![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 7236 |
FusionGeneSummary for CIDEB_ADCY4 |
![]() |
Fusion gene information | Fusion gene name: CIDEB_ADCY4 | Fusion gene ID: 7236 | Hgene | Tgene | Gene symbol | CIDEB | ADCY4 | Gene ID | 27141 | 196883 |
Gene name | cell death-inducing DFFA-like effector b | adenylate cyclase 4 | |
Synonyms | - | AC4 | |
Cytomap | 14q12 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | cell death activator CIDE-B | adenylate cyclase type 4ATP pyrophosphate-lyase 4adenylate cyclase type IVadenylyl cyclase 4 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9UHD4 | Q8NFM4 | |
Ensembl transtripts involved in fusion gene | ENST00000554411, ENST00000336557, ENST00000258807, ENST00000555817, | ENST00000310677, ENST00000554068, ENST00000418030, ENST00000396747, ENST00000558563, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CIDEB [Title/Abstract] AND ADCY4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CIDEB | GO:0006915 | apoptotic process | 12429024 |
Hgene | CIDEB | GO:0010942 | positive regulation of cell death | 12595532 |
Hgene | CIDEB | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 12595532 |
Hgene | CIDEB | GO:0097202 | activation of cysteine-type endopeptidase activity | 12595532 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-CF-A1HR-01A | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000554411 | ENST00000310677 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Frame-shift | ENST00000554411 | ENST00000554068 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Frame-shift | ENST00000554411 | ENST00000418030 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000554411 | ENST00000396747 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000554411 | ENST00000558563 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
In-frame | ENST00000336557 | ENST00000310677 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
In-frame | ENST00000336557 | ENST00000554068 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
In-frame | ENST00000336557 | ENST00000418030 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000336557 | ENST00000396747 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000336557 | ENST00000558563 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Frame-shift | ENST00000258807 | ENST00000310677 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Frame-shift | ENST00000258807 | ENST00000554068 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Frame-shift | ENST00000258807 | ENST00000418030 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000258807 | ENST00000396747 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
5CDS-intron | ENST00000258807 | ENST00000558563 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
intron-3CDS | ENST00000555817 | ENST00000310677 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
intron-3CDS | ENST00000555817 | ENST00000554068 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
intron-3CDS | ENST00000555817 | ENST00000418030 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
intron-intron | ENST00000555817 | ENST00000396747 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
intron-intron | ENST00000555817 | ENST00000558563 | CIDEB | chr14 | 24776577 | - | ADCY4 | chr14 | 24787984 | - |
Top |
FusionProtFeatures for CIDEB_ADCY4 |
![]() |
Hgene | Tgene |
CIDEB | ADCY4 |
Activates apoptosis. | Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling.{ECO:0000250|UniProtKB:P26770}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CIDEB_ADCY4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CIDEB_ADCY4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CIDEB | DFFB, DFFA, CIDEB, CIDEA, MVB12A, TRIM25 | ADCY4 | TRIM54 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CIDEB_ADCY4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CIDEB_ADCY4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |