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Fusion gene ID: 7266 |
FusionGeneSummary for CIT_SPPL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CIT_SPPL3 | Fusion gene ID: 7266 | Hgene | Tgene | Gene symbol | CIT | SPPL3 | Gene ID | 79947 | 121665 |
| Gene name | dehydrodolichyl diphosphate synthase subunit | signal peptide peptidase like 3 | |
| Synonyms | CIT|CPT|DEDSM|DS|HDS|RP59 | IMP2|MDHV1887|PRO4332|PSH1|PSL4 | |
| Cytomap | 1p36.11 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dehydrodolichyl diphosphate synthase complex subunit DHDDScis-IPTasecis-isoprenyltransferasecis-prenyl transferasededol-PP synthasedehydrodolichyl diphosphate syntase complex subunit DHDDSepididymis tissue protein Li 189m | signal peptide peptidase-like 3SPP-like 3intramembrane protease 2presenilin homologous protein 1presenilin-like protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14578 | Q8TCT6 | |
| Ensembl transtripts involved in fusion gene | ENST00000392521, ENST00000261833, ENST00000537607, | ENST00000353487, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 6 X 5 X 4=120 |
| # samples | 6 | 6 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CIT [Title/Abstract] AND SPPL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPPL3 | GO:0033619 | membrane protein proteolysis | 2313285 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-E6-A8L9-01A | CIT | chr12 | 120189855 | - | SPPL3 | chr12 | 121204175 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392521 | ENST00000353487 | CIT | chr12 | 120189855 | - | SPPL3 | chr12 | 121204175 | - |
| In-frame | ENST00000261833 | ENST00000353487 | CIT | chr12 | 120189855 | - | SPPL3 | chr12 | 121204175 | - |
| 5UTR-3CDS | ENST00000537607 | ENST00000353487 | CIT | chr12 | 120189855 | - | SPPL3 | chr12 | 121204175 | - |
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FusionProtFeatures for CIT_SPPL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CIT | SPPL3 |
| Plays a role in cytokinesis. Required for KIF14localization to the central spindle and midbody. Putative RHO/RACeffector that binds to the GTP-bound forms of RHO and RAC1. Itprobably binds p21 with a tighter specificity in vivo. Displaysserine/threonine protein kinase activity. Plays an important rolein the regulation of cytokinesis and the development of thecentral nervous system. Phosphorylates MYL9/MLC2.{ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929,ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. | Intramembrane-cleaving aspartic protease (I-CLiP) thatcleaves type II membrane protein substrates in or close to theirluminal transmembrane domain boundaries (PubMed:16873890,PubMed:25354954, PubMed:25827571). Acts like a sheddase bymediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase andglycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1(PubMed:25354954, PubMed:25827571). Catalyzes the intramembranecleavage of the envelope glycoprotein gp130 and/or the leaderpeptide gp18LP of the simian foamy virus independent of priorectodomain shedding by furin or furin-like proprotein convertase(PC)-mediated cleavage proteolysis (PubMed:23132852). May alsohave the ability to serve as a shedding protease for subsequentintramembrane proteolysis by SPPL2A and SPPL2B of the envelopeglycoprotein gp130 (PubMed:23132852). Plays a role in theregulation of cellular glycosylation processes (PubMed:25354954).Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting theassociation of STIM1 and ORAI1 during store-operated calcium entry(SOCE) in a protease-independent manner (PubMed:25384971).{ECO:0000269|PubMed:16873890, ECO:0000269|PubMed:23132852,ECO:0000269|PubMed:25354954, ECO:0000269|PubMed:25384971,ECO:0000269|PubMed:25827571}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 361_431 | 926 | 2028 | Domain | Note=AGC-kinase C-terminal |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 97_360 | 926 | 2028 | Domain | Protein kinase |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 361_431 | 968 | 2070 | Domain | Note=AGC-kinase C-terminal |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 97_360 | 968 | 2070 | Domain | Protein kinase |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 103_111 | 926 | 2028 | Nucleotide binding | ATP |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 103_111 | 968 | 2070 | Nucleotide binding | ATP |
| Tgene | >SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 374_379 | 324 | 385 | Compositional bias | Note=Poly-Ser |
| Tgene | >SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 341_343 | 324 | 385 | Motif | Note=PAL |
| Tgene | >SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 333_339 | 324 | 385 | Topological domain | Lumenal |
| Tgene | >SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 361_384 | 324 | 385 | Topological domain | Cytoplasmic |
| Tgene | >SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 340_360 | 324 | 385 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 453_1297 | 926 | 2028 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 453_1297 | 968 | 2070 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 1443_1563 | 926 | 2028 | Domain | PH |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 1591_1881 | 926 | 2028 | Domain | CNH |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 1443_1563 | 968 | 2070 | Domain | PH |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 1591_1881 | 968 | 2070 | Domain | CNH |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 1953_1958 | 926 | 2028 | Motif | SH3-binding |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 1953_1958 | 968 | 2070 | Motif | SH3-binding |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 1362_1411 | 926 | 2028 | Zinc finger | Phorbol-ester/DAG-type |
| Hgene | >CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 1362_1411 | 968 | 2070 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 119_136 | 324 | 385 | Topological domain | Cytoplasmic |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 160_164 | 324 | 385 | Topological domain | Lumenal |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 186_190 | 324 | 385 | Topological domain | Cytoplasmic |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 1_8 | 324 | 385 | Topological domain | Lumenal |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 212_262 | 324 | 385 | Topological domain | Lumenal |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 284_311 | 324 | 385 | Topological domain | Cytoplasmic |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 30_74 | 324 | 385 | Topological domain | Cytoplasmic |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 96_97 | 324 | 385 | Topological domain | Lumenal |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 137_159 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 165_185 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 191_211 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 263_283 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 312_332 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 75_95 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 98_118 | 324 | 385 | Transmembrane | Helical |
| Tgene | SPPL3 | chr12:120189855 | chr12:121204175 | ENST00000353487 | - | 8 | 11 | 9_29 | 324 | 385 | Transmembrane | Helical |
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FusionGeneSequence for CIT_SPPL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CIT_ENST00000392521_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_1028aa MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQEL QPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLT VMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKK LLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKI NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDD IQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMIN AMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTACSLLLWRLAFTGPPSPPFSIW >In-frame_CIT_ENST00000261833_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_986aa MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQEL QPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLT VMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKK LLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKI NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CIT_ENST00000392521_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_3086nt ATGTTGAAGTTCAAATATGGAGCGCGGAATCCTTTGGATGCTGGTGCTGCTGAACCCATTGCCAGCCGGGCCTCCAGGCTGAATCTGTTC TTCCAGGGGAAACCACCCTTTATGACTCAACAGCAGATGTCTCCTCTTTCCCGAGAAGGGATATTAGATGCCCTCTTTGTTCTCTTTGAA GAATGCAGTCAGCCTGCTCTGATGAAGATTAAGCACGTGAGCAACTTTGTCCGGAAGTATTCCGACACCATAGCTGAGTTACAGGAGCTC CAGCCTTCGGCAAAGGACTTCGAAGTCAGAAGTCTTGTAGGTTGTGGTCACTTTGCTGAAGTGCAGGTGGTAAGAGAGAAAGCAACCGGG GACATCTATGCTATGAAAGTGATGAAGAAGAAGGCTTTATTGGCCCAGGAGCAGGTTTCATTTTTTGAGGAAGAGCGGAACATATTATCT CGAAGCACAAGCCCGTGGATCCCCCAATTACAGTATGCCTTTCAGGACAAAAATCACCTTTATCTGGTCATGGAATATCAGCCTGGAGGG GACTTGCTGTCACTTTTGAATAGATATGAGGACCAGTTAGATGAAAACCTGATACAGTTTTACCTAGCTGAGCTGATTTTGGCTGTTCAC AGCGTTCATCTGATGGGATACGTGCATCGAGACATCAAGCCTGAGAACATTCTCGTTGACCGCACAGGACACATCAAGCTGGTGGATTTT GGATCTGCCGCGAAAATGAATTCAAACAAGATGGTGAATGCCAAACTCCCGATTGGGACCCCAGATTACATGGCTCCTGAAGTGCTGACT GTGATGAACGGGGATGGAAAAGGCACCTACGGCCTGGACTGTGACTGGTGGTCAGTGGGCGTGATTGCCTATGAGATGATTTATGGGAGA TCCCCCTTCGCAGAGGGAACCTCTGCCAGAACCTTCAATAACATTATGAATTTCCAGCGGTTTTTGAAATTTCCAGATGACCCCAAAGTG AGCAGTGACTTTCTTGATCTGATTCAAAGCTTGTTGTGCGGCCAGAAAGAGAGACTGAAGTTTGAAGGTCTTTGCTGCCATCCTTTCTTC TCTAAAATTGACTGGAACAACATTCGTAACTCTCCTCCCCCCTTCGTTCCCACCCTCAAGTCTGACGATGACACCTCCAATTTTGATGAA CCAGAGAAGAATTCGTGGGTTTCATCCTCTCCGTGCCAGCTGAGCCCCTCAGGCTTCTCGGGTGAAGAACTGCCGTTTGTGGGGTTTTCG TACAGCAAGGCACTGGGGATTCTTGGTAGATCTGAGTCTGTTGTGTCGGGTCTGGACTCCCCTGCCAAGACTAGCTCCATGGAAAAGAAA CTTCTCATCAAAAGCAAAGAGCTACAAGACTCTCAGGACAAGTGTCACAAGATGGAGCAGGAAATGACCCGGTTACATCGGAGAGTGTCA GAGGTGGAGGCTGTGCTTAGTCAGAAGGAGGTGGAGCTGAAGGCCTCTGAGACTCAGAGATCCCTCCTGGAGCAGGACCTTGCTACCTAC ATCACAGAATGCAGTAGCTTAAAGCGAAGTTTGGAGCAAGCACGGATGGAGGTGTCCCAGGAGGATGACAAAGCACTGCAGCTTCTCCAT GATATCAGAGAGCAGAGCCGGAAGCTCCAAGAAATCAAAGAGCAGGAGTACCAGGCTCAAGTGGAAGAAATGAGGTTGATGATGAATCAG TTGGAAGAGGATCTTGTCTCAGCAAGAAGACGGAGTGATCTCTACGAATCTGAGCTGAGAGAGTCTCGGCTTGCTGCTGAAGAATTCAAG CGGAAAGCGACAGAATGTCAGCATAAACTGTTGAAGGCTAAGGATCAAGGGAAGCCTGAAGTGGGAGAATATGCGAAACTGGAGAAGATC AATGCTGAGCAGCAGCTCAAAATTCAGGAGCTCCAAGAGAAACTGGAGAAGGCTGTAAAAGCCAGCACGGAGGCCACCGAGCTGCTGCAG AATATCCGCCAGGCAAAGGAGCGAGCCGAGAGGGAGCTGGAGAAGCTGCAGAACCGAGAGGATTCTTCTGAAGGCATCAGAAAGAAGCTG GTGGAAGCTGAGGAACGCCGCCATTCTCTGGAGAACAAGGTAAAGAGACTAGAGACCATGGAGCGTAGAGAAAACAGACTGAAGGATGAC ATCCAGACAAAATCCCAACAGATCCAGCAGATGGCTGATAAAATTCTGGAGCTCGAAGAGAAACATCGGGAGGCCCAAGTCTCAGCCCAG CACCTAGAAGTGCACCTGAAACAGAAAGAGCAGCACTATGAGGAAAAGATTAAAGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGAC AAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAAT GCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACC CAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCC CAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTG CGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCA CAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCT GAAGAGGAGATCCAGGCACTCACGGCCTGCTCACTGCTACTGTGGCGTCTCGCATTCACCGGGCCGCCCAGCCCGCCCTTCTCTATTTGG TGCCATTTACTTTATTGCCACTCCTCACGATGGCCTATTTAAAGGGCGACCTCCGGCGGATGTGGTCTGAGCCTTTCCACTCCAAGTCCA >In-frame_CIT_ENST00000261833_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_2960nt ATGTTGAAGTTCAAATATGGAGCGCGGAATCCTTTGGATGCTGGTGCTGCTGAACCCATTGCCAGCCGGGCCTCCAGGCTGAATCTGTTC TTCCAGGGGAAACCACCCTTTATGACTCAACAGCAGATGTCTCCTCTTTCCCGAGAAGGGATATTAGATGCCCTCTTTGTTCTCTTTGAA GAATGCAGTCAGCCTGCTCTGATGAAGATTAAGCACGTGAGCAACTTTGTCCGGAAGTATTCCGACACCATAGCTGAGTTACAGGAGCTC CAGCCTTCGGCAAAGGACTTCGAAGTCAGAAGTCTTGTAGGTTGTGGTCACTTTGCTGAAGTGCAGGTGGTAAGAGAGAAAGCAACCGGG GACATCTATGCTATGAAAGTGATGAAGAAGAAGGCTTTATTGGCCCAGGAGCAGGTTTCATTTTTTGAGGAAGAGCGGAACATATTATCT CGAAGCACAAGCCCGTGGATCCCCCAATTACAGTATGCCTTTCAGGACAAAAATCACCTTTATCTGGTCATGGAATATCAGCCTGGAGGG GACTTGCTGTCACTTTTGAATAGATATGAGGACCAGTTAGATGAAAACCTGATACAGTTTTACCTAGCTGAGCTGATTTTGGCTGTTCAC AGCGTTCATCTGATGGGATACGTGCATCGAGACATCAAGCCTGAGAACATTCTCGTTGACCGCACAGGACACATCAAGCTGGTGGATTTT GGATCTGCCGCGAAAATGAATTCAAACAAGATGGTGAATGCCAAACTCCCGATTGGGACCCCAGATTACATGGCTCCTGAAGTGCTGACT GTGATGAACGGGGATGGAAAAGGCACCTACGGCCTGGACTGTGACTGGTGGTCAGTGGGCGTGATTGCCTATGAGATGATTTATGGGAGA TCCCCCTTCGCAGAGGGAACCTCTGCCAGAACCTTCAATAACATTATGAATTTCCAGCGGTTTTTGAAATTTCCAGATGACCCCAAAGTG AGCAGTGACTTTCTTGATCTGATTCAAAGCTTGTTGTGCGGCCAGAAAGAGAGACTGAAGTTTGAAGGTCTTTGCTGCCATCCTTTCTTC TCTAAAATTGACTGGAACAACATTCGTAACTCTCCTCCCCCCTTCGTTCCCACCCTCAAGTCTGACGATGACACCTCCAATTTTGATGAA CCAGAGAAGAATTCGTGGGTTTCATCCTCTCCGTGCCAGCTGAGCCCCTCAGGCTTCTCGGGTGAAGAACTGCCGTTTGTGGGGTTTTCG TACAGCAAGGCACTGGGGATTCTTGGTAGATCTGAGTCTGTTGTGTCGGGTCTGGACTCCCCTGCCAAGACTAGCTCCATGGAAAAGAAA CTTCTCATCAAAAGCAAAGAGCTACAAGACTCTCAGGACAAGTGTCACAAGATGGAGCAGGAAATGACCCGGTTACATCGGAGAGTGTCA GAGGTGGAGGCTGTGCTTAGTCAGAAGGAGGTGGAGCTGAAGGCCTCTGAGACTCAGAGATCCCTCCTGGAGCAGGACCTTGCTACCTAC ATCACAGAATGCAGTAGCTTAAAGCGAAGTTTGGAGCAAGCACGGATGGAGGTGTCCCAGGAGGATGACAAAGCACTGCAGCTTCTCCAT GATATCAGAGAGCAGAGCCGGAAGCTCCAAGAAATCAAAGAGCAGGAGTACCAGGCTCAAGTGGAAGAAATGAGGTTGATGATGAATCAG TTGGAAGAGGATCTTGTCTCAGCAAGAAGACGGAGTGATCTCTACGAATCTGAGCTGAGAGAGTCTCGGCTTGCTGCTGAAGAATTCAAG CGGAAAGCGACAGAATGTCAGCATAAACTGTTGAAGGCTAAGGATCAAGGGAAGCCTGAAGTGGGAGAATATGCGAAACTGGAGAAGATC AATGCTGAGCAGCAGCTCAAAATTCAGGAGCTCCAAGAGAAACTGGAGAAGGCTGTAAAAGCCAGCACGGAGGCCACCGAGCTGCTGCAG AATATCCGCCAGGCAAAGGAGCGAGCCGAGAGGGAGCTGGAGAAGCTGCAGAACCGAGAGGATTCTTCTGAAGGCATCAGAAAGAAGCTG GTGGAAGCTGAGGAGCTCGAAGAGAAACATCGGGAGGCCCAAGTCTCAGCCCAGCACCTAGAAGTGCACCTGAAACAGAAAGAGCAGCAC TATGAGGAAAAGATTAAAGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAG GAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGG ATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCT GAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATC AGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTG GAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTG GAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCCTGCTCACTG CTACTGTGGCGTCTCGCATTCACCGGGCCGCCCAGCCCGCCCTTCTCTATTTGGTGCCATTTACTTTATTGCCACTCCTCACGATGGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CIT_ENST00000392521_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_5631nt GGCGCGGGGCGGAACAGATCGCAGACCTGGGGGTTCGCAGAGCCGCCAGTGGGGAGATGTTGAAGTTCAAATATGGAGCGCGGAATCCTT TGGATGCTGGTGCTGCTGAACCCATTGCCAGCCGGGCCTCCAGGCTGAATCTGTTCTTCCAGGGGAAACCACCCTTTATGACTCAACAGC AGATGTCTCCTCTTTCCCGAGAAGGGATATTAGATGCCCTCTTTGTTCTCTTTGAAGAATGCAGTCAGCCTGCTCTGATGAAGATTAAGC ACGTGAGCAACTTTGTCCGGAAGTATTCCGACACCATAGCTGAGTTACAGGAGCTCCAGCCTTCGGCAAAGGACTTCGAAGTCAGAAGTC TTGTAGGTTGTGGTCACTTTGCTGAAGTGCAGGTGGTAAGAGAGAAAGCAACCGGGGACATCTATGCTATGAAAGTGATGAAGAAGAAGG CTTTATTGGCCCAGGAGCAGGTTTCATTTTTTGAGGAAGAGCGGAACATATTATCTCGAAGCACAAGCCCGTGGATCCCCCAATTACAGT ATGCCTTTCAGGACAAAAATCACCTTTATCTGGTCATGGAATATCAGCCTGGAGGGGACTTGCTGTCACTTTTGAATAGATATGAGGACC AGTTAGATGAAAACCTGATACAGTTTTACCTAGCTGAGCTGATTTTGGCTGTTCACAGCGTTCATCTGATGGGATACGTGCATCGAGACA TCAAGCCTGAGAACATTCTCGTTGACCGCACAGGACACATCAAGCTGGTGGATTTTGGATCTGCCGCGAAAATGAATTCAAACAAGATGG TGAATGCCAAACTCCCGATTGGGACCCCAGATTACATGGCTCCTGAAGTGCTGACTGTGATGAACGGGGATGGAAAAGGCACCTACGGCC TGGACTGTGACTGGTGGTCAGTGGGCGTGATTGCCTATGAGATGATTTATGGGAGATCCCCCTTCGCAGAGGGAACCTCTGCCAGAACCT TCAATAACATTATGAATTTCCAGCGGTTTTTGAAATTTCCAGATGACCCCAAAGTGAGCAGTGACTTTCTTGATCTGATTCAAAGCTTGT TGTGCGGCCAGAAAGAGAGACTGAAGTTTGAAGGTCTTTGCTGCCATCCTTTCTTCTCTAAAATTGACTGGAACAACATTCGTAACTCTC CTCCCCCCTTCGTTCCCACCCTCAAGTCTGACGATGACACCTCCAATTTTGATGAACCAGAGAAGAATTCGTGGGTTTCATCCTCTCCGT GCCAGCTGAGCCCCTCAGGCTTCTCGGGTGAAGAACTGCCGTTTGTGGGGTTTTCGTACAGCAAGGCACTGGGGATTCTTGGTAGATCTG AGTCTGTTGTGTCGGGTCTGGACTCCCCTGCCAAGACTAGCTCCATGGAAAAGAAACTTCTCATCAAAAGCAAAGAGCTACAAGACTCTC AGGACAAGTGTCACAAGATGGAGCAGGAAATGACCCGGTTACATCGGAGAGTGTCAGAGGTGGAGGCTGTGCTTAGTCAGAAGGAGGTGG AGCTGAAGGCCTCTGAGACTCAGAGATCCCTCCTGGAGCAGGACCTTGCTACCTACATCACAGAATGCAGTAGCTTAAAGCGAAGTTTGG AGCAAGCACGGATGGAGGTGTCCCAGGAGGATGACAAAGCACTGCAGCTTCTCCATGATATCAGAGAGCAGAGCCGGAAGCTCCAAGAAA TCAAAGAGCAGGAGTACCAGGCTCAAGTGGAAGAAATGAGGTTGATGATGAATCAGTTGGAAGAGGATCTTGTCTCAGCAAGAAGACGGA GTGATCTCTACGAATCTGAGCTGAGAGAGTCTCGGCTTGCTGCTGAAGAATTCAAGCGGAAAGCGACAGAATGTCAGCATAAACTGTTGA AGGCTAAGGATCAAGGGAAGCCTGAAGTGGGAGAATATGCGAAACTGGAGAAGATCAATGCTGAGCAGCAGCTCAAAATTCAGGAGCTCC AAGAGAAACTGGAGAAGGCTGTAAAAGCCAGCACGGAGGCCACCGAGCTGCTGCAGAATATCCGCCAGGCAAAGGAGCGAGCCGAGAGGG AGCTGGAGAAGCTGCAGAACCGAGAGGATTCTTCTGAAGGCATCAGAAAGAAGCTGGTGGAAGCTGAGGAACGCCGCCATTCTCTGGAGA ACAAGGTAAAGAGACTAGAGACCATGGAGCGTAGAGAAAACAGACTGAAGGATGACATCCAGACAAAATCCCAACAGATCCAGCAGATGG CTGATAAAATTCTGGAGCTCGAAGAGAAACATCGGGAGGCCCAAGTCTCAGCCCAGCACCTAGAAGTGCACCTGAAACAGAAAGAGCAGC ACTATGAGGAAAAGATTAAAGTGTTGGACAATCAGATAAAGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACG AGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAACAGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGA GGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAAATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTT CTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGGCTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGA TCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGGAACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAAC TGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCCTGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCC TGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAGAGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCCTGCTCAC TGCTACTGTGGCGTCTCGCATTCACCGGGCCGCCCAGCCCGCCCTTCTCTATTTGGTGCCATTTACTTTATTGCCACTCCTCACGATGGC CTATTTAAAGGGCGACCTCCGGCGGATGTGGTCTGAGCCTTTCCACTCCAAGTCCAGCAGCTCCCGATTCCTGGAAGTATGATGGATCAC GTGGAAAGTGACCAGATGGCCGTCATAGTCCTTTTCTCTCAACTCATGGTTTGTTTCCTCTTAGAGCTGGCCTGGTACTCAGAAATGTAC CTGTGTTTAAGGAACTGCCGTGTGACTGGATTTGGCATTTAAAGGGAGCTCGTTTGCAGGAGAGAGGTGCTGGAGCCCTGTTTGGTTCCT TCTCTTCCTGCGGATGTAGAGGTGGGGCCCCTTCCAAGAGGGACAGGCCTCTCCCCAGCGCGCCTTCCTCCCACGTTTTTATGGATCTGC ACCAGACTGTTACCTTCTGGGGGAGATGGAGATTTGACTGTTTAAAAACTGAAAACAGCGAGGAGTCTTTCTAGAACTTTTGAACACTAA AAGGATGAAAAAAATTAGCAAACCGAAGTTTCTTCAATGACCCCTCGAGAACTTTGGGACCAGTTTCCTATAGGGGACTCAGTTTCAGAG AACTGAGACAGAAGCTCTTCTGTCGTTATATTCTTCTTTCCTTTTTTTGGATTTATTAAATATTTTCTGTGGTGTGAAGTGACTTATTAA ATCCACAGACATTGAGTGACTTCTTACAACATCCACATAAGAATTTGTTGTAATGAGTTCATGTCCACCCAGATGTTGTGTTGGCAGTGA ACAAGGGCACGGTTTTTATACATACGTACATATATATATATAAACACACACATAGATATATATGAATAAACAAAAATGAAATCCTGCTAA GATCACGCTGTGTAGCTGACAGGGGCTTGCTGTCGTTTTGAGCATGTCGAGCAGTTTACTGTGGCTTCCTTGTATATGGATAAGCTGCTG TCCTTCCCCTTCACAACTGACCCCGCAGTTACAAACTAGTATAGCATTTGTGCTGATTGATGATAGACTCATGGACTTCAGGAGCCCTTA CTTGGTTTTGATCAGTGTAGCAAATTAGGGATGAAGAGTTCAAACCTTTTGGCCCTTTCTTTCTTTTCTAGGCTTCTCCCTCGCAGGGTG TTCCGTAGTTTCTTCTCGAGCCAATGCATGTATTATAGCAGCAGGTGTCTTTGTGCTTTCTCATCATAGTAACGTACTACTTGTAAATAC ATTTTTCTATTTTCTATTTTTTTGTATTTTTTTTTTTGACATTTTGTTTCATTGGTGTGCTGTATATTTTCCATGCCCTCACTCCTTTAA GAAAAAAAAAAAGGAAAAAAGCAACACAATCCTGTCCTTGCTGTTGTGATTATAGTCTTGGTTTACCTGTGGTGACAACCGGGTGTTGGG GACACATGTCAAATGCCCCTCTGAGATGGGCCCTAAATTCCAGTAACTGGGGAAAGAACCAGCTGCTGTGTCCTGAGAGCCTGGCCCTGT GCTGTGGTCTCTGCTGCAAGCCCAGATTTCTGGGAGTAACTAGTGTTAGGTCTGCTGACCTTTACCTAAGCAGCCCCTGCCTGGTAAGAA GGTGCCCATTGTTCAGAGGCAAAGAGAAGCCTGCGGTTGGCATGAGGATGCCTGACAACAAAGGCTGGAGAAGGGCCCTGAGTTCCAGCC TCTCCCCAAGGGTCCCCGCCCCAGTGGCTGCCTCTGTCTTGACCTGTGTAATGAATTAGTGTGCTGTGTCACTGTGGCTTGAAGTCACTG TGGATCGAGCTCACAGGGGGCACCCATCCTGTTGTCAACAGAGTCTGAAGCAGTCAGGGTGTTGGATTCCTCTGTTGTTGTCATCAATTC CTGCTGAGGGGTTTCTGGGGTTTTGTTTTTAATAAATGACTCCTTTGTAGCCTTTGTCACATAATCTTCACTTTGGTTGTTGGTACCAAA CAGAGCTCCCAGCCATCTCCTCCCTGTTCTGGAAGACTGATGGGAAGACTCTGTCTGTCCCCAGACCTGGTCATCTGCAGCTCTGGCCCA GTCATAGATACATCAAAGAACTGAAGCTTCTGCTGTCCACAGAACTCAAAACTGCCTCTGCATTGGGTGAAGACTAAAAATCCACTTGCG GACTCTCCCTTCCTTCCTTCTCAGCCCTCGAGGATGCATATAGCTAATTAAGCAGGCCCAGAGACAGAGAGGGGGGCTCCAAAATGACTC GGATTAAGGGCAAGTGCCAGTGATGGGTAGAAATAACGTTATCCTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGAT CACAAGGTTGGGAGCTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAATTAGCTGGGCATGGTGGCAG GCGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCAGAGATTGCGCCA CTGCACTCAAGTCTGGGCGACAGGGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAGGAAATGTTATCCTGGCAGTGGGTCATTTTAATT >In-frame_CIT_ENST00000261833_chr12_120189855_-_SPPL3_ENST00000353487_chr12_121204175_-_5502nt GCGGGGCGGAACAGATCGCAGACCTGGGGGTTCGCAGAGCCGCCAGTGGGGAGATGTTGAAGTTCAAATATGGAGCGCGGAATCCTTTGG ATGCTGGTGCTGCTGAACCCATTGCCAGCCGGGCCTCCAGGCTGAATCTGTTCTTCCAGGGGAAACCACCCTTTATGACTCAACAGCAGA TGTCTCCTCTTTCCCGAGAAGGGATATTAGATGCCCTCTTTGTTCTCTTTGAAGAATGCAGTCAGCCTGCTCTGATGAAGATTAAGCACG TGAGCAACTTTGTCCGGAAGTATTCCGACACCATAGCTGAGTTACAGGAGCTCCAGCCTTCGGCAAAGGACTTCGAAGTCAGAAGTCTTG TAGGTTGTGGTCACTTTGCTGAAGTGCAGGTGGTAAGAGAGAAAGCAACCGGGGACATCTATGCTATGAAAGTGATGAAGAAGAAGGCTT TATTGGCCCAGGAGCAGGTTTCATTTTTTGAGGAAGAGCGGAACATATTATCTCGAAGCACAAGCCCGTGGATCCCCCAATTACAGTATG CCTTTCAGGACAAAAATCACCTTTATCTGGTCATGGAATATCAGCCTGGAGGGGACTTGCTGTCACTTTTGAATAGATATGAGGACCAGT TAGATGAAAACCTGATACAGTTTTACCTAGCTGAGCTGATTTTGGCTGTTCACAGCGTTCATCTGATGGGATACGTGCATCGAGACATCA AGCCTGAGAACATTCTCGTTGACCGCACAGGACACATCAAGCTGGTGGATTTTGGATCTGCCGCGAAAATGAATTCAAACAAGATGGTGA ATGCCAAACTCCCGATTGGGACCCCAGATTACATGGCTCCTGAAGTGCTGACTGTGATGAACGGGGATGGAAAAGGCACCTACGGCCTGG ACTGTGACTGGTGGTCAGTGGGCGTGATTGCCTATGAGATGATTTATGGGAGATCCCCCTTCGCAGAGGGAACCTCTGCCAGAACCTTCA ATAACATTATGAATTTCCAGCGGTTTTTGAAATTTCCAGATGACCCCAAAGTGAGCAGTGACTTTCTTGATCTGATTCAAAGCTTGTTGT GCGGCCAGAAAGAGAGACTGAAGTTTGAAGGTCTTTGCTGCCATCCTTTCTTCTCTAAAATTGACTGGAACAACATTCGTAACTCTCCTC CCCCCTTCGTTCCCACCCTCAAGTCTGACGATGACACCTCCAATTTTGATGAACCAGAGAAGAATTCGTGGGTTTCATCCTCTCCGTGCC AGCTGAGCCCCTCAGGCTTCTCGGGTGAAGAACTGCCGTTTGTGGGGTTTTCGTACAGCAAGGCACTGGGGATTCTTGGTAGATCTGAGT CTGTTGTGTCGGGTCTGGACTCCCCTGCCAAGACTAGCTCCATGGAAAAGAAACTTCTCATCAAAAGCAAAGAGCTACAAGACTCTCAGG ACAAGTGTCACAAGATGGAGCAGGAAATGACCCGGTTACATCGGAGAGTGTCAGAGGTGGAGGCTGTGCTTAGTCAGAAGGAGGTGGAGC TGAAGGCCTCTGAGACTCAGAGATCCCTCCTGGAGCAGGACCTTGCTACCTACATCACAGAATGCAGTAGCTTAAAGCGAAGTTTGGAGC AAGCACGGATGGAGGTGTCCCAGGAGGATGACAAAGCACTGCAGCTTCTCCATGATATCAGAGAGCAGAGCCGGAAGCTCCAAGAAATCA AAGAGCAGGAGTACCAGGCTCAAGTGGAAGAAATGAGGTTGATGATGAATCAGTTGGAAGAGGATCTTGTCTCAGCAAGAAGACGGAGTG ATCTCTACGAATCTGAGCTGAGAGAGTCTCGGCTTGCTGCTGAAGAATTCAAGCGGAAAGCGACAGAATGTCAGCATAAACTGTTGAAGG CTAAGGATCAAGGGAAGCCTGAAGTGGGAGAATATGCGAAACTGGAGAAGATCAATGCTGAGCAGCAGCTCAAAATTCAGGAGCTCCAAG AGAAACTGGAGAAGGCTGTAAAAGCCAGCACGGAGGCCACCGAGCTGCTGCAGAATATCCGCCAGGCAAAGGAGCGAGCCGAGAGGGAGC TGGAGAAGCTGCAGAACCGAGAGGATTCTTCTGAAGGCATCAGAAAGAAGCTGGTGGAAGCTGAGGAGCTCGAAGAGAAACATCGGGAGG CCCAAGTCTCAGCCCAGCACCTAGAAGTGCACCTGAAACAGAAAGAGCAGCACTATGAGGAAAAGATTAAAGTGTTGGACAATCAGATAA AGAAAGACCTGGCTGACAAGGAGACACTGGAGAACATGATGCAGAGACACGAGGAGGAGGCCCATGAGAAGGGCAAAATTCTCAGCGAAC AGAAGGCGATGATCAATGCTATGGATTCCAAGATCAGATCCCTGGAACAGAGGATTGTGGAACTGTCTGAAGCCAATAAACTTGCAGCAA ATAGCAGTCTTTTTACCCAAAGGAACATGAAGGCCCAAGAAGAGATGATTTCTGAACTCAGGCAACAGAAATTTTACCTGGAGACACAGG CTGGGAAGTTGGAGGCCCAGAACCGAAAACTGGAGGAGCAGCTGGAGAAGATCAGCCACCAAGACCACAGTGACAAGAATCGGCTGCTGG AACTGGAGACAAGATTGCGGGAGGTCAGTCTAGAGCACGAGGAGCAGAAACTGGAGCTCAAGCGCCAGCTCACAGAGCTACAGCTCTCCC TGCAGGAGCGCGAGTCACAGTTGACAGCCCTGCAGGCTGCACGGGCGGCCCTGGAGAGCCAGCTTCGCCAGGCGAAGACAGAGCTGGAAG AGACCACAGCAGAAGCTGAAGAGGAGATCCAGGCACTCACGGCCTGCTCACTGCTACTGTGGCGTCTCGCATTCACCGGGCCGCCCAGCC CGCCCTTCTCTATTTGGTGCCATTTACTTTATTGCCACTCCTCACGATGGCCTATTTAAAGGGCGACCTCCGGCGGATGTGGTCTGAGCC TTTCCACTCCAAGTCCAGCAGCTCCCGATTCCTGGAAGTATGATGGATCACGTGGAAAGTGACCAGATGGCCGTCATAGTCCTTTTCTCT CAACTCATGGTTTGTTTCCTCTTAGAGCTGGCCTGGTACTCAGAAATGTACCTGTGTTTAAGGAACTGCCGTGTGACTGGATTTGGCATT TAAAGGGAGCTCGTTTGCAGGAGAGAGGTGCTGGAGCCCTGTTTGGTTCCTTCTCTTCCTGCGGATGTAGAGGTGGGGCCCCTTCCAAGA GGGACAGGCCTCTCCCCAGCGCGCCTTCCTCCCACGTTTTTATGGATCTGCACCAGACTGTTACCTTCTGGGGGAGATGGAGATTTGACT GTTTAAAAACTGAAAACAGCGAGGAGTCTTTCTAGAACTTTTGAACACTAAAAGGATGAAAAAAATTAGCAAACCGAAGTTTCTTCAATG ACCCCTCGAGAACTTTGGGACCAGTTTCCTATAGGGGACTCAGTTTCAGAGAACTGAGACAGAAGCTCTTCTGTCGTTATATTCTTCTTT CCTTTTTTTGGATTTATTAAATATTTTCTGTGGTGTGAAGTGACTTATTAAATCCACAGACATTGAGTGACTTCTTACAACATCCACATA AGAATTTGTTGTAATGAGTTCATGTCCACCCAGATGTTGTGTTGGCAGTGAACAAGGGCACGGTTTTTATACATACGTACATATATATAT ATAAACACACACATAGATATATATGAATAAACAAAAATGAAATCCTGCTAAGATCACGCTGTGTAGCTGACAGGGGCTTGCTGTCGTTTT GAGCATGTCGAGCAGTTTACTGTGGCTTCCTTGTATATGGATAAGCTGCTGTCCTTCCCCTTCACAACTGACCCCGCAGTTACAAACTAG TATAGCATTTGTGCTGATTGATGATAGACTCATGGACTTCAGGAGCCCTTACTTGGTTTTGATCAGTGTAGCAAATTAGGGATGAAGAGT TCAAACCTTTTGGCCCTTTCTTTCTTTTCTAGGCTTCTCCCTCGCAGGGTGTTCCGTAGTTTCTTCTCGAGCCAATGCATGTATTATAGC AGCAGGTGTCTTTGTGCTTTCTCATCATAGTAACGTACTACTTGTAAATACATTTTTCTATTTTCTATTTTTTTGTATTTTTTTTTTTGA CATTTTGTTTCATTGGTGTGCTGTATATTTTCCATGCCCTCACTCCTTTAAGAAAAAAAAAAAGGAAAAAAGCAACACAATCCTGTCCTT GCTGTTGTGATTATAGTCTTGGTTTACCTGTGGTGACAACCGGGTGTTGGGGACACATGTCAAATGCCCCTCTGAGATGGGCCCTAAATT CCAGTAACTGGGGAAAGAACCAGCTGCTGTGTCCTGAGAGCCTGGCCCTGTGCTGTGGTCTCTGCTGCAAGCCCAGATTTCTGGGAGTAA CTAGTGTTAGGTCTGCTGACCTTTACCTAAGCAGCCCCTGCCTGGTAAGAAGGTGCCCATTGTTCAGAGGCAAAGAGAAGCCTGCGGTTG GCATGAGGATGCCTGACAACAAAGGCTGGAGAAGGGCCCTGAGTTCCAGCCTCTCCCCAAGGGTCCCCGCCCCAGTGGCTGCCTCTGTCT TGACCTGTGTAATGAATTAGTGTGCTGTGTCACTGTGGCTTGAAGTCACTGTGGATCGAGCTCACAGGGGGCACCCATCCTGTTGTCAAC AGAGTCTGAAGCAGTCAGGGTGTTGGATTCCTCTGTTGTTGTCATCAATTCCTGCTGAGGGGTTTCTGGGGTTTTGTTTTTAATAAATGA CTCCTTTGTAGCCTTTGTCACATAATCTTCACTTTGGTTGTTGGTACCAAACAGAGCTCCCAGCCATCTCCTCCCTGTTCTGGAAGACTG ATGGGAAGACTCTGTCTGTCCCCAGACCTGGTCATCTGCAGCTCTGGCCCAGTCATAGATACATCAAAGAACTGAAGCTTCTGCTGTCCA CAGAACTCAAAACTGCCTCTGCATTGGGTGAAGACTAAAAATCCACTTGCGGACTCTCCCTTCCTTCCTTCTCAGCCCTCGAGGATGCAT ATAGCTAATTAAGCAGGCCCAGAGACAGAGAGGGGGGCTCCAAAATGACTCGGATTAAGGGCAAGTGCCAGTGATGGGTAGAAATAACGT TATCCTTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAGGTTGGGAGCTCGAGACCAGCCTGGCCAACATGG TGAAACCCCGTCTCTACTAAAAACACAAAAATTAGCTGGGCATGGTGGCAGGCGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCAGAA GAATCGCTTGAACCTGGAAGGCGGAGGTTGCAGTGAGCAGAGATTGCGCCACTGCACTCAAGTCTGGGCGACAGGGTGAGACTCCATCTC AAAAAAAAAAAAAAAAAGGAAATGTTATCCTGGCAGTGGGTCATTTTAATTTTTCTGTCTTTGTTTTCATAAGAAAATTAAATTCCAGAC |
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FusionGenePPI for CIT_SPPL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CIT | RHOA, RND3, RHOC, RHOB, RAC1, DISC1, ELAVL1, HGS, ZNF706, USP28, HECW2, CUL7, OBSL1, EZH2, ANLN, MTNR1A, CYLD, RPAP3, G3BP1, WWC1 | SPPL3 | ELAVL1, CHRND, YIPF3, SLC2A12, SPPL2B, SLC6A15, GPR114, P2RX2, HTR3A, SLC15A1, TPRA1, PDCD1, SLC39A8, SLC22A16, SLC1A5, C3AR1, SLC18A1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000261833 | - | 22 | 47 | 1091_1302 | 926 | 2028 | Rho/Rac |
| Hgene | CIT | chr12:120189855 | chr12:121204175 | ENST00000392521 | - | 23 | 48 | 1091_1302 | 968 | 2070 | Rho/Rac |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CIT_SPPL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CIT_SPPL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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