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Fusion gene ID: 7145 |
FusionGeneSummary for CHP1_RAD51 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHP1_RAD51 | Fusion gene ID: 7145 | Hgene | Tgene | Gene symbol | CHP1 | RAD51 | Gene ID | 26973 | 5888 |
| Gene name | cysteine and histidine rich domain containing 1 | RAD51 recombinase | |
| Synonyms | CHP1 | BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA | |
| Cytomap | 11q14.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine and histidine-rich domain-containing protein 1CHORD-containing protein 1CHP-1chord domain-containing protein 1cysteine and histidine-rich domain (CHORD) containing 1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein | DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q99653 | Q06609 | |
| Ensembl transtripts involved in fusion gene | ENST00000558351, ENST00000334660, ENST00000560397, | ENST00000423169, ENST00000267868, ENST00000557850, ENST00000532743, ENST00000382643, ENST00000530766, | |
| Fusion gene scores | * DoF score | 6 X 7 X 4=168 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHP1 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAD51 | GO:0000724 | double-strand break repair via homologous recombination | 16428451 |
| Tgene | RAD51 | GO:0006268 | DNA unwinding involved in DNA replication | 7988572 |
| Tgene | RAD51 | GO:0006974 | cellular response to DNA damage stimulus | 23509288|25585578 |
| Tgene | RAD51 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Tgene | RAD51 | GO:0031297 | replication fork processing | 25585578 |
| Tgene | RAD51 | GO:0051106 | positive regulation of DNA ligation | 8929543 |
| Tgene | RAD51 | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Tgene | RAD51 | GO:0072757 | cellular response to camptothecin | 23509288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-8085-01A | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000558351 | ENST00000423169 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 3UTR-3CDS | ENST00000558351 | ENST00000267868 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 3UTR-intron | ENST00000558351 | ENST00000557850 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 3UTR-intron | ENST00000558351 | ENST00000532743 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 3UTR-intron | ENST00000558351 | ENST00000382643 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 3UTR-intron | ENST00000558351 | ENST00000530766 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| In-frame | ENST00000334660 | ENST00000423169 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| In-frame | ENST00000334660 | ENST00000267868 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000334660 | ENST00000557850 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000334660 | ENST00000532743 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000334660 | ENST00000382643 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000334660 | ENST00000530766 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| In-frame | ENST00000560397 | ENST00000423169 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| In-frame | ENST00000560397 | ENST00000267868 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000560397 | ENST00000557850 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000560397 | ENST00000532743 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000560397 | ENST00000382643 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
| 5CDS-intron | ENST00000560397 | ENST00000530766 | CHP1 | chr15 | 41562816 | + | RAD51 | chr15 | 41011003 | + |
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FusionProtFeatures for CHP1_RAD51 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHP1 | RAD51 |
| Calcium-binding protein involved in different processessuch as regulation of vesicular trafficking, plasma membraneNa(+)/H(+) exchanger and gene transcription. Involved in theconstitutive exocytic membrane traffic. Mediates the associationbetween microtubules and membrane-bound organelles of theendoplasmic reticulum and Golgi apparatus and is also required forthe targeting and fusion of transcytotic vesicles (TCV) with theplasma membrane. Functions as an integral cofactor in cell pHregulation by controlling plasma membrane-type Na(+)/H(+) exchangeactivity. Affects the pH sensitivity of SLC9A1/NHE1 by increasingits sensitivity at acidic pH. Required for the stabilization andlocalization of SLC9A1/NHE1 at the plasma membrane. Inhibitsserum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role asan inhibitor of ribosomal RNA transcription by repressing thenucleolar UBF1 transcriptional activity. May sequester UBF1 in thenucleoplasm and limit its translocation to the nucleolus.Associates to the ribosomal gene promoter. Acts as a negativeregulator of the calcineurin/NFAT signaling pathway. Inhibits NFATnuclear translocation and transcriptional activity by suppressingthe calcium-dependent calcineurin phosphatase activity. Alsonegatively regulates the kinase activity of the apoptosis-inducedkinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.{ECO:0000269|PubMed:10593895, ECO:0000269|PubMed:11350981,ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}. | Plays an important role in homologous strand exchange, akey step in DNA repair through homologous recombination (HR)(PubMed:28575658). Binds to single and double-stranded DNA andexhibits DNA-dependent ATPase activity. Catalyzes the recognitionof homology and strand exchange between homologous DNA partners toform a joint molecule between a processed DNA break and the repairtemplate. Binds to single-stranded DNA in an ATP-dependent mannerto form nucleoprotein filaments which are essential for thehomology search and strand exchange (PubMed:26681308). Part of aPALB2-scaffolded HR complex containing BRCA2 and RAD51C and whichis thought to play a role in DNA repair by HR. Plays a role inregulating mitochondrial DNA copy number under conditions ofoxidative stress in the presence of RAD51C and XRCC3. Alsoinvolved in interstrand cross-link repair (PubMed:26253028).{ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171,ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364,ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593,ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376,ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308,ECO:0000269|PubMed:28575658}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHP1_RAD51 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_273aa MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHF RPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDN VAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEIVSEERKRGNQNLQNLRLSL >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_332aa MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHF RPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDN VAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAM >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_273aa MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHF RPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDN VAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEIVSEERKRGNQNLQNLRLSL >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_332aa MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHF RPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDN VAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_819nt ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTG >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_996nt ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATG TTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAA ACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAA >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_819nt ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTG >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_996nt ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATG TTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAA ACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_1528nt CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGCCTCTACAGCCGGTTCACCAGCCTGGACAAA GGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAACCCACTGGGGGACCGGATCATCAATGCCTTC TTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTCCGCCCCATTGAGGATAATGAAAAGAGCAAA GATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGACTATATGATTTGGATAAAGATGAAAAGATC TCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCA GAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGAC CACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTAC AGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAG ATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCAT TAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGC ACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTG ATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTT GGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTT >In-frame_CHP1_ENST00000334660_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_2214nt CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGCCTCTACAGCCGGTTCACCAGCCTGGACAAA GGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAACCCACTGGGGGACCGGATCATCAATGCCTTC TTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTCCGCCCCATTGAGGATAATGAAAAGAGCAAA GATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGACTATATGATTTGGATAAAGATGAAAAGATC TCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCA GAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGAC CACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTAC AGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAG TTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGA GGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCC TGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAA AAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTT CCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTT CTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGT TTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTA AAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGT TGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTT GGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCA CTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAA TGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAG GTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAG >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000423169_chr15_41011003_+_1378nt TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTG TCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAA ACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCC GGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCT GTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTT AACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAA >In-frame_CHP1_ENST00000560397_chr15_41562816_+_RAD51_ENST00000267868_chr15_41011003_+_2064nt TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT CTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATG TTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAA ACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAA GACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCT CTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAG TCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCT TTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCT GACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTG TCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTA GGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCA GTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCC AAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCC TGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAG |
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FusionGenePPI for CHP1_RAD51 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CHP1 | SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, PRSS23, ELAVL1, SHMT2, MOV10, NXF1, TMEM216, XPO1, DUSP22, DUSP6, UBC | RAD51 | BRCA2, RAD51AP1, DMC1, EIF2D, CAB39, TIMM13, H2AFX, BRCA1, BARD1, BRE, BRCC3, TP53, ABL1, RAD52, BLM, RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, ATM, VIM, CHD3, RAD54B, ATRX, DNAJA3, SUMO1, UBE2I, RPA1, MSH4, RAD18, MCPH1, SP1, MDC1, PALB2, MORF4L1, POLN, WRN, UHRF2, MSH2, MSH6, TERF2IP, PML, SWI5, SFR1, RECQL5, CHEK1, SWSAP1, AICDA, RPA3, PFN1, FBXO18, UGDH, NXF1, HNRNPA2B1, HNRNPC, ZDHHC17, TEAD1, PDS5B, CDH13, CST6, FAM84B, IL24, ITIH5, NAT2, ST14, TFF1, WHSC1L1, NELFB, CSNK2B, HSP90AA1, MAPK8IP3, PCSK1N, SIRT2, UMPS, USP10, CDC42, IGBP1, MYH11, PPP3CB, RAB5C, LRP8, CBX4, SLC33A1, HMG20A, RNASEH2A, TUBGCP2, POLK, RTEL1, KIF21A, UGGT1, CDC73, CXXC4, ELMSAN1, NAF1, SGOL1, HMGXB4, CASP3, TUBG1, ESR1, FANCD2, PCNA, ERCC5, SHFM1, UCHL3, DUSP21, FIGNL1, SNX32, DNA2, HSFY1, PARPBP, TUBA1A, LMNB1, FANCA, SPTA1, WDR48, KEAP1, BCR, RFWD3, USP21, RNF115 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHP1_RAD51 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CHP1 | Q99653 | DB11093 | Calcium Citrate | Calcineurin B homologous protein 1 | small molecule | approved |
| Hgene | CHP1 | Q99653 | DB11348 | Calcium Phosphate | Calcineurin B homologous protein 1 | small molecule | approved |
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RelatedDiseases for CHP1_RAD51 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RAD51 | C0006142 | Malignant neoplasm of breast | 1 | UNIPROT |
| Tgene | RAD51 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Tgene | RAD51 | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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