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Fusion gene ID: 7161 |
FusionGeneSummary for CHRFAM7A_CRLF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHRFAM7A_CRLF2 | Fusion gene ID: 7161 | Hgene | Tgene | Gene symbol | CHRFAM7A | CRLF2 | Gene ID | 89832 | 64109 |
| Gene name | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion | cytokine receptor like factor 2 | |
| Synonyms | CHRNA7|CHRNA7-DR1|D-10 | CRL2|CRLF2Y|TSLPR | |
| Cytomap | 15q13.2 | Xp22.33 and Yp11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CHRNA7-FAM7A fusion proteinCHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusionCHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with seq | cytokine receptor-like factor 2IL-XRTSLP receptorcytokine receptor CRL2 precusorthymic stromal lymphopoietin protein receptorthymic stromal-derived lymphopoietin receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q494W8 | Q9HC73 | |
| Ensembl transtripts involved in fusion gene | ENST00000397827, ENST00000299847, ENST00000401522, ENST00000567722, | ENST00000381567, ENST00000467626, ENST00000381566, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 1=9 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHRFAM7A [Title/Abstract] AND CRLF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CRLF2 | GO:0008284 | positive regulation of cell proliferation | 11418668 |
| Tgene | CRLF2 | GO:0019221 | cytokine-mediated signaling pathway | 11418668 |
| Tgene | CRLF2 | GO:1904894 | positive regulation of STAT cascade | 11418668 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC062414 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000397827 | ENST00000381567 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000397827 | ENST00000467626 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000397827 | ENST00000381566 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000299847 | ENST00000381567 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000299847 | ENST00000467626 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000299847 | ENST00000381566 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000401522 | ENST00000381567 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000401522 | ENST00000467626 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000401522 | ENST00000381566 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000567722 | ENST00000381567 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000567722 | ENST00000467626 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
| intron-intron | ENST00000567722 | ENST00000381566 | CHRFAM7A | chr15 | 30685017 | - | CRLF2 | chrY | 1332347 | + |
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FusionProtFeatures for CHRFAM7A_CRLF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHRFAM7A | CRLF2 |
| Receptor for thymic stromal lymphopoietin (TSLP). Formsa functional complex with TSLP and IL7R which is capable ofstimulating cell proliferation through activation of STAT3 andSTAT5. Also activates JAK2 (By similarity). Implicated in thedevelopment of the hematopoietic system. {ECO:0000250,ECO:0000269|PubMed:11418668}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHRFAM7A_CRLF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHRFAM7A_CRLF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHRFAM7A_CRLF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHRFAM7A_CRLF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CHRFAM7A | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | CHRFAM7A | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | CRLF2 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| Tgene | CRLF2 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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