FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7036

FusionGeneSummary for CHD9_KSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD9_KSR1
Fusion gene ID: 7036
HgeneTgene
Gene symbol

CHD9

KSR1

Gene ID

80205

8844

Gene namechromodomain helicase DNA binding protein 9kinase suppressor of ras 1
SynonymsAD013|CHD-9|CReMM|KISH2|PRIC320KSR|RSU2
Cytomap

16q12.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 9ATP-dependent helicase CHD9PPAR-alpha-interacting complex protein 320 kDaPPAR{gamma}-interacting cofactor 320 kDachromatin remodeling factor CHROM1chromatin-related mesenchymal modulatorciprofibrate bound pkinase suppressor of Ras 1
Modification date2018051920180523
UniProtAcc

Q3L8U1

Q8IVT5

Ensembl transtripts involved in fusion geneENST00000447540, ENST00000566029, 
ENST00000564845, ENST00000398510, 
ENST00000564582, 		ENST00000509603, 
ENST00000319524, ENST00000268763, 
ENST00000398988, ENST00000581975, 
ENST00000582410, ENST00000578981, 
Fusion gene scores* DoF score8 X 5 X 5=20010 X 7 X 5=350
# samples 89
** MAII scorelog2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/350*10)=-1.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD9 [Title/Abstract] AND KSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A081-01ACHD9chr16

53088989

+KSR1chr17

25877594

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000447540ENST00000509603CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-3CDSENST00000447540ENST00000319524CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-5UTRENST00000447540ENST00000268763CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-5UTRENST00000447540ENST00000398988CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000447540ENST00000581975CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000447540ENST00000582410CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000447540ENST00000578981CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-3CDSENST00000566029ENST00000509603CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-3CDSENST00000566029ENST00000319524CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-5UTRENST00000566029ENST00000268763CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-5UTRENST00000566029ENST00000398988CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000566029ENST00000581975CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000566029ENST00000582410CHD9chr16

53088989

+KSR1chr17

25877594

+
5UTR-intronENST00000566029ENST00000578981CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000564845ENST00000509603CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000564845ENST00000319524CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000564845ENST00000268763CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000564845ENST00000398988CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564845ENST00000581975CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564845ENST00000582410CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564845ENST00000578981CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000398510ENST00000509603CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000398510ENST00000319524CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000398510ENST00000268763CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000398510ENST00000398988CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000398510ENST00000581975CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000398510ENST00000582410CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000398510ENST00000578981CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000564582ENST00000509603CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-3CDSENST00000564582ENST00000319524CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000564582ENST00000268763CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-5UTRENST00000564582ENST00000398988CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564582ENST00000581975CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564582ENST00000582410CHD9chr16

53088989

+KSR1chr17

25877594

+
intron-intronENST00000564582ENST00000578981CHD9chr16

53088989

+KSR1chr17

25877594

+

Top

FusionProtFeatures for CHD9_KSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD9

Q3L8U1

KSR1

Q8IVT5

Acts as a transcriptional coactivator for PPARA andpossibly other nuclear receptors. Proposed to be a ATP-dependentchromatin remodeling protein. Has DNA-dependent ATPase activityand binds to A/T-rich DNA. Associates with A/T-rich regulatoryregions in promoters of genes that participate in thedifferentiation of progenitors during osteogenesis (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:16095617,ECO:0000269|PubMed:16554032}. Scaffolding protein that is part of a multiproteinsignaling complex. Promotes phosphorylation of Raf family membersand activation of downstream MAP kinases. Promotes activation ofMAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does nothave kinase activity by itself. {ECO:0000250|UniProtKB:Q61097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CHD9_KSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CHD9_KSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHD9ESR1, NR1I3, PPARA, RXRA, SOX2, FGG, PRICKLE3, MYC, PRKCD, EDEM1, VPS26B, C10orf2, C11orf30, PHF12, EPB41L5, PIP4K2A, NKAP, MDK, CAMKV, BRCA1KSR1MAP2K1, BRAF, BRAP, KSR1, MARK3, RAF1, LSP1, HSP90AA1, YWHAE, YWHAB, SDF4, SKAP1, PRMT2, XPO1, VPRBP, NF2, PJA2, KCTD3, KIF13B, ZBTB21, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, DENND4C, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LPIN3, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, MAPKAP1, NF1, HDAC4, CBY1, SH3RF3, SRSF12, CDC25C, SYDE1, AGAP1, NADK, GIGYF2, CDC25B, CDK16, TANC2, CAMSAP2, PTPN13, RALGPS2, FAM110B, USP21, KIAA1804, RASAL2, TIAM1, ANKRD34A, FAM53C, PHLDB2, RPTOR, PLEKHA7, OSBPL6, KIF1C, MELK, NAV1, DENND4A, FAM110A, GAB2, STARD13, PTPN14, DEPDC1B, HDAC7, CWC25, INPP5E, LARP1, RAB11FIP2, PLEKHA5, MTFR1L, MLLT4, CHEK1, KIF1B, CSNK1A1, TBC1D25, EDC3, HDAC5, TBC1D1, DACT3, PANK2, REEP3, CRTC2, CRTC3, MICALL1, SH3BP4, BAIAP2, FGD6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CHD9_KSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CHD9_KSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource