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Fusion gene ID: 704 |
FusionGeneSummary for ADAM29_PEG10 |
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Fusion gene information | Fusion gene name: ADAM29_PEG10 | Fusion gene ID: 704 | Hgene | Tgene | Gene symbol | ADAM29 | PEG10 | Gene ID | 11086 | 23089 |
Gene name | ADAM metallopeptidase domain 29 | paternally expressed 10 | |
Synonyms | CT73|svph1 | EDR|HB-1|MEF3L|Mar2|Mart2|RGAG3|RTL2|SIRH1 | |
Cytomap | 4q34.1 | 7q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 29a disintegrin and metalloproteinase domain 29cancer/testis antigen 73metallaproteinase-disintegrin (ADAM29)testis secretory sperm-binding protein Li 207a | retrotransposon-derived protein PEG10MEF3 like 1Sushi-Ichi retrotransposon homolog 1embryonal carcinoma differentiation regulatedmammalian retrotransposon-derived 2mammalian retrotransposon-derived protein 2myelin expression factor 3-like protein 1 | |
Modification date | 20180329 | 20180519 | |
UniProtAcc | Q9UKF5 | Q86TG7 | |
Ensembl transtripts involved in fusion gene | ENST00000507652, ENST00000359240, ENST00000445694, ENST00000404450, ENST00000514159, | ENST00000482108, ENST00000488574, ENST00000465184, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 10 X 1=70 |
# samples | 1 | 12 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/70*10)=0.777607578663552 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ADAM29 [Title/Abstract] AND PEG10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PEG10 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 15611116 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF171931 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000507652 | ENST00000482108 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
intron-intron | ENST00000507652 | ENST00000488574 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
intron-intron | ENST00000507652 | ENST00000465184 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-3UTR | ENST00000359240 | ENST00000482108 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000359240 | ENST00000488574 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000359240 | ENST00000465184 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-3UTR | ENST00000445694 | ENST00000482108 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000445694 | ENST00000488574 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000445694 | ENST00000465184 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-3UTR | ENST00000404450 | ENST00000482108 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000404450 | ENST00000488574 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000404450 | ENST00000465184 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-3UTR | ENST00000514159 | ENST00000482108 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000514159 | ENST00000488574 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
5CDS-intron | ENST00000514159 | ENST00000465184 | ADAM29 | chr4 | 175898962 | + | PEG10 | chr7 | 94295024 | + |
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FusionProtFeatures for ADAM29_PEG10 |
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Hgene | Tgene |
ADAM29 | PEG10 |
May be involved in spermatogenesis and fertilization.Seems to be a non catalytic metalloprotease-like protein. | Prevents apoptosis in hepatocellular carcinoma (HCC)cells through interaction with SIAH1, a mediator of apoptosis. Mayalso have a role in cell growth promotion and hepatoma formation.Inhibits the TGF-beta signaling by interacting with the TGF-betareceptor ALK1. When overexpressed, induces the formation ofcellular extension, such as filipodia in association with ALK1.Involved at the immediate early stage of adipocyte differentiation(By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence ofthe MB1 domain in the myelin basic protein (MBP) promoter (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12810624,ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995,ECO:0000269|PubMed:17369855}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAM29_PEG10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAM29_PEG10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAM29_PEG10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAM29_PEG10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |