	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 7255

FusionGeneSummary for CIRBP_WDR18

Fusion gene summary

Fusion gene information	Fusion gene name: CIRBP_WDR18
	Fusion gene ID: 7255
		Hgene	Tgene
	Gene symbol	CIRBP	WDR18
	Gene ID	1153	57418
	Gene name	cold inducible RNA binding protein	WD repeat domain 18
	Synonyms	CIRP	Ipi3\|R32184_1
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	cold-inducible RNA-binding proteinA18 hnRNPglycine-rich RNA binding proteintesticular tissue protein Li 39	WD repeat-containing protein 18Involved in Processing ITS2 3 homolog
	Modification date	20180523	20180523
	UniProtAcc	Q14011	Q9BV38
	Ensembl transtripts involved in fusion gene	ENST00000588030, ENST00000589660, ENST00000588090, ENST00000591935, ENST00000589710, ENST00000588230, ENST00000413636, ENST00000586472, ENST00000589686, ENST00000444172, ENST00000587323, ENST00000320936, ENST00000587896, ENST00000589235, ENST00000585630, ENST00000586773, ENST00000590188,	ENST00000591997, ENST00000251289, ENST00000587001,
Fusion gene scores	* DoF score	5 X 4 X 5=100	5 X 3 X 5=75
	# samples	6	5
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CIRBP [Title/Abstract] AND WDR18 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CIRBP	GO:0009411	response to UV	11574538
Hgene	CIRBP	GO:0045727	positive regulation of translation	11574538
Hgene	CIRBP	GO:0048255	mRNA stabilization	11574538

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-91-6831-01A	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000588030	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000588030	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000588030	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000589660	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000589660	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000589660	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000588090	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000588090	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000588090	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000591935	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000591935	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000591935	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589710	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589710	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589710	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000588230	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000588230	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000588230	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000413636	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000413636	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000413636	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000586472	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000586472	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000586472	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589686	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589686	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589686	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000444172	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000444172	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000444172	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587323	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587323	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587323	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000320936	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000320936	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000320936	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587896	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587896	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000587896	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589235	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589235	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
5UTR-intron	ENST00000589235	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000585630	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000585630	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000585630	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000586773	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000586773	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000586773	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000590188	ENST00000591997	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000590188	ENST00000251289	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+
intron-intron	ENST00000590188	ENST00000587001	CIRBP	chr19	1269409	+	WDR18	chr19	994019	+

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FusionProtFeatures for CIRBP_WDR18

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CIRBP Q14011	WDR18 Q9BV38
Cold-inducible mRNA binding protein that plays aprotective role in the genotoxic stress response by stabilizingtranscripts of genes involved in cell survival. Acts as atranslational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically tothe 3'-untranslated regions (3'-UTRs) of stress-responsivetranscripts RPA2 and TXN. Acts as a translational repressor (Bysimilarity). Promotes assembly of stress granules (SGs), whenoverexpressed. {ECO:0000250, ECO:0000269\|PubMed:11574538,ECO:0000269\|PubMed:16513844}.	Functions as a component of the Five Friends ofMethylated CHTOP (5FMC) complex; the 5FMC complex is recruited toZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 andsubsequent transactivation of ZNF148 target genes(PubMed:22872859). Component of the PELP1 complex involved in thenucleolar steps of 28S rRNA maturation and the subsequentnucleoplasmic transit of the pre-60S ribosomal subunit(PubMed:21326211). {ECO:0000269\|PubMed:21326211,ECO:0000269\|PubMed:22872859}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CIRBP_WDR18

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CIRBP_WDR18

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
CIRBP	RBMX, LXN, PRMT1, ELAVL1, SF3A2, CUL3, CUL5, CUL2, CUL1, COPS5, CAND1, NEDD8, PRNP, ATXN1, APP, SF1, RTN4, CNOT3, PRKAR2A, LSM14A, TPR, KHSRP, GTF2F1, NUP88, CAPRIN1, TMPO, HNRNPH2, POLR1C, LOC100132057, BARD1, PAXIP1, SMURF1, FN1, HNRNPA0, HNRNPK, KHDRBS1, CSNK2A1, IL7R, SRF, BAG5, PARK2, RBMY1A1, SNRPA, LNX1, RBMY1F, KHDRBS2, MOV10, NXF1, RNF2, BMI1, ESR1, CCNB2, ZFAND6, NAA20, NARS, AHSA1, HNRNPA1, ORC1, PLK1, NOP56, PAPOLA, NANOG, RC3H1, EGFR, CDC14B, DUSP23, PRMT5, COPRS, RIOK1, YARS2, NGRN, PAIP2B, PRMT6, MRPL1, WDR77, MALSU1, FOXA1	WDR18	USP42, CSNK2B, TK1, SMN1, ANXA7, SMARCAD1, SIRT7, CUL3, SF3B3, HNRNPU, EIF4A3, HNRNPC, CDC5L, SAP18, LMNA, UTP14A, NHP2L1, SF3B6, NCSTN, VTN, IK, RFC1, SRSF1, ESR1, MDC1, PAXIP1, LAS1L, PELP1, MOK, GPRASP2, SHMT2, MOV10, CUL7, OBSL1, SENP3, ISCA1, NOL9, TEX10, ACOT2, CHD8, IFI16, NPM1, KIF2C, EXOSC4, FOXQ1, FOXS1, SNW1, DUSP22

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CIRBP_WDR18

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CIRBP_WDR18

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CIRBP	C0151744	Myocardial Ischemia	1	CTD_human
Hgene	CIRBP	C0600467	Neurogenic Inflammation	1	CTD_human
Hgene	CIRBP	C0751865	Alcohol-Induced Disorders, Nervous System	1	CTD_human
Hgene	CIRBP	C1510586	Autism Spectrum Disorders	1	CTD_human

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Fusion gene ID: 7255

FusionGeneSummary for CIRBP_WDR18

FusionProtFeatures for CIRBP_WDR18

FusionGeneSequence for CIRBP_WDR18

FusionGenePPI for CIRBP_WDR18

RelatedDrugs for CIRBP_WDR18

RelatedDiseases for CIRBP_WDR18