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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7236

FusionGeneSummary for CIDEB_ADCY4

check button Fusion gene summary
Fusion gene informationFusion gene name: CIDEB_ADCY4
Fusion gene ID: 7236
HgeneTgene
Gene symbol

CIDEB

ADCY4

Gene ID

27141

196883

Gene namecell death-inducing DFFA-like effector badenylate cyclase 4
Synonyms-AC4
Cytomap

14q12

14q12

Type of geneprotein-codingprotein-coding
Descriptioncell death activator CIDE-Badenylate cyclase type 4ATP pyrophosphate-lyase 4adenylate cyclase type IVadenylyl cyclase 4
Modification date2018052320180522
UniProtAcc

Q9UHD4

Q8NFM4

Ensembl transtripts involved in fusion geneENST00000554411, ENST00000336557, 
ENST00000258807, ENST00000555817, 
ENST00000310677, ENST00000554068, 
ENST00000418030, ENST00000396747, 
ENST00000558563, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CIDEB [Title/Abstract] AND ADCY4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIDEB

GO:0006915

apoptotic process

12429024

HgeneCIDEB

GO:0010942

positive regulation of cell death

12595532

HgeneCIDEB

GO:0090200

positive regulation of release of cytochrome c from mitochondria

12595532

HgeneCIDEB

GO:0097202

activation of cysteine-type endopeptidase activity

12595532


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-CF-A1HR-01ACIDEBchr14

24776577

-ADCY4chr14

24787984

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000554411ENST00000310677CIDEBchr14

24776577

-ADCY4chr14

24787984

-
Frame-shiftENST00000554411ENST00000554068CIDEBchr14

24776577

-ADCY4chr14

24787984

-
Frame-shiftENST00000554411ENST00000418030CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000554411ENST00000396747CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000554411ENST00000558563CIDEBchr14

24776577

-ADCY4chr14

24787984

-
In-frameENST00000336557ENST00000310677CIDEBchr14

24776577

-ADCY4chr14

24787984

-
In-frameENST00000336557ENST00000554068CIDEBchr14

24776577

-ADCY4chr14

24787984

-
In-frameENST00000336557ENST00000418030CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000336557ENST00000396747CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000336557ENST00000558563CIDEBchr14

24776577

-ADCY4chr14

24787984

-
Frame-shiftENST00000258807ENST00000310677CIDEBchr14

24776577

-ADCY4chr14

24787984

-
Frame-shiftENST00000258807ENST00000554068CIDEBchr14

24776577

-ADCY4chr14

24787984

-
Frame-shiftENST00000258807ENST00000418030CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000258807ENST00000396747CIDEBchr14

24776577

-ADCY4chr14

24787984

-
5CDS-intronENST00000258807ENST00000558563CIDEBchr14

24776577

-ADCY4chr14

24787984

-
intron-3CDSENST00000555817ENST00000310677CIDEBchr14

24776577

-ADCY4chr14

24787984

-
intron-3CDSENST00000555817ENST00000554068CIDEBchr14

24776577

-ADCY4chr14

24787984

-
intron-3CDSENST00000555817ENST00000418030CIDEBchr14

24776577

-ADCY4chr14

24787984

-
intron-intronENST00000555817ENST00000396747CIDEBchr14

24776577

-ADCY4chr14

24787984

-
intron-intronENST00000555817ENST00000558563CIDEBchr14

24776577

-ADCY4chr14

24787984

-

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FusionProtFeatures for CIDEB_ADCY4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIDEB

Q9UHD4

ADCY4

Q8NFM4

Activates apoptosis. Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling.{ECO:0000250|UniProtKB:P26770}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CIDEB_ADCY4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CIDEB_ADCY4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CIDEBDFFB, DFFA, CIDEB, CIDEA, MVB12A, TRIM25ADCY4TRIM54


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CIDEB_ADCY4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CIDEB_ADCY4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource