FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7067

FusionGeneSummary for CHI3L1_THBS3

check button Fusion gene summary
Fusion gene informationFusion gene name: CHI3L1_THBS3
Fusion gene ID: 7067
HgeneTgene
Gene symbol

CHI3L1

THBS3

Gene ID

1116

7059

Gene namechitinase 3 like 1thrombospondin 3
SynonymsASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YKL-40|YKL40|YYL-40|hCGP-39TSP3
Cytomap

1q32.1

1q22

Type of geneprotein-codingprotein-coding
Descriptionchitinase-3-like protein 139 kDa synovial proteincartilage glycoprotein 39chitinase 3-like 1 (cartilage glycoprotein-39)thrombospondin-3
Modification date2018052720180519
UniProtAcc

P36222

P49746

Ensembl transtripts involved in fusion geneENST00000255409, ENST00000368378, 
ENST00000541576, ENST00000457183, 
ENST00000541990, ENST00000486260, 
Fusion gene scores* DoF score11 X 8 X 7=6166 X 6 X 2=72
# samples 127
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHI3L1 [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF912932CHI3L1chr1

203152781

-THBS3chr1

155169591

+
ChiTaRS3.1BF914338CHI3L1chr1

203152781

-THBS3chr1

155169591

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000255409ENST00000368378CHI3L1chr1

203152781

-THBS3chr1

155169591

+
intron-intronENST00000255409ENST00000541576CHI3L1chr1

203152781

-THBS3chr1

155169591

+
intron-intronENST00000255409ENST00000457183CHI3L1chr1

203152781

-THBS3chr1

155169591

+
intron-intronENST00000255409ENST00000541990CHI3L1chr1

203152781

-THBS3chr1

155169591

+
intron-intronENST00000255409ENST00000486260CHI3L1chr1

203152781

-THBS3chr1

155169591

+

Top

FusionProtFeatures for CHI3L1_THBS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHI3L1

P36222

THBS3

P49746

Carbohydrate-binding lectin with a preference forchitin. Has no chitinase activity. May play a role in tissueremodeling and in the capacity of cells to respond to and copewith changes in their environment. Plays a role in T-helper celltype 2 (Th2) inflammatory response and IL-13-induced inflammation,regulating allergen sensitization, inflammatory cell apoptosis,dendritic cell accumulation and M2 macrophage differentiation.Facilitates invasion of pathogenic enteric bacteria into colonicmucosa and lymphoid organs. Mediates activation of AKT1 signalingpathway and subsequent IL8 production in colonic epithelial cells.Regulates antibacterial responses in lung by contributing tomacrophage bacterial killing, controlling bacterial disseminationand augmenting host tolerance. Also regulates hyperoxia-inducedinjury, inflammation and epithelial apoptosis in lung.{ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556,ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}. Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CHI3L1_THBS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CHI3L1_THBS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CHI3L1_THBS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CHI3L1_THBS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHI3L1C0017636Glioblastoma1CTD_human
HgeneCHI3L1C0017638Glioma1CTD_human
HgeneCHI3L1C0027626Neoplasm Invasiveness1CTD_human
HgeneCHI3L1C0029408Degenerative polyarthritis1CTD_human