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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7034

FusionGeneSummary for CHD9_DLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD9_DLC1
Fusion gene ID: 7034
HgeneTgene
Gene symbol

CHD9

DLC1

Gene ID

80205

10395

Gene namechromodomain helicase DNA binding protein 9DLC1 Rho GTPase activating protein
SynonymsAD013|CHD-9|CReMM|KISH2|PRIC320ARHGAP7|HP|STARD12|p122-RhoGAP
Cytomap

16q12.2

8p22

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 9ATP-dependent helicase CHD9PPAR-alpha-interacting complex protein 320 kDaPPAR{gamma}-interacting cofactor 320 kDachromatin remodeling factor CHROM1chromatin-related mesenchymal modulatorciprofibrate bound prho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia
Modification date2018051920180519
UniProtAcc

Q3L8U1

Q96QB1

Ensembl transtripts involved in fusion geneENST00000447540, ENST00000566029, 
ENST00000564845, ENST00000398510, 
ENST00000564582, 		ENST00000276297, 
ENST00000358919, ENST00000512044, 
ENST00000316609, ENST00000511869, 
ENST00000510318, ENST00000520226, 
Fusion gene scores* DoF score8 X 5 X 5=2008 X 7 X 4=224
# samples 88
** MAII scorelog2(8/200*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD9 [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDLC1

GO:0006915

apoptotic process

17292327

TgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

TgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

TgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

TgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

TgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

TgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

TgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AN-01ACHD9chr16

53308214

+DLC1chr8

13162811

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000447540ENST00000276297CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000358919CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000512044CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000316609CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000511869CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000510318CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000447540ENST00000520226CHD9chr16

53308214

+DLC1chr8

13162811

-
Frame-shitENST00000566029ENST00000276297CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000358919CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000512044CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000316609CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000511869CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000510318CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000566029ENST00000520226CHD9chr16

53308214

+DLC1chr8

13162811

-
Frame-shitENST00000564845ENST00000276297CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000358919CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000512044CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000316609CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000511869CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000510318CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000564845ENST00000520226CHD9chr16

53308214

+DLC1chr8

13162811

-
Frame-shitENST00000398510ENST00000276297CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000358919CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000512044CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000316609CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000511869CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000510318CHD9chr16

53308214

+DLC1chr8

13162811

-
5CDS-intronENST00000398510ENST00000520226CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-3CDSENST00000564582ENST00000276297CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000358919CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000512044CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000316609CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000511869CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000510318CHD9chr16

53308214

+DLC1chr8

13162811

-
intron-intronENST00000564582ENST00000520226CHD9chr16

53308214

+DLC1chr8

13162811

-

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FusionProtFeatures for CHD9_DLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD9

Q3L8U1

DLC1

Q96QB1

Acts as a transcriptional coactivator for PPARA andpossibly other nuclear receptors. Proposed to be a ATP-dependentchromatin remodeling protein. Has DNA-dependent ATPase activityand binds to A/T-rich DNA. Associates with A/T-rich regulatoryregions in promoters of genes that participate in thedifferentiation of progenitors during osteogenesis (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:16095617,ECO:0000269|PubMed:16554032}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHD9_DLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHD9_DLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHD9ESR1, NR1I3, PPARA, RXRA, SOX2, FGG, PRICKLE3, MYC, PRKCD, EDEM1, VPS26B, C10orf2, C11orf30, PHF12, EPB41L5, PIP4K2A, NKAP, MDK, CAMKV, BRCA1DLC1WWC1, S100A10, TENC1, CAV1, CUL1, CUL2, CUL3, CUL4A, DDB1, FBXW5, AKT1, RPS6KA1, WWC2, WWC3, FBXW7, LACC1, FEM1B, C17orf75, PTEN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHD9_DLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHD9_DLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLC1C0038356Stomach Neoplasms1CTD_human;HPO
TgeneDLC1C0919267ovarian neoplasm1CTD_human