![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 7067 |
FusionGeneSummary for CHI3L1_THBS3 |
![]() |
Fusion gene information | Fusion gene name: CHI3L1_THBS3 | Fusion gene ID: 7067 | Hgene | Tgene | Gene symbol | CHI3L1 | THBS3 | Gene ID | 1116 | 7059 |
Gene name | chitinase 3 like 1 | thrombospondin 3 | |
Synonyms | ASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YKL-40|YKL40|YYL-40|hCGP-39 | TSP3 | |
Cytomap | 1q32.1 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | chitinase-3-like protein 139 kDa synovial proteincartilage glycoprotein 39chitinase 3-like 1 (cartilage glycoprotein-39) | thrombospondin-3 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P36222 | P49746 | |
Ensembl transtripts involved in fusion gene | ENST00000255409, | ENST00000368378, ENST00000541576, ENST00000457183, ENST00000541990, ENST00000486260, | |
Fusion gene scores | * DoF score | 11 X 8 X 7=616 | 6 X 6 X 2=72 |
# samples | 12 | 7 | |
** MAII score | log2(12/616*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHI3L1 [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF912932 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + | ||
ChiTaRS3.1 | BF914338 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000255409 | ENST00000368378 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
intron-intron | ENST00000255409 | ENST00000541576 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
intron-intron | ENST00000255409 | ENST00000457183 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
intron-intron | ENST00000255409 | ENST00000541990 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
intron-intron | ENST00000255409 | ENST00000486260 | CHI3L1 | chr1 | 203152781 | - | THBS3 | chr1 | 155169591 | + |
Top |
FusionProtFeatures for CHI3L1_THBS3 |
![]() |
Hgene | Tgene |
CHI3L1 | THBS3 |
Carbohydrate-binding lectin with a preference forchitin. Has no chitinase activity. May play a role in tissueremodeling and in the capacity of cells to respond to and copewith changes in their environment. Plays a role in T-helper celltype 2 (Th2) inflammatory response and IL-13-induced inflammation,regulating allergen sensitization, inflammatory cell apoptosis,dendritic cell accumulation and M2 macrophage differentiation.Facilitates invasion of pathogenic enteric bacteria into colonicmucosa and lymphoid organs. Mediates activation of AKT1 signalingpathway and subsequent IL8 production in colonic epithelial cells.Regulates antibacterial responses in lung by contributing tomacrophage bacterial killing, controlling bacterial disseminationand augmenting host tolerance. Also regulates hyperoxia-inducedinjury, inflammation and epithelial apoptosis in lung.{ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556,ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}. | Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CHI3L1_THBS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CHI3L1_THBS3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CHI3L1_THBS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CHI3L1_THBS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHI3L1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | CHI3L1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | CHI3L1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | CHI3L1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |