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Fusion gene ID: 7003 |
FusionGeneSummary for CHD6_MYH7B |
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Fusion gene information | Fusion gene name: CHD6_MYH7B | Fusion gene ID: 7003 | Hgene | Tgene | Gene symbol | CHD6 | MYH7B | Gene ID | 84181 | 57644 |
Gene name | chromodomain helicase DNA binding protein 6 | myosin heavy chain 7B | |
Synonyms | CHD-6|CHD5|RIGB | MHC14|MYH14 | |
Cytomap | 20q12 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | myosin-7BU937-associated antigenantigen MLAA-21myosin heavy chain 7B, cardiac muscle beta isoformmyosin, heavy chain 7B, cardiac muscle, betamyosin, heavy polypeptide 7B, cardiac muscle, betaslow A MYH14 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TD26 | A7E2Y1 | |
Ensembl transtripts involved in fusion gene | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | ENST00000262873, ENST00000481922, | |
Fusion gene scores | * DoF score | 22 X 14 X 10=3080 | 2 X 2 X 2=8 |
# samples | 25 | 2 | |
** MAII score | log2(25/3080*10)=-3.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CHD6 [Title/Abstract] AND MYH7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-AB2Q-01A | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000373233 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
5CDS-intron | ENST00000373233 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
Frame-shift | ENST00000309279 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
5CDS-intron | ENST00000309279 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
intron-3CDS | ENST00000373222 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
intron-intron | ENST00000373222 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
intron-3CDS | ENST00000480022 | ENST00000262873 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
intron-intron | ENST00000480022 | ENST00000481922 | CHD6 | chr20 | 40068640 | - | MYH7B | chr20 | 33583139 | + |
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FusionProtFeatures for CHD6_MYH7B |
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Hgene | Tgene |
CHD6 | MYH7B |
Involved in muscle contraction.{ECO:0000269|PubMed:11919279}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHD6_MYH7B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHD6_MYH7B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CHD6 | AIRE, ARAF, TOLLIP, CHD3, ATXN1L, ZFYVE9, SOX2, HIST3H3, HIST1H2BG, SEC16A, RACGAP1, PAPD5, CDCA5, ESR1, EGFR | MYH7B | SP1, SMYD1, ACO2, ACTN4, ALDOA, ALDOC, CKB, GPD1L, CYC1, TPM1, TPM3, TPM4, TENC1, CACNA2D1, KPNA4, RBBP5, SEC62, FXR1, BCLAF1, PDCD6, SRRM1, NCBP2, MRPS27, TRPC4AP, COPS7B, POLDIP3, PGAM5, LRRCC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHD6_MYH7B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHD6_MYH7B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHD6 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | CHD6 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | CHD6 | C0027819 | Neuroblastoma | 1 | CTD_human |