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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7150

FusionGeneSummary for CHPF2_IRS2

check button Fusion gene summary
Fusion gene informationFusion gene name: CHPF2_IRS2
Fusion gene ID: 7150
HgeneTgene
Gene symbol

CHPF2

IRS2

Gene ID

54480

8660

Gene namechondroitin polymerizing factor 2insulin receptor substrate 2
SynonymsCSGLCA-T|CSGlcAT|ChSy-3|chPF-2IRS-2
Cytomap

7q36.1

13q34

Type of geneprotein-codingprotein-coding
Descriptionchondroitin sulfate glucuronyltransferaseN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferasechondroitin synthase-3insulin receptor substrate 2
Modification date2018051920180523
UniProtAcc

Q9P2E5

Q9Y4H2

Ensembl transtripts involved in fusion geneENST00000495645, ENST00000035307, 
ENST00000375856, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHPF2 [Title/Abstract] AND IRS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF753816CHPF2chr7

150932276

+IRS2chr13

110433111

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000495645ENST00000375856CHPF2chr7

150932276

+IRS2chr13

110433111

+
5CDS-intronENST00000035307ENST00000375856CHPF2chr7

150932276

+IRS2chr13

110433111

+

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FusionProtFeatures for CHPF2_IRS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHPF2

Q9P2E5

IRS2

Q9Y4H2

Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of theelongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.{ECO:0000269|PubMed:12145278, ECO:0000269|PubMed:18316376}. May mediate the control of various cellular processes byinsulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHPF2_IRS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHPF2_IRS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHPF2_IRS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHPF2_IRS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIRS2C0020456Hyperglycemia2CTD_human
TgeneIRS2C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneIRS2C0021655Insulin Resistance1CTD_human
TgeneIRS2C0025149Medulloblastoma1CTD_human
TgeneIRS2C0038356Stomach Neoplasms1CTD_human
TgeneIRS2C2239176Liver carcinoma1CTD_human