|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7279 |
FusionGeneSummary for CKAP5_STATH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CKAP5_STATH | Fusion gene ID: 7279 | Hgene | Tgene | Gene symbol | CKAP5 | STATH | Gene ID | 9793 | 6779 |
| Gene name | cytoskeleton associated protein 5 | statherin | |
| Synonyms | CHTOG|MSPS|TOG|TOGp|ch-TOG | STR | |
| Cytomap | 11p11.2 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene protein | statherin | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14008 | P02808 | |
| Ensembl transtripts involved in fusion gene | ENST00000529230, ENST00000415402, ENST00000312055, ENST00000354558, ENST00000532321, | ENST00000246895, ENST00000381060, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 1=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CKAP5 [Title/Abstract] AND STATH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AX747668 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000529230 | ENST00000246895 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000529230 | ENST00000381060 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000415402 | ENST00000246895 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000415402 | ENST00000381060 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000312055 | ENST00000246895 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000312055 | ENST00000381060 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000354558 | ENST00000246895 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000354558 | ENST00000381060 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000532321 | ENST00000246895 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
| intron-5UTR | ENST00000532321 | ENST00000381060 | CKAP5 | chr11 | 46829625 | - | STATH | chr4 | 70861681 | + |
Top |
FusionProtFeatures for CKAP5_STATH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CKAP5 | STATH |
| Binds to the plus end of microtubules and regulatesmicrotubule dynamics and microtubule organization. Acts asprocessive microtubule polymerase. Promotes cytoplasmicmicrotubule nucleation and elongation. Plays a major role inorganizing spindle poles. In spindle formation protectskinetochore microtubules from depolymerization by KIF2C and has anessential role in centrosomal microtubule assembly independentlyof KIF2C activity. Contributes to centrosome integrity. Acts ascomponent of the TACC3/ch-TOG/clathrin complex proposed tocontribute to stabilization of kinetochore fibers of the mitoticspindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance ofkinetochore fiber tension (PubMed:23532825). Enhances the strengthof NDC80 complex-mediated kinetochore-tip microtubule attachments(PubMed:27156448). {ECO:0000269|PubMed:12569123,ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582,ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825,ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. | Salivary protein that stabilizes saliva supersaturatedwith calcium salts by inhibiting the precipitation of calciumphosphate salts. It also modulates hydroxyapatite crystalformation on the tooth surface. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CKAP5_STATH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CKAP5_STATH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CKAP5_STATH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CKAP5_STATH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CKAP5 | C0002938 | Aneuploidy | 1 | CTD_human |
| Hgene | CKAP5 | C1257806 | Chromosomal Instability | 1 | CTD_human |
| Tgene | STATH | C0004352 | Autistic Disorder | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|