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Fusion gene ID: 7245 |
FusionGeneSummary for CIR1_FIP1L1 |
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Fusion gene information | Fusion gene name: CIR1_FIP1L1 | Fusion gene ID: 7245 | Hgene | Tgene | Gene symbol | CIR1 | FIP1L1 | Gene ID | 9541 | 81608 |
Gene name | corepressor interacting with RBPJ, 1 | factor interacting with PAPOLA and CPSF1 | |
Synonyms | CIR | FIP1|Rhe|hFip1 | |
Cytomap | 2q31.1 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | corepressor interacting with RBPJ 1CBF1-interacting corepressorrecepin | pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q86X95 | Q6UN15 | |
Ensembl transtripts involved in fusion gene | ENST00000342016, ENST00000362053, | ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 9 X 10 X 5=450 |
# samples | 4 | 13 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CIR1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CIR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 9874765 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF064126 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000342016 | ENST00000507166 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000342016 | ENST00000358575 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000342016 | ENST00000337488 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000342016 | ENST00000507922 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000342016 | ENST00000306932 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3UTR | ENST00000342016 | ENST00000510668 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000362053 | ENST00000507166 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000362053 | ENST00000358575 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000362053 | ENST00000337488 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000362053 | ENST00000507922 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3CDS | ENST00000362053 | ENST00000306932 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
intron-3UTR | ENST00000362053 | ENST00000510668 | CIR1 | chr2 | 175215440 | + | FIP1L1 | chr4 | 54245408 | - |
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FusionProtFeatures for CIR1_FIP1L1 |
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Hgene | Tgene |
CIR1 | FIP1L1 |
May modulate splice site selection during alternativesplicing of pre-mRNAs (By similarity). Regulates transcription andacts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histonedeacetylase complex (HDAC). Required for RBPJ-mediated repressionof transcription. {ECO:0000250, ECO:0000269|PubMed:19409814,ECO:0000269|PubMed:9874765}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CIR1_FIP1L1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CIR1_FIP1L1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CIR1_FIP1L1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CIR1_FIP1L1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FIP1L1 | C1540912 | Hypereosinophilic syndrome | 1 | CTD_human |