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Fusion gene ID: 7109 |
FusionGeneSummary for CHMP3_REEP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHMP3_REEP1 | Fusion gene ID: 7109 | Hgene | Tgene | Gene symbol | CHMP3 | REEP1 | Gene ID | 51652 | 65055 |
| Gene name | charged multivesicular body protein 3 | receptor accessory protein 1 | |
| Synonyms | CGI-149|NEDF|VPS24 | C2orf23|HMN5B|SPG31|Yip2a | |
| Cytomap | 2p11.2 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | charged multivesicular body protein 325.1 proteinCHMP family, member 3chromatin-modifying protein 3neuroendocrine differentiation factorvacuolar protein sorting 24 homologvacuolar protein sorting-associated protein 24 | receptor expression-enhancing protein 1spastic paraplegia 31 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y3E7 | Q9H902 | |
| Ensembl transtripts involved in fusion gene | ENST00000263856, ENST00000409727, ENST00000409225, ENST00000439940, ENST00000494623, | ENST00000165698, ENST00000535845, ENST00000541910, ENST00000538924, ENST00000540790, ENST00000473407, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 2 X 6=48 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/48*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHMP3 [Title/Abstract] AND REEP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHMP3 | GO:0039702 | viral budding via host ESCRT complex | 24878737 |
| Hgene | CHMP3 | GO:0051258 | protein polymerization | 23051622 |
| Tgene | REEP1 | GO:0051205 | protein insertion into membrane | 15550249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-8355-01A | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263856 | ENST00000165698 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000263856 | ENST00000535845 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| Frame-shift | ENST00000263856 | ENST00000541910 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000263856 | ENST00000538924 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000263856 | ENST00000540790 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5CDS-5UTR | ENST00000263856 | ENST00000473407 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000409727 | ENST00000165698 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000409727 | ENST00000535845 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| Frame-shift | ENST00000409727 | ENST00000541910 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000409727 | ENST00000538924 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| In-frame | ENST00000409727 | ENST00000540790 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5CDS-5UTR | ENST00000409727 | ENST00000473407 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-3CDS | ENST00000409225 | ENST00000165698 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-3CDS | ENST00000409225 | ENST00000535845 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-3CDS | ENST00000409225 | ENST00000541910 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-3CDS | ENST00000409225 | ENST00000538924 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-3CDS | ENST00000409225 | ENST00000540790 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| 5UTR-5UTR | ENST00000409225 | ENST00000473407 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000439940 | ENST00000165698 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000439940 | ENST00000535845 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000439940 | ENST00000541910 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000439940 | ENST00000538924 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000439940 | ENST00000540790 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-5UTR | ENST00000439940 | ENST00000473407 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000494623 | ENST00000165698 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000494623 | ENST00000535845 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000494623 | ENST00000541910 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000494623 | ENST00000538924 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-3CDS | ENST00000494623 | ENST00000540790 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
| intron-5UTR | ENST00000494623 | ENST00000473407 | CHMP3 | chr2 | 86790427 | - | REEP1 | chr2 | 86459925 | - |
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FusionProtFeatures for CHMP3_REEP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHMP3 | REEP1 |
| Required for endoplasmic reticulum (ER) networkformation, shaping and remodeling; it links ER tubules to thecytoskeleton. May also enhance the cell surface expression ofodorant receptors (PubMed:20200447). May play a role in long-termaxonal maintenance (PubMed:24478229).{ECO:0000269|PubMed:20200447, ECO:0000269|PubMed:24478229}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >REEP1 | chr2:86790427 | chr2:86459925 | ENST00000165698 | - | 4 | 7 | 170_173 | 139 | 202 | Compositional bias | Note=Poly-Pro |
| Tgene | >REEP1 | chr2:86790427 | chr2:86459925 | ENST00000535845 | - | 3 | 6 | 170_173 | 112 | 175 | Compositional bias | Note=Poly-Pro |
| Tgene | >REEP1 | chr2:86790427 | chr2:86459925 | ENST00000538924 | - | 4 | 7 | 170_173 | 146 | 209 | Compositional bias | Note=Poly-Pro |
| Tgene | >REEP1 | chr2:86790427 | chr2:86459925 | ENST00000541910 | - | 2 | 5 | 170_173 | 60 | 144 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 141_222 | 15 | 223 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 22_54 | 15 | 223 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 141_222 | -31 | 157 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 22_54 | -31 | 157 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 141_222 | 15 | 183 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 22_54 | 15 | 183 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 141_222 | -81 | 252 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 22_54 | -81 | 252 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 201_211 | 15 | 223 | Motif | Note=MIT-interacting motif |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 201_211 | -31 | 157 | Motif | Note=MIT-interacting motif |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 201_211 | 15 | 183 | Motif | Note=MIT-interacting motif |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 201_211 | -81 | 252 | Motif | Note=MIT-interacting motif |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 59_64 | 15 | 223 | Region | Note=Important for autoinhibitory function |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 59_64 | -31 | 157 | Region | Note=Important for autoinhibitory function |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 59_64 | 15 | 183 | Region | Note=Important for autoinhibitory function |
| Hgene | >CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 59_64 | -81 | 252 | Region | Note=Important for autoinhibitory function |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000165698 | - | 4 | 7 | 1_21 | 139 | 202 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000165698 | - | 4 | 7 | 35_55 | 139 | 202 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000535845 | - | 3 | 6 | 1_21 | 112 | 175 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000535845 | - | 3 | 6 | 35_55 | 112 | 175 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000538924 | - | 4 | 7 | 1_21 | 146 | 209 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000538924 | - | 4 | 7 | 35_55 | 146 | 209 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000541910 | - | 2 | 5 | 1_21 | 60 | 144 | Transmembrane | Helical |
| Tgene | REEP1 | chr2:86790427 | chr2:86459925 | ENST00000541910 | - | 2 | 5 | 35_55 | 60 | 144 | Transmembrane | Helical |
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FusionGeneSequence for CHMP3_REEP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_78aa >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_78aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_234nt ATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAG GACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_3470nt TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_3464nt TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_3464nt TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC CACAGAATGTTTCTTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACA AACATGGCCTTTTCTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAA GGTAGTAGGGGCGGGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTT TTAGAAAGATAAGAGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCA AACACAGCATTTTTTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAA TGGACTTGCAAGGGCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCA GATGTGCTTATAAAGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAG TCAAAAGACCAGACAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAA AGAGAAGAGTCACAGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCT TGGTGCAATTTCTTGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGAC CAGTGCTGCCGATTTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAAC AAACACACAAAAAACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCT AGAATGGTTTTGGAGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCT GGCCTGTGCAGAATGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAG GGGAATAAGGCATTCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGG TAGCTGCTCTCCCCACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCA GTGGTCACAACCCAGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATAT AGAACTTACTGTCAGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACA CATTAGCTGGATCTTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGT TCCTCTGAAGGTGATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGT TTGCTCATGTTCTGTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCA GACAGAAGAAGAATATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAA AAAAAAAAAGCTTACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTG AACAACCTATATTTTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGA AGCGCTCTATTCTCAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGT AACTATTTTTCCTTCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGG CAAAATGTGTTTACGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTG GTGTTCTGTCTAGAGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTA ATGTTCATGTCATAACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTT AGTCATAATCCCTCCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTT GTGATAAGAGTGCTTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTC ATCCTCTAACAGTGTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAAT GATCTGTAATAAAATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATA >In-frame_CHMP3_ENST00000263856_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_499nt TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAG GGTGCCTTATCGGAGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCA CCACCGGGGTCTGGGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCC TAGAATCCTTCGATCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATC >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000165698_chr2_86459925_-_3367nt AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000535845_chr2_86459925_-_3361nt AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000538924_chr2_86459925_-_3361nt AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC TTCTCTGCCTTAAAGAGCTATTCACTAATAACATAGAAATCCGCAAGCTGGGTGTGCTTTGAGTGTGCAGCCTCACAAACATGGCCTTTT CTCTCTCCCCTTCCACTTTTAAGGATTTATTTTTTTCCCCCTTTTCTTTATTTTGCTGGGGAGAGGCTAAAGGGAAAGGTAGTAGGGGCG GGGGTGGTGACCTTTAAGTCTTCTGAGGTTGGTAATTTTCCACAATTGGATTGTCATTATAGACAGCAGTGTGTTTTTTAGAAAGATAAG AGAATCACCCCTATGCTGCTGAGATGTACATTTGTAATTTATCTGTTGCATACTTAGTTTTTAGTCCTGTAAATGCAAACACAGCATTTT TTACAACTTTCTTTGTTCTTGGTACTTATACTTTGAACTATGATGTACATATTTATGGCTTTTGGCTTTTAATATAATGGACTTGCAAGG GCTGCCAGAGGTTCTGATATGTAAGAAAACTGCAAAAACAAATATAGACAAATATTTTGATTCTAGAGAACGTCTCAGATGTGCTTATAA AGCTTCCAAATACAACTCCAGTAAGACATCCCTTTCCCTGCAGGAGTGTGGTCTATATTCTTTAGATAGTTGTTTAGTCAAAAGACCAGA CAAGTTACAAACTAAGAGAAACAATATTTCACAACACAGTAAAGTGTGATGAGAGGTCAGGGGAACATCCCAGTAAAAGAGAAGAGTCAC AGGAAGCTCATCTCCTCCCTGGATTCTGGATTAGGAGCTTCTGAATCTTTTCCAGGGATAGGCAGGTAGCTCACTCTTGGTGCAATTTCT TGAGGATGGGAACATGTAGAGCTGCTGGAAGGAGTAATTCTGTGCTTGACAAAGGACGATTTCTCCTTTATCGTGACCAGTGCTGCCGAT TTCCTGACAGAGGAGCTTACACTCTGAGCACCTTGTTTTAGCGAACTCTAGCAAAACTTGTTTAGCTTAGCAAAAACAAACACACAAAAA ACTGAGAACTCTGCTGTTTCAGATATGCCATAACATACATCTGAAACACATGTGTAACAATCAAAATGGTGGGCTCTAGAATGGTTTTGG AGCTCGAGATCTTCATGGGTTAGACTTGCTGGTCAGACCCAGGAGCACCTGTGGCTCACACCTTCTGTTCCCCTCCTGGCCTGTGCAGAA TGTAAACAGCAGACTCATACTCAATGGGCACTACAGGCCTTATCAGACGTTTTATACAAGCCTGGATTGCTTAGTAGGGGAATAAGGCAT TCTCTGAGGGGGCTTTCCACTTAGATTGAGAATTTTATTTGAAAAGAATCTGGTTTAAATGGCATTGTGGTCCGAGGTAGCTGCTCTCCC CACTGAGAGCTGAGCCGAAATATAAGAATAATATATTTGTGCTTCGAGTTGGTGTTTCTTTCAGTGTAATGCATGCAGTGGTCACAACCC AGTTACTCATAATATTTGGATTGTATTTGTTCGTAGATATGCCCAGAAGACTAGAGAATTAGTGTTATATACCATATAGAACTTACTGTC AGTCAACTATAAACAGGCCCAATTAAAAACTGTTCCATTACTACGCAAACACATATTAGAGGCCTTTGCTGATGACACATTAGCTGGATC TTAGCCACCCCAGAAAGGGTTTGATTTGAAGCTGATTGTTGCCAGATATGCATATTGGAATCCCATCTACCCATAGTTCCTCTGAAGGTG ATTTTGTAATTTGCAAAAGGGTATAGGAAAATATACCTAAAAGCGAATTTGTGGCTGAGAGGATAAACAGAAGCTGTTTGCTCATGTTCT GTGCCCCACACCCACCAATACCTAAATCTGTTAAGGAAGACAGAAAATGTTTTCTTTGTGCTCATTGAGTAGTTCCAGACAGAAGAAGAA TATACTCTTTAAAATGTATTTACCTGTTAGTTGGAAGTACCCAGAATTATCAGAAACGAATGCAAAAAAAAAAAAAAAAAAAAAAAGCTT ACACAGCTTCTTAGCAATTTTTTTTTTTTTGCCGAAACAATAAATTGCCTTTAGCAGCAGTTTAAAATCCTATCGTGAACAACCTATATT TTCGCCATTTTACAATGGAGAGTTGTGACAAGTACAGGTTATCAAGTTTGCACTTAACTATGCCAAAAAAAGTTTGAAGCGCTCTATTCT CAGACATGCTGTATTATTACTTCTCATTCAAGATTGAAAAATATAAAGGTATCCAAACTCTGTCTTAATGTAAATGTAACTATTTTTCCT TCAAGTGTTGACTAGGGAGTCGGTTTCTCTCTTAAAGACACTCACTGTACAACTGAAAGCAGCTGTCATATTTCTGGCAAAATGTGTTTA CGTATCTGACAAGTTGTACATTTGTGTATGAACTGACATAAAATGTGAAAGCCTGTAAGTGTACATGTAGTGGTGTGGTGTTCTGTCTAG AGGATACAACTGAATGTTTTTAATTTGCTGACTTACAGACACAGGCTGTTTACAAAATGCTAGCTGGAAAGTCTGTAATGTTCATGTCAT AACTTTTAGTTAATTGCCATTGAGCACCTGTTCTGAGGAGGTGAGATGTGGACTTGTGCTTATAAACTGGAGAGTTTAGTCATAATCCCT CCTGGCTTTGTGTGAATAGCTTGCTCACTTTGCTGGCCTTTGAAATGTGTTCTCCGTGATAAGCTATCCATGTGTTTGTGATAAGAGTGC TTGTCAACCATGACCATCTTTGAGCCTTCCTAGTCCTCCACCTGGCACAGTATTTGAAATGGCAAAGGATGTGCTTCATCCTCTAACAGT GTACACTCCCAGAGCTGATATTCTGGATTTTGACTGTGCACATTTCCTCTAGTTCATGTCTGTAGTCCCTATAGAATGATCTGTAATAAA ATAGTATACTGGACTGTGCATCAAAGGGATGTAAAATTACAGTATTCCAAAGGTTGAAGTTCTGCTGTTTTGTTATAATGCCTGATACAC >In-frame_CHMP3_ENST00000409727_chr2_86790427_-_REEP1_ENST00000540790_chr2_86459925_-_396nt AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGGACAGGGTGCCTTATCGG AGAGACTGCGGAGCTTCAGCATGCAGGACCTCACCACCATCAGGGGAGACGGCGCCCCTGCTCCCTCGGGCCCCCCACCACCGGGGTCTG GGCGGGCCAGCGGCAAACACGGCCAGCCTAAGATGTCCAGGAGTGCTTCTGAGAGCGCTAGCAGCTCAGGCACCGCCTAGAATCCTTCGA TCTCGCTTCAGGAAGAAAAGTACCTCATCCTCGGCCACCGAAACCACGTGAGTGAGATGAGCCAACAGCACCGGATCCACAGAATGTTTC |
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FusionGenePPI for CHMP3_REEP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CHMP3 | IGFBP7, STAMBP, CHMP2A, VTA1, VPS4A, VAV2, CHMP4A, CHMP3, CHMP4B, CHMP2B, TNPO3, RAB11A, ATP6V1B1, APP, SMAD1, SMAD5, MEPCE, CXorf56, VAX2, CHMP1B, DAXX, TFG, SIX2, CHMP5 | REEP1 | ELAVL1, YWHAE, KCNA10, PLSCR1, LYPD3, CAV3, REEP4, NCAM1, YWHAZ, REEP2, YWHAG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 203_207 | 15 | 223 | STAMBP |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 203_207 | -31 | 157 | STAMBP |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 203_207 | 15 | 183 | STAMBP |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 203_207 | -81 | 252 | STAMBP |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000263856 | - | 1 | 6 | 151_222 | 15 | 223 | VPS4A |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409225 | - | 1 | 5 | 151_222 | -31 | 157 | VPS4A |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000409727 | - | 1 | 6 | 151_222 | 15 | 183 | VPS4A |
| Hgene | CHMP3 | chr2:86790427 | chr2:86459925 | ENST00000439940 | - | 1 | 8 | 151_222 | -81 | 252 | VPS4A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHMP3_REEP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHMP3_REEP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | REEP1 | C1853247 | SPASTIC PARAPLEGIA 31, AUTOSOMAL DOMINANT | 4 | CTD_human;ORPHANET;UNIPROT |
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