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Fusion gene ID: 7077 |
FusionGeneSummary for CHIC2_SPINK2 |
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Fusion gene information | Fusion gene name: CHIC2_SPINK2 | Fusion gene ID: 7077 | Hgene | Tgene | Gene symbol | CHIC2 | SPINK2 | Gene ID | 26511 | 6691 |
Gene name | cysteine rich hydrophobic domain 2 | serine peptidase inhibitor, Kazal type 2 | |
Synonyms | BTL | HUSI-II | |
Cytomap | 4q12 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich hydrophobic domain-containing protein 2BRX-like translocated in leukemiacystein-rich hydrophobic domain 2cysteine-rich hydrophobic domain 2 protein | serine protease inhibitor Kazal-type 2epididymis tissue protein Li 172serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UKJ5 | P20155 | |
Ensembl transtripts involved in fusion gene | ENST00000263921, ENST00000512964, | ENST00000248701, ENST00000506738, ENST00000504762, | |
Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 5 X 3 X 5=75 |
# samples | 6 | 5 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHIC2 [Title/Abstract] AND SPINK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-20-1684-01A | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263921 | ENST00000248701 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000263921 | ENST00000506738 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000263921 | ENST00000504762 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000512964 | ENST00000248701 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000512964 | ENST00000506738 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000512964 | ENST00000504762 | CHIC2 | chr4 | 54915122 | - | SPINK2 | chr4 | 57686745 | - |
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FusionProtFeatures for CHIC2_SPINK2 |
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Hgene | Tgene |
CHIC2 | SPINK2 |
Strong inhibitor of acrosin in male and/or femalegenital tract. Also inhibits trypsin.{ECO:0000269|PubMed:19422058}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHIC2_SPINK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHIC2_SPINK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CHIC2 | TOP3B, MDFI, U2AF2, KRTAP4-12, HOXA1, OTX1, CATSPER1, PLEKHF2, ITSN2, ELAVL1, TUBGCP4, CDR2, KRTAP5-9, MEOX2, TCF4, PNMA1, GMCL1, CEP44, KRTAP4-2, KRT40, SPERT, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, DHRS9, UBE2N | SPINK2 | KRTAP5-9, ADAMTSL4, KRTAP10-3, NOTCH2NL, MAPK8IP2, GCHFR, ATP5S, NUDT8, MIPEP, DCAF15, CTTNBP2NL, PRTFDC1, UBR2, PDP2, IDE, PMPCB, RSPRY1, PMPCA, MOB4, STRIP1, IKBIP, STRN, UBR1, STRN3, STRN4, ATP6V1D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHIC2_SPINK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHIC2_SPINK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |