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Fusion gene ID: 7137 |
FusionGeneSummary for CHN2_SKAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHN2_SKAP2 | Fusion gene ID: 7137 | Hgene | Tgene | Gene symbol | CHN2 | SKAP2 | Gene ID | 1124 | 8935 |
| Gene name | chimerin 2 | src kinase associated phosphoprotein 2 | |
| Synonyms | ARHGAP3|BCH|CHN2-3|RHOGAP3 | PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R | |
| Cytomap | 7p14.3 | 7p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-chimaerinbeta-chimerinbeta3-chimaerinchimerin (chimaerin) 2chimerin, beta-2chimerin, testis-specificrho-GTPase-activating protein 3 | src kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P52757 | O75563 | |
| Ensembl transtripts involved in fusion gene | ENST00000539406, ENST00000222792, ENST00000435288, ENST00000495789, ENST00000539389, ENST00000546235, ENST00000409041, ENST00000424025, ENST00000439711, ENST00000421775, ENST00000410098, | ENST00000345317, ENST00000539623, ENST00000489977, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 6 X 5=180 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHN2 [Title/Abstract] AND SKAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-31-1956-01A | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000539406 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000539406 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000539406 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| In-frame | ENST00000222792 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000222792 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000222792 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| In-frame | ENST00000435288 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000435288 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000435288 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| In-frame | ENST00000495789 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000495789 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000495789 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| In-frame | ENST00000539389 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000539389 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| 5CDS-5UTR | ENST00000539389 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000546235 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000546235 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000546235 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000409041 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000409041 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000409041 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000424025 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000424025 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000424025 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000439711 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000439711 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000439711 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000421775 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000421775 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000421775 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-3CDS | ENST00000410098 | ENST00000345317 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000410098 | ENST00000539623 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
| intron-5UTR | ENST00000410098 | ENST00000489977 | CHN2 | chr7 | 29234606 | + | SKAP2 | chr7 | 26779583 | - |
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FusionProtFeatures for CHN2_SKAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHN2 | SKAP2 |
| May be involved in B-cell and macrophage adhesionprocesses. In B-cells, may act by coupling the B-cell receptor(BCR) to integrin activation. May play a role in src signalingpathway. {ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:9837776}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHN2_SKAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CHN2_ENST00000222792_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_274aa MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM >In-frame_CHN2_ENST00000435288_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_274aa MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM >In-frame_CHN2_ENST00000495789_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_274aa MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM >In-frame_CHN2_ENST00000539389_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_274aa MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CHN2_ENST00000222792_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_822nt ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG >In-frame_CHN2_ENST00000435288_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_822nt ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG >In-frame_CHN2_ENST00000495789_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_822nt ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG >In-frame_CHN2_ENST00000539389_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_822nt ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CHN2_ENST00000222792_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_3956nt TTCTTCCTTTGTGTGTGCGCGAGCGGAGTTGGGGCGGAGGGAGAAGGGGGAGGTCGCTCTGTCTGTCCGTCTCCCGCCGCCTCTGCCCGG TCTACTCGAAGTGCGGCGGGAGAGGCGGGAGCCCAGGAGAGGGTGCGGGAGCTGGCGGGGCGGCTCGGAGCTGCCAGGACGCCCTGGTCC CAGCCGCGCACAGGGGAGCGTGGACGGCAGAGGGGCTCGGCGGGAGCCGAGATCCGCCCGTCCCGGCTGCCCCTCGGCCTCCCTCTGCTC CCACCTACCCCCTGACACCCATAGAAAAGCGTGCAAAGGCGCGGAGCGGGACGGAAACCACAAATAAATAGCGGCGGCGGCAGCGCGTCA TCTGGTGGAGCAGGAAGTGCAGGCAGAGTCCGGAGGCTGGTGCTTTCTGCGCGTCCCCAGGACTTTGCCATGGGCTGGGGGCCGCGGAGG CTGCGAGCGGCCGGGCGAGGGCAGCGGCGGCGGCGTCCGCACCGGGGCTGAGCGAGCAGCGACGCGAGGGGCGCGCGGAGATGGCAGCGT CCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGG CTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCT ATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGG ATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAAT GGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATG TTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGG ACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTA ATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGG AATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTT GAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACC TCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAA GGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGA TTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGT AATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTT TTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTT TCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGT GCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTT TGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACAT GGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTG CTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAA AAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATT TACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGT AGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAG ATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATA TGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGG AACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTT TATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTT GATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTT TTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAAC TTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTT TAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGG AAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGT CTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGG AGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTG ATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTA ATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGA ACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGT >In-frame_CHN2_ENST00000435288_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_3863nt ACTCGAAGTGCGGCGGGAGAGGCGGGAGCCCAGGAGAGGGTGCGGGAGCTGGCGGGGCGGCTCGGAGCTGCCAGGACGCCCTGGTCCCAG CCGCGCACAGGGGAGCGTGGACGGCAGAGGGGCTCGGCGGGAGCCGAGATCCGCCCGTCCCGGCTGCCCCTCGGCCTCCCTCTGCTCCCA CCTACCCCCTGACACCCATAGAAAAGCGTGCAAAGGCGCGGAGCGGGACGGAAACCACAAATAAATAGCGGCGGCGGCAGCGCGTCATCT GGTGGAGCAGGAAGTGCAGGCAGAGTCCGGAGGCTGGTGCTTTCTGCGCGTCCCCAGGACTTTGCCATGGGCTGGGGGCCGCGGAGGCTG CGAGCGGCCGGGCGAGGGCAGCGGCGGCGGCGTCCGCACCGGGGCTGAGCGAGCAGCGACGCGAGGGGCGCGCGGAGATGGCAGCGTCCA GCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGGCTG GCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCTATT ATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGGATG GAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAATGGG TACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATGTTG ATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGGACA GTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATT TTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAAT ACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAG AGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCT CCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGA TATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGATTT GTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAAT GTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTT GGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCA CACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCG TACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTGT TTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACATGGT GAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTGCTT GAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAAAAA AAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTAC ATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGA AATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATT TGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGT CAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGGAAC TTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTTTAT AAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTTGAT TTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTTTTC CTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTG AGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAG TCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAA GCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTC GTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAGA CATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTGATG AAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTAATA TAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGAACA GTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACT >In-frame_CHN2_ENST00000495789_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_3443nt GCGAGGGGCGCGCGGAGATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAG CACAAGACCTTCCTTTTGTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGT GGTGTGCTCTCAGTAAAACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTG TCAGAATGAATAACACTCTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAG CAGCTTCTCCCAAAGATGCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATG ATGAGAGAGGAGAATTATATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTT ATGAAGAACTTCCAGAAGAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCT CAGGGGATAAGAGCACTGATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTG GTGATGTGATTTACATTCTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAG CCTACATAATGGAGATGTATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCA TGAAAGCACGAGTGACAGCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAA TATTCCTCTGATGTGAAATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAAT AATTATAGTTTTTATTTACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCT ACTATTGCTACTTCTGGTGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTT TAAATTTAGTGTATCATGCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTAT AGATAACTTTATTGTTATTATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGG CAGTGTGCTGTCACCTGCAACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGG GCCTGGCAACATTTTCTACTGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTA TAAAGAATCTCCCAGCCAGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCT ACTTGGGAGGCCAAGGCACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGC GACAGAGTGAGACTCCATCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCT CTTATCTTGCCTTATTGCTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAG AAAGGAAGGGTTTGCAGAGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTG AGTTATACTCTGTGCTGCCTGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCT ATGAGATACCAATGTAGCCTTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATC ATTACCTATCAGGTATTATCTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAA AATCTCCATTATTTGTGTAAAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATC TCAAATGTGAAAAAAAAAAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAG AAGTTACATTTGTGCAGTTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGA CGACTTTAGTGGACTGGTTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGT TTGTGCTTTGGGTTGAAAAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCC CCCATGGCACAAACTCGCCCATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTG ATGACCAACAGTTCCAAGCCAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTG TTCTTTTAAAACTTGAATATAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTC AATTCATGACTGCTTTATATTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATA CTCTTCAAGATCATAATAATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTT GCTTAGCTTTTATTTGTTTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCT TGATTATTTGCTCTGTACTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAGGTTCAAATAAA >In-frame_CHN2_ENST00000539389_chr7_29234606_+_SKAP2_ENST00000345317_chr7_26779583_-_3426nt ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG TATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACA GCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAA ATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTT ACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGG TGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCAT GCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTA TTATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTG CAACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCT ACTGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCC AGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGC ACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCA TCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTG CTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAG AGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTG CCTGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAG CCTTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATT ATCTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTG TAAAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAA AAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAG TTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGG TTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAA AAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCG CCCATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAA GCCAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAA TATAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTA TATTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAAT AATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGT TTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTA CTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAGGTTCAAATAAAGTTTAATTGTTTGCAAA |
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FusionGenePPI for CHN2_SKAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CHN2 | BAG6, RAC1, ERBB3, RANBP3, RB1, SMARCD1, TP53RK, CHN1, PTGDS | SKAP2 | PRAM1, FYN, LYN, HCK, KHDRBS1, FASLG, PTK2B, SRC, GRB2, APP, SKAP1, RGS3, ABHD5, FRMD1, SNRPN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHN2_SKAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHN2_SKAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CHN2 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | CHN2 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | SKAP2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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