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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 705

FusionGeneSummary for ADAM2_MTMR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM2_MTMR2
Fusion gene ID: 705
HgeneTgene
Gene symbol

ADAM2

MTMR2

Gene ID

2515

8898

Gene nameADAM metallopeptidase domain 2myotubularin related protein 2
SynonymsCRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-betaCMT4B|CMT4B1
Cytomap

8p11.22

11q21

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit betamyotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatase
Modification date2018051920180519
UniProtAcc

Q99965

Q13614

Ensembl transtripts involved in fusion geneENST00000347580, ENST00000379853, 
ENST00000265708, ENST00000521880, 
ENST00000523181, 
ENST00000393223, 
ENST00000346299, ENST00000409459, 
ENST00000352297, ENST00000484818, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 2=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADAM2 [Title/Abstract] AND MTMR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTMR2

GO:0046856

phosphatidylinositol dephosphorylation

12668758

TgeneMTMR2

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-A4D0-01AADAM2chr8

39603991

-MTMR2chr11

95598840

-
TCGALDLUADTCGA-86-A4D0-01AADAM2chr8

39603991

-MTMR2chr11

95599650

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000347580ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000347580ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000347580ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000347580ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000347580ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000379853ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000379853ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000379853ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000379853ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000379853ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000265708ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000265708ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000265708ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000265708ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000265708ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000521880ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000521880ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000521880ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000521880ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-5UTRENST00000521880ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95598840

-
intron-5UTRENST00000523181ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95598840

-
intron-5UTRENST00000523181ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95598840

-
intron-5UTRENST00000523181ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95598840

-
intron-5UTRENST00000523181ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95598840

-
intron-5UTRENST00000523181ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95598840

-
5CDS-intronENST00000347580ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000347580ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000347580ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000347580ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000347580ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000379853ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000379853ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000379853ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000379853ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000379853ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000265708ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000265708ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000265708ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000265708ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000265708ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000521880ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000521880ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000521880ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000521880ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95599650

-
5CDS-intronENST00000521880ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95599650

-
intron-intronENST00000523181ENST00000393223ADAM2chr8

39603991

-MTMR2chr11

95599650

-
intron-intronENST00000523181ENST00000346299ADAM2chr8

39603991

-MTMR2chr11

95599650

-
intron-intronENST00000523181ENST00000409459ADAM2chr8

39603991

-MTMR2chr11

95599650

-
intron-intronENST00000523181ENST00000352297ADAM2chr8

39603991

-MTMR2chr11

95599650

-
intron-intronENST00000523181ENST00000484818ADAM2chr8

39603991

-MTMR2chr11

95599650

-

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FusionProtFeatures for ADAM2_MTMR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM2

Q99965

MTMR2

Q13614

Sperm surface membrane protein that may be involved insperm-egg plasma membrane adhesion and fusion duringfertilization. Could have a direct role in sperm-zona binding ormigration of sperm from the uterus into the oviduct. Interactionswith egg membrane could be mediated via binding between itsdisintegrin-like domain to one or more integrins receptors on theegg. This is a non catalytic metalloprotease-like protein. Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate.{ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758,ECO:0000269|PubMed:21372139}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAM2_MTMR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAM2_MTMR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAM2CLGN, CRYAB, DNM1, ASPHD2, C6orf120, ADAMTS2, LRRC3, TTN, LCLAT1MTMR2SBF1, MTMR2, ELAVL1, RFC5, SNTA1, HSF1, SZRD1, CTPS2, EHD4, LRSAM1, PLIN3, XPNPEP1, UNK, MTMR11, CCDC22, MTMR1, MTMR10, MTMR12, NFKB1, SBF2, TUBA1B, MTMR9, EYA3, SEPSECS, NUDT16, GADD45GIP1, RPS19BP1, MRTO4, EBNA1BP2, RPL3L, ERBB4, ERBB3, ROR2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAM2_MTMR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAM2_MTMR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMTMR2C1832399Charcot-Marie-Tooth disease, Type 4B11CTD_human;ORPHANET;UNIPROT