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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7139

FusionGeneSummary for CHN2_TSPAN33

check button Fusion gene summary
Fusion gene informationFusion gene name: CHN2_TSPAN33
Fusion gene ID: 7139
HgeneTgene
Gene symbol

CHN2

TSPAN33

Gene ID

1124

340348

Gene namechimerin 2tetraspanin 33
SynonymsARHGAP3|BCH|CHN2-3|RHOGAP3PEN|PEN.|TSPAN-33
Cytomap

7p14.3

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionbeta-chimaerinbeta-chimerinbeta3-chimaerinchimerin (chimaerin) 2chimerin, beta-2chimerin, testis-specificrho-GTPase-activating protein 3tetraspanin-33penumbraproerythroblast new membrane
Modification date2018051920180523
UniProtAcc

P52757

Q86UF1

Ensembl transtripts involved in fusion geneENST00000539406, ENST00000222792, 
ENST00000435288, ENST00000495789, 
ENST00000539389, ENST00000546235, 
ENST00000409041, ENST00000424025, 
ENST00000439711, ENST00000421775, 
ENST00000410098, 
ENST00000289407, 
Fusion gene scores* DoF score3 X 2 X 3=183 X 1 X 3=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHN2 [Title/Abstract] AND TSPAN33 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTSPAN33

GO:0051604

protein maturation

23091066

TgeneTSPAN33

GO:0072659

protein localization to plasma membrane

23091066


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-27-2528-01ACHN2chr7

29186576

+TSPAN33chr7

128801520

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000539406ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000222792ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000435288ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000495789ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000539389ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000546235ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000409041ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000424025ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000439711ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000421775ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+
intron-3CDSENST00000410098ENST00000289407CHN2chr7

29186576

+TSPAN33chr7

128801520

+

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FusionProtFeatures for CHN2_TSPAN33


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHN2

P52757

TSPAN33

Q86UF1

Plays an important role in normal erythropoiesis (Bysimilarity). It has a role in the differentiation of erythroidprogenitors (By similarity). Regulates maturation and traffickingof the transmembrane metalloprotease ADAM10 (PubMed:26686862).Negatively regulates ligand-induced Notch activity probably byregulating ADAM10 activity (PubMed:26686862).{ECO:0000250|UniProtKB:Q8R3S2, ECO:0000269|PubMed:26686862}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHN2_TSPAN33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHN2_TSPAN33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHN2BAG6, RAC1, ERBB3, RANBP3, RB1, SMARCD1, TP53RK, CHN1, PTGDSTSPAN33ADAM10, MSN, PDZD11, PLEKHA7, EZR, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHN2_TSPAN33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHN2_TSPAN33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHN2C0023903Liver neoplasms1CTD_human
HgeneCHN2C0032927Precancerous Conditions1CTD_human