![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 705 |
FusionGeneSummary for ADAM2_MTMR2 |
![]() |
Fusion gene information | Fusion gene name: ADAM2_MTMR2 | Fusion gene ID: 705 | Hgene | Tgene | Gene symbol | ADAM2 | MTMR2 | Gene ID | 2515 | 8898 |
Gene name | ADAM metallopeptidase domain 2 | myotubularin related protein 2 | |
Synonyms | CRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-beta | CMT4B|CMT4B1 | |
Cytomap | 8p11.22 | 11q21 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta | myotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q99965 | Q13614 | |
Ensembl transtripts involved in fusion gene | ENST00000347580, ENST00000379853, ENST00000265708, ENST00000521880, ENST00000523181, | ENST00000393223, ENST00000346299, ENST00000409459, ENST00000352297, ENST00000484818, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ADAM2 [Title/Abstract] AND MTMR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MTMR2 | GO:0046856 | phosphatidylinositol dephosphorylation | 12668758 |
Tgene | MTMR2 | GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 16787938 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-86-A4D0-01A | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
TCGA | LD | LUAD | TCGA-86-A4D0-01A | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000347580 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000347580 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000347580 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000347580 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000347580 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000379853 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000379853 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000379853 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000379853 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000379853 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000265708 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000265708 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000265708 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000265708 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000265708 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000521880 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000521880 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000521880 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000521880 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-5UTR | ENST00000521880 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
intron-5UTR | ENST00000523181 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
intron-5UTR | ENST00000523181 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
intron-5UTR | ENST00000523181 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
intron-5UTR | ENST00000523181 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
intron-5UTR | ENST00000523181 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95598840 | - |
5CDS-intron | ENST00000347580 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000347580 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000347580 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000347580 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000347580 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000379853 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000379853 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000379853 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000379853 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000379853 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000265708 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000265708 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000265708 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000265708 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000265708 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000521880 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000521880 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000521880 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000521880 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
5CDS-intron | ENST00000521880 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
intron-intron | ENST00000523181 | ENST00000393223 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
intron-intron | ENST00000523181 | ENST00000346299 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
intron-intron | ENST00000523181 | ENST00000409459 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
intron-intron | ENST00000523181 | ENST00000352297 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
intron-intron | ENST00000523181 | ENST00000484818 | ADAM2 | chr8 | 39603991 | - | MTMR2 | chr11 | 95599650 | - |
Top |
FusionProtFeatures for ADAM2_MTMR2 |
![]() |
Hgene | Tgene |
ADAM2 | MTMR2 |
Sperm surface membrane protein that may be involved insperm-egg plasma membrane adhesion and fusion duringfertilization. Could have a direct role in sperm-zona binding ormigration of sperm from the uterus into the oviduct. Interactionswith egg membrane could be mediated via binding between itsdisintegrin-like domain to one or more integrins receptors on theegg. This is a non catalytic metalloprotease-like protein. | Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol3-phosphate and phosphatidylinositol 3,5-bisphosphate.{ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758,ECO:0000269|PubMed:21372139}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ADAM2_MTMR2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ADAM2_MTMR2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADAM2 | CLGN, CRYAB, DNM1, ASPHD2, C6orf120, ADAMTS2, LRRC3, TTN, LCLAT1 | MTMR2 | SBF1, MTMR2, ELAVL1, RFC5, SNTA1, HSF1, SZRD1, CTPS2, EHD4, LRSAM1, PLIN3, XPNPEP1, UNK, MTMR11, CCDC22, MTMR1, MTMR10, MTMR12, NFKB1, SBF2, TUBA1B, MTMR9, EYA3, SEPSECS, NUDT16, GADD45GIP1, RPS19BP1, MRTO4, EBNA1BP2, RPL3L, ERBB4, ERBB3, ROR2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ADAM2_MTMR2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ADAM2_MTMR2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MTMR2 | C1832399 | Charcot-Marie-Tooth disease, Type 4B1 | 1 | CTD_human;ORPHANET;UNIPROT |