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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7245

FusionGeneSummary for CIR1_FIP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: CIR1_FIP1L1
Fusion gene ID: 7245
HgeneTgene
Gene symbol

CIR1

FIP1L1

Gene ID

9541

81608

Gene namecorepressor interacting with RBPJ, 1factor interacting with PAPOLA and CPSF1
SynonymsCIRFIP1|Rhe|hFip1
Cytomap

2q31.1

4q12

Type of geneprotein-codingprotein-coding
Descriptioncorepressor interacting with RBPJ 1CBF1-interacting corepressorrecepinpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2018052720180523
UniProtAcc

Q86X95

Q6UN15

Ensembl transtripts involved in fusion geneENST00000342016, ENST00000362053, 
ENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
Fusion gene scores* DoF score4 X 4 X 4=649 X 10 X 5=450
# samples 413
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/450*10)=-1.79141337818858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CIR1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIR1

GO:0045892

negative regulation of transcription, DNA-templated

9874765


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF064126CIR1chr2

175215440

+FIP1L1chr4

54245408

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000342016ENST00000507166CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000342016ENST00000358575CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000342016ENST00000337488CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000342016ENST00000507922CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000342016ENST00000306932CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3UTRENST00000342016ENST00000510668CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000362053ENST00000507166CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000362053ENST00000358575CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000362053ENST00000337488CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000362053ENST00000507922CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3CDSENST00000362053ENST00000306932CIR1chr2

175215440

+FIP1L1chr4

54245408

-
intron-3UTRENST00000362053ENST00000510668CIR1chr2

175215440

+FIP1L1chr4

54245408

-

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FusionProtFeatures for CIR1_FIP1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIR1

Q86X95

FIP1L1

Q6UN15

May modulate splice site selection during alternativesplicing of pre-mRNAs (By similarity). Regulates transcription andacts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histonedeacetylase complex (HDAC). Required for RBPJ-mediated repressionof transcription. {ECO:0000250, ECO:0000269|PubMed:19409814,ECO:0000269|PubMed:9874765}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CIR1_FIP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CIR1_FIP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CIR1_FIP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CIR1_FIP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFIP1L1C1540912Hypereosinophilic syndrome1CTD_human