|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 725 |
FusionGeneSummary for ADAMTS12_FBXO38 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS12_FBXO38 | Fusion gene ID: 725 | Hgene | Tgene | Gene symbol | ADAMTS12 | FBXO38 | Gene ID | 81792 | 81545 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 12 | F-box protein 38 | |
| Synonyms | PRO4389 | Fbx38|HMN2D|MOKA|SP329 | |
| Cytomap | 5p13.3-p13.2 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 | F-box only protein 38modulator of KLF7 activity homolog | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P58397 | Q6PIJ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000504830, ENST00000352040, ENST00000504582, ENST00000515401, | ENST00000340253, ENST00000296701, ENST00000394370, ENST00000509699, ENST00000513826, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ADAMTS12 [Title/Abstract] AND FBXO38 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADAMTS12 | GO:0030167 | proteoglycan catabolic process | 17895370 |
| Hgene | ADAMTS12 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
| Hgene | ADAMTS12 | GO:0050727 | regulation of inflammatory response | 23019333 |
| Hgene | ADAMTS12 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 16611630 |
| Hgene | ADAMTS12 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
| Hgene | ADAMTS12 | GO:1901509 | regulation of endothelial tube morphogenesis | 17895370 |
| Hgene | ADAMTS12 | GO:1902203 | negative regulation of hepatocyte growth factor receptor signaling pathway | 17895370 |
| Hgene | ADAMTS12 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus | 17895370 |
| Hgene | ADAMTS12 | GO:2001113 | negative regulation of cellular response to hepatocyte growth factor stimulus | 17895370 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-21-5782-01A | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000504830 | ENST00000340253 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| In-frame | ENST00000504830 | ENST00000296701 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| In-frame | ENST00000504830 | ENST00000394370 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5CDS-intron | ENST00000504830 | ENST00000509699 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5CDS-intron | ENST00000504830 | ENST00000513826 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| In-frame | ENST00000352040 | ENST00000340253 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| In-frame | ENST00000352040 | ENST00000296701 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| In-frame | ENST00000352040 | ENST00000394370 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5CDS-intron | ENST00000352040 | ENST00000509699 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5CDS-intron | ENST00000352040 | ENST00000513826 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5UTR-3CDS | ENST00000504582 | ENST00000340253 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5UTR-3CDS | ENST00000504582 | ENST00000296701 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5UTR-3CDS | ENST00000504582 | ENST00000394370 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5UTR-intron | ENST00000504582 | ENST00000509699 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| 5UTR-intron | ENST00000504582 | ENST00000513826 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| intron-3CDS | ENST00000515401 | ENST00000340253 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| intron-3CDS | ENST00000515401 | ENST00000296701 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| intron-3CDS | ENST00000515401 | ENST00000394370 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| intron-intron | ENST00000515401 | ENST00000509699 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
| intron-intron | ENST00000515401 | ENST00000513826 | ADAMTS12 | chr5 | 33751509 | - | FBXO38 | chr5 | 147812987 | + |
Top |
FusionProtFeatures for ADAMTS12_FBXO38 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS12 | FBXO38 |
| Metalloprotease that may play a role in the degradationof COMP. Cleaves also alpha-2 macroglobulin and aggregan. Hasanti-tumorigenic properties. {ECO:0000269|PubMed:16611630,ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}. | Probably recognizes and binds to some phosphorylatedproteins and promotes their ubiquitination and degradation. Maycoactivate KLF7, but does not seem to promote KLF7 ubiquitination(By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 208_213 | 211 | 1510 | Motif | Cysteine switch |
| Hgene | ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 208_213 | 211 | 1595 | Motif | Cysteine switch |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 302_305 | 211 | 1510 | Compositional bias | Note=Poly-Glu |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 597_700 | 211 | 1510 | Compositional bias | Note=Cys-rich |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 302_305 | 211 | 1595 | Compositional bias | Note=Poly-Glu |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 597_700 | 211 | 1595 | Compositional bias | Note=Cys-rich |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 1313_1366 | 211 | 1510 | Domain | TSP type-1 5 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 1368_1422 | 211 | 1510 | Domain | TSP type-1 6 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 1423_1471 | 211 | 1510 | Domain | TSP type-1 7 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 1472_1532 | 211 | 1510 | Domain | TSP type-1 8 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 1535_1575 | 211 | 1510 | Domain | PLAC |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 246_456 | 211 | 1510 | Domain | Peptidase M12B |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 465_544 | 211 | 1510 | Domain | Note=Disintegrin |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 542_597 | 211 | 1510 | Domain | TSP type-1 1 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 823_883 | 211 | 1510 | Domain | TSP type-1 2 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 887_943 | 211 | 1510 | Domain | TSP type-1 3 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 944_997 | 211 | 1510 | Domain | TSP type-1 4 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 1313_1366 | 211 | 1595 | Domain | TSP type-1 5 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 1368_1422 | 211 | 1595 | Domain | TSP type-1 6 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 1423_1471 | 211 | 1595 | Domain | TSP type-1 7 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 1472_1532 | 211 | 1595 | Domain | TSP type-1 8 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 1535_1575 | 211 | 1595 | Domain | PLAC |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 246_456 | 211 | 1595 | Domain | Peptidase M12B |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 465_544 | 211 | 1595 | Domain | Note=Disintegrin |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 542_597 | 211 | 1595 | Domain | TSP type-1 1 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 823_883 | 211 | 1595 | Domain | TSP type-1 2 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 887_943 | 211 | 1595 | Domain | TSP type-1 3 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 944_997 | 211 | 1595 | Domain | TSP type-1 4 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 701_827 | 211 | 1510 | Region | Note=Spacer 1 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000352040 | - | 3 | 22 | 997_1316 | 211 | 1510 | Region | Note=Spacer 2 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 701_827 | 211 | 1595 | Region | Note=Spacer 1 |
| Hgene | >ADAMTS12 | chr5:33751509 | chr5:147812987 | ENST00000504830 | - | 3 | 24 | 997_1316 | 211 | 1595 | Region | Note=Spacer 2 |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000296701 | + | 13 | 21 | 30_75 | 639 | 944 | Domain | Note=F-box |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000340253 | + | 14 | 22 | 30_75 | 884 | 1189 | Domain | Note=F-box |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000394370 | + | 14 | 22 | 30_75 | 809 | 1114 | Domain | Note=F-box |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000513826 | + | 12 | 20 | 30_75 | 639 | 944 | Domain | Note=F-box |
Top |
FusionGeneSequence for ADAMTS12_FBXO38 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_516aa MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLK DCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEF SNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_1548nt ATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCT CAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTA GATGCCAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGG GTGTACTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAG AAGAGATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACC AGAGTTGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAG AAGCATCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTA AAGGAAGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAG GATGACCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAA GACTGTCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTT GACTATGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTA CGCCCAATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTC AGTAACCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAA TTCTTCCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTT GTGGATGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGAC TTTGAAGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAA ATTTCAGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_2573nt GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_2564nt GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG >In-frame_ADAMTS12_ENST00000504830_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_2573nt GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCA CACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGGAAAAAGGTGTCTAGCTCCTTTCTGCTTAAA AAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCG AGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGG CTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG GACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGCCAGTGGGCATTTTTTGTCA TATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTACTACAGAATTTCTCACGAG GAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAGATATGGGAACCTCTCCCAT GTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGTTGGGACGGCAGCCCTCAGT GCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCATCCACTGGTTGAGGGAGGG TACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGAAGTAGCCAAAACAAAGCCA CGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGACCATGTGCAGGTTCTTGTA TTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTGTCCAAAGATGATGTTCATC CATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAACTG AACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCCAATGCAGCAGGTGGACACT CTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAACCCTCCCAATGTCCGGAAT AAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTTCCCTGAAGCCACTCGAAGT GAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGATGGAGCTCCATATTCCATG ATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGAAGACGATGAAGAAAGCACT ATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTCAGAGATGCGTCAGATGAAG AAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGATGACTACATTTAATTGGTC CCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGACTTGAGGCATGCAGTTGGGA GGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATAAAAAATATACAAAGACGCT TCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGATAATTTGAAAGACTTTTGTT TTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTGTCATCCCTTTAAATCTGTG CCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTGTTGTTATTAAAACACCAAC TAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTGCCATGTTTCTTAAAATCAA GTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTAGTAATTTATTTCCACATTG >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000340253_chr5_147812987_+_2322nt TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000296701_chr5_147812987_+_2313nt TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA >In-frame_ADAMTS12_ENST00000352040_chr5_33751509_-_FBXO38_ENST00000394370_chr5_147812987_+_2322nt TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCC ATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCC AGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGAGCATTTTATCAAGGGCCTGCCAGAATACCACGTGGTGGGTCCAGTCCGAGTAGATGC CAGTGGGCATTTTTTGTCATATGGCTTGCACTATCCCATCACGAGCAGCAGGAGGAAGAGAGATTTGGATGGCTCAGAGGACTGGGTGTA CTACAGAATTTCTCACGAGGAGAAGGACCTGTTTTTTAACTTGACGGTCAATCAAGGATTTCTTTCCAATAGCTACATCATGGAGAAGAG ATATGGGAACCTCTCCCATGTTAAGATGATGGCTTCCTCTGCCCCCCTCTGCCATCTCAGTGGCACGGTTCTACAGCAGGGCACCAGAGT TGGGACGGCAGCCCTCAGTGCCTGCCATGGACTGACTGGATTTTTCCAACTACCACATGGAGACTTTTTCATTGAACCCGTGAAGAAGCA TCCACTGGTTGAGGGAGGGTACCACCCGCACATCGTTTACAGGAGGCAGAAAGTTCCAGAAACCAAGGAGCCAACCTGTGGATTAAAGGA AGTAGCCAAAACAAAGCCACGTCACGCCATGAAACGGAAGCGGACAGCAGATAAATCCACTAGTACAAGTGATCCTGTGATCGAGGATGA CCATGTGCAGGTTCTTGTATTAAAATCCAAGAATCTTGTTGGAGTCACTATGACCAATTGTGGAATCACAGATCTAGTGCTAAAAGACTG TCCAAAGATGATGTTCATCCATGCTACCAGGTGCAGGGTACTAAAACATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTA TGCACAGTGCAAGAAACTGAACATGGATCAGGTACTAGACCAGATACTAAGAATGCCACCCGAGAGAAACCGCATCATATACCTACGCCC AATGCAGCAGGTGGACACTCTAACTTTGGAGCAGAAGCTATTTAGTGGTCCCTACCCCTATCACATCTGTATTATCCATGAATTCAGTAA CCCTCCCAATGTCCGGAATAAGGTGCGCATTCGCAGCTGGATGGACACTATAGCAAACATCAATCAAGAGCTCATTAAATATGAATTCTT CCCTGAAGCCACTCGAAGTGAAGAAGACTTAAAGAAATACCCCAAGTACCCCTGGGGGAGAGAAATCTATACTTTAGAAGGTGTTGTGGA TGGAGCTCCATATTCCATGATTTCTGACTTCCCTTGGCTGAGGTCATTACGAGCTGCAGAGCCCAACAGCTTCGCTCGATACGACTTTGA AGACGATGAAGAAAGCACTATCTATGCTCCTAGAAGGAAAGGACAGCTGTCTGCAGACATCTGTATGGAAACAATAGGAGAGGAAATTTC AGAGATGCGTCAGATGAAGAAGGGTGTATTTCAGCGAGTAGTGGCAATTTTTATCCACTATTGTGATGTCAATGGAGAGCCAGTTGAAGA TGACTACATTTAATTGGTCCCTCCTCCTTTCCAGCTATTTTGTCAGAAAGCAAGTAGGGCCATCCAGCTGCCAGAGTGCTCCACAGGGAC TTGAGGCATGCAGTTGGGAGGTCCTGGCTCGGTTTGCTATATAGGGAATATATAAGGAACATCGAAATTGTATACAAAGATTTGTACATA AAAAATATACAAAGACGCTTCCTAAAGTACCAACTTTATATCATATGTTTATACAATTTAATTTAAAAATTCATTTTAAGGAAGACAGAT AATTTGAAAGACTTTTGTTTTTCTTGACTTAATTCATGAAGTATCATTTTTTGACTGAGTCTCCATTTACTTCATTCTTAATGATTATTG TCATCCCTTTAAATCTGTGCCTTTTTCTTCTTGAGCGAAGCTGTTTGAGTAAACCTGTTGAAGAGTGTTTGTGTCTTTTGTGCTTTTTTG TTGTTATTAAAACACCAACTAAACCTTATAGTCAAGACAAGGCTCTATGTTTCTGTACAAAGCTGTAGTTCTTTCTTAGTATTATAGTTG CCATGTTTCTTAAAATCAAGTAAAAAGACTTATGAGCTTAAAAAAAAGTGAGTTTGAGAGGGAAATGGAAAAGTTTCCAGAGTATTTCTA |
Top |
FusionGenePPI for ADAMTS12_FBXO38 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADAMTS12 | CALM2, MEOX2, MYL6, UBR1, FKBP9, SP3, PPM1A, SNRK, USF2, USF1, RUFY3 | FBXO38 | KLF7, USP7, APP, HSP90AA1, ABL2, RING1, PPM1G, SOX30, SHMT2, MOV10, NXF1, FGL1, DYNLL1, STYX, ZNF331, KIR3DL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000296701 | + | 13 | 21 | 59_119 | 639 | 944 | KLF7 |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000340253 | + | 14 | 22 | 59_119 | 884 | 1189 | KLF7 |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000394370 | + | 14 | 22 | 59_119 | 809 | 1114 | KLF7 |
| Tgene | FBXO38 | chr5:33751509 | chr5:147812987 | ENST00000513826 | + | 12 | 20 | 59_119 | 639 | 944 | KLF7 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ADAMTS12_FBXO38 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ADAMTS12_FBXO38 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADAMTS12 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | FBXO38 | C3888271 | NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IID | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|