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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7073

FusionGeneSummary for CHIC2_LPHN3

check button Fusion gene summary
Fusion gene informationFusion gene name: CHIC2_LPHN3
Fusion gene ID: 7073
HgeneTgene
Gene symbol

CHIC2

LPHN3

Gene ID

26511

23284

Gene namecysteine rich hydrophobic domain 2adhesion G protein-coupled receptor L3
SynonymsBTLCIRL3|CL3|LEC3|LPHN3
Cytomap

4q12

4q13.1

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich hydrophobic domain-containing protein 2BRX-like translocated in leukemiacystein-rich hydrophobic domain 2cysteine-rich hydrophobic domain 2 proteinadhesion G protein-coupled receptor L3CIRL-3calcium-independent alpha-latrotoxin receptor 3latrophilin homolog 3 (cow)latrophilin-3lectomedin 3
Modification date2018052320180523
UniProtAcc

Q9UKJ5

Ensembl transtripts involved in fusion geneENST00000263921, ENST00000512964, 
ENST00000512091, ENST00000514591, 
ENST00000511324, ENST00000506700, 
ENST00000509896, ENST00000545650, 
ENST00000508693, ENST00000507164, 
ENST00000507625, ENST00000514157, 
ENST00000504896, ENST00000514996, 
ENST00000506720, ENST00000506746, 
ENST00000508946, ENST00000508078, 
Fusion gene scores* DoF score6 X 3 X 5=903 X 3 X 3=27
# samples 63
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHIC2 [Title/Abstract] AND LPHN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLPHN3

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-19-0957-02ACHIC2chr4

54880004

-LPHN3chr4

62248842

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263921ENST00000512091CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-5UTRENST00000263921ENST00000514591CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000511324CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000506700CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000509896CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000545650CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000508693CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000507164CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000507625CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000514157CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000504896CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000514996CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000506720CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000506746CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000508946CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000263921ENST00000508078CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-5UTRENST00000512964ENST00000512091CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-5UTRENST00000512964ENST00000514591CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000511324CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000506700CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000509896CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000545650CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000508693CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000507164CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000507625CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000514157CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000504896CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000514996CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000506720CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000506746CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000508946CHIC2chr4

54880004

-LPHN3chr4

62248842

+
5CDS-intronENST00000512964ENST00000508078CHIC2chr4

54880004

-LPHN3chr4

62248842

+

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FusionProtFeatures for CHIC2_LPHN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHIC2

Q9UKJ5

LPHN3

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHIC2_LPHN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHIC2_LPHN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHIC2TOP3B, MDFI, U2AF2, KRTAP4-12, HOXA1, OTX1, CATSPER1, PLEKHF2, ITSN2, ELAVL1, TUBGCP4, CDR2, KRTAP5-9, MEOX2, TCF4, PNMA1, GMCL1, CEP44, KRTAP4-2, KRT40, SPERT, KRTAP10-7, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, DHRS9, UBE2NLPHN3ASGR2, FLRT1, LPAR1, C3AR1, MMP26, CLEC2D, IPPK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHIC2_LPHN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHIC2_LPHN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource