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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7146

FusionGeneSummary for CHP1_RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: CHP1_RAD51B
Fusion gene ID: 7146
HgeneTgene
Gene symbol

CHP1

RAD51B

Gene ID

26973

5890

Gene namecysteine and histidine rich domain containing 1RAD51 paralog B
SynonymsCHP1R51H2|RAD51L1|REC2
Cytomap

11q14.3

14q24.1

Type of geneprotein-codingprotein-coding
Descriptioncysteine and histidine-rich domain-containing protein 1CHORD-containing protein 1CHP-1chord domain-containing protein 1cysteine and histidine-rich domain (CHORD) containing 1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2018051920180523
UniProtAcc

Q99653

O15315

Ensembl transtripts involved in fusion geneENST00000558351, ENST00000334660, 
ENST00000560397, 
ENST00000487861, 
ENST00000471583, ENST00000487270, 
ENST00000488612, ENST00000390683, 
ENST00000469165, 
Fusion gene scores* DoF score6 X 7 X 4=16825 X 15 X 8=3000
# samples 733
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3000*10)=-3.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHP1 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2027-01ACHP1chr15

41549188

+RAD51Bchr14

68758601

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000558351ENST00000487861CHP1chr15

41549188

+RAD51Bchr14

68758601

+
3UTR-3CDSENST00000558351ENST00000471583CHP1chr15

41549188

+RAD51Bchr14

68758601

+
3UTR-3CDSENST00000558351ENST00000487270CHP1chr15

41549188

+RAD51Bchr14

68758601

+
3UTR-3CDSENST00000558351ENST00000488612CHP1chr15

41549188

+RAD51Bchr14

68758601

+
3UTR-3CDSENST00000558351ENST00000390683CHP1chr15

41549188

+RAD51Bchr14

68758601

+
3UTR-3UTRENST00000558351ENST00000469165CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000334660ENST00000487861CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000334660ENST00000471583CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000334660ENST00000487270CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000334660ENST00000488612CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000334660ENST00000390683CHP1chr15

41549188

+RAD51Bchr14

68758601

+
5CDS-3UTRENST00000334660ENST00000469165CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000560397ENST00000487861CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000560397ENST00000471583CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000560397ENST00000487270CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000560397ENST00000488612CHP1chr15

41549188

+RAD51Bchr14

68758601

+
Frame-shiftENST00000560397ENST00000390683CHP1chr15

41549188

+RAD51Bchr14

68758601

+
5CDS-3UTRENST00000560397ENST00000469165CHP1chr15

41549188

+RAD51Bchr14

68758601

+

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FusionProtFeatures for CHP1_RAD51B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHP1

Q99653

RAD51B

O15315

Calcium-binding protein involved in different processessuch as regulation of vesicular trafficking, plasma membraneNa(+)/H(+) exchanger and gene transcription. Involved in theconstitutive exocytic membrane traffic. Mediates the associationbetween microtubules and membrane-bound organelles of theendoplasmic reticulum and Golgi apparatus and is also required forthe targeting and fusion of transcytotic vesicles (TCV) with theplasma membrane. Functions as an integral cofactor in cell pHregulation by controlling plasma membrane-type Na(+)/H(+) exchangeactivity. Affects the pH sensitivity of SLC9A1/NHE1 by increasingits sensitivity at acidic pH. Required for the stabilization andlocalization of SLC9A1/NHE1 at the plasma membrane. Inhibitsserum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role asan inhibitor of ribosomal RNA transcription by repressing thenucleolar UBF1 transcriptional activity. May sequester UBF1 in thenucleoplasm and limit its translocation to the nucleolus.Associates to the ribosomal gene promoter. Acts as a negativeregulator of the calcineurin/NFAT signaling pathway. Inhibits NFATnuclear translocation and transcriptional activity by suppressingthe calcium-dependent calcineurin phosphatase activity. Alsonegatively regulates the kinase activity of the apoptosis-inducedkinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.{ECO:0000269|PubMed:10593895, ECO:0000269|PubMed:11350981,ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHP1_RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHP1_RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHP1SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, PRSS23, ELAVL1, SHMT2, MOV10, NXF1, TMEM216, XPO1, DUSP22, DUSP6, UBCRAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHP1_RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCHP1Q99653DB11093Calcium CitrateCalcineurin B homologous protein 1small moleculeapproved
HgeneCHP1Q99653DB11348Calcium PhosphateCalcineurin B homologous protein 1small moleculeapproved

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RelatedDiseases for CHP1_RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human