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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7049

FusionGeneSummary for CHERP_RHAG

check button Fusion gene summary
Fusion gene informationFusion gene name: CHERP_RHAG
Fusion gene ID: 7049
HgeneTgene
Gene symbol

CHERP

RHAG

Gene ID

10523

6005

Gene namecalcium homeostasis endoplasmic reticulum proteinRh associated glycoprotein
SynonymsDAN16|SCAF6|SRA1CD241|OHS|OHST|RH2|RH50A|RHNR|Rh50|Rh50GP|SLC42A1
Cytomap

19p13.11

6p12.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium homeostasis endoplasmic reticulum proteinERPROT 213-21ERPROT213-21SR-related CTD associated factor 6protein with polyglutamine repeatammonium transporter Rh type ARh 50 glycoproteinRhesus associated polypeptide, 50-KDRhesus blood group-associated glycoproteinerythrocyte membrane glycoprotein Rh50erythrocyte plasma membrane 50 kDa glycoproteinrh family type A glycoproteinrh type
Modification date2018051920180523
UniProtAcc

Q8IWX8

Q02094

Ensembl transtripts involved in fusion geneENST00000546361, ENST00000198939, 
ENST00000544299, 		ENST00000371175, 
ENST00000229810, 
Fusion gene scores* DoF score5 X 3 X 4=603 X 2 X 3=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHERP [Title/Abstract] AND RHAG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHERP

GO:0006874

cellular calcium ion homeostasis

10794731

HgeneCHERP

GO:0008285

negative regulation of cell proliferation

10794731

TgeneRHAG

GO:0006873

cellular ion homeostasis

15856280

TgeneRHAG

GO:0015670

carbon dioxide transport

16574458|17712059|19273840

TgeneRHAG

GO:0015672

monovalent inorganic cation transport

18931342

TgeneRHAG

GO:0015696

ammonium transport

15856280|15929723|16574458|16866382|17712059|19273840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TM-A7CF-01ACHERPchr19

16652681

-RHAGchr6

49587075

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000546361ENST00000371175CHERPchr19

16652681

-RHAGchr6

49587075

-
Frame-shiftENST00000546361ENST00000229810CHERPchr19

16652681

-RHAGchr6

49587075

-
In-frameENST00000198939ENST00000371175CHERPchr19

16652681

-RHAGchr6

49587075

-
Frame-shiftENST00000198939ENST00000229810CHERPchr19

16652681

-RHAGchr6

49587075

-
intron-3CDSENST00000544299ENST00000371175CHERPchr19

16652681

-RHAGchr6

49587075

-
intron-3CDSENST00000544299ENST00000229810CHERPchr19

16652681

-RHAGchr6

49587075

-

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FusionProtFeatures for CHERP_RHAG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHERP

Q8IWX8

RHAG

Q02094

Involved in calcium homeostasis, growth andproliferation. {ECO:0000269|PubMed:10794731,ECO:0000269|PubMed:12656674}. Associated with rhesus blood group antigen expression(PubMed:19744193). May be part of an oligomeric complex which islikely to have a transport or channel function in the erythrocytemembrane (PubMed:11062476, PubMed:11861637). Involved in ammoniatransport across the erythrocyte membrane (PubMed:21849667,PubMed:22012326). Seems to act in monovalent cation transport(PubMed:18931342, PubMed:21849667). {ECO:0000269|PubMed:11062476,ECO:0000269|PubMed:11861637, ECO:0000269|PubMed:18931342,ECO:0000269|PubMed:19744193, ECO:0000269|PubMed:21849667,ECO:0000269|PubMed:22012326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-21715_5766917RepeatSURP motif
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09101_11352290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09135_14252290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09164_16752290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09189_20852290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09230_23952290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09261_26852290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09292_29552290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09319_33252290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09354_36252290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09384_40952290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-0973_7952290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010101_11352410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010135_14252410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010164_16752410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010189_20852410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010230_23952410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010261_26852410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010292_29552410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010319_33252410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010354_36252410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010384_40952410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-01073_7952410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09114_13452290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09143_16352290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09168_18852290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09209_22952290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09240_26052290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09269_29152290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09296_31852290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09333_35352290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-09363_38352290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-0952_7252290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-0980_10052290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010114_13452410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010143_16352410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010168_18852410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010209_22952410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010240_26052410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010269_29152410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010296_31852410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010333_35352410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-010363_38352410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-01052_7252410TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-01080_10052410TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-217279_34666917Compositional biasGln-rich
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-217355_68266917Compositional biasPro-rich
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-217718_81666917Compositional biasArg-rich
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-217149_28966917DomainCID
HgeneCHERPchr19:16652681chr6:49587075ENST00000546361-217841_89166917DomainG-patch
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-091_252290Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-0924_5152290Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-0101_252410Topological domainCytoplasmic
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-01024_5152410Topological domainExtracellular
TgeneRHAGchr19:16652681chr6:49587075ENST00000229810-093_2352290TransmembraneHelical
TgeneRHAGchr19:16652681chr6:49587075ENST00000371175-0103_2352410TransmembraneHelical


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FusionGeneSequence for CHERP_RHAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CHERP_ENST00000546361_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_424aa
MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQQQLFQDVHVMIFVGFGFLMTFLKKYG
FSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFSAATVLISFGAVLGKTSPTQMLIMTILEIVFFAHNEYLVSEIFKAS
DIGASMTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMFWPSFNSAIAEPGDKQCRAIVNTYFSLAACVLTAFA
FSSLVEHRGKLNMVHIQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTPLFTTKLRIHDTCGVHNLHGLPGVVGGLAGI

>In-frame_CHERP_ENST00000198939_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_424aa
MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKFSFLFGGEFYSYYKCKLALEQQQLFQDVHVMIFVGFGFLMTFLKKYG
FSSVGINLLVAALGLQWGTIVQGILQSQGQKFNIGIKNMINADFSAATVLISFGAVLGKTSPTQMLIMTILEIVFFAHNEYLVSEIFKAS
DIGASMTIHAFGAYFGLAVAGILYRSGLRKGHENEESAYYSDLFAMIGTLFLWMFWPSFNSAIAEPGDKQCRAIVNTYFSLAACVLTAFA
FSSLVEHRGKLNMVHIQNATLAGGVAVGTCADMAIHPFGSMIIGSIAGMVSVLGYKFLTPLFTTKLRIHDTCGVHNLHGLPGVVGGLAGI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CHERP_ENST00000546361_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_1272nt
ATGGAGATGCCGCTGCCCCCCGATGACCAGGAGCTTCGAAATGTCATCGACAAGCTCGCCCAGTTCGTGGCTCGCAATGGGCCCGAGTTT
GAGAAGATGACTATGGAGAAGCAGAAGGACAACCCCAAATTCTCGTTTCTTTTCGGAGGCGAATTCTACAGTTACTACAAGTGCAAGCTG
GCGCTGGAGCAGCAGCAGCTGTTCCAAGATGTACATGTTATGATATTTGTTGGGTTTGGCTTCCTCATGACCTTCCTGAAGAAATATGGC
TTCAGCAGTGTGGGTATCAACCTACTCGTTGCTGCTTTGGGCCTCCAGTGGGGCACTATTGTACAGGGAATCCTGCAAAGCCAGGGACAG
AAATTTAACATTGGAATCAAAAACATGATAAATGCAGACTTCAGTGCAGCCACAGTTCTGATATCTTTTGGAGCTGTCCTGGGAAAAACG
AGCCCCACCCAAATGCTGATCATGACAATTTTAGAAATTGTTTTCTTTGCCCACAATGAATACCTGGTTAGTGAAATATTTAAGGCCTCT
GACATTGGAGCATCAATGACGATCCATGCCTTTGGGGCCTACTTTGGCTTGGCTGTAGCAGGCATCTTGTATCGATCTGGACTGAGAAAG
GGGCATGAAAATGAAGAGTCCGCATACTACTCAGACTTGTTTGCAATGATTGGGACTCTCTTTCTGTGGATGTTTTGGCCCAGCTTTAAC
TCGGCCATTGCTGAACCTGGAGACAAACAGTGCAGGGCCATTGTAAACACGTACTTCTCTCTCGCTGCCTGTGTGCTCACAGCCTTTGCC
TTCTCCAGCCTAGTGGAGCACCGAGGCAAGCTCAACATGGTTCACATTCAGAATGCCACCCTTGCTGGAGGAGTTGCTGTGGGCACTTGT
GCGGATATGGCAATTCACCCATTTGGTTCTATGATTATTGGGAGCATTGCAGGAATGGTCTCTGTGCTTGGATACAAGTTCCTGACTCCA
CTTTTTACTACTAAACTGAGGATCCATGATACATGTGGGGTCCATAACCTCCACGGCTTACCTGGTGTAGTGGGAGGCCTTGCAGGCATT
GTGGCAGTAGCAATGGGCGCCTCCAACACGTCTATGGCCATGCAGGCAGCTGCACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGT
CTGATGACAGGTTTAATTCTAAAGTTGCCTCTCTGGGGACAGCCATCTGACCAGAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCT

>In-frame_CHERP_ENST00000198939_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_1272nt
ATGGAGATGCCGCTGCCCCCCGATGACCAGGAGCTTCGAAATGTCATCGACAAGCTCGCCCAGTTCGTGGCTCGCAATGGGCCCGAGTTT
GAGAAGATGACTATGGAGAAGCAGAAGGACAACCCCAAATTCTCGTTTCTTTTCGGAGGCGAATTCTACAGTTACTACAAGTGCAAGCTG
GCGCTGGAGCAGCAGCAGCTGTTCCAAGATGTACATGTTATGATATTTGTTGGGTTTGGCTTCCTCATGACCTTCCTGAAGAAATATGGC
TTCAGCAGTGTGGGTATCAACCTACTCGTTGCTGCTTTGGGCCTCCAGTGGGGCACTATTGTACAGGGAATCCTGCAAAGCCAGGGACAG
AAATTTAACATTGGAATCAAAAACATGATAAATGCAGACTTCAGTGCAGCCACAGTTCTGATATCTTTTGGAGCTGTCCTGGGAAAAACG
AGCCCCACCCAAATGCTGATCATGACAATTTTAGAAATTGTTTTCTTTGCCCACAATGAATACCTGGTTAGTGAAATATTTAAGGCCTCT
GACATTGGAGCATCAATGACGATCCATGCCTTTGGGGCCTACTTTGGCTTGGCTGTAGCAGGCATCTTGTATCGATCTGGACTGAGAAAG
GGGCATGAAAATGAAGAGTCCGCATACTACTCAGACTTGTTTGCAATGATTGGGACTCTCTTTCTGTGGATGTTTTGGCCCAGCTTTAAC
TCGGCCATTGCTGAACCTGGAGACAAACAGTGCAGGGCCATTGTAAACACGTACTTCTCTCTCGCTGCCTGTGTGCTCACAGCCTTTGCC
TTCTCCAGCCTAGTGGAGCACCGAGGCAAGCTCAACATGGTTCACATTCAGAATGCCACCCTTGCTGGAGGAGTTGCTGTGGGCACTTGT
GCGGATATGGCAATTCACCCATTTGGTTCTATGATTATTGGGAGCATTGCAGGAATGGTCTCTGTGCTTGGATACAAGTTCCTGACTCCA
CTTTTTACTACTAAACTGAGGATCCATGATACATGTGGGGTCCATAACCTCCACGGCTTACCTGGTGTAGTGGGAGGCCTTGCAGGCATT
GTGGCAGTAGCAATGGGCGCCTCCAACACGTCTATGGCCATGCAGGCAGCTGCACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGT
CTGATGACAGGTTTAATTCTAAAGTTGCCTCTCTGGGGACAGCCATCTGACCAGAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CHERP_ENST00000546361_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_2079nt
GGAGTTTCCCAGCGACGGCCGTAAGTGGCGGGCGGAAGCGGCCCTAGAAGCCCGCCGTAAACGGCTCCCTCGCGCCACTTCCGGCCGGCT
TCCGCAGACGGCGCTGGTGGTCGATCGTGTGGCGCCGGAGGACGTTCCCCGCGGCCGGAGCCATGGAGATGCCGCTGCCCCCCGATGACC
AGGAGCTTCGAAATGTCATCGACAAGCTCGCCCAGTTCGTGGCTCGCAATGGGCCCGAGTTTGAGAAGATGACTATGGAGAAGCAGAAGG
ACAACCCCAAATTCTCGTTTCTTTTCGGAGGCGAATTCTACAGTTACTACAAGTGCAAGCTGGCGCTGGAGCAGCAGCAGCTGTTCCAAG
ATGTACATGTTATGATATTTGTTGGGTTTGGCTTCCTCATGACCTTCCTGAAGAAATATGGCTTCAGCAGTGTGGGTATCAACCTACTCG
TTGCTGCTTTGGGCCTCCAGTGGGGCACTATTGTACAGGGAATCCTGCAAAGCCAGGGACAGAAATTTAACATTGGAATCAAAAACATGA
TAAATGCAGACTTCAGTGCAGCCACAGTTCTGATATCTTTTGGAGCTGTCCTGGGAAAAACGAGCCCCACCCAAATGCTGATCATGACAA
TTTTAGAAATTGTTTTCTTTGCCCACAATGAATACCTGGTTAGTGAAATATTTAAGGCCTCTGACATTGGAGCATCAATGACGATCCATG
CCTTTGGGGCCTACTTTGGCTTGGCTGTAGCAGGCATCTTGTATCGATCTGGACTGAGAAAGGGGCATGAAAATGAAGAGTCCGCATACT
ACTCAGACTTGTTTGCAATGATTGGGACTCTCTTTCTGTGGATGTTTTGGCCCAGCTTTAACTCGGCCATTGCTGAACCTGGAGACAAAC
AGTGCAGGGCCATTGTAAACACGTACTTCTCTCTCGCTGCCTGTGTGCTCACAGCCTTTGCCTTCTCCAGCCTAGTGGAGCACCGAGGCA
AGCTCAACATGGTTCACATTCAGAATGCCACCCTTGCTGGAGGAGTTGCTGTGGGCACTTGTGCGGATATGGCAATTCACCCATTTGGTT
CTATGATTATTGGGAGCATTGCAGGAATGGTCTCTGTGCTTGGATACAAGTTCCTGACTCCACTTTTTACTACTAAACTGAGGATCCATG
ATACATGTGGGGTCCATAACCTCCACGGCTTACCTGGTGTAGTGGGAGGCCTTGCAGGCATTGTGGCAGTAGCAATGGGCGCCTCCAACA
CGTCTATGGCCATGCAGGCAGCTGCACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGTCTGATGACAGGTTTAATTCTAAAGTTGC
CTCTCTGGGGACAGCCATCTGACCAGAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCTAAGACGAGATAACTTGACAATCAGTTCC
ATGGACATGGTGACCACAGCCAGCTGGAACCTGAAGTCTAAACACCATTCCTGCTCTCCAGCTTCCTTTCCCATTATCCAGAATCAAGTC
CAAATAAACAAAAAGGGAGTAACCAAAGAGAGTATGGACCAGAGTGAATAGATCCTAAGTCCCAAATGGCCAGTGTAAAAATGTCCTTAT
GTCTGATGCTGTCTCTTGCTCTTCAATGATTAATTGAGGGGATGTTACTCATAAAACAGATAATCAAATAGATCTTCTCCAGGATTCCCA
AAAAGCTTTTGGCAGTGAGTAAATACAGAGTAAACATGTCAGTTTCTTAATGTAGACACTATGTCTTCAATCCCAAAAATTATAAAACTG
AAACCCATGAAGCAAGAATAGATGTGAGAAATCTATGTAAAAAAATAATTAAAGAAATGCATGTGTGTAAAGTAGTAATATGATGATTTT
AGGTAGTGCTTTTTATTTTAAAAATAGTCTAGTTAGTAATGTTGTATCCTTGCATGAATATTATTCTTAATTCCTTTTGCATGTTGACTA
TTTGCAACGAGCTCAAATGCTATCTGATCAAAGTCTATTTTGCATAAAATGTCCAATAATTAAATATTGTTATAAAATAAAACATCAGTC

>In-frame_CHERP_ENST00000198939_chr19_16652681_-_RHAG_ENST00000371175_chr6_49587075_-_1964nt
CGTGTGGCGCCGGAGGACGTTCCCCGCGGCCGGAGCCATGGAGATGCCGCTGCCCCCCGATGACCAGGAGCTTCGAAATGTCATCGACAA
GCTCGCCCAGTTCGTGGCTCGCAATGGGCCCGAGTTTGAGAAGATGACTATGGAGAAGCAGAAGGACAACCCCAAATTCTCGTTTCTTTT
CGGAGGCGAATTCTACAGTTACTACAAGTGCAAGCTGGCGCTGGAGCAGCAGCAGCTGTTCCAAGATGTACATGTTATGATATTTGTTGG
GTTTGGCTTCCTCATGACCTTCCTGAAGAAATATGGCTTCAGCAGTGTGGGTATCAACCTACTCGTTGCTGCTTTGGGCCTCCAGTGGGG
CACTATTGTACAGGGAATCCTGCAAAGCCAGGGACAGAAATTTAACATTGGAATCAAAAACATGATAAATGCAGACTTCAGTGCAGCCAC
AGTTCTGATATCTTTTGGAGCTGTCCTGGGAAAAACGAGCCCCACCCAAATGCTGATCATGACAATTTTAGAAATTGTTTTCTTTGCCCA
CAATGAATACCTGGTTAGTGAAATATTTAAGGCCTCTGACATTGGAGCATCAATGACGATCCATGCCTTTGGGGCCTACTTTGGCTTGGC
TGTAGCAGGCATCTTGTATCGATCTGGACTGAGAAAGGGGCATGAAAATGAAGAGTCCGCATACTACTCAGACTTGTTTGCAATGATTGG
GACTCTCTTTCTGTGGATGTTTTGGCCCAGCTTTAACTCGGCCATTGCTGAACCTGGAGACAAACAGTGCAGGGCCATTGTAAACACGTA
CTTCTCTCTCGCTGCCTGTGTGCTCACAGCCTTTGCCTTCTCCAGCCTAGTGGAGCACCGAGGCAAGCTCAACATGGTTCACATTCAGAA
TGCCACCCTTGCTGGAGGAGTTGCTGTGGGCACTTGTGCGGATATGGCAATTCACCCATTTGGTTCTATGATTATTGGGAGCATTGCAGG
AATGGTCTCTGTGCTTGGATACAAGTTCCTGACTCCACTTTTTACTACTAAACTGAGGATCCATGATACATGTGGGGTCCATAACCTCCA
CGGCTTACCTGGTGTAGTGGGAGGCCTTGCAGGCATTGTGGCAGTAGCAATGGGCGCCTCCAACACGTCTATGGCCATGCAGGCAGCTGC
ACTGGGTTCCTCTATCGGAACAGCAGTTGTTGGAGGTCTGATGACAGGTTTAATTCTAAAGTTGCCTCTCTGGGGACAGCCATCTGACCA
GAACTGCTATGATGATTCTGTTTATTGGAAGGTCCCTAAGACGAGATAACTTGACAATCAGTTCCATGGACATGGTGACCACAGCCAGCT
GGAACCTGAAGTCTAAACACCATTCCTGCTCTCCAGCTTCCTTTCCCATTATCCAGAATCAAGTCCAAATAAACAAAAAGGGAGTAACCA
AAGAGAGTATGGACCAGAGTGAATAGATCCTAAGTCCCAAATGGCCAGTGTAAAAATGTCCTTATGTCTGATGCTGTCTCTTGCTCTTCA
ATGATTAATTGAGGGGATGTTACTCATAAAACAGATAATCAAATAGATCTTCTCCAGGATTCCCAAAAAGCTTTTGGCAGTGAGTAAATA
CAGAGTAAACATGTCAGTTTCTTAATGTAGACACTATGTCTTCAATCCCAAAAATTATAAAACTGAAACCCATGAAGCAAGAATAGATGT
GAGAAATCTATGTAAAAAAATAATTAAAGAAATGCATGTGTGTAAAGTAGTAATATGATGATTTTAGGTAGTGCTTTTTATTTTAAAAAT
AGTCTAGTTAGTAATGTTGTATCCTTGCATGAATATTATTCTTAATTCCTTTTGCATGTTGACTATTTGCAACGAGCTCAAATGCTATCT


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FusionGenePPI for CHERP_RHAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHERPSF3A2, SIRT7, PDE6A, ZNF827, PFAS, SNRNP70, PRPF40A, SF3B4, U2AF2, U2AF1, CCAR1, RBM23, RBM39, SART1, PRPF38A, SNIP1, DHX8, RNPS1, FRA10AC1, RBM7, ARGLU1, AGGF1, PPIL4, SNRNP27, HNRNPH3, TTC14, GNB2L1, LUC7L, EWSR1, SRPK2, SRPK1, WBP4, APBB1, RPA3, RPA2, RPA1, OBSL1, BMI1, RPS2, RPSA, RPS8, WDFY2, ZRSR2, NTRK1, U2SURP, SCARNA22, HIST1H3E, CD44, MYO1C, XRCC3, TRIM26, EMC2, ZMYND8, USP37, SNW1, CDC5L, NANOG, RBM17, PLOD1, SNRPE, FGFR2, JMJD6, HIST1H1T, FGF8, CYLD, TRIM25, UHRF2RHAGANK1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHERP_RHAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHERP_RHAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRHAGC1849387Rh-Null, Regulator Type4CTD_human;UNIPROT
TgeneRHAGC1861455STOMATOCYTOSIS I3ORPHANET;UNIPROT