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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7170

FusionGeneSummary for CHRNA9_IK

check button Fusion gene summary
Fusion gene informationFusion gene name: CHRNA9_IK
Fusion gene ID: 7170
HgeneTgene
Gene symbol

CHRNA9

IK

Gene ID

55584

3783

Gene namecholinergic receptor nicotinic alpha 9 subunitpotassium calcium-activated channel subfamily N member 4
SynonymsHSA243342|NACHRA9DHS2|IK|IK1|IKCA1|KCA4|KCa3.1|SK4|hIKCa1|hKCa4|hSK4
Cytomap

4p14

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionneuronal acetylcholine receptor subunit alpha-9NACHR alpha 9acetylcholine receptor, neuronal nicotinic, alpha-9 subunitcholinergic receptor, nicotinic alpha 9cholinergic receptor, nicotinic, alpha 9 (neuronal)cholinergic receptor, nicotinic, alpha pointermediate conductance calcium-activated potassium channel protein 4SKCa 4SKCa4potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4potassium intermediate/small conductance calcium-activated channel, subfami
Modification date2018052320180523
UniProtAcc

Q9UGM1

Q13123

Ensembl transtripts involved in fusion geneENST00000310169, ENST00000502377, 
ENST00000417647, ENST00000523672, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CHRNA9 [Title/Abstract] AND IK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIK

GO:0006816

calcium ion transport

18796614

TgeneIK

GO:0030322

stabilization of membrane potential

18796614

TgeneIK

GO:0050862

positive regulation of T cell receptor signaling pathway

18796614


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM983660CHRNA9chr4

40349601

+IKchr5

140042063

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000310169ENST00000417647CHRNA9chr4

40349601

+IKchr5

140042063

-
intron-intronENST00000310169ENST00000523672CHRNA9chr4

40349601

+IKchr5

140042063

-
intron-intronENST00000502377ENST00000417647CHRNA9chr4

40349601

+IKchr5

140042063

-
intron-intronENST00000502377ENST00000523672CHRNA9chr4

40349601

+IKchr5

140042063

-

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FusionProtFeatures for CHRNA9_IK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHRNA9

Q9UGM1

IK

Q13123

Ionotropic receptor with a probable role in themodulation of auditory stimuli. Agonist binding induces aconformation change that leads to the opening of an ion-conductingchannel across the plasma membrane (PubMed:11752216,PubMed:25282151). The channel is permeable to a range of divalentcations including calcium, the influx of which may activate apotassium current which hyperpolarizes the cell membrane(PubMed:11752216, PubMed:25282151). In the ear, this may lead to areduction in basilar membrane motion, altering the activity ofauditory nerve fibers and reducing the range of dynamic hearing.This may protect against acoustic trauma. May also regulatekeratinocyte adhesion (PubMed:11021840).{ECO:0000269|PubMed:11021840, ECO:0000269|PubMed:11752216,ECO:0000269|PubMed:25282151, ECO:0000305}. Involved in pre-mRNA splicing as a component of thespliceosome (PubMed:28781166). Auxiliary spliceosomal protein thatregulates selection of alternative splice sites in a small set oftarget pre-mRNA species (Probable). Required for normal mitoticcell cycle progression (PubMed:22351768, PubMed:24252166).Recruits MAD1L1 and MAD2L1 to kinetochores, and is required totrigger the spindle assembly checkpoint (PubMed:22351768).Required for normal accumulation of SMU1 (PubMed:24945353).{ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166,ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166,ECO:0000305}. (Microbial infection) Required, together with SMU1, fornormal splicing of influenza A virus NS1 pre-mRNA, which isrequired for the production of the exportin NS2 and for theproduction of influenza A virus particles. Not required for theproduction of VSV virus particles. {ECO:0000269|PubMed:24945353}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHRNA9_IK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHRNA9_IK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHRNA9_IK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCHRNA9Q9UGM1DB00184NicotineNeuronal acetylcholine receptor subunit alpha-9small moleculeapproved
HgeneCHRNA9Q9UGM1DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-9small moleculeapproved
HgeneCHRNA9Q9UGM1DB00898EthanolNeuronal acetylcholine receptor subunit alpha-9small moleculeapproved

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RelatedDiseases for CHRNA9_IK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource