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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7168

FusionGeneSummary for CHRNA3_CHRNA3

check button Fusion gene summary
Fusion gene informationFusion gene name: CHRNA3_CHRNA3
Fusion gene ID: 7168
HgeneTgene
Gene symbol

CHRNA3

CHRNA3

Gene ID

1136

1136

Gene namecholinergic receptor nicotinic alpha 3 subunitcholinergic receptor nicotinic alpha 3 subunit
SynonymsLNCR2|NACHRA3|PAOD2LNCR2|NACHRA3|PAOD2
Cytomap

15q25.1

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionneuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunitneuronal acetylcholine receptor subunit alpha-3cholinergic receptor, nicotinic alpha 3cholinergic receptor, nicotinic, alpha 3 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 3neuronal nicotinic acetylcholine receptor, alpha3 subunit
Modification date2018052320180523
UniProtAcc

P32297

P32297

Ensembl transtripts involved in fusion geneENST00000348639, ENST00000326828, 
ENST00000559941, 
ENST00000348639, 
ENST00000326828, ENST00000559941, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHRNA3 [Title/Abstract] AND CHRNA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHRNA3

GO:0007165

signal transduction

8906617

TgeneCHRNA3

GO:0007165

signal transduction

8906617


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM728759CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000348639ENST00000348639CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-3CDSENST00000348639ENST00000326828CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-intronENST00000348639ENST00000559941CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-3CDSENST00000326828ENST00000348639CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-3CDSENST00000326828ENST00000326828CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-intronENST00000326828ENST00000559941CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-3CDSENST00000559941ENST00000348639CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-3CDSENST00000559941ENST00000326828CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-
intron-intronENST00000559941ENST00000559941CHRNA3chr15

78888336

-CHRNA3chr15

78893963

-

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FusionProtFeatures for CHRNA3_CHRNA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHRNA3

P32297

CHRNA3

P32297

After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane. After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHRNA3_CHRNA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHRNA3_CHRNA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHRNA3_CHRNA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCHRNA3P32297DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
HgeneCHRNA3P32297DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
HgeneCHRNA3P32297DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
HgeneCHRNA3P32297DB00898EthanolNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
HgeneCHRNA3P32297DB01156BupropionNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
HgeneCHRNA3P32297DB01227Levomethadyl AcetateNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational
HgeneCHRNA3P32297DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational
HgeneCHRNA3P32297DB00848LevamisoleNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational|vet_approved|withdrawn
TgeneCHRNA3P32297DB00184NicotineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
TgeneCHRNA3P32297DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
TgeneCHRNA3P32297DB00674GalantamineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
TgeneCHRNA3P32297DB00898EthanolNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
TgeneCHRNA3P32297DB01156BupropionNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved
TgeneCHRNA3P32297DB01227Levomethadyl AcetateNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational
TgeneCHRNA3P32297DB01273VareniclineNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational
TgeneCHRNA3P32297DB00848LevamisoleNeuronal acetylcholine receptor subunit alpha-3small moleculeapproved|investigational|vet_approved|withdrawn

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RelatedDiseases for CHRNA3_CHRNA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHRNA3C0001973Alcoholic Intoxication, Chronic4CTD_human;PSYGENET
HgeneCHRNA3C0600427Cocaine Dependence2PSYGENET
HgeneCHRNA3C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)2CTD_human
HgeneCHRNA3C0024121Lung Neoplasms1CTD_human
HgeneCHRNA3C0036341Schizophrenia1PSYGENET
HgeneCHRNA3C0036572Seizures1CTD_human
HgeneCHRNA3C0040336Tobacco Use Disorder1CTD_human
TgeneCHRNA3C0001973Alcoholic Intoxication, Chronic4CTD_human;PSYGENET
TgeneCHRNA3C0600427Cocaine Dependence2PSYGENET
TgeneCHRNA3C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)2CTD_human
TgeneCHRNA3C0024121Lung Neoplasms1CTD_human
TgeneCHRNA3C0036341Schizophrenia1PSYGENET
TgeneCHRNA3C0036572Seizures1CTD_human
TgeneCHRNA3C0040336Tobacco Use Disorder1CTD_human