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Fusion gene ID: 7139 |
FusionGeneSummary for CHN2_TSPAN33 |
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Fusion gene information | Fusion gene name: CHN2_TSPAN33 | Fusion gene ID: 7139 | Hgene | Tgene | Gene symbol | CHN2 | TSPAN33 | Gene ID | 1124 | 340348 |
Gene name | chimerin 2 | tetraspanin 33 | |
Synonyms | ARHGAP3|BCH|CHN2-3|RHOGAP3 | PEN|PEN.|TSPAN-33 | |
Cytomap | 7p14.3 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | beta-chimaerinbeta-chimerinbeta3-chimaerinchimerin (chimaerin) 2chimerin, beta-2chimerin, testis-specificrho-GTPase-activating protein 3 | tetraspanin-33penumbraproerythroblast new membrane | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P52757 | Q86UF1 | |
Ensembl transtripts involved in fusion gene | ENST00000539406, ENST00000222792, ENST00000435288, ENST00000495789, ENST00000539389, ENST00000546235, ENST00000409041, ENST00000424025, ENST00000439711, ENST00000421775, ENST00000410098, | ENST00000289407, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 1 X 3=9 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CHN2 [Title/Abstract] AND TSPAN33 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TSPAN33 | GO:0051604 | protein maturation | 23091066 |
Tgene | TSPAN33 | GO:0072659 | protein localization to plasma membrane | 23091066 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-27-2528-01A | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000539406 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000222792 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000435288 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000495789 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000539389 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000546235 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000409041 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000424025 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000439711 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000421775 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
intron-3CDS | ENST00000410098 | ENST00000289407 | CHN2 | chr7 | 29186576 | + | TSPAN33 | chr7 | 128801520 | + |
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FusionProtFeatures for CHN2_TSPAN33 |
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Hgene | Tgene |
CHN2 | TSPAN33 |
Plays an important role in normal erythropoiesis (Bysimilarity). It has a role in the differentiation of erythroidprogenitors (By similarity). Regulates maturation and traffickingof the transmembrane metalloprotease ADAM10 (PubMed:26686862).Negatively regulates ligand-induced Notch activity probably byregulating ADAM10 activity (PubMed:26686862).{ECO:0000250|UniProtKB:Q8R3S2, ECO:0000269|PubMed:26686862}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHN2_TSPAN33 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHN2_TSPAN33 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CHN2 | BAG6, RAC1, ERBB3, RANBP3, RB1, SMARCD1, TP53RK, CHN1, PTGDS | TSPAN33 | ADAM10, MSN, PDZD11, PLEKHA7, EZR, LMNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHN2_TSPAN33 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHN2_TSPAN33 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHN2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | CHN2 | C0032927 | Precancerous Conditions | 1 | CTD_human |