTTGTGAAGAAGGATGTCTGGGATGCAGCTTGGATGATCCAGGAACATGTACATCTTGCGCTATGGGGTATTACAGGTTT
GATCACCATTGTTATAAAACCTGTCCTGAGAAGACCTACAGTGAGGAAGTGGAATGCAAGGCGTGTGATAGTAACTGTGGCAGCTGTGAC
CAGAATGGGTGTTACTGGTGTGAAGAGGGCTTCTTTCTCTTAGGTGGCAGTTGTGTGAGGAAATGTGGTCCTGGATTCTATGGTGACCAA
GAAATGGGAGAATGTGAGTCCTGCCACCGAGCATGCGAAACCTGCACAGGCCCTGGTCATGACGAGTGCAGCAGCTGCCAGGAAGGACTG
CAGCTGCTGCGTGGGATGTGCGTGCATGCCACCAAGACCCAGGAGGAGGGCAAATTCTGGAATGATATTTTGAGAAAACTCCAGCCTTGT
CATTCTTCTTGTAAAACCTGCAATGGATCTGCAACTCTGTGCACTTCATGTCCCAAAGGTGCATATCTTCTGGCTCAGGCCTGTGTTTCC
TCCTGTCCCCAAGGCACATGGCCTTCCGTAAGGAGTGGGAGCTGCGAGAACTGTACGGAGGCCTGTGCCATCTGCTCTGGAGCCGATCTT
TGCAAAAAATGCCAGATGCAGCCGGGCCACCCTCTCTTCCTCCATGAAGGCAGGTGCTACTCCAAGTGCCCGGAGGGCTCTTATGCAGAA
GACGGCATATGTGAACGCTGTAGCTCTCCTTGCAGAACATGTGAAGGAAACGCCACCAACTGCCATTCTTGTGAAGGAGGCCACGTCCTG
CACCACGGAGTGTGCCAGGAAAACTGCCCCGAGAGGCACGTGGCTGTGAAGGGGGTATGCAAGCATTGCCCAGAGATGTGTCAGGACTGC
ATCCATGAGAAAACATGCAAAGAGTGCACGCCTGAGTTCTTCCTGCACGATGATATGTGCCACCAGTCCTGTCCCCGTGGCTTCTATGCA
GACTCGCGCCACTGTGTCCCCTGCCATAAAGACTGTCTGGAGTGCAGTGGCCCCAAAGCCGACGACTGCGAGCTCTGTCTTGAGAGTTCC
TGGGTCCTCTATGATGGACTGTGCTTGGAGGAGTGTCCAGCAGGAACCTATTATGAAAAGGAGACTAAGGAGTGCAGAGATTGCCACAAG
TCCTGCTTGACCTGCTCATCATCTGGGACCTGCACCACCTGTCAGAAAGGCCTGATCATGAACCCTCGTGGGAGCTGCATGGCCAACGAG
AAGTGCTCACCCTCCGAGTACTGGGATGAGGATGCTCCCGGGTGCAAGCCCTGCCATGTTAAGTGCTTCCACTGCATGGGGCCGGCGGAG
GACCAGTGTCAAACATGCCCCATGAACAGCCTTCTTCTCAACACAACCTGTGTGAAGGACTGCCCAGAGGGCTATTATGCCGATGAGGAC
AGCAACCGGTGTGCCCACTGCCACAGCTCTTGCAGGACATGTGAAGGGAGACACAGCAGGCAGTGCCACTCCTGCCGACCGGGCTGGTTC
CAGCTAGGAAAAGAGTGCCTGCTCCAGTGCAGGGAAGGATATTACGCAGACAACTCCACTGGCCGGTGTGAGAGGTGCAACAGGAGCTGC
AAGGGGTGCCAGGGCCCACGGCCCACAGACTGCCTGTCTTGCGATAGATTTTTCTTTCTGCTCCGCTCCAAAGGAGAGTGTCATCGCTCC
TGCCCAGACCATTACTATGTAGAGCAAAGCACACAGACCTGTGAGAGATGCCATCCGACTTGTGATCAATGCAAAGGAAAAGGAGCGTTG
AATTGTTTATCCTGTGTGTGGAGTTACCACCTCATGGGAGGGATCTGCACCTCGGACTGTCTTGTGGGGGAATACAGAGTGGGAGAGGGA
GAGAAGTTTAACTGTGAAAAATGCCACGAGAGCTGCATGGAATGCAAGGGACCAGGGGCCAAGAACTGCACCTTGTGCCCTGCCAACCTG
GTGCTGCACATGGACGACAGCCACTGCCTCCACTGCTGCAACACCTCTGATCCCCCCAGTGCCCAGGAGTGCTGTGACTGCCAGGACACC
ACGGACGAATGCATCCTTCGAACAAGCAAGGTTAGGCCTGCAACTGAGCATTTCAAGACAGCTCTGTTCATCACCTCCTCCATGATGCTG
GTGCTTCTGCTCGGGGCAGCTGTGGTAGTGTGGAAGAAATCTCGTGGCCGAGTCCAGCCAGCAGCAAAGGCCGGCTATGAAAAACTGGCC
GACCCCAACAAGTCTTACTCCTCCTATAAGAGCAGCTATAGAGAGAGCACCAGCTTTGAAGAGGATCAGGTGATTGAGTACAGGGATCGG
GACTATGATGAGGATGATGATGATGACATCGTCTACATGGGCCAGGATGGCACAGTCTACCGGAAATTTAAATATGGGCTGCTGGATGAC

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376767_chr9_78789902_+_504nt
ATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTTCCAAA
CAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGATTCAT
GAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAA
CGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTGAGCTGGCTTCCAGTGGGACACAGGCT
AAAAAGAGGCAGCTCATGCATCATCCCACCACATGGGAGAACAGAATGGAATGGAATGGAATGAAATGGAATGGAATGAAATGGAATGGA

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376752_chr9_78789902_+_1173nt
ATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTTCCAAA
CAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGATTCAT
GAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAGTGGAA
CGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTGAGGTT
GGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCTCCAGC
TGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTGACCAA
TGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATACCAAG
AAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCCTGCAG
GGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTTGTGCT
GGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCTATTAC
TTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGAACTGT
ACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGCAACGGAAGAGTCCTGGGCGGAA
GGAGGCTTCTGTATGCTTGTGAAAAAGAACAATCTGTGCCAACGGAAGGTTCTTCAACAACTTTGCTGCAAAACATGTACATTTCAAGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000545128_chr9_78789902_+_7526nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTG
AGGTTGGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCT
CCAGCTGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTG
ACCAATGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATA
CCAAGAAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCC
TGCAGGGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTT
GTGCTGGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCT
ATTACTTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGA
ACTGTACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGGAGAATATGTTGATGAGC
ATGGCCACTGCCAGACCTGTGAGGCCTCATGTGCCAAGTGCCAGGGACCAACCCAGGAAGACTGCACTACCTGCCCCATGACAAGGATTT
TTGATGATGGCCGCTGTGTTTCGAACTGCCCCTCATGGAAATTTGAATTTGAGAACCAATGCCATCCATGCCACCACACCTGCCAGAGAT
GCCAAGGAAGTGGCCCTACCCACTGCACCTCCTGTGGAGCAGACAACTATGGCCGAGAGCACTTCCTGTACCAGGGAGAGTGTGGAGATA
GCTGCCCAGAGGGCCACTATGCCACTGAGGGGAACACCTGCCTGCCCTGCCCAGACAACTGTGAGCTTTGCCACAGCGTGCATGTCTGCA
CAAGATGCATGAAGGGCTACTTCATAGCGCCCACCAACCACACATGCCAGAAGTTAGAGTGTGGACAAGGTGAAGTCCAAGACCCAGACT
ATGAAGAATGTGTCCCTTGTGAAGAAGGATGTCTGGGATGCAGCTTGGATGATCCAGGAACATGTACATCTTGCGCTATGGGGTATTACA
GGTTTGATCACCATTGTTATAAAACCTGTCCTGAGAAGACCTACAGTGAGGAAGTGGAATGCAAGGCGTGTGATAGTAACTGTGGCAGCT
GTGACCAGAATGGGTGTTACTGGTGTGAAGAGGGCTTCTTTCTCTTAGGTGGCAGTTGTGTGAGGAAATGTGGTCCTGGATTCTATGGTG
ACCAAGAAATGGGAGAATGTGAGTCCTGCCACCGAGCATGCGAAACCTGCACAGGCCCTGGTCATGACGAGTGCAGCAGCTGCCAGGAAG
GACTGCAGCTGCTGCGTGGGATGTGCGTGCATGCCACCAAGACCCAGGAGGAGGGCAAATTCTGGAATGATATTTTGAGAAAACTCCAGC
CTTGTCATTCTTCTTGTAAAACCTGCAATGGATCTGCAACTCTGTGCACTTCATGTCCCAAAGGTGCATATCTTCTGGCTCAGGCCTGTG
TTTCCTCCTGTCCCCAAGGCACATGGCCTTCCGTAAGGAGTGGGAGCTGCGAGAACTGTACGGAGGCCTGTGCCATCTGCTCTGGAGCCG
ATCTTTGCAAAAAATGCCAGATGCAGCCGGGCCACCCTCTCTTCCTCCATGAAGGCAGGTGCTACTCCAAGTGCCCGGAGGGCTCTTATG
CAGAAGACGGCATATGTGAACGCTGTAGCTCTCCTTGCAGAACATGTGAAGGAAACGCCACCAACTGCCATTCTTGTGAAGGAGGCCACG
TCCTGCACCACGGAGTGTGCCAGGAAAACTGCCCCGAGAGGCACGTGGCTGTGAAGGGGGTATGCAAGCATTGCCCAGAGATGTGTCAGG
ACTGCATCCATGAGAAAACATGCAAAGAGTGCACGCCTGAGTTCTTCCTGCACGATGATATGTGCCACCAGTCCTGTCCCCGTGGCTTCT
ATGCAGACTCGCGCCACTGTGTCCCCTGCCATAAAGACTGTCTGGAGTGCAGTGGCCCCAAAGCCGACGACTGCGAGCTCTGTCTTGAGA
GTTCCTGGGTCCTCTATGATGGACTGTGCTTGGAGGAGTGTCCAGCAGGAACCTATTATGAAAAGGAGACTAAGGAGTGCAGAGATTGCC
ACAAGTCCTGCTTGACCTGCTCATCATCTGGGACCTGCACCACCTGTCAGAAAGGCCTGATCATGAACCCTCGTGGGAGCTGCATGGCCA
ACGAGAAGTGCTCACCCTCCGAGTACTGGGATGAGGATGCTCCCGGGTGCAAGCCCTGCCATGTTAAGTGCTTCCACTGCATGGGGCCGG
CGGAGGACCAGTGTCAAACATGCCCCATGAACAGCCTTCTTCTCAACACAACCTGTGTGAAGGACTGCCCAGAGGGCTATTATGCCGATG
AGGACAGCAACCGGTGTGCCCACTGCCACAGCTCTTGCAGGACATGTGAAGGGAGACACAGCAGGCAGTGCCACTCCTGCCGACCGGGCT
GGTTCCAGCTAGGAAAAGAGTGCCTGCTCCAGTGCAGGGAAGGATATTACGCAGACAACTCCACTGGCCGGTGTGAGAGGTGCAACAGGA
GCTGCAAGGGGTGCCAGGGCCCACGGCCCACAGACTGCCTGTCTTGCGATAGATTTTTCTTTCTGCTCCGCTCCAAAGGAGAGTGTCATC
GCTCCTGCCCAGACCATTACTATGTAGAGCAAAGCACACAGACCTGTGAGAGATGCCATCCGACTTGTGATCAATGCAAAGGAAAAGGAG
CGTTGAATTGTTTATCCTGTGTGTGGAGTTACCACCTCATGGGAGGGATCTGCACCTCGGACTGTCTTGTGGGGGAATACAGAGTGGGAG
AGGGAGAGAAGTTTAACTGTGAAAAATGCCACGAGAGCTGCATGGAATGCAAGGGACCAGGGGCCAAGAACTGCACCTTGTGCCCTGCCA
ACCTGGTGCTGCACATGGACGACAGCCACTGCCTCCACTGCTGCAACACCTCTGATCCCCCCAGTGCCCAGGAGTGCTGTGACTGCCAGG
ACACCACGGACGAATGCATCCTTCGAACAAGCAAGGTTAGGCCTGCAACTGAGCATTTCAAGACAGCTCTGTTCATCACCTCCTCCATGA
TGCTGGTGCTTCTGCTCGGGGCAGCTGTGGTAGTGTGGAAGAAATCTCGTGGCCGAGTCCAGCCAGCAGCAAAGGCCGGCTATGAAAAAC
TGGCCGACCCCAACAAGTCTTACTCCTCCTATAAGAGCAGCTATAGAGAGAGCACCAGCTTTGAAGAGGATCAGGTGATTGAGTACAGGG
ATCGGGACTATGATGAGGATGATGATGATGACATCGTCTACATGGGCCAGGATGGCACAGTCTACCGGAAATTTAAATATGGGCTGCTGG
ATGACGATGACATAGATGAGCTGGAATATGATGACGAGAGTTACTCCTACTACCAGTAAACAGGCACTCCCCCACCAACACCACCATTCC
ACTCTCAGGCATGCCTGTGAGCATCACTGTTTTTGGTTTTATCCCCACACCAGGCTGATGTGTGAGTTTTTCTATTTGTCTTCTTTAACC
ATGAGTCCAACCAGAATATGTAAGAATGATGAAATACTTTGTTCTTCTTTTGAGTGGCTAAACTCAATTAACAGTTCCTGTTCAACCGTA
ATTGAAGAGCAAGGATAAAATTCAGAGGCATTTTCCTCAAAATAATGTGTTAAGACACAAAAATGAAGGAAGTGAAAACAAATGAGATTT
GTACAAACTCTTCTATGTGATTTTAAAAAAAGGACAGCAGATCTATAGAAATTCTGTTTCCGAGCTGCATTGTGGAGGTGTCTGCTGCCT
CCTGGTATTCTAATTTTTCTTTATCTAATTTTGGGGATAATGGAGGTACAAAGGAGTTGTTGGTTTGGTGGTGTTTTTCTTCCCTTTAGC
TGTCTTTAGGCAGAAATTTGTTTTGTAAGGGCCAAGAAAAGAGGGCTCTTATCAATTGACTCCAGGCCACCCCTGGTGAGCAGAAGAGAC
CACCTGGGCTGGGCTGCTCAGGACCTACTTGAGATAAGGGAAGAAAAGAGAAGGTGCATCATAGCTGAGGAGCCATGAGGTCACCCCAGG
CCCTAGTTCCTCCGCAGGAATCCAGAGTCACAACAATTCTAAAGGCAGAGCAAGCCCAGCGAGAAAGAAATAACTGAATTTCCAGGAACT
GCACTCTCATGATTTTCTGGGTACTTTTCGCCTGGGAGACATCAGCTAAGACATCGAATAATAAAAGAAAAATGGCAGTGTTAACCTAAC
ATAAAATGGAATAAAATGACAAACACTTCATCCGCTCTAAAAAATTCAGAGCTTTCCTTCATCAACAACCCATCACAAAACCGTGGACTC
TCAATAGAAAGAGTTGGAATAGAGTCTAACATGGAAAAAAAAAAATCCCAATATGCTGCTCACAAGCTGTACTCTAGCTGCTGACCAGCC
TTCCAGCACTGCTCATCACTATGATTTTTGTTTCTAGACTTCCTAGGCTTCCTTTTTTCCATTCTTCTGTCAAGTGTATTCTTGGATTCA
TGCAACTGAGGACAGTTTTTGTCCAGATTGTAACACAGAGAAGGGCTCTTGCTATGCAAAATGATGTTGGCAGGGTCTTACAGATTTCCT
TGTCAAAATAGACCTTACAGGCAGTACTAGAAATGGAGCACCAGAAAGCAAAAATGACATTTTCAGAGAATGATGATAATTATAATCTAT
TGCACACCTACTACCAGATAACAAGCTAAGTAATTCCCCCCCAAAAATGCCCCACTTATCCATTTTGGTACTTACCATACTCCCATGAGG
TTGGTATTGCTATTATTCTGTTCTTGTAGGAAACCTGAGGCTTACAAGAGGTTAGGTAACTAGTCCAAGGTCATGCAAAGCTCAACAAAA
TTCAAGAAAAAAGAATGATCACCCTAAAGCGTGTGTTCTTATAACTATGCTACTGAAATAAGGTGGGAAAATAAGCATCCTAAATATAAT
TAAAGTCATGCCTATTGTTTTAGTCTATAATATCAATGTTATCTTTACTAAATTCATGGATTTTCTTTTTTTAACATAATGTATCACTGA
CACAGAAAATCTTTATGAAGAAGTCTTCAGTTTACTAAAGGCTTGTGCTTCTTTAGAGGAAAGCTCTTAAAACAGGGTTGACAAACAGTC
TCTGGAAAGAGCCAGCTAGTAAGTACATTAGGCTTTCTTGGCCAGAAAGTCTCTGTCATAACCACTCAGCTCTGCTATTATAGCATGAAT
GCAGCTGGTACATAACGGATGGGTGAGCTGTGCTTCAATAAAACCTTATTTATGGACACTGACATTTGAAATTCAGGTAATTTTCACATA
TTATAAAATTTTATTCTTCTTTTGATTTTTTTCAACCTTTTAAAATTTAAAAATGCAAAAGCTATTCTCAGTTCACAGCATTACAAGAAC
AGGTGGTGGGTCAGATTTGGCCAACAGGCTGTACTTTGCTGACTTTATCTTTAAAACAGTTTTCAGAGATCATACATGTACATGTATGAT
ATGCCTCCAAAAATTTTGATCATTTAAAATTATCTCCTTGGCCAGGCGTGGTGGCTCATACCTCTAATCCTAGCACTTTGGGAGACTGAG
GCAGGCAGATCACCTGAAGTCAGGAGTTTGATACCAGCTTAGCCAACATGGTGAAACCCCATTTCTACTAAAAATACAATAAAAATCTGG
GCATGTTGGTGCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGCAAATCACTTGAGCCCGGGAGGCAGAGGTTGCAGTGAGCG
GAGATGGCACCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAGTAACTAACTAACTAACTAAATAAATAAAT
AAATAAAATTATCTCCTTGCCAGGACTGCTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTAAGGCAGGAGGATTGCTGACCCACC
ACCTGTTCTTGAGCCCAGGAGTTCGACATCAGCCTTGGACAACATAGTGAGACTCCCGTGTCTACAAAAAATTTAAAAATTAGCCAGGCA
TGGTGGCAAGTGTCTGTAGTCTCAGCTACTCAGGAGGCTAAGGTGGAAGGATCACTTGAACCCGGGAGGTCGAGGCTGCAGTGAGCTGTG
ATCTTGCTATTGCACTTCAGCCTGAATGACAGAGCTAAGACCCTGACTCAAAATAAATAAATAACATTATCTCTTCAAAATGTATCTGAA
GCCCTGATAGTTCTACTTTCAATTCTTAGAAACATATAAAAATATATGCATGATAGCCATCATATCAATGGAAGACTTTCTCACCTCTGT
GGTTGCAGTTAGCTTACAAAAACGAGCAATTTTGCTTATACTGTGTTGTTCATCTTCCTTGTTAATTCTAAAGCTCTGATAGACTGAGTT
TGACATTTCTTTCTGTAAACTGGAAATTGTTTTCTATGAAAAAAAAACTCTATGATACACAGTTAAAGATTGGTTGAGGTTGAGATGAAC
TTCAATACTAAGAAAAATTGTGGTGTTCCTCTGTGTGGCCTGCAATGAAAAGAAGGCTCATGCTTGTGTATTGAGGTTTGACATCTTTCC
TTCTTTGTTTTTAGTCATGCAACGTCATTCTTAGATGGCTTTTGAATACTATGCTAATGACTATCTAAATAGATAAATATGTGATTGGAA
AACAAAGTCACCTTTTAGTTTTCTACTTGGAAATATTAAGAGAATCCTTGTAGACTGGAAACACACCAAAAGGCTGGGTAAAGCATGGGA

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376767_chr9_78789902_+_859nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTGAGCTGGCTTCCAGTGGGACAC
AGGCTAAAAAGAGGCAGCTCATGCATCATCCCACCACATGGGAGAACAGAATGGAATGGAATGGAATGAAATGGAATGGAATGAAATGGA
ATGGAATGGAATGGAATGGAATGGAATGGAATCGAATCGAATCGAATCGAATAGAATAGAATAGAATAGAACAGAACAGAATAGAATAGA
ACAGAACAATCTACTACCCATATTCTGACATATTTTCTTCCCCTTAAATATTTGTGTGTGTATATCAGTGCACTCATATATTCAAATATC
CATATGTGTTATCTGCAAAGCTAATAGTCCATATTGCGATTGTACCATAATATAGTTAATCTGTAATCTGGGACATATTGTTCGCTTACA

>In-frame_CKS2_ENST00000314355_chr9_91930212_+_PCSK5_ENST00000376752_chr9_78789902_+_3805nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTG
AGGTTGGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCT
CCAGCTGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTG
ACCAATGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATA
CCAAGAAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCC
TGCAGGGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTT
GTGCTGGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCT
ATTACTTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGA
ACTGTACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGCAACGGAAGAGTCCTGGG
CGGAAGGAGGCTTCTGTATGCTTGTGAAAAAGAACAATCTGTGCCAACGGAAGGTTCTTCAACAACTTTGCTGCAAAACATGTACATTTC
AAGGCTGAGCAGCCATCTTAGATTTCTTTGTTCCTGTAGACTTATAGATTATTCCATATTATTAAAAAGAAAAAAGCCAAAAAGAAAAAA
AAAAAAAGCAAGCCACCTCTCTCTTTCTTTTCTTGCTCTCTTTTTCTTTCTCTCTCTCTCAAGTTTGTGCAGGGAGATGGTGAACTGTTT
TGTCAGAACTTAAATGGAAAAAAAAATAAAACTACAACAAGCCTACCTTTTATAACTGGGTGTTTAGTGCTAAACAGCCAGAACCACAGA
GACAGTATTGTATGACCAAAGCATTTGATGCCAAAATTTGACGTTAAAGTAATGATTTGATTTCCTGCCCTGGTTTTGAAGGTCCATTTT
TTTCCCTTTTGCATTGACTTGCTTGTTTCCCCTTTGAAACACCTAAAAATACCTTTCCAAAACATCGCGAGAGCATACATAGACAAAAAT
GAAATAGAAAGCTCTTGCATGCTTGAGTCCACCATTGGGGGAAATGACAGAAAACTGGACCTGAGGGCATTAGGAACATCCTACAGAGTT
GTGTTTAGTGTCGTTTGCCATGGTATTTCACAGTGAAACATGGATACTCTCCACACATCATTTACTTCATGCTGTGTACTTATGTACTGG
TTTTTGCATTTTACTCACTTGATAAGTCTGCTCCACTGGTTTCATCAGATAGACTTGCTGCTACTGGCTTTTCCATTGTAGATTGGGTTA
TTTTACACGCAGTTCGCCAAATGGGATTGCTCTGTATAGTCAAATTGGTGATGGACAGATGGACAGAATGCAGAGGTACATAGATGAGCT
GAGGCTGATCCAGCTCCCCTGAAATTCAGAGTGTTAACTTTGTAGACCCTGCACAATCTCTTGGTGCTATCTAGCCATTACCCCCATTTT
TTTTTTAAAGGCCATCTGAAATTCCATTTGTCATGGTGGGAAGCATTTTGGATATGATGCAGGAAATCTCTTCCTGGAGTCAAAAGTTCC
CAAGAGGTCCTGTATTTTTAAGAAATGGAATTTATTTAAATAATATTTAAGCTTGTGCCCATGTTGGCCGGGCAACTTTTTTCAATGGTG
CTTATTAGAAGAAGTTTTTTCATCTTGTCATTTTAAGAAAATAAAACTGGAAATTGAATATGGGTGGCATGATTGTACCCTTTTAGTTCT
CTTATTTTTCTACTCCTCTGTCCCTCTATAACTATGCCATACTATTATATGCTGGTCCACTGAATGCTGAGATGATCTGTTTTTTGGGGT
TTTTTTTTTTTAAGAAATATTTTCACTGGTTTTCTGTGACTCTCTAAACACTTCATCGAAACTAGAAGACTGAATTATGAGGAAACTATT
TGGATTAGTGGCCAGAAACGATGAAATCTTATAGATCTTTTGACAGTTTCTCTGTTTAGGGGAGCCTAGACTGATATCAAGTTTCTTCAT
ATCAAAGCTTCATTGGTGACCTCATTTGCTTTACAAGTGACCAGCCATCTTGCAGGCTTCATGCTTCTGAGAGCCTTACTTAGAAGATGC
TGCTGGAGTCACAGCTGAGGAGAGGAATACTATCAACATGGACTATCCTGGGAAAGAGCTAGGAAGTAGATGCTGAGGTCCCCATCCAAA
CAGCAAGCTAGGAAAAAGCCTGCCTTGAAAATATTTCTAGACATCAAAGATAACTTACAACCCAAAGTGAATAATAAGTAAATAGTCTGA
TGACCCTCTTAATAGCATTGCAATTGTATTGAATCACATAATGATTCATAAGTAACTAGGGAACCAACTGATTTTGCTAAGCAGTCTTCC
CCTTATAACACCACAGGCCCTTCTGACACACAAAAAAATGAAAGTTAATCCTGGGTACAGCATACAGTTTTACATTTAAACGCACAGTCT
TACGTGGACAAATGCAAGCACAAGCCTAAAGCAAGGTCAAGCAGATGGCAAAACCGAATTTGCCTGCAAAGAAATCTATTTAACTGAATC
AGCCCATAATATTTGAGGCACGAGGTTACTGTGATTGATAGGAAAGATAAAAATGATGTCTGTTTTTGTAGACGAATAACCATCAACATG
ACAACAAAATTCATTGGGGTCTACCAGCGTGCATTCCATTTCCCACTGACCATGCAGGTGCACGTCGCGGAAATACTGGTTTAACTACTA
GTGTGTTACTGCCTCATTTATCTACATAACATTATTAACTAGAACATAATGCTTTCAAAGTTTAAGTTAATGTTATATATTATGTATAAA
TATATATATTCATAATGAGATATATGTAATGGATAGTACAAAGTTTGGAGACTCAACAAATGCTCTAACCTTCTAGAGACAAAAGTCCTA
TTTCTGTTTTCTTTTGTCTTTTTATTTTCAATTAGTGACCCATTGTTAAATCCAAATCCACTTTTACTGAAAAATACTGTACATGTGTAA
AATGTTCAGTTGTTTTTTTGTAAAATATAGTAGAACGGTTGTAACTGATACTGGCCAAAATCAATGTTATTCCATATTTTATTTTTTCTA


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FusionGenePPI for CKS2_PCSK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CKS2TSC22D4, EEF1A1, UNC119, CKS2, SSBP1, CCNA2, CCNB1, CDK1, GRB2, VTN, LDHB, CDC37, HSP90AA1, CCNB2, CCNA1, CDK2, CDKN1A, CAMK1D, LACC1, CDK3, CFL1, DUT, BLZF1, GMNN, CDKN1B, CDT1, PKMYT1, CCNE1, FZR1, IKZF5, CKS1B, GAS2L1, CDC20, ZADH2PCSK5APPBP2, CACNA1A, ATN1, KRTAP5-9, MEOX2, STK16, GLRX3, NUFIP2, KRTAP4-12, LCE3C, KRTAP10-7, KRTAP10-8, KRTAP10-3, NOTCH2NL, PLAUR, PTPRK, NAAA, GPHA2, PLA2G10, LYPD1, PRG3, INSL5, LYPD4, CELA3A, SLAMF1, PRG2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CKS2_PCSK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CKS2_PCSK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCKS2C0032460Polycystic Ovary Syndrome1CTD_human
TgenePCSK5C0003466Anus, Imperforate1CTD_human
TgenePCSK5C0005941Bone Diseases, Developmental1CTD_human
TgenePCSK5C0018816Heart Septal Defects1CTD_human
TgenePCSK5C0018818Ventricular Septal Defects1CTD_human
TgenePCSK5C0022360Jaw Abnormalities1CTD_human
TgenePCSK5C0022658Kidney Diseases1CTD_human
TgenePCSK5C0024115Lung diseases1CTD_human
TgenePCSK5C0026633Mouth Abnormalities1CTD_human
TgenePCSK5C0040588Tracheoesophageal Fistula1CTD_human
TgenePCSK5C0220708VATER Association1CTD_human
TgenePCSK5C0431943Lower Extremity Deformities, Congenital1CTD_human
TgenePCSK5C1306503Congenital exomphalos1CTD_human
TgenePCSK5C1531773Currarino triad1CTD_human
TgenePCSK5C1838568Sacral defect and anterior sacral meningocele1CTD_human